ライフサイエンスコーパス: degradative

1 . reveal a heterogeneity in lysosomal pH and degradative ability that correlates with lysosome subcel

2 numerous small LDs within the cytoplasm and degradative acidic vesicles.

3 of cell types and their unique mechanisms of degradative action provide evidence that they are involv

4 rgets, providing a binding platform for mRNA degradative activities.

5 y shows that PIKfyve modulation of lysosomal degradative activity and protein expression is essential

6 ing a Glu157-to-Gln mutation lost its cortex degradative activity completely.

7 The degradative activity of extracts immunoprecipitated with

8 ess may promote malignant phenotypes and the degradative activity of invadopodia, our findings show t

9 Atg16L1, but not induction of autophagy, the degradative activity of lysosomal proteases, fusion of a

10 Another important defense mechanism is the degradative activity of macroautophagy (herein autophagy

11 Further analysis demonstrated that the degradative activity of the lysosome created by protease

12 c C-terminal domain (SleB(C)) exhibited high degradative activity on cortex PG in vitro, although Sle

13 The resulting increase in the proteasome's degradative activity was recently shown to be mediated b

14 function mechanically, independent of their degradative activity, and cells do not form fully mature

15 The matrix degradative activity, but not the assembly, of the focal

16 (YpeB(N) and YpeB(C)) alone did not exhibit degradative activity, but YpeB(N) inhibited SleB(M) and

17 ation to control invadopodium maturation and degradative activity.

18 conserved active site residues abolished its degradative activity.

19 Degradative amino acid decarboxylation pathways in bacte

20 Lysosomes and the yeast vacuole are degradative and acidic organelles.

21 Altogether, these results suggest that the degradative and cytotoxic activities exhibited by StmPr1

22 entified seven lysines that were attached to degradative and non-degradative forms of polyubiquitin.

23 iquitin ligase complexes and triaged between degradative and nondegradative fates.

24 ding of lysosomes; once thought to be simple degradative and recycling centers, lysosomes are now kno

25 ions between retromer and ESCRT that balance degradative and recycling functions.

26 r tension combined with diffusion of general degradative and regenerative particles associated with d

27 ness to adjust the production and release of degradative and regenerative particles.

28 s by promoting local inflammatory and tissue degradative and remodeling events.

29 n level, B7-H1 molecules were stored in both degradative and unconventional secretory lysosomes.

30 dation but instead promote the generation of degradative autolysosomes, which are the endpoint compar

31 RE complexes implicated in secretory but not degradative autophagy and occur with significantly faste

32 intracellular survival by inducing the bulk degradative autophagy pathway in host cells.

33 In contrast, pharmacologic modulation of the degradative autophagy pathway or genetic deletion of oth

34 How secretory autophagy diverges from degradative autophagy remains unclear.

35 Recent research has shown that degradative autophagy, as well as various combinations o

36 phagy genes, but not all genes essential for degradative autophagy, have a key function in maintainin

37 range substrate exploration, associated with degradative behavior.

38 iosynthesis is based in part on co-option of degradative biochemical pathways.

39 This points to a degradative but not synthetic phenotype.

40 nads, a group of bacteria well-known for its degradative capabilities and oligotrophic metabolism.

41 llilysin and Tp0750 host protein binding and degradative capability is positively correlated with tre

42 ass of enzymes associated with extracellular degradative capacities, and cwr-2 encodes a predicted tr

43 educed ability to regulate lysosome size and degradative capacity in response to activation of this m

44 When the intracellular degradative capacity is exceeded, juxtanuclear aggresome

45 In Firmicutes, degradative capacity is largely restricted to the cell s

46 pport this practical method of enhancing the degradative capacity of macrophages as a therapy for ath

47 in Cln3(Deltaex1) (-) (6) RPE have a reduced degradative capacity that impairs the final steps of the

48 Matrix degradative capacity, three-dimensional migration throug

49 from Munc13-4-KO neutrophils show decreased degradative capacity.

50 h undigested membranes, indicating a reduced degradative capacity.

51 grated dual function that increases neuronal degradative capacity.

52 Macroautophagy (hereafter autophagy) is a degradative cellular pathway that protects eukaryotic ce

53 t some fundamental roles played by these non-degradative chains in neuronal function and plasticity.

54 nd then change physical properties through a degradative, charge-neutralizing intramolecular rearrang

55 whereas SSTR-2 and -3 directed virions to a degradative compartment in which cytosol penetration was

56 l by entrapping and delivering microbes to a degradative compartment.

57 phagosomes, which transport the cargo to the degradative compartments (vacuoles or lysosomes).

58 While lysosomes are degradative compartments and one of the defenses against

59 somes and basal phagolysosomes, the terminal degradative compartments of autophagy and phagocytosis,

60 of autophagosomes into acidic and ultimately degradative compartments to promote their replication.

61 and recycling and influence the delivery to degradative compartments.

62 for acidification once endosomes mature into degradative compartments.

63 event that targets the channel to lysosomal-degradative compartments.

64 MT1-MMP/MMP14), the main invadopodial matrix degradative component.

65 levels of MFalpha transcripts in a synthetic/degradative cycle, providing a mechanism of mRNA inducti

66 This degradative effect cannot be emulated by iron or free pr

67 tilage, demonstrating the specificity of the degradative effect of E2.

68 musical training provides resilience to the degradative effects of reverberation on subcortical repr

69 s (lipopolysaccharides and lipoproteins) and degradative effects of secreted bacterial proteases.

70 s via a caveolae-mediated pathway, bypassing degradative endolysosomal trafficking.

71 traffic to a nonrecycling, calpain-dependent degradative endosomal route.

72 STM1, which serves to protect CLC-7 from the degradative environment of the lysosomal lumen.

73 , dissolved organic matter concentrations or degradative enzyme activities among treatments.

74 nd miR-20a-5p mimics significantly decreased degradative enzyme activity levels while also decreasing

75 bacterial pathogen by functioning as both a degradative enzyme and an RNA maturase.

76 onoacylglycerol lipase (MAGL), the principal degradative enzyme for the endocannabinoid 2-arachidonoy

77 onoacylglycerol lipase (MAGL), the principal degradative enzyme for the endocannabinoid 2-arachidonoy

78 mutations disrupt the maturation of a major degradative enzyme in lysosome contributing to neuropath

79 of monoacylglycerol lipase (MAGL), the major degradative enzyme of the endocannabinoid 2-arachidonoyl

80 ting AEA signaling through inhibition of its degradative enzyme, fatty acid amide hydrolase (FAAH), r

81 anced due to the increased expression of its degradative enzyme, monoacylglycerol lipase.

82 HSA and carboxyl ester lipase (CEL), a PAHSA degradative enzyme, selectively hydrolyzing S-9-PAHSA.

83 well as the regulation of the production of degradative enzymes and antibiotic synthesis.

84 induce aberrant expression of catabolic and degradative enzymes and inflammatory cytokines in OA and

85 and characterization of such lignocellulose degradative enzymes could be fast-tracked by availabilit

86 Use of blocking Abs and degradative enzymes demonstrated that CXCL8-stimulated f

87 re needed for maximal activity of the 1,2-PD degradative enzymes encased within the MCP shell.

88 Mining of genome data for cellulose degradative enzymes followed by experimental verificatio

89 Peptidoglycan degradative enzymes have important roles at many stages

90 e S1P precursor, sphingosine kinase, and the degradative enzymes S1P lyase and S1PP phosphatase are n

91 Pathogenic bacteria secrete toxins and degradative enzymes that facilitate their growth by libe

92 road range of proteins, including toxins and degradative enzymes that play important roles in the pat

93 benefit nonpathogenic species by delivering degradative enzymes to defend an ecological niche agains

94 es the endocannabinoids, their synthetic and degradative enzymes, and cannabinoid (CB) receptors.

95 topentaose, which can now be acted on by the degradative enzymes, and one molecule of glucose that ca

96 ins, encompassing a diverse array of toxins, degradative enzymes, and other effectors, including nove

97 onoylglycerol (2-AG), their biosynthetic and degradative enzymes, and the cannabinoid (CB) receptors

98 2S system include both virulence factors and degradative enzymes, this secretion system is considered

99 hemical machinery (precursors, synthetic and degradative enzymes, transporters).

