ライフサイエンスコーパス: dehydratase

1 the Ser-derived enamine/imine product of Thr dehydratase.

2 serine hydroxymethyltransferase, and serine dehydratase.

3 fucose biosynthetic enzyme GDP-d-mannose-4,6-dehydratase.

4 iosynthetic enzyme delta-aminolevulinic acid dehydratase.

5 sopropylmalate isomerase, a key iron-sulphur dehydratase.

6 nase, and a possible NAD-dependent epimerase/dehydratase.

7 This superfamily includes 2-methylcitrate dehydratase.

8 e 3-dehydroshikimate (3-DHS) by AsbF-a 3-DHS dehydratase.

9 amino acid biosynthesis enzyme dihydroxyacid dehydratase.

10 scherichia coli chorismate mutase-prephenate dehydratase.

11 thione peroxidase, and 4 alpha-carbinolamine dehydratase.

12 l as enzymatic assay of B(12)-dependent diol dehydratase.

13 ing arginine deiminase and a putative serine dehydratase.

14 trolling the catalytic efficacy of scytalone dehydratase.

15 demonstrate that the RiDD is in fact a diol dehydratase.

16 vitro inhibitor of an AdoCbl-dependent diol dehydratase.

17 lose homolog CYP71A12, also encoding an IAOx dehydratase.

18 ocalization of the Arabidopsis epimerase and dehydratase.

19 it belongs to a third subfamily of inverting dehydratases.

20 '-phosphate (PLP)-dependent serine/threonine dehydratases.

21 may impact the binding of ISO and TAC to the dehydratases.

22 e the MoFe-nitrogenase and 2-hydroxyacyl-CoA dehydratases.

23 found in a large protein family of epimerase/dehydratases.

24 of homologous nucleotide sugar epimerases or dehydratases.

25 ts into substrate recognition by lantibiotic dehydratases.

26 in the regulatory domain of ADT2 (arogenate dehydratase 2).

27 del of the Escherichia coli dTDP-glucose-4,6-dehydratase (4,6-dehydratase) active site has been gener

28 glucose by Escherichia coli dTDP-glucose 4,6-dehydratase (4,6-dehydratase) takes place in the active

29 coli, including the oxidative conversion of dehydratase [4Fe-4S] clusters to an inactive [3Fe-4S] fo

30 Mg534 is a 4,6-dehydratase 5-epimerase; its three-dimensional structure

31 lori mutants deficient in 6-phosphogluconate dehydratase (6PGD) were constructed.

32 a 3-hydroxy-3-methylglutaryl-CoA synthase, a dehydratase, a decarboxylase and a dedicated acyl carrie

33 pendent glycerol dehydratase by the glycerol dehydratase activating enzyme results in formation of 5'

34 are discussed within the context of the 4,6-dehydratase active site model and chemical mechanism.

35 ichia coli dTDP-glucose-4,6-dehydratase (4,6-dehydratase) active site has been generated by combining

36 nal enzymes, SimC7, was proposed to supply a dehydratase activity missing from two modules of the pol

37 equired for the stability or function of the dehydratase activity of the elongase system.

38 eron was derepressed unmasking the threonine dehydratase activity of the threonine synthase ThrC.

39 tramer, displays pterin-4alpha-carbinolamine dehydratase activity, and binds HNF1alpha in vivo and in

40 domains were also found to possess intrinsic dehydratase activity, whereas the conventional DH domain

41 d increase in KM for the ATP-dependent NADHX dehydratase activity.

42 d/or phenylpyruvate route in which arogenate dehydratase (ADT) or prephenate dehydratase, respectivel

43 very/deduction that a six-membered arogenate dehydratase (ADT1-6) gene family encodes the final step

44 Plant PPA-ATs and succeeding arogenate dehydratases (ADTs) were found to be most closely relate

45 iosynthesis enzyme delta-aminolevulinic acid dehydratase (ALAD) is normally repressed by the Irr prot

46 modification by a delta-aminolevulinic acid dehydratase (ALAD) polymorphism.

47 5-Aminolaevulinic acid dehydratase (ALAD), an early enzyme of the tetrapyrrole

48 new assay of human delta-aminolevulinic acid dehydratase (ALAD), an enzyme converting delta-aminolevu

49 al co-regulator of delta-aminolevulinic acid dehydratase (Alad), but not 5-aminolevulinate synthase g

50 our discovery that human aminolevulinic acid dehydratase (ALAD), which catalyzes the second step of h

51 rocess is catalyzed by 2-hydroxyglutaryl-CoA dehydratase, an enzyme with two components (A and D) tha

52 reatment rapidly inactivated isopropylmalate dehydratase, an iron-sulfur cluster enzyme in this pathw

53 ase active site into one that can serve as a dehydratase and a multifunctional pericyclase.

