ライフサイエンスコーパス: deleterious

1 e, excessive engagement of the system can be deleterious.

2 icrobe, whereas S aureus has been considered deleterious.

3 lity of all mutations, whether beneficial or deleterious.

4 d FMT, and transmission of Bacteroidetes was deleterious.

5 ico algorithms predicted five variants to be deleterious.

6 to sepsis through its ability to reduce the deleterious action of immunothrombi while maintaining in

7 tected in dsDNA, it is commonly assumed that deleterious alkylation damage to the Watson-Crick faces

8 ulation, variant allele frequency > 0.3 of a deleterious allele in a known germline predisposition ge

9 s for which sexual reproduction would reveal deleterious alleles in less fit genotypes.

10 by breaking linkage between advantageous and deleterious alleles in the case of introgressions.

11 nuclear genome evolves to compensate for the deleterious alleles in the mitochondrial genome, present

12 Here, we identified two deleterious alleles of RABL2A, a gene essential for norm

13 otypes, complicating strategies to eradicate deleterious alleles or stack beneficial alleles via meio

14 recombine, and is subject to accumulation of deleterious alleles via Muller's ratchet.

15 Such deleterious alterations, including epigenetic drift, irr

16 of rDNA double-strand break (DSB) repair are deleterious, and can lead to rDNA transcriptional arrest

17 )/angiotensin type 1 receptor (AT1R) axis, a deleterious arm of RAS, unleashing its detrimental effec

18 hich is advantageous at high temperature but deleterious at low temperature for both nitrogen fixatio

19 NM status (DNM or familial mutation [FM]) of deleterious autosomal dominant germline mutations for an

20 ed to be functional by ChromHMM and more are deleterious based on their Combined Annotation Dependent

21 g the protein aggregation process in driving deleterious biological function and establish a direct c

22 Furthermore, the consequences of deleterious brain-heart interactions are not limited to

23 safety populations included patients with a deleterious BRCA alteration who received >= 1 dose of ru

24 itumor activity in patients with mCRPC and a deleterious BRCA alteration, but with a manageable safet

25 thetic lethality between PARP inhibition and deleterious BRCA1/2 mutations, leading to clinical appro

26 TNNT2:p.R286H, 2.7%) but are predicted to be deleterious by computational tools.

27 ecipitate the disease process and initiate a deleterious cascade involving tau pathology and neurodeg

28 ave as strong loss-of-function variants, and deleterious CDK19 variants underlie a syndromic neurodev

29 le contacts coordinate responses to mitigate deleterious cellular effects caused by disrupted NPC ass

30 ed to cause competitive exclusion leading to deleterious changes in food web diversity.

31 Conversely, many of these deleterious CLDN5-related molecular changes were reduced

32 d cell wall metabolism and could combat some deleterious climate change effects.

33 Deleterious collateral fitness effects occurred more fre

34 The surprising prevalence of deleterious collateral fitness effects suggests they may

35 Tannins were the most deleterious compounds for iron solubility, while phytate

36 brain now appears a strong possibility with deleterious consequences and an urgent need for addressi

37 disruptions to these processes can result in deleterious consequences for the structure and function

38 the damaged glycocalyx and to attenuate its deleterious consequences have been suggested.

39 the mGluR4 PAM VU0155041 relieves long-term deleterious consequences of morphine exposure.

40 croglia to the region thereby curtailing the deleterious consequences of neuroinflammation.

41 an EP2 receptor antagonist relieves multiple deleterious consequences of SE.

42 This adaptive process was likely not without deleterious consequences to health.

43 financial hardship from medical bills, with deleterious consequences.

44 Deleterious copy number variants (CNVs) are identified i

45 nt HIV from T cells in culture, it can cause deleterious cytokine dysregulation in patients.

46 striction, as well as their vulnerability to deleterious diet effects at different life stages.

47 tistical approach to systematically evaluate deleterious DNMs in inherited cancer syndromes.

48 The proportion of cases harboring likely deleterious dnSNVs/indels did not differ significantly b

49 Likely deleterious dnSNVs/indels were detected in 9 of 67 (13%)

50 ecular processes underlying the induction of deleterious donor-specific antibody (DSA) responses rema

51 This is another example of the deleterious ecological effects of antibiotic use and sho

52 and dietary zinc deficiency exaggerated the deleterious effect of alcohol on PC bactericidal activit

53 on is fundamentally limited by crowding, the deleterious effect of clutter that disrupts the recognit

54 D1R deletion blocked the deleterious effect of cocaine on SVZ cell proliferation

55 The deleterious effect of Col1 mutations on global skeletal

56 that of natural hosts, supporting a general deleterious effect of excessive CUB similarity between v

57 s lack of homogeneity could suggest that the deleterious effect of OSA and its contribution to CVD co

58 oxification, a pathway which complements the deleterious effect of radicals generated via parent drug

59 To prove the genuine deleterious effect of the mutation on heart tissue, we f

60 Functional assays in yeast support the deleterious effect of these variants on protein function

61 ct of the pandemic on cancer care due to its deleterious effect on cancer research, as well as biolog

62 porter assay revealed that each mutant had a deleterious effect on gene regulation, even when compens

63 red nucleotide pathway in each subtype has a deleterious effect on in vivo tumor growth, whereas knoc

64 Whether deleterious effects are direct on the offspring or secon

65 enesis, yet the mechanisms preventing Ca(2+) deleterious effects are poorly understood.

66 ncreasing the levels of Hsp27 suppressed the deleterious effects induced by MGO.

67 cological activation of HDAC1 alleviates the deleterious effects of 8-oxoG in aged wild-type and 5XFA

68 ME using tissue nanotransfection negated the deleterious effects of a high-fat diet on cardiac functi

69 5xFAD mice, and uPA treatment abrogates the deleterious effects of Abeta on the synapse.

70 scription of uPA mRNA, leaving unopposed the deleterious effects of Abeta on the synapse.

71 cepted that exercise effectively combats the deleterious effects of aging in the musculoskeletal syst

72 a therapy to mitigate, at least in part, the deleterious effects of BD in small bowel donors.

73 Moreover, the deleterious effects of brain movement on high-speed imag

74 he mechanisms by which these cells evade the deleterious effects of CDCs are largely unknown.

75 ation is often lifesaving, but the long-term deleterious effects of combinatorial immunosuppression r

76 tal muscles utilize miR-133b to mitigate the deleterious effects of DMD.

77 tivated neuropeptide, CRH, contribute to the deleterious effects of early-life adversity on hippocamp

78 ipotoxicity (GLT), which refers to combined, deleterious effects of elevated glucose and fatty acid l

79 h the weight of evidence presently favouring deleterious effects of EVs in asthma.

80 ned plant processes that help to prevent the deleterious effects of high and excess light on plant ce

81 from the separation channel, mitigating the deleterious effects of Joule heating.

82 aling pathways can be leveraged to attenuate deleterious effects of O(2) .

83 Thus, the deleterious effects of ocean acidification are modulated

84 removal is safe and feasible and avoids the deleterious effects of positive-pressure mechanical vent

85 Deleterious effects of protein carbonylation by reactive

86 Our results demonstrate deleterious effects of reducing EphA4 levels in juvenile

87 s for existing interventions that reduce the deleterious effects of resistance and allows exploration

88 ally high expression of Srrt in ESCs offsets deleterious effects of retrotransposable sequences accum

89 roximal to the ribosome, which may limit the deleterious effects of RNH misfolding and assist in fold

90 mune and brain endothelia contributes to the deleterious effects of SE, and will assist in the develo

91 Thus, deleterious effects of shear stress are initiated by Pie

92 ase-type (uPA) protects the synapse from the deleterious effects of soluble Abeta.

93 vivo dystrophin gene excision revealed acute deleterious effects of tamoxifen on striated muscles, in

94 To mitigate the deleterious effects of temperature increases on cellular

95 cious circle that maintains the long-lasting deleterious effects of the reciprocal interaction betwee

96 rve as a protective mechanism to prevent the deleterious effects of TWEAK on atherosclerotic plaque d

97 The deleterious effects of WD on the gut microbiota can be r

98 in transmembrane domains exhibiting strongly deleterious effects on abundance and activity.

99 fects occurred more frequently in TEM-1 than deleterious effects on antibiotic resistance in environm

100 Kmt2d haploinsufficiency has broad deleterious effects on B-cell differentiation, specifica

101 ile manipulation of SIRT3 expression has few deleterious effects on cancer cells in attached conditio

102 ing, particularly RV apical pacing, can have deleterious effects on cardiac function.

103 ow dissolved oxygen (DO) conditions may have deleterious effects on early life stages in fishes.

104 t the therapeutic potential of EGCG, and the deleterious effects on growth and skeletal phenotypes un

105 Persisting circadian misalignment leads to deleterious effects on health and healthspan.

106 hat insecure and stressful settings may have deleterious effects on health, understanding the sources

107 gical inhibition of mTOR using Rapamycin has deleterious effects on hematopoiesis.

108 let activation and reduce thrombosis without deleterious effects on hemostasis.

109 SA due to RI mismatches has many deleterious effects on imaging.

110 on can be sustained for long periods without deleterious effects on longevity.

111 uces neuronal damage, and NAC reverses these deleterious effects on mitochondrial function.IMPORTANCE

112 contribution to fitness is buffered against deleterious effects on protein activity and protein abun

113 ies of these foods could be enhanced without deleterious effects on quality.

114 Prolonged exposure to hyperoxia has deleterious effects on the lung, provoking both inflamma

115 n of fibrinolysis, which could have possible deleterious effects on the tooth-supporting structures o

116 balance of the southern tropical Andes with deleterious effects on this densely populated region of

117 ldosterone levels, which are associated with deleterious effects on various organ systems including t

118 of rare alleles genome-wide, with predicted deleterious effects that are equivalent to loss-of-funct

119 s imposed by this principle could circumvent deleterious effects that limit the performance of photon

120 m can unexpectedly have either beneficial or deleterious effects to plants.

121 lts in some dose delivered to the bowel with deleterious effects to the small and large intestines.

122 t growth under low external Pi supply and no deleterious effects under Pi-sufficient conditions.

123 No deleterious effects were observed in WRN(-/-) or BLM(-/-

124 can have a wide range of effects (including deleterious effects) on the host immune response.

125 iate frequencies, such as late-life-specific deleterious effects, antagonistic pleiotropic effects on

126 re and cancer could have platelet off-target deleterious effects.

127 lifestyle changes required to mitigate their deleterious effects.

128 t3 expression in Sirt3OX mice prevents these deleterious effects.

129 t cortical inputs was sensitive to alcohol's deleterious effects.

130 hat have comparative effectiveness and fewer deleterious effects; and provide thoughts on the future

131 r to proceed in good yields while minimizing deleterious elimination reactions.

132 Exposure to these xenoestrogens may cause deleterious estrogenic responses, such as DNA damage, in

133 interferon response and lacks human-specific deleterious events, such as downregulation of neurotroph

134 ng of the quinone cocatalyst overcomes these deleterious features.

135 It may also help mitigate deleterious folding events between neighboring RDs that

136 al infections, being protective for some but deleterious for others.

137 d across diverse species and its mutation is deleterious for protein functions, as demonstrated by ou

138 l mutant carrying Rcr3 and Pip1 alleles with deleterious frame-shift mutations.

139 king functions for Rep and RecA in resolving deleterious G4 structures.

140 the nuclear pore assembly and sponging away deleterious (G4C2)-RNA repeats.

141 ered by evolutionary biology for survival of deleterious genes is antagonistic pleiotropy.

142 onary dynamics of genetic variation, so that deleterious genetic variants, including antibiotic resis

143 ched DNA intermediates such that potentially deleterious genome rearrangements arising from frequent

144 ration entails risks, as fusion can transmit deleterious genotypes or infectious components that redu

145 reast cancer at age <= 40 years and harbored deleterious germline BRCA mutations.

146 Eligible patients (aged >=18 years) had deleterious germline BRCA1 or BRCA2 mutation-associated,

147 r identifying an individual likely to have a deleterious germline variant include a strong family his

148 utational framework for identifying putative deleterious germline variants (pDGVs) from WES data.

149 Genome sequencing has identified a host of deleterious germline variants in key cardiomyocyte genes

150 erved an increased burden of rare, predicted deleterious germline variants in TET2 in PAH patients of

151 he prevalence and biological consequences of deleterious germline variants in urothelial cancer (UC)

152 evelopment of novel therapeutics that target deleterious glial activity.

153 , in addition to the potential of MD1003 for deleterious health consequences from interference of lab

154 cer, and assays for cytotoxicity can predict deleterious health effects.

155 ein-FKBP-MCAK CRISPR cells we found that one deleterious hot-spot mutation increased chromosome insta

156 n protections, add new protections, mitigate deleterious human impacts and restore forest structure.

157 nder identical conditions owing to competing deleterious hydride transfer chemistry.

158 y sometimes be outweighed by the potentially deleterious hyperinflammatory consequences of activating

159 an be targeted by antibody therapy to reduce deleterious immune signaling caused by chronic overexpre

160 ble targets for preventing the initiation of deleterious immunity after alloSCT.

161 Human studies show the deleterious impact of prenatal inflammation and low n-3

162 Vascular comorbidities have a deleterious impact on multiple sclerosis clinical outcom

163 Further, obstetrical injury has significant deleterious impact on recovery of the vaginal wall from

164 eval and restrict prospective planning, with deleterious impacts on behavior.

165 Drought has many known deleterious impacts on human health, but little is known

166 BADC3, or BADC1 present increasingly greater deleterious impacts on morphological and biochemical phe

167 llution from coastal cities is likely having deleterious impacts on seafloor ecosystems which provide

168 actions involving genetic mutations that are deleterious in a permissive environment but beneficial i

169 IL-4Ralpha signaling on B cells is deleterious in allergic asthma because it is required fo

170 at exhibit high fitness in one strain can be deleterious in another, indicating that the evolutionary

171 beneficial in the presence of rifampicin and deleterious in its absence.

172 accumulate that are neutral in multimers but deleterious in monomers; purifying selection would then

173 east 42% of missense mutations in TEM-1 were deleterious, indicating that for some proteins collatera

174 estinal barrier disruption, genotoxicity and deleterious inflammation.

175 Crowding is the deleterious influence of surrounding objects (flankers)

176 sults show that it is possible to reduce the deleterious influences of isoprene on the atmosphere, wh

177 cts against endogenous dsRNA formation and a deleterious innate immune response during mammalian hema

178 cterizing the pathophysiological overlap and deleterious interactions between AF and HF; preventing H

179 e transiently exposed, and the likelihood of deleterious interactions is quite high.

180 es revealed that antioxidant enzymes acquire deleterious isoAsp residues during stress, which adverse

181 E (PIMT) repairs other proteins by reverting deleterious isoAsp residues to functional aspartyl resid

182 adrenergic receptor activation, however, has deleterious long-term effects leading to hypertrophy and

183 (gain-of-function) significantly worse than deleterious (loss-of-function).

184 Severe immunopathology may drive the deleterious manifestations that are observed in the adva

185 rochromatin, LSH may be essential to prevent deleterious meiotic recombination events at repetitive c

186 rgy metabolism in a manner that reverses the deleterious metabolic adaptations of the failing heart.

187 l role of non-microglial IL-10 in preventing deleterious microglia hyperactivation.

188 to protein function because they destabilize deleterious misfolded conformations and inter-chain inte

189 It reflects a gene's tolerance to deleterious missense mutations and serves as a useful to

190 id models revealed ASM and ceramide-mediated deleterious mode-of-action: when ceramide reduced the nu

191 computer simulations needed to minimize the deleterious moisture effects on long-time deformations,

192 engage in shift work are susceptible to its deleterious mood effects.

193 We found that deleterious mutation burden was significantly greater in

194 ucidate the mechanisms underlying how ARID1A deleterious mutation contributes to tumorigenesis, we es

195 iciency (GBED) is the result of one of these deleterious mutations (102C > A), in the first exon of t

196 selective sweeps [SSWs]), the elimination of deleterious mutations (background selection [BGS]), or b

197 We concluded that the rates of deleterious mutations affecting genes associated with th

198 le-gene deletions, deleterious or presumably deleterious mutations affecting TP53 (n = 3), CHEK2 (n =

199 Deleterious mutations and differentially expressed allel

200 Here, we use improved modeling of weakly deleterious mutations and the demographic history of the

201 nd lacks conventional DNA repair mechanisms, deleterious mutations are exceedingly rare.

202 dation for future studies evaluating how new deleterious mutations can be established in the germline

203 Deleterious mutations caused improper posttranslational

204 ination and results from the accumulation of deleterious mutations due to selective interference-the

205 enomic diversity, including 22,134 predicted deleterious mutations in 10,642 annotated genes.

206 quasi-mesenchymal phenotype, suggesting that deleterious mutations in ARID1A associated with protein

207 Our hypothesis was that deleterious mutations in channelopathy genes may have a

208 Furthermore, based on the human deleterious mutations in citrin, we found a potential in

209 Assays in diploids are consistent with deleterious mutations in diploids tending towards recess

210 ge have small population size and accumulate deleterious mutations in genes significantly enriched in

211 more vigorously than mitochondria containing deleterious mutations in hetreoplasmic cells.

212 ) is a fatal neuromuscular disease caused by deleterious mutations in the DMD gene which encodes the

213 apes; and (3) the frequency and magnitude of deleterious mutations increase with background fitness,

214 ated autoimmunity trade-offs, hitchhiking of deleterious mutations linked to the MHC, geographic subd

215 Cancer cells with germline deleterious mutations of BRCA1 or BRCA2 are deficient in

216 which become selectively haploidized to mask deleterious mutations on coding sequences.

217 bining regions of various factors, including deleterious mutations or transposable elements resulting

218 The DNA glycosylase MutY prevents deleterious mutations resulting from guanine oxidation b

219 s decreases tend to decelerate and harm from deleterious mutations shrinks during the accumulation of

220 genetic variability of the virus resulted in deleterious mutations that affected viral protein functi

221 higher frequency at first, but more frequent deleterious mutations undermined their eventual success.

222 tt sites, active 'attB' sites flanking human deleterious mutations were previously identified that ma

223 onmental DNA can prevent the accumulation of deleterious mutations, but LGT was abandoned by the firs

224 rugs, post-transcriptional modification, and deleterious mutations.

225 on has resulted in unwanted incorporation of deleterious mutations.

226 ss that results from the continual influx of deleterious mutations.

227 on(s), (e) functional consequence (including deleterious, neutral, or advantageous), and (f) addition

228 a target for alleviating the consequences of deleterious NLGN1/3 mutations, supported by assays with

229 r, expression of a subset of variants led to deleterious nucleolytic degradation of stalled DNA repli

230 zing whole brain radiation therapy result in deleterious off-target effects on the normal developing

231 their proper function and the elimination of deleterious off-target effects.

232 ying assumption that beta-arrestin2 mediates deleterious opioid effects.

233 ult, and the resulting pathologies are often deleterious or fatal.

234 we found a total of 15 whole-gene deletions, deleterious or presumably deleterious mutations affectin

235 e is damage to biomolecules with potentially deleterious outcome in pathophysiology and disease, "oxi

236 promote accurate homolog segregation without deleterious outcomes, such as aneuploidy.

237 access to the binding site and (2) limiting deleterious oxidation of the protein scaffold.

238 exon definition prevents the accumulation of deleterious, partially spliced retention products during

239 strates the C-H activation step in favour of deleterious pathways.

240 ruit fly, Ceratitis capitata Wiedemann, is a deleterious pest worldwide affecting fruit production.

241 noids have been linked to more sustained and deleterious pharmacodynamic effects.

242 a defined order of interaction that prevents deleterious, premature activation of crossovers.

243 naemia, in the absence of IFD, can result in deleterious pro-inflammatory immune responses.

244 so offers a cautionary note on the potential deleterious, pro-fibrotic effects of exogenous MSCs once

245 let repeat expansion, but its action in this deleterious process has remained unknown.

246 s and eroded mitochondrial function(1)-these deleterious processes interact with extraordinary comple

247 ending with cell membrane rupture may incite deleterious proinflammatory responses, which can exacerb

248 as resulting in either nonfunctional or even deleterious protein products.

249 a futile cycle, the byproducts of which are deleterious reactive oxygen species.

250 drives cellular dysfunction, cell death, and deleterious remodeling within various body tissues.

251 and presentation pathway to stimulate these deleterious responses.

252 Altogether, we uncover a deleterious role for Siglec-1 in TB-HIV-1 co-infection a

253 The inferred deleterious role of APP and DR6 is confirmed in vitro in

254 mouse model where activated microglia play a deleterious role.

255 osition (RT) can play either advantageous or deleterious roles in tumor progression, depending on the

256 most of the TA-associated variants received deleterious scores by potentially destabilizing or preve

257 inject drugs (PWID) are at increased risk of deleterious sequelae due to infective endocarditis (IE).

258 limit the duration and extent of potentially deleterious signaling through CysLT(2)R, and it may cont

259 y constitute the genetic basis, including 1) deleterious single-nucleotide polymorphisms (SNPs), in-f

260 irreversible, ratchet-like, accumulation of deleterious somatic alterations, provided that they occu

261 ns that are beneficial at one time to become deleterious soon after because of antagonistic pleiotrop

262 wth and apoptosis in response to a myriad of deleterious stimuli, including failed cytokinesis.

263 t is predicted to be in the top 0.3% of most deleterious substitutions in the human genome.

264 igh levels in the circulation to prevent the deleterious systemic effects of Il-18.

265 efenses during early development can lead to deleterious TE mobilization.

266 ariable regimens including daily forays into deleterious temperatures.

267 A novel deleterious TMEM98 variant (NM_015544.3, c.602G>C, p.(Ar

268 ays change over time and can transition from deleterious to beneficial and vice versa as degeneration

269 The impact of this overload is deleterious to brain health, and it results in vulnerabi

270 uency within a population even when they are deleterious to individuals carrying them.

271 fate of microbial pathogens and may also be deleterious to the host during bacterial and viral infec

272 Translational frameshift errors are often deleterious to the synthesis of functional proteins and

273 f Kras-driven lung and pancreatic cancer was deleterious to tumor initiation and progression.

274 iversal loss of the G1/S checkpoint (through deleterious TP53 mutations), premature S phase entry (du

275 enomes and have allowed the establishment of deleterious traits that serve as the raw materials for g

276 The beneficial-to-deleterious transition is dependent on availability of p

277 ngiogenesis, intratumoral heterogeneity, and deleterious tumor microenvironmental (TME) crosstalk.

278 DNA double-strand breaks (DSB) are the most deleterious type of DNA damage.

279 Among the most deleterious types of DNA damage are DNA double-strand br

280 advantageous to their wild ancestors but are deleterious under cultivation, such as pod dehiscence (P

281 We report a de novo and ultra-rare deleterious variant burden of NCKAP1 in individuals with

282 rious variants in SB patients, while no rare deleterious variant was identified in the controls (P =

283 We identified 354 deleterious variants (DV, 12.6% of patients); 39 were no

284 However, the overall spectrum of deleterious variants (point mutations and structural var

285 the relationships between rare, large-effect deleterious variants and neurodevelopmental phenotypes;

286 se findings, human disorders associated with deleterious variants in EIF2AK1 and EIF2AK2 have not bee

287 Deleterious variants in genes encoding EIF2B proteins ca

288 the five patients harboring these predicted deleterious variants in KDR.

289 Deleterious variants in NCKAP1 have been identified in i

290 ls from 20 unrelated families with predicted deleterious variants in NCKAP1.

291 ples, we identified five rare (MAF <= 0.001) deleterious variants in SB patients, while no rare delet

292 o variants in 66 genes including potentially deleterious variants in STIP1 and REV1.

293 Despite evidence that deleterious variants in the same genes are implicated ac

294 variants, to identify compound heterozygous deleterious variants in the Ubiquitin protein ligase E3

295 Among inherited cases, there is evidence of deleterious variants segregating with neuropsychiatric d

296 The same applied to three further deleterious variants that had been genotyped in the coho

297 Moreover, identified deleterious variants were validated in a populational an

298 s limiting policy discussions in potentially deleterious ways.

299 the alpaca, featuring 53 genes known to have deleterious X-linked phenotypes in humans.

300 (FMOs) to detoxify numerous and potentially deleterious xenobiotics; this activity extends to many d