100 ation facilitates the optimal functioning of degradative enzymes, ultimately contributing to bacteria

101 ns, transporter solute-binding proteins, and degradative enzymes.

102 e resulting in the production and release of degradative enzymes.

103 cts the limiting membrane from the action of degradative enzymes.

104 is tightly regulated by eCB biosynthetic and degradative enzymes.

105 ("endocannabinoids") is tightly regulated by degradative enzymes.

106 pili (TFP), and multiple secreted toxins and degradative enzymes.

107 and inhibitors of individual endocannabinoid degradative enzymes.

108 rded as to a source of membranes and luminal degradative enzymes.

109 d immune activation and production of tissue degradative enzymes.

110 FLASH utilizes non-degradative epitope recovery and membrane solubilization

111 the endoribonuclease SMG6 is often the first degradative event in non-sense-mediated mRNA decay (NMD)

112 rafficking pathways, including endolysosomal degradative events such as epidermal growth factor recep

113 e typically relegated to tissue-invasive or -degradative events.

114 The amount of RNase R, an important degradative exoribonuclease, increases 3-10-fold under a

115 ating protein quality control systems in the degradative fate of mutant tumor suppressor proteins.

116 hromosome is unknown because of the powerful degradative forces that act to decay the nonrecombining

117 es that were attached to degradative and non-degradative forms of polyubiquitin.

118 This defect impaired lysosomal degradative function causing accumulation of undegraded

119 IF4AI, and eIF4AII, suggesting that its mRNA degradative function is somehow linked to translation.

120 ction correlates directly with a loss in the degradative function of the lysosome.

121 exhibit impaired lysosomal acidification and degradative function, as well as increased cytotoxicity.

122 somal compartments and impairs the lysosomal degradative function.

123 nsport while FcRn is expressed but switch to degradative functions after weaning, when the jejunum do

124 f the vacuolar ATPase required for lysosomal degradative functions and autophagy, a pathway frequentl

125 f the vacuolar ATPase required for lysosomal degradative functions and autophagy.

126 Together, these combined synthetic and degradative functions ensure correct selection, extensio

127 ential regulator of lysosomal biogenesis and degradative functions in macrophages.

128 BORC-dependent centrifugal transport for non-degradative functions of lysosomes.

129 , whose actions converge on the dynamics and degradative functions of podosome rosettes.

130 Proper membrane trafficking and degradative functions of the endolysosomal system are kn

131 s apparently carrying out autophagy-mediated degradative functions, but where autophagy inhibition do

132 the increase was attributed to a decrease in degradative H2AX Lys48-linked polyubiquitination with a

133 strates, enzymes performing biosynthetic and degradative halogenation chemistry utilize numerous mech

134 of as the biosynthetic (i.e., anabolic) and degradative (i.e., catabolic) branches of the endomembra

135 substrate of APC(CDH1) and was modified with degradative K11-linked polyubiquitin.

136 This leads to the degradative K48 ubiquitination of TBK1 via its K372 resi

137 ate endosomes unable to progress into mature degradative late endosomes and lysosomes.

138 We anticipate the non-degradative, long-term nature of both RF read-out and ph

139 t feature of this approach is that it allows degradative losses of contaminants to be distinguished f

140 presumably destabilizes c-MYC by supporting degradative lysine 48-linked polyubiquitination.

141 tion and melanosome biogenesis away from the degradative lysosomal pathway toward early stage melanos

142 nto the host cells and subsequent evasion of degradative lysosomes, it was impaired in the ability to

143 y autophagosomes that subsequently fuse with degradative lysosomes.

144 lular and nuclear uptake, bypassing cellular degradative machinery, and improving gene expression in

145 osomal recycling can be coordinated with the degradative machinery.

146 E3 ligase, PJA2, ubiquitinates Tat in a non-degradative manner and specifically regulates the step o

147 ynamic pathway that functions primarily in a degradative manner.

148 Often regarded as a mere degradative mechanism in destruction of proteins or turn

149 Autophagy is a bulk degradative mechanism that serves to augment energy prod

150 attractive therapeutic target to counteract degradative mechanisms associated with OA.

151 emediation and the exploitation of bacterial degradative mechanisms of plastic.

152 S) and autophagy are two major intracellular degradative mechanisms that mediate the turnover of comp

153 cribes the contributions of biosynthetic and degradative mechanisms to r-protein abundance and proteo

154 relative contributions of translational and degradative mechanisms to the control of r-protein abund

155 stress through translational suppression and degradative mechanisms using the proteasome and autophag

156 es in p62 and NBR1 often suggest compromised degradative mechanisms, we found normal ubiquitin-protea

157 n followed by reductive cleavage, a chemical degradative method that cleaves beta-ether bonds in lign

158 vatization followed by reductive cleavage, a degradative method that cleaves beta-ether bonds, indica

159 Expression of inflammatory and degradative molecules was lower in chondrocytes from des

160 , the mucosal route can be utilized, however degradative mucosal barriers must be overcome.

161 Snc1 to quality control via sorting into the degradative multivesicular endosome pathway.

162 In spite of the degradative nature of the pathway, some pathogens are ab

163 ells to establish a framework for predicting degradative or non-degradative outcomes of ubiquitylatio

164 that specific chaperones exhibit either pro-degradative or pro-folding activities.

165 oning the messengers' relevant biosynthetic, degradative, or target proteins, at all times seeking po

166 A build-up of degradative organellar by-products and decreased recycli

167 ly target lysosomes, the major intracellular degradative organelle.

168 nt and subsequent phagosomal maturation to a degradative organelle.

169 Compromised function in lysosomes and other degradative organelles that intersect with the lysosomal

170 -related dysfunction of lysosomes, the major degradative organelles wherein Abeta localizes after upt

171 Lysosomes have traditionally been viewed as degradative organelles, although a growing body of evide

172 fective transport of vesicles, mitochondria, degradative organelles, and signaling endosomes in model

173 gy impairs axonal transport of signaling and degradative organelles.

174 Moreover, the degradative outcome of Hsc70 binding appears highly sens

175 framework for predicting degradative or non-degradative outcomes of ubiquitylation.

176 evidence that ubiquitylation can direct non-degradative outcomes, most investigations of ubiquitylat

177 xy substituent, reduction, N-protection, and degradative oxidation, afforded varied pyrrolidine struc

178 PI(4)P that maintains MT1-MMP traffic in the degradative pathway and suppresses the formation of inva

179 -dependent manner and that key steps in this degradative pathway are the activation of the small GTPa

180 Autophagy is a key degradative pathway coordinated by external cues, includ

181 Macroautophagy is a lysosomal degradative pathway essential for neuron survival.

182 n was due to differences in synthetic versus degradative pathway expression, we generated mice lackin

183 e possibility that a newly discovered normal degradative pathway for axons might contribute to glauco

184 ation of enzymology and gene-analysis, a new degradative pathway for caffeine has been proposed via T

185 Autophagy, a major degradative pathway for proteins and organelles, is esse

186 Autophagy is an essential degradative pathway in neurons, yet little is known abou

187 Autophagy, a lysosomal degradative pathway in response to nutrient limitation,

188 ein-coupled receptor (GPCR) sorting into the degradative pathway is important for limiting the durati

189 Finally, we demonstrate that the proposed degradative pathway is partially reversible, showing tha

190 Autophagy is a degradative pathway necessary for differentiation, organ

191 The cellular degradative pathway of autophagy has a fundamental role

192 The function of the lysosomal degradative pathway of autophagy in cellular injury is u

193 identify an essential role for the cellular degradative pathway of autophagy in governing a balanced

194 vated L. braziliensis are susceptible to the degradative pathway of macrophages with upregulation of

195 tophagy, an intracellular lysosome-dependent degradative pathway that clears the cytoplasm of dysfunc

196 Autophagy is a degradative pathway that delivers cellular components to

197 s and promote autophagy-a lysosome-dependent degradative pathway that disposes of dysfunctional organ

198 Autophagy is an evolutionarily conserved degradative pathway that has been implicated in a number

199 Autophagy is an essential degradative pathway that maintains neuronal homeostasis

200 pha enhances autophagy, a lysosome-dependent degradative pathway that removes dangerous constituents,

201 d functionality are linked to the autophagic degradative pathway under several stress conditions.

202 Autophagy is a key cellular degradative pathway, important for neuronal homeostasis

203 hat luteolin improves the autophagy-lysosome degradative pathway, is a powerful antioxidant, and has

204 ested that autophagy, the principal cellular degradative pathway, is impaired in pancreatitis, but it

205 Although autophagy is usually a degradative pathway, it also participates in biosyntheti

206 translocated through the endosomal-lysosomal degradative pathway, rather than through the recycling p

207 Despite dysfunction of a major degradative pathway, renal and glomerular involvement is

208 Cs of knockin mice suggested a defect in the degradative pathway, which may explain the observed loss

209 esis or maturation and transport through the degradative pathway.

210 Rab35 are key elements of this use-dependent degradative pathway.

211 es and largely avoid the endosomal/lysosomal degradative pathway.

212 R-II expression is regulated via a lysosomal degradative pathway.

213 cell surface receptors via the endolysosomal degradative pathway.

214 ts the messenger ribonucleoproteins into the degradative pathway.

215 membrane trafficking, escaping the lysosomal degradative pathway.

216 s are sequestered by the endosomal-lysosomal degradative pathway.

217 not with IGF-II, targeted the receptor to a degradative pathway.

218 nizes and sorts ubiquitinated cargo into the degradative pathway.

219 an organism for the study of this important degradative pathway.

220 to sort a SNARE into COPI vesicles in a non-degradative pathway.

221 AT is sorted differentially to recycling and degradative pathways after psychostimulant exposure or P

222 he engineering of efficient biosynthetic and degradative pathways and gateways for genomic manipulati

223 al consequences of degradation through these degradative pathways are unknown.

224 h during starvation conditions; however, WTA degradative pathways have not been described for this or

225 here they are sorted and either channeled to degradative pathways or recycled to the plasma membrane.

226 trin as a central integrator of anabolic and degradative pathways preventing muscle wasting.

227 te that TFEB enhances flux through lysosomal degradative pathways to induce APP degradation and reduc

228 ns, including the proteasomal and autophagic degradative pathways, could play a key role in the varia

229 rface activity by diverting ADAM17 away from degradative pathways.

230 conserved process that enables catabolic and degradative pathways.

231 tion of organic hydrocarbons and lignin-like degradative pathways.

232 ested a role for ubiquitination and cellular degradative pathways.

233 ly relied on global perturbation of cellular degradative pathways.

234 deubiquitinase USP37 binds CDH1 and removes degradative polyubiquitin from cyclin A.

235 Additionally, non-degradative polyubiquitination of Malt1, critical for NF

236 nd Malt1 K648 are targeted by Hectd3 for non-degradative polyubiquitination to mediate robust generat

237 How folding and degradative PQC systems interact and coordinate their re

238 (designated SM N100) are necessary for this degradative process and represent the shortest cholester

239 In other words, xenophagy, a degradative process documented after infection with HSVD

240 Autophagy is a self-degradative process in which cellular material is enclos

241 Atg16L1 mediates the cellular degradative process of autophagy and is considered a cri

242 been attributed primarily to its role in the degradative process of macroautophagy.

243 Autophagy is a highly conserved self-degradative process that has a key role in cellular stre

244 Autophagy is a conserved degradative process that is crucial for cellular homeost

245 Autophagy is a lysosome-dependent degradative process that protects cancer cells from mult

246 Autophagy is a cell-protective and degradative process that recycles damaged and long-lived

247 Autophagy is a highly conserved degradative process that removes damaged or unnecessary

248 luctuations serve as the driving force for a degradative process that requires both an unfolded cleav

249 atic physiology and the contribution of this degradative process to diseases of these organs.

250 Autophagy is a lysosomal degradative process used to recycle obsolete cellular co

251 h macroautophagy is known to be an essential degradative process whereby autophagosomes mediate the e

252 s high levels of autophagy, a conserved self-degradative process.

253 esent a point of regulatory control for this degradative process.

254 These degradative processes are better documented for inflamma

255 ne products involved in the inflammatory and degradative processes in cartilage (MMP-9, COX-2, and ca

256 er research for quantifying the magnitude of degradative processes in the environment.

257 L tempers proinflammatory, promigratory, and degradative processes, and through actions on endotheliu

258 , M. tuberculosis dramatically decreases the degradative processing and major histocompatibility comp

259 critical step in antigen presentation is the degradative processing of peptides by aminopeptidases in

260 The bile pigment bilirubin-IXalpha is the degradative product of heme, distributed among mammals a

261 ence-associated transcriptome in response to degradative products of the lysosome.

262 However, the degradative properties of the mature PV are unknown, and

263 ide capsule and the secretion of a myriad of degradative proteases and lipases.

264 Cancer cells form actin-rich degradative protrusions (invasive pseudopods and invadop

265 ells, triggering the formation of actin-rich degradative protrusions called invadopodia, enabling tum

266 emoval of HCHs from the surface ocean by the degradative pump due to hydrolysis and microbial degrada

267 events, suggesting an important role of the degradative pump in the overall oceanic sink of HCHs.

268 he relative importance of the biological and degradative pumps on the atmospheric deposition of the l

269 eal loading and release behavior, showing no degradative release of encapsulated salmon calcitonin in

270 In order to harness this degradative response therapeutically, we also describe a

271 tive factors as well as with adapters of the degradative RNA exosome.

272 In particular, how the degradative role of the lysosome cooperates with its sig

273 e phosphorylase (PNPase) plays synthetic and degradative roles in bacterial RNA metabolism; it is als

274 s occurs continuously at axon terminals, non-degradative roles of autophagy at boutons are barely des

275 show that autophagy impacts the other major degradative route involving the ubiquitin-proteasome sys

276 These degradative sites lack the punctate shape of conventiona

277 The degradative SMC phenotype also worsens atherosclerotic d

278 These vascular SMCs, termed degradative SMCs, compromise the medial properties and f

279 S-4 and BBS-5 disrupts the lysosome-targeted degradative sorting of ciliary sensory receptors.

280 Degradative sorting requires lysine residues in the juxt

281 rves additional roles in receptor recycling, degradative sorting, or constitutive secretion has remai

282 e connectivity and a focally protrusive, non-degradative state.

283 hanolamine and a fatty aldehyde is the final degradative step in the sphingolipid metabolic pathway.

284 d cell invasion and localizes to subcellular degradative structures termed invadopodia.

285 , but a system-wide approach to define which degradative systems are involved is lacking.

286 Insufficient capacity of cellular degradative systems, chaperone shortage or high levels o

287 tes exceeding the capacity of other cellular degradative systems.

288 Degradative thiolases, which are part of the thiolase su

289 ural elements are required for the selective degradative trafficking of S1P(1).

290 essing and reveal an unexpected role for non-degradative ubiquitination in the manipulation of cellul

291 osphorylation, little is known about how non-degradative ubiquitination modulates protein structure,

292 also enhances RNF125-mediated, Lys48-linked degradative ubiquitination of RIG-I.

293 In contrast, degradative ubiquitination of TRAF3 was not affected in

294 Peli1 mediates non-degradative ubiquitination of TSC1, thereby promoting TS

295 2 interacted with Twist and promoted the non-degradative ubiquitination of Twist.

296 of CD4(+) T cells led to an increase in non-degradative ubiquitylation.

297 nocyte (KC) terminal differentiation and the degradative variability observed between light and dark

298 We hypothesize that the degradative versatility of F. succinogenes OMVs is used

299 Both growth factors and degradative vesicles carrying aged organelles or aggrega

300 ted via large M6PR-positive vacuoles without degradative xenophagy to the plasma membrane.IMPORTANCE