54 sis through their action as dTDP-glucose-4,6-dehydratase and dTDP-4-keto-6-deoxyglucose-3,5-epimerase

55 nockdown of the nonredundant hydroxyacyl-CoA dehydratase and enoyl-CoA reductase enzymes in the ELO p

56 All plant NAD(P)HX dehydratase and epimerase sequences examined had predict

57 parum presents homologues of GDP-mannose 4,6-dehydratase and GDP-L-fucose synthase enzymes that are a

58 ed versions of P. falciparum GDP-mannose 4,6-dehydratase and GDP-L-fucose synthase expressed in trans

59 two genes: TGDS encoding the TDP-glucose 4,6-dehydratase and GPR180 encoding the G protein-coupled re

60 l that encases coenzyme B(12)-dependent diol dehydratase and perhaps other enzymes involved in 1,2-pr

61 n genes encoding delta-aminolevulinate (ALA) dehydratase and porphobilinogen deaminase, the second an

62 type sequences for 4a-OH-tetrahydrobiopterin dehydratase and therefore ruling out the previously susp

63 Although dehydratase and thioesterase activities are known activi

64 how that AprD4 is the first radical SAM diol-dehydratase and, along with AprD3, is responsible for 3'

65 resent in the activator of 2-hydroxyacyl-CoA dehydratases and a ferredoxin-like [2Fe-2S] cluster doma

66 ivating modern enzymes such as esterases and dehydratases and also for proteins like opsins for the c

67 atases differ from mammalian L- and D-serine dehydratases and bacterial D-serine dehydratases by the

68 e thus provisionally classified as arogenate dehydratases and designated ADT1-ADT6.

69 hermore, these mutant proteins are excellent dehydratases and provide useful tools to investigate the

70 GL) lactonase, 6-deoxy-6-sulfogluconate (SG) dehydratase, and 2-keto-3,6-dideoxy-6-sulfogluconate (KD

71 ) and has distinct UDP-GlcNAc 4-oxidase, 5,6-dehydratase, and 4-reductase activities.

72 lase, hyaluronan synthase, GDP-D-mannose 4,6 dehydratase, and a potassium ion channel protein.

73 majority of the cell's B(12)-dependent diol dehydratase, and additional unidentified proteins.

74 he homologous mandelate racemase, l-fuconate dehydratase, and d-tartrate dehydratase, the active site

75 us far, the identities of the ketoreductase, dehydratase, and enoyl reductase remain a mystery becaus

76 thetic enzymes chorismate mutase, prephenate dehydratase, and prephenate dehydrogenase in cell extrac

77 mponents-an elongase protein (Elop), a novel dehydratase, and two reductases-catalyzed repeated round

78 es UDP-galactose epimerase, dTDP-glucose-4,6-dehydratase, and UDP-xylose synthase in oxidizing the C-

79 ke UDP-galactose epimerase, dTDP-glucose-4,6-dehydratase, and UDP-xylose synthase.

80 ation, the oxidation of [4Fe-4S] clusters of dehydratases, and DNA damage.

81 and ApeF bound to the thioesterase ApeK, the dehydratases ApeI and ApeP, and the ketosynthase ApeO in

82 ion of a putative methionine salvage pathway dehydratase, apoptotic protease activating factor 1 (APA

83 fusions showed that Arabidopsis RidA and Thr dehydratase are chloroplast targeted.

84 Several specific dehydratases are known to catalyze the first proposed st

85 The reaction mechanisms for these types of dehydratases are quite complicated with proton abstracti

86 The [4Fe-4S]2+ clusters of dehydratases are rapidly damaged by univalent oxidants,

87 Hydroxyacyl-coA dehydratases are required for elongation of very long ch

88 ) clusters found at the active sites of many dehydratases are susceptible to damage by univalent oxid

89 em supported the activity of 1,2-propanediol dehydratase as effectively as authentic adenosylcobalami

90 The combination of a dehydratase assay with a high-resolution crystal structu

91 (1.12 +/- 0.06 g L(-1)) in the presence of a dehydratase at 44% and 87% yield of fed propionate, resp

92 ssfully produced in E. coli by employing the dehydratase BsjM and the dehydrogenase NpnJA.

