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1 confirmed by construction of an independent deletion mutation.
2 Finally, we generated an ftsH deletion mutation.
3 red the Op phenotype in strains with the wzb deletion mutation.
4 t with a dominant negative mechanism for the deletion mutation.
5 redominantly a -2 frameshift GC dinucleotide deletion mutation.
6 cted in the context of a glycoprotein L (gL) deletion mutation.
7 or a GAA expansion and a FXN point/insertion/deletion mutation.
8 r frequency of single base substitution than deletion mutations.
9 ional factor contributing to the bias toward deletion mutations.
10 pecies transgene rescue and more recently on deletion mutations.
11 ression of homology-mediated duplication and deletion mutations.
12 latter sequences mimic the bulged SMI for -2 deletion mutations.
13 e generation of more mutations, particularly deletion mutations.
14 ccumulated homology-mediated duplication and deletion mutations.
15 ression of homology-mediated duplication and deletion mutations.
16 , including some with nonsense and insertion/deletion mutations.
17 ermined the locations, rates, and extents of deletion mutations.
18 and used it to screen a series of point and deletion mutations.
19 eshift mutations, as well as splice-site and deletion mutations.
20 rrangement and end joining without insertion/deletion mutations.
21 We discovered 1 patient with an intronic deletion mutation, 4 patients with point mutations withi
22 ons of single fibers demonstrated that these deletion mutations accumulate to detrimental levels (>90
23 ogenase subunits NifD and NifK, and 2OG or a deletion mutation affecting the T-loop of NifI(2) preven
24 CLL/small lymphocytic lymphoma harboring ATM deletions/mutations; all but 1 patient had a decrease in
25 ming this interpretation, a constructed vanS deletion mutation also resulted in constitutive expressi
26 on proteolytic susceptibility and C-terminal deletion mutations also confirms the proposed structure.
28 were identified by measuring the effects of deletion mutations, amino acid substitution mutations, a
41 ntaneously arising and MMS-induced insertion/deletion mutations and large rearrangements were also mo
43 ation have a unique association with exon 19 deletion mutations and show distinct clinicopathologic f
46 he plasticity of gD to tolerate insertion or deletion mutations and to construct an oncolytic HSV-1 t
48 ucleotide substitutions, small insertion and deletion mutations, and large genomic duplications and d
51 82 intraspecific substitution and insertion/deletion mutations, and provided evidence for correction
52 REB) protein in Caco2-BBE cells, whereas our deletion, mutation, and CDX2 overexpression analyses dem
56 genesis is a multistep process that involves deletions, mutations, and changes in expression of genes
57 ng the alterations newly identified, genomic deletions, mutations, and rearrangements recurrently tar
61 om NDMM patients identified presence of TP53 deletions/mutations as a necessary requirement for high-
62 This hydrogen bond network, along with a deletion mutation at alpha53, may lead to HLA-DM insensi
66 The erb1Delta161-200 and erb1Delta201-245 deletion mutations block a later step than depletion of
69 (Delta170)-F1 vector, bearing an attenuating deletion mutation (C(Delta170)) in the P/C gene and expr
70 e mutations (E399K, G709E and T754M) and one deletion mutation (c.99-100delTC)] absent in ethnically
73 Ms), structurally heterogeneous missense and deletion mutations concentrate at the ECD for unclear re
76 r shows that the naturally occurring robl(Z) deletion mutation contains the majority of the IC bindin
78 ies show that a naturally occurring in-frame deletion mutation (Del-L955) of NaV1.7 channel, identifi
80 xotrophic Salmonella vaccine strain with the deletion mutation Delta(wza-wcaM)8 developed higher vagi
81 es of a Bacillus subtilis strain with a gerD deletion mutation (Delta gerD) responded much slower tha
82 E111A, R116V/K118A, and R160V/H162A, and two deletion mutations, Delta(61-78) and Delta(121-142), on
83 s was attenuated by the inclusion of a codon deletion mutation (Delta1313) and a missense mutation (I
84 the primary loop, W180G and Y185G, plus the deletion mutation Delta491RSRR494 and point mutation 491
87 c disease cystic fibrosis (CF) often carry a deletion mutation DeltaF508 on the gene encoding the CF
88 phatase assays utilizing a virus with a UL97 deletion mutation (DeltaUL97 virus) indicated that Cdh1
90 PCR products confirmed that this was a 2-bp deletion mutation, designated c.442delAG, leading to a p
93 NA ternary complex was inhibited unless a 5' deletion mutation disrupted the second stem-loop structu
95 wn as CDX-110), a vaccine targeting the EGFR deletion mutation EGFRvIII, consists of an EGFRvIII-spec
97 , our data provide an example of an in-frame deletion mutation exerting a 'polar' effect on nearby ge
99 t domains in the Ctr9 sequence, and based on deletion mutation experiments, we demonstrated the role
102 s (hiPSCs), we efficiently create pathogenic deletion mutations for demonstrable disease models with
104 ment did not increase mitochondrial point or deletion mutation frequencies, despite evidence both com
105 ients with KIT exon 11 deletion or insertion-deletion mutation had better RFS when allocated to the 3
106 Seven missense mutations and one in-frame deletion mutation have been reported in the coagulation
108 Similarly, in the subset with KIT exon 11 deletion mutations, higher-than-the-median mitotic count
109 to generate Hsp70-deficient virions with gag deletion mutations, Hsp70 transdominant mutants, or RNA
110 HV mutational status, 11q deletion, and TP53 deletion/mutation identified CYP2B6*6 and TP53 mutation/
115 vl indicates these phenotypes result from a deletion mutation in an uncharacterized orphan G protein
116 -catenin or the prominent cancer-related S45 deletion mutation in beta-catenin present in human colon
119 tica strain RBX9, which contains an in-frame deletion mutation in fhaB, encoding filamentous haemaggl
123 identified increased levels of mtDNA common deