ライフサイエンスコーパス: deiodinase

1 d retain intrathyroidal iodine (iodotyrosine deiodinase).

2 late identified the gene responsible for the deiodinase.

3 PPARgamma, PPARalpha, PGC-1alpha, and type 2 deiodinase.

4 levels of Pgc-1alpha, Pparalpha, and type 2 deiodinase.

5 family, type 1 (D1; 8 h) or type 2 (D2; 2 h) deiodinase.

6 he short-lived, membrane-bound enzyme type 2 deiodinase.

7 sed endocytosis of the type II iodothyronine deiodinase.

8 atalytically active type II iodothyronine 5'-deiodinase.

9 played by polymorphisms in the iodothyronine deiodinase 1 (DIO1) and 2 (DIO2) genes in this associati

10 w that targeting SMRT/N-CoR complexes to the deiodinase 1 gene (D1) requires at least two interaction

11 tional 3' UTR of another selenoprotein mRNA, deiodinase 1.

12 thyroid FT4 regulated by genetic variants in deiodinases 1 and 2 genes (DIO1/DIO2), corresponding to

13 the activity and expression of iodothyronine deiodinase 2 (DIO2), an enzyme that activates TH, were h

14 amma (PPARgamma), and increased hypothalamic deiodinase 2 expression.

15 ive-period mediator gene DIO2 (iodothyronine deiodinase 2) in the right retina.

16 nd expression of deiodinases 2 and 3 (mainly deiodinase 2) in whole skin biopsy specimens, and in the

17 We also found expression of deiodinases 2 and 3 (mainly deiodinase 2) in whole skin

18 d elevation in deiodinase-3 and reduction in deiodinase-2 decreases TH signaling that can be worsened

19 We found that deiodinase-2 levels were reduced, whereas deiodinase-3 l

20 els of TH are regulated by deiodinases, with deiodinase-2 mediating TH activation and deiodinase-3 TH

21 ing and thermogenesis (uncoupling protein-1, deiodinase-2, and peroxisome proliferator-activated rece

22 O enhances expression of Dio3, which encodes deiodinase 3 (D3) to catabolize triiodothyronine (T3), w

23 l structure of the catalytic domain of mouse deiodinase 3 (Dio3), which reveals a close structural si

24 n infants with IVH the combined elevation in deiodinase-3 and reduction in deiodinase-2 decreases TH

25 at deiodinase-2 levels were reduced, whereas deiodinase-3 levels were increased in brain samples of b

26 ith deiodinase-2 mediating TH activation and deiodinase-3 TH inactivation.

27 ecreased activity of type I iodothyronine 5'-deiodinase (5' D-I), the hepatic enzyme that converts th

28 regulates levels of type II iodothyronine 5'-deiodinase (5'D-II) by modulating enzyme inactivation an

29 es protection from thyroid hormone by type 3 deiodinase, a thyroid hormone-inactivating enzyme.

30 The deiodinases activate or inactivate thyroid hormone, and

31 phenotypes associated with the reduction of deiodinase activities and selenoprotein N expression in

32 ecreased brain TH content as well as altered deiodinase activities and TH target gene expression.

33 ding vitamin A/E and metabolites and hepatic deiodinase activity (DI).

34 Brain deiodinase activity (T4-ORD) was reduced by approximatel

35 astrocytes lacking type II iodothyronine 5'-deiodinase activity and examined the effects of cAMP on

36 analogue dramatically suppresses its native deiodinase activity and leads to significant nitroreduct

37 ells, TBMEHP inhibited rat hepatic microsome deiodinase activity and was an agonist for PPARs in muri

38 The resulting protein retained deiodinase activity and was purified using anion exchang

39 These transgenic tadpoles had high levels of deiodinase activity and were resistant to exogenous TH a

40 ycytes and that DARPP-32 may modulate type 2 deiodinase activity by regulating the phosphorylation st

41 Since type 2 deiodinase activity can be induced by substances that in

42 explain the heterogeneous response of type 2 deiodinase activity in these two loci in response to spe

43 l CMZ cells can be induced to proliferate if deiodinase activity is inhibited.

44 In this paper, the deiodinase activity of a series of peri-substituted naph

45 ndent activation of type II iodothyronine 5'-deiodinase activity results from the synthesis of additi

46 NA was present in tissues showing type II 5'-deiodinase activity such as brain and cAMP-stimulated as

47 ls in the peri-positions exhibit much higher deiodinase activity than those having two thiols or a th

48 In vitro, TBMEHP inhibited deiodinase activity, induced adipocyte differentiation i

49 thyroid gland activity and increased hepatic deiodinase activity.

50 of high intracellular expression of type II deiodinase, adult BAT has enhanced thyroid-hormone signa

51 Type 2 iodothyronine deiodinase, an enzyme involved in the conversion of thyr

52 12F1, respectively, and code for the type 3 deiodinase, an enzyme that inactivates thyroid hormones

53 tial subunit of rat type II iodothyronine 5'-deiodinase and 2) identify the first non-selenocysteine

54 , GPX3, and GPX4), one or more iodothyronine deiodinases and two thioredixin reductases.

55 H signaling via changes in the expression of deiodinases and/or TRs, and normalization of TH signalin

56 Deiodinases apparently evolved from the ubiquitous Prx s

57 sition and the physical nature of the active deiodinase are unknown.

58 The iodothyronine deiodinases are a family of oxidoreductases that catalyz

59 The deiodinases are a family of selenoproteins expressed in

60 Deiodinases are at the interface between the beta-cateni

61 Types 1 and 3 iodothyronine deiodinases are known to be selenocysteine-containing en

62 Deiodinases are selenocysteine-dependent membrane protei

63 A three-dimensional model of the deiodinase based on the coordinates of the minor nitrore

64 hosphoenolpyruvate carboxykinase, and type I deiodinase but not hydroxymethylglutaryl-CoA reductase,

65 nase), as well as the diet-responsive type I deiodinase, but not those involved in mitochondrial resp

66 DARPP-32 may regulate the activity of type 2 deiodinase by prolonging the activation of CREB.

67 ated following the discovery that the type 2 deiodinase can be an important component in both the Hed

68 Type II iodothyronine 5'-deiodinase catalyzes the bioactivation of thyroid hormon

69 redox-active cysteines or the iodothyronine deiodinases containing an active site selenocysteine.

70 signaling in colorectal CSCs (CR-CSC), where deiodinases control cell division and chemosensitivity.

71 Of particular interest in the type I deiodinase (D1) is Cys124, which is vicinal to the selen

72 Surprisingly, while type 1 deiodinase (D1) is known to be present in human thyroid,

73 Type I deiodinase (D1) is the best characterized family member

74 The other activating deiodinase, D1, or a truncated D2 molecule (Delta18-D2)

75 Type II deiodinase (D2) activates thyroid hormone by converting

76 persistent increase in type 2 iodothyronine deiodinase (D2) activity in the mediobasal hypothalamus

77 Type 2 5'-deiodinase (D2) activity rose dramatically in the mouse

78 atalyzed by the enzyme type II iodothyronine deiodinase (D2) and the local effect (cell autonomy) of

79 Type 2 deiodinase (D2) catalyzes the 5'-deiodination of thyroxi

80 Type 2 deiodinase (D2) converts the prohormone thyroxine (T4) t

81 The enzyme type II iodothyronine deiodinase (D2) converts thyroxine (T4) to the active ho

82 though a putative human type 2 iodothyronine deiodinase (D2) gene (hDio2) encoding a similar selenopr

83 s that regulate TH action through the type 2 deiodinase (D2) in glial cells.

84 The type 2 deiodinase (D2) in the neonatal liver accelerates local

85 Type 2 iodothyronine deiodinase (D2) is a recently cloned selenodeiodinase th

86 Type 2 iodothyronine deiodinase (D2) is a selenoenzyme, the product of the re

87 The type 2 iodothyronine deiodinase (D2) is an integral membrane ER-resident sele

88 The type 2 iodothyronine deiodinase (D2) is critical for the intracellular produc

89 m resident thyroid hormone-activating type 2 deiodinase (D2) is inactivated by ubiquitination via the

90 (BAT), thyroid hormone activation via type 2 deiodinase (D2) is necessary for adaptive thermogenesis,

91 re is a transient surge in hepatocyte type 2 deiodinase (D2) that activates the prohormone thyroxine

92 The Dio2 gene encodes the type 2 deiodinase (D2) that activates thyroxine (T4) to 3,3',5-

93 tem is the thyroid hormone-activating type 2 deiodinase (D2), an endoplasmic reticulum-resident type

94 The mouse cochlea expresses type 2 deiodinase (D2), an enzyme that converts thyroxine, the

95 AMP-responsive gene for type 2 iodothyronine deiodinase (D2), an intracellular enzyme that activates

96 s also variability in the activity of type 2 deiodinase (D2), the enzyme that generates most brain T3

97 The expression of type 2 deiodinase (D2), which activates thyroid hormone in skel

98 Skeletal myocytes express the type 2 deiodinase (D2), which generates 3,5,3'-triiodothyronine

99 is converted to the active form T3 by type 2 deiodinase (D2).

100 in the inactivation of type 2 iodothyronine deiodinase (D2).

101 ne MGC: 19375; (B). Type II iodothyronine 5'-deiodinase (D2); (C). reduced expression 3 gene; (D). la

102 ed locally by T4 deiodination via the type 2 deiodinase (D2); this pathway is self-limited by ubiquit

103 the blood are stable, but the action of the deiodinases (D2-D3) provides cell-specific regulation of

104 In neurons, the type 3 deiodinase (D3) inactivates thyroid hormone and reduces

105 TH-inactivating) enzyme type 3 iodothyronine deiodinase (D3) is an oncofetal protein that is rarely e

106 opus laevis metamorphosis encodes a type III deiodinase (D3) that inactivates TH.

107 show that dorsal CMZ cells express type III deiodinase (D3), an enzyme that inactivates TH.

108 Type 3 deiodinase (D3), the selenoenzyme that inactivates thyro

109 Type 3 iodothyronine deiodinase (D3), the thyroid hormone-inactivating enzyme

110 n that neurons express high levels of type 3 deiodinase (D3), which inactivates both T4 and T3.

111 mely high levels of the type 3 iodothyronine deiodinase (D3), which inactivates thyroxine and 3,3', 5

112 rinatal exposure of tissues to THs is type 3 deiodinase (D3).

113 increasingly clear with the availability of deiodinase-deficient animals.

114 mentary DNAs (cDNAs) for the types I and III deiodinases (DI and DIII, respectively) have been isolat

115 The type II deiodinase (DII) converts thyroxine to the active hormon

116 ressions of crystallin genes increased; T4/3-deiodinase DIII (DIO3) increased 10-fold; and sodium-pot

117 Direct visualization of the deiodinase dimer showed that the holoenzyme was sorted t

118 cyclohexane (beta-TBECH), on thyroid hormone deiodinase (DIO) and sulfotransferase (SULT) activity we

119 spatiotemporal expression of thyroid hormone deiodinase (dio) genes.

120 ilability by regulating the expression of TH deiodinases (DIO).

121 (T3) concentrations and type 1 iodothyronine deiodinase DIO1 mRNA expression in the non-human primate

122 odothyronine (T3)), and type 1 iodothyronine deiodinase (DIO1) mRNA expression.

123 Decreased activity of type I 5'-deiodinase (DIO1), which converts T4 to T3, contributes

124 ed through the upregulation of iodothyronine deiodinase DIO2, a critical modulator of the thyroid hor

125 ating hormone beta subunit (tshb) and type 2 deiodinase (dio2) are coexpressed in zebrafish thyrotrop

126 ormed molecular scanning of the human type 2 deiodinase (DIO2) gene and evaluated a novel variant for

127 y reduced expression of type 2 iodothyronine deiodinase (Dio2), a gene that is required for T4-mediat

128 ormone receptor (Trhr), type 2 iodothyronine deiodinase (Dio2), mediator complex subunit 12 (Med12/Tr

129 Ppp1r3d, Ppp1r3g) and type II iodothyronine deiodinase (Dio2).

130 zyme responsible for this conversion, type 2 deiodinase (DIO2).

131 regulation of types II and III iodothyronine deiodinases (Dio2 and Dio3, respectively), key enzymes i

132 hyroid hormone induced bZip protein (thibz), deiodinases (dio2, dio3), thyroid receptors (tralpha, tr

133 on of the proximal promoter for the type III deiodinase (dio3) gene in the hamster hypothalamus is re

134 s by ~22% and increased type 3 iodothyronine deiodinase (DIO3) mRNA expression in both sexes.

135 ts, express high levels of a T3-inactivating deiodinase, Dio3.

136 ation complexes at the TR target gene type I deiodinase (DioI) together with RNA polymerase II (Pol I

137 Iodothyronine deiodinases (Dios) are important selenoproteins that con

138 Deiodinases (DIOs) are selenoproteins involved in thyroi

139 d drug treatment and targeting iodothyronine deiodinases (DIOs) to suppress cellular tri-iodothyronin

140 Type 3 deiodinase, encoded by Dio3, is expressed in the immatur

141 hyroid hormone availability is controlled by deiodinase enzymes (DIO2 and DIO3) expressed in tanycyte

142 is at the active center of the iodothyronine deiodinase enzymes that catalyze the conversion of the p

143 In addition, deiodinase enzymes that regulate levels of the main acti

144 lation of supply of triiodothyronine (T3) by deiodinase enzymes.

145 f IMC-H7 on hypothalamic expression of these deiodinase enzymes.

146 of activating and inactivating iodothyronine deiodinase enzymes.

147 non-selenocysteine containing subunit of the deiodinase family of enzymes.

148 athione peroxidase family of enzymes, the 5' deiodinases, formate dehydrogenases, glycine reductase,

149 ng of the 29-kDa subunit (p29) of type II 5'-deiodinase from a lambdazapII cDNA library prepared from

150 Deregulation of deiodinase function and thyroid hormone status has been

151 omolog 1 gene and the type III iodothyronine deiodinase gene (Dlk1-Dio3) is located on distal mouse c

152 ts from the GPX1 and type I iodothyronine 5'-deiodinase genes in RNA electrophoretic mobility shift a

153 Additionally, the deiodinase has been discovered to act as a debrominase a

154 g, particularly through induction of type II deiodinase, has a central role in brown adipogenesis in

155 and Cys194, which has been conserved in all deiodinases identified to date.

156 3 (GPx3; <86.9 ng mL(-1)) and iodothyronine deiodinase (IDI; <64.8 ng mL(-1)), respectively.

157 Iodothyronine deiodinases (IDs) are mammalian selenoenzymes that catal

158 omodulin, collagen types II/X downregulated, deiodinase II and netrin-1 upregulated.

159 of the TGR5 receptor with triamterene or of deiodinase II downstream of the TGR5 receptor with iopan

160 in the thyroid hormone-inactivating enzyme, deiodinase-III (Dio3) and insulin-like growth factor 2 (

161 imprinted thyroid hormone-inactivating gene deiodinase-III (Dio3) is responsible.

162 tamorphic changes, suggesting a role for the deiodinase in modulating the influence of TH on these ti

163 of thyroxine to triiodothyronine via type 2 deiodinase in mouse skeletal muscle and in a cell model

164 hese data suggest that the native type II 5'-deiodinase in rat brain is unrelated to this artificial

165 s thyroid hormone (TH) receptor isoforms and deiodinases in an age-dependent pattern as glucose respo

166 PT to control expression of thyroid hormone deiodinases in ependymal cells (tanycytes) of the fetal

167 The discovery of these new roles for the deiodinases indicates that tissue-specific deiodination

168 compounds with distinct thyroperoxidase and deiodinase inhibition potencies (methimazole, iopanoic a

169 We also assessed TBMEHP for deiodinase inhibition using rat liver microsomes and for

170 The deiodinase inhibitor iopanoic acid blocks T4- but not T3

171 rom fish transferred to SW plus or minus the deiodinase inhibitor, iopanoic acid, revealed SW-induced

172 The cellular TH level is mainly regulated by deiodinase iodothyronine (DIO)-2 and -3.

173 at miRNAs of the delta-like homolog 1 (Dlk1)-deiodinase iodothyronine type III (Dio3) locus are up-re

174 ly regulated DLK1-DIO3 (delta-like 1 homolog-deiodinase, iodothyronine 3) cluster on human chromosome

175 Type I iodothyronine deiodinase is a approximately 50-kDa, integral membrane

176 Iodotyrosine deiodinase is a member of the same structural superfamil

177 Type II iodothyronine 5'-deiodinase is an approximately 200-kDa multimeric enzyme

178 Iodotyrosine deiodinase is essential for iodide homeostasis and prope

179 However, the deiodinase is not structurally related to other known fl

180 Type I deiodinase is the best characterized member of a small f

181 Expression of the type III deiodinase is up-regulated in growing tissues nearing co

182 The flavoprotein iodotyrosine deiodinase (IYD) is responsible for iodide salvage by re

183 The flavoprotein iodotyrosine deiodinase (IYD) salvages iodide from mono- and diiodoty

184 o-, and chlorotyrosine, analogous to related deiodinases (IYDs) from humans and other mesophiles.

185 thyroxine modulates type II iodothyronine 5'-deiodinase levels by initiating the binding of the endos

186 als, local regulation of thyroid hormones by deiodinases likely plays a role in erythropoiesis.

187 The results suggest that type 3 deiodinase limits hormonal exposure of the cone to level

188 Targeting iodothyronine deiodinases locally in the retina is a therapeutic strat

189 velopmental expression patterns suggest that deiodinases may control the concentration of active thyr

190 age, and 2) the identification of peripheral deiodinase-mediated T4-to-T3 conversion provided a physi

191 tochemical studies were performed for type 2 deiodinase mRNA and DARPP-32 immunoreactivity (IR), or D

192 Both type 2 deiodinase mRNA and DARPP-32-IR also extended into tanyc

193 gene nor lovastatin treatment reduced type I deiodinase mRNA levels.

194 Type 2 deiodinase mRNA was found in the cell bodies of all DARP

195 pot 14, Bcl-3, glucose 6-phosphatase, and 5'-deiodinase mRNA was higher in transgenic mice than litte

196 In contrast, type 2 deiodinase mRNA was not present in the same cells that c

197 e relative mRNA expression of genes encoding deiodinases, nuclear thyroid receptors, and membrane tra

198 T4 metabolism is regulated by the deiodinases of which type 2 is expressed in humans in sk

199 We identified two type 2 deiodinase paralogs, dio2a and dio2b, responsible for co

200 ible role for personalized medicine based on deiodinase polymorphisms.

201 of translation or degradation of the type I deiodinase protein.

202 n genes encoding type I and II iodothyronine deiodinases, respectively.

203 l fat a robust induction occurred for type 2 deiodinase, sarcoendoplasmic reticulum Ca2+-ATPase, mito

204 Extensive deiodinase studies indicated that T1AM was derived from

205 re required for activity in the iodotyrosine deiodinase subgroup of this superfamily, attention was d

206 The amino acid sequence of the deiodinase suggests the presence of three domains.

207 A similar decrease in type I deiodinase synthesis was observed when transfected cells

208 ane receptor (integrin), four proteinases, a deiodinase that degrades thyroid hormone, and a protein

209 catenin reduced D3 levels and induced type 2 deiodinase (the D3 antagonist that converts 3,5,3',5' te

210 ith the Shh-mediated reduction of the type 2 deiodinase, the thyroxine-activating enzyme, and both ef

211 The deiodinases thus appear to play an important role in reg

212 s) linking inhibition of thyroperoxidase and deiodinase to impaired swim bladder inflation in fish ha

213 ne (TH) receptor or a type-III iodothyronine deiodinase transgene in the nervous system have reduced

214 eroid receptor superfamily), a TH-converting deiodinase, two metabolic enzymes, a protein disulfide i

215 2 and beta1, with regional colocalization of deiodinase type 2 (D2) mRNA in the developing forebrain,

216 iodide symporter, and deiodinase type 2, and deiodinase type 2 enzyme activity.

217 hyroperoxidase, sodium iodide symporter, and deiodinase type 2, and deiodinase type 2 enzyme activity

218 Deiodinase type 3 (D3) mRNA expression was confined to t

219 Thyroid hormone (TH) metabolism, mediated by deiodinase types 1, 2, and 3 (D1, D2, and D3) is profoun

220 iodide salvage in the thyroid, iodotyrosine deiodinase, was solubilized from porcine thyroid microso

221 unctions of Se-dependent enzymes, such as TH deiodinases, which convert thyroxine (T4) to the physiol

222 y, we investigated the role of iodothyronine deiodinases, which in target tissues convert the prohorm

223 rain, cellular levels of TH are regulated by deiodinases, with deiodinase-2 mediating TH activation a