93 may not only attack the [4Fe-4S] clusters in dehydratases, but also block the [4Fe-4S] cluster assemb

94 yl radical on the B(12)-independent glycerol dehydratase by the glycerol dehydratase activating enzym

95 D-serine dehydratases and bacterial D-serine dehydratases by the presence of an iron-sulfur center ra

96 polyketide synthase (PKS) has the predicted dehydratase catalytic domain in modules 1, 2, and 5 requ

97 CDP-D-glucose 4,6-dehydratase catalyzes the conversion of CDP-D-glucose to

98 GDP-D-mannose 4,6-dehydratase catalyzes the first step in the de novo synt

99 e heat-induced genes is the serine deamidase/dehydratase Cha1 known to be regulated by increased seri

100 novel chemical reaction centre for aldoxime dehydratase, cis-trans isomerase, N-N bond formation, hy

101 l hydroquinone by the reductase ClaC and the dehydratase ClaB.

102 nvestigation, GDP-4-keto-6-deoxy-d-mannose-3-dehydratase (ColD), catalyzes the third step in the path

103 ine synthase and GDP-4-keto-6-deoxymannose-3-dehydratase (ColD), respectively.

104 h are components of the beta-hydroxyacyl-ACP dehydratase complex that participates in the mycolic aci

105 rolysis of ATP to deliver an electron to the dehydratase component (CompD), where the electron is use

106 he inducible pathway and D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase (D-PBE) of

107 Arabidopsis thaliana biosynthetic threonine dehydratase/deaminase (TD), to the CaMV 35S promoter and

108 cted mutagenesis, of the bacillaene synthase dehydratase/decarboxylase enzyme couple PksH/PksI, respo

109 tary coproporphyria, and aminolevulinic acid dehydratase deficient porphyria) manifest in attacks and

110 c acid (in patients with aminolevulinic acid dehydratase deficient porphyria) or increased 5-aminolev

111 nical diagnosis of delta-aminolevulinic acid dehydratase-deficient porphyria, a rare enzymatic defici

112 have additive effects on 6-phosphogluconate dehydratase-dependent growth during nitrosative stress,

113 other or both isoforms of GDP-D-mannose 4,6-dehydratase, depending on the cell type and/or developme

114 Dehydratase (DH) catalytic domains play an important rol

115 The dehydratase (DH) domain of module 4 of the 6-deoxyerythr

116 R) domain of EpoC and then dehydrated by the dehydratase (DH) domain to produce the methylthiazolylme

117 ss-link ACPs with catalytic beta-hydroxy-ACP dehydratase (DH) domains by means of a 3-alkynyl sulfone

118 Dehydratase (DH) domains of cryptic function are often f

119 The dehydratase (DH) domains of PKSs, which generate an alph

120 The dehydration that is catalyzed by the dehydratase (DH) domains of TYLS module 2 to give the un

121 yl-ACP thioesterase, a ketoreductase (KR), a dehydratase (DH), and an enoyl reductase (ER).

122 odule may also include a ketoreductase (KR), dehydratase (DH), and/or enoyl reductase (ER) domain.

123 PICS module 2 is a dehydratase (DH)-containing module that catalyzes the fo

124 We targeted the development of a dehydratase (DH)-specific reactive probe that can facili

125 functional characterization of dihydroxyacid dehydratase (DHAD) from Mycobacterium tuberculosis (Mtb)

126 tep in the de novo pathway, 3-dehydroquinate dehydratase (DHQ), was deleted.

127 third enzyme in the pathway, dehydroquinate dehydratase (DHQD), catalyzes the dehydration of 3-dehyd

128 The dehydratases (DHs) of modular polyketide synthases (PKSs

129 Bacterial L-serine dehydratases differ from mammalian L- and D-serine dehyd

130 etion in PCBD1 (pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear

131 n, a deletion mutant of MAB_4780, encoding a dehydratase, distinct from the beta-hydroxyacyl-ACP dehy

132 AcnA and other dehydratases do not show this trait.

133 The dehydratase domain FosDH1 from module 1 of the fostrieci

134 The recombinant dehydratase domain from NANS module 2, NANS DH2, was sho

135 as presented an enigma because the predicted dehydratase domain in module 7 is absent.

136 Unexpectedly, the structure reveals that the dehydratase domain of CylM resembles the catalytic core

137 a PKS mutant specifically inactivated in the dehydratase domain of extension-module 1 showed that thi

138 y ten conserved residues were mutated in the dehydratase domain of the best characterized family memb

139 h competes with dehydration catalyzed by the dehydratase domain.

140 The dehydratase domains (DHs) of the iso-migrastatin (iso-MG

141 plmT2 gene product, with no homology to PKS dehydratase domains, is required for efficient formation

142 ugh the sequential actions of dehydroquinate dehydratase (DQD) and shikimate dehydrogenase (SDH) cont

143 Dehydroshikimate dehydratases (DSDs) play a central role in this process,

144 SDH (L-serine dehydratase, EC 4.3.1.17) catalyzes the pyridoxal 5'-pho

145 The halogenase from CurA, and the dehydratases (ECH(1)s), decarboxylases (ECH(2)s) and eno

146 THIORIBOSE-1-PHOSPHATE-ISOMERASE1 (MTI1) and DEHYDRATASE-ENOLASE-PHOSPHATASE-COMPLEX1 (DEP1) under di

147 yl synthase, ketoacyl reductase, hydroxyacyl dehydratase, enoyl reductase and thioesterase enzyme gro

148 erium encodes a protein with 2-methylcitrate dehydratase enzyme activity.

149 tive site of type I dehydroquinase (DHQ1), a dehydratase enzyme that is a promising target for antivi

150 encoding an Fe/S-independent 2-methylcitrate dehydratase enzyme.

151 which encode for putative decarboxylase and dehydratase enzymes, respectively, afforded mutant strai

152 obacteria requires two functionally distinct dehydratases, FabA and FabZ.

153 A second dehydratase, FabZ, functions in acyl chain elongation bu

154 and an aspA sdaA mutant (also lacking serine dehydratase) failed to grow in complex media unless supp

155 andii aconitase A, a member of the monomeric dehydratase family of proteins that requires a [4Fe-4S]

156 Other enzymes in this iron-sulfur dehydratase family were similarly affected.

157 elonging to the new B12-independent glycerol dehydratase family, in contrast to S. enterica, which re

158 yze the enamine/imine intermediates that Thr dehydratase forms from Ser or Thr.

159 In detail, an aldoxime dehydratase from Bacillus sp. OxB-1 was used as a biocat

160 aracterization of a B12-independent glycerol dehydratase from Clostridium butyricum has recently been

161 ructural similarity to the GRE-type glycerol dehydratase from Clostridium butyricum, we demonstrate t

162 D-Glucarate dehydratase from Escherichia coli (GlucD), a member of t

163 The L-serine dehydratase from Legionella pneumophila (lpLSD) has rece

164 hydrolyzed the enamines/imines formed by Thr dehydratase from Ser or Thr and protected the Arabidopsi

165 ical and structural data for a GRE-type diol dehydratase from the organism Roseburia inulinivorans (R

166 ution crystal structure of CDP-D-glucose 4,6-dehydratase from Yersinia pseudotuberculosis in the rest

167 triking kinetic differences between L-serine dehydratases from Bacillus subtilis (bsLSD, type 1) and

168 rary of acid sugars to assign the L-fuconate dehydratase (FucD) function to a member of the mandelate

169 coding superoxide dismutase (sodA), fumarate dehydratase (fumC), bacterioferritin (bfr), bacterioferr

170 ng A0NXQ8 both (1) confirms its novel c3LHyp dehydratase function and (2) provides evidence for metab

171 talarate dehydratase (TalrD) and galactarate dehydratase (GalrD) functions to a group of orthologous

172 nctional assignment of Ob2843 as galactarate dehydratase (GalrD-II).

173 Both the glycerol dehydratase (GD) and the GD-activating enzyme (GD-AE) co

174 oupled to an increased abundance of the diol dehydratase gene cluster (pduCDE) in Firmicutes metageno

175 Ablation of the Arabidopsis dehydratase gene raised seedling levels of all NADHX for

176 olymorphism in the delta-aminolevulinic acid dehydratase gene, ALAD, were measured.

177 panosome de novo pathway enzymes GDP-mannose dehydratase (GMD) and GDP-fucose synthetase (GMER) were

178 which requires the action of GDP-mannose 4,6-dehydratase (GMD) and GDP-L-fucose synthase (FS), is con

179 Here we identify GDP-mannose 4,6-dehydratase (GMD) as a binding partner of tankyrase 1.

180 nd the non-PARylated partner GDP-mannose 4,6-dehydratase (GMD).

181 ential reactions mediated by GDP-mannose 4,6-dehydratase (GMDS) and GDP-4-keto-6-deoxymannose 3,5-epi

182 ential reactions mediated by GDP-mannose 4,6-dehydratase (GMDS) and GDP-4-keto-6-deoxymannose 3,5-epi

183 ha-1,6 linked fucosylation, GDP-mannose 4, 6-dehydratase (Gmds) and to a lesser extent fucosyltransfe

184 Arabidopsis (Arabidopsis thaliana) NAD(P)HX dehydratases (GRMZM5G840928, At5g19150) were able to rec

185 -regulated edd mutant (gluconate-6-phosphate dehydratase) had similar gluconate levels as the rpoN mu

186 identification of the (3 R)-hydroxyacyl-ACP dehydratases, HadAB and HadBC, of Mtb FAS-II complex req

187 tase, distinct from the beta-hydroxyacyl-ACP dehydratase HadABC complex, was constructed in the R mor

188 but to date only a small family of [4Fe-4S] dehydratases have been identified as direct targets.

189 ta gene encoding imidazoleglycerol-phosphate dehydratase (HIS3).

190 f either arogenate (ADT) or prephenate (PDT) dehydratases; however, neither enzyme(s) nor encoding ge

191 ntly, a GRE, trans-4-hydroxy-L-proline (Hyp) dehydratase (HypD), was discovered that catalyzes the de

192 Imidazole glycerol-phosphate dehydratase (IGPD) catalyzes the sixth step of histidine

193 dehydration to 2-keto-3-deoxy-L-fuconate via dehydratase, (iii) 2-keto-3-deoxy-L-fuconate cleavage to

194 The threonine dehydratase IlvA is part of the isoleucine biosynthesis

195 phosphoribosyltransferase (TrpD), threonine dehydratase (IlvA), threonine, and phosphoribosyl pyroph

196 e pyridoxal 5'-phosphate-dependent threonine dehydratase (IlvA).

197 '-phosphate (PLP)-dependent serine/threonine dehydratases, IlvA and TdcB, as sources of endogenous 2-

198 ctivity measurements show that dihydroxyacid dehydratase (IlvD), an iron-sulphur enzyme essential for

199 ion of the [2Fe-2S]-containing dihydroxyacid dehydratase, important for branched-chain amino acid syn

200 ehydrogenase and Bacillus subtilis threonine dehydratase in a modified threonine-hyperproducing Esche

201 itively and independently; one is in fabZ, a dehydratase in fatty acid biosynthesis; the other is in

202 o 2-oxobutyrate (an alternative to threonine dehydratase in isoleucine biosynthesis) evolved several

203 The data indicate that dehydratase-independent pathways also function in establ

204 hat, indeed, has been converted from a sugar dehydratase into an aminotransferase.

205 tion in wbpM, which encodes a UDP-4,6-GlcNAc dehydratase involved in O-antigen synthesis.

206 We show here the in vitro activity of the dehydratase involved in the biosynthesis of the food pre

207 haracterization of the many lantibiotic-like dehydratases involved in the biosynthesis of other class

208 ved in diketopiperazine synthesis, LanB-like dehydratases involved in the posttranslational modificat

209 r anaerobic conditions, in part by oxidizing dehydratase iron-sulfur clusters.

210 nd the activity of the Fe-S enzyme gluconate dehydratase is diminished in the suf mutant during iron

211 isomerase potential of beta-hydroxyacyl-ACP dehydratases is determined by the properties of the beta

212 337, annotated as enolase or phosphopyruvate dehydratase, is associated with spirochete outer membran

213 PBGS, also called "delta-aminolevulinate dehydratase," is encoded by the ALAD gene and catalyzes

214 the three-dimensional structure of the MUR1 dehydratase isoform from Arabidopsis thaliana complexed

215 (UFA) biosynthesis is introduced by the FabA dehydratase/isomerase of the bacterial type II fatty aci

216 nthase I) and fabA (beta-hydroxydecanoyl-ACP dehydratase/isomerase) genes.

217 herefore E. faecalis FabZ1 is a bifunctional dehydratase/isomerase, an enzyme activity heretofore con

218 le, methylcitrate synthase and methylcitrate dehydratase, it does not appear to contain a distinct 2-

219 contained four enzymes: B(12)-dependent diol dehydratase, its putative reactivating factor, aldehyde

220 ationally installed by class I lanthipeptide dehydratases (LanBs) on a linear peptide substrate throu

221 e, homoaconitase (Lys4p) and isopropylmalate dehydratase (Leu1p), respectively.

222 Knowledge of the distinct dehydratase-like enzymes Pen and Pal and their role in C

223 The 4,6-dehydratase makes use of tightly bound NAD(+) as the coe

224 The d-mannonate dehydratase (ManD) function was assigned to a group of o

225 ain amino acids, inhibition of dihydroxyacid dehydratase may have served to foster the role of NO in

226 thylcitrate synthase (MCS) and methylcitrate dehydratase (MCD) but not 2-methylisocitrate lyase (MCL)

227 ydride transfer step of the dTDP-glucose 4,6-dehydratase mechanism has been studied by mutagenesis an

228 e is formed through the action of this 3-DHS dehydratase metalloenzyme.

229 also known as coenzyme B(12))-dependent diol dehydratase model reactions of (i).

230 uloma formation in embryos infected with the dehydratase mutant was associated with a failure to repl

231 -phosphate cytidylyltransferase, CDP-Glc 4,6-dehydratase, NADH-dependent SAM:C-methyltransferase, and

232 The highly conserved enzyme NAD(P)HX dehydratase (NAXD) is essential for intracellular repair

233 he dehydration of Ser/Thr by the lantibiotic dehydratase NisB.

234 the nisA structural gene, cyclase (nisC) and dehydratase (nisB), together with an orthogonal nonsense

235 athway in plants comprising a stereospecific dehydratase (NNRD) and an epimerase (NNRE), the latter b

236 report that inactivation of the wbtA-encoded dehydratase of the O-antigen polysaccharide (O-PS) locus

237 epresents the first CDP nucleotide utilizing dehydratase of the short-chain dehydrogenase/reductase (

238 dent enzyme, GDP-4-keto-6-deoxy- d-mannose 3-dehydratase or ColD, catalyzes a dehydration reaction us

239 estigation is GDP-4-keto-6-deoxy-D-mannose 3-dehydratase or ColD, which catalyzes the removal of the

240 uding the non-PLP-dependent serine/threonine dehydratases or aconitases, the mechanisms of action of

241 dent enzyme, GDP-4-keto-6-deoxy- d-mannose-3-dehydratase (or ColD), was determined in our laboratory,

242 to n-octanenitrile catalysed by an aldoxime dehydratase (OxdB) overexpressed in E. coli.

243 molecules in the binding sites of scytalone dehydratase, p38-alphaMAP kinase, and EGFR kinase.

244 generated by an unusual, small and monomeric dehydratase, Pac13, which catalyses the dehydration of u

245 tant homology to pterin-4alpha-carbinolamine dehydratase (PCD) enzymes.

246 Pterin-4a-carbinolamine dehydratase (PCD) is a highly conserved enzyme that evol

247 factor 1 (DCoH)/pterin-4alpha-carbinolamine dehydratases (PCD)-like protein is the causative mutatio

248 Pterin-4a-carbinolamine dehydratases (PCDs) recycle oxidized pterin cofactors ge

249 ckaging of itself and other subunits of diol dehydratase (PduC and PduE) into the Pdu MCP.

250 packaging the coenzyme B(12)-dependent diol dehydratase (PduCDE) into the lumen of the Pdu MCP.

251 the recycling enzyme pterin 4a-carbinolamine dehydratase, PhhB, rescues tyrosine auxotrophy.

252 A specific prephenate dehydratase protein (PD1) was discovered to have a stron

253 Here, we report the discovery of a third dehydratase protein, HadD(Mtb) (Rv0504c), whose gene is

254 ar methylases and nucleotide sugar epimerase-dehydratase proteins.

255 h we propose are not substrates for the 2-MC dehydratase (PrpD) enzyme, accumulate inside the cell, a

256 ch arogenate dehydratase (ADT) or prephenate dehydratase, respectively, plays a key role.

257 ia coli ACP and fatty acid 3-hydroxyacyl-ACP dehydratase, respectively.

258 ng the (3R)-hydroxyacyl-acyl carrier protein dehydratases resulted in more than a 16- and 80-fold inc

259 affected by the presence of serine/threonine dehydratases, revealing another mechanism of endogenous

260 The l-rhamnonate dehydratase (RhamD) function was assigned to a previousl

261 s thus undertaken to attempt to identify the dehydratase(s) involved in Phe formation in Arabidopsis,

262 Z (3-R-hydroxymyristoyl acyl carrier protein dehydratase), slrA (novel RpoE-regulated non-coding sRNA

263 ty acids, suggestive of an inhibition of the dehydratase step of the fatty-acid synthase type II elon

264 (SDR), belonging to the NDP-sugar epimerases/dehydratases subclass.

265 xameric complex of six Escherichia coli FabZ dehydratase subunits with six AcpP acyl carrier proteins

266 different from the one found in archetypical dehydratases such as aconitase, which use a serine resid

267 enolization capabilities of D135N and D135A dehydratases suggest an additional role for this residue

268 ichia coli dTDP-glucose 4,6-dehydratase (4,6-dehydratase) takes place in the active site in three ste

269 We assigned l-talarate dehydratase (TalrD) and galactarate dehydratase (GalrD)

270 cterized bifunctional l-talarate/galactarate dehydratase (TalrD/GalrD).

271 consistent with assignment of the d-tartrate dehydratase (TarD) function.

272 e produces a functional cytosolic prephenate dehydratase that catalyzes the conversion of prephenate

273 four DHs, identifying DH10 as the dedicated dehydratase that catalyzes the dehydration of the C17 hy

274 he tandem action of an ADP- or ATP-dependent dehydratase that converts (S)-NAD(P)HX to NAD(P)H and an

275 ing a yet to be identified plastid-localized dehydratase that converts tocopherolquinone to TMPBQ.

276 The first gene encodes a UDP-glucose-4,6-dehydratase that converts UDP-glucose to UDP-4-keto-6-de

277 fatty acids, for example, requires a second dehydratase that is not essential for their synthesis.

278 amine synthase, however, ColD functions as a dehydratase that removes the sugar C-3' hydroxyl group.

279 y utilize the same reductases and presumably dehydratase that the Elop proteins rely upon.

280 ising three elongases, two reductases, and a dehydratase that were localized to the endoplasmic retic

281 This enzyme belongs to a family of [4Fe-4S] dehydratases that are notoriously sensitive to univalent

282 Superoxide damages dehydratases that contain catalytic [4Fe-4S](2+) cluster

283 logy to be present in all bacterial L-serine dehydratases that utilize an Fe-S catalytic center.

284 mase, l-fuconate dehydratase, and d-tartrate dehydratase, the active site of TalrD/GalrD contains a g

285 he [4Fe-4S] cluster in E. coli dihydroxyacid dehydratase, the DinG [4Fe-4S] cluster is stable, and th

286 ated incorrectly as NAD-dependent epimerases/dehydratases; therefore, their prevalence in bacteria is

287 Although NO damaged the [Fe-S] clusters of dehydratases, this did not increase the amount of free i

288 0NXQ7 ; 4HypE) and trans-3-hydroxy-l-proline dehydratase (UniProt ID A0NXQ9 ; t3LHypD).

289 nd NAD(P)H to reaction mixtures in which 4,6-dehydratase WbpM had acted on the precursor substrate UD

290 in 81-176, we previously showed that the 4,6-dehydratase WcbK and the reductase WcaG generated GDP-6-

291 y to the elimination domain of lanthipeptide dehydratases, wherein insertions of secondary structural

292 th significant homology to a GDP-mannose 4,6-dehydratase, which catalyzes the first step in the biosy

293 rectly regulates the expression of scytalone dehydratase, which catalyzes the transition of scytalone

294 e genes, desIV, codes for a dTDP-glucose 4,6-dehydratase, which is referred to as DesIV.

295 ially refined 3-dimensional structure of 4,6-dehydratase, which lacks substrate-nucleotide but contai

296 rther indicated that pterin-4a-carbinolamine dehydratase, which regenerates the AAH cofactor, is also

297 s of l-Fuc is catalyzed by GDP-d-mannose 4,6-dehydratase, which, in Arabidopsis, is encoded by the GM

298 yme, the GRE, is a dedicated 1,2-propanediol dehydratase with a new type of intramolecular encapsulat

299 line-2-carboxylate (beta-elimination; c3LHyp dehydratase), with eventual total dehydration.

300 lobacter crescentus, native E. coli xylonate dehydratase (yjhG), a 2-keto acid decarboxylase from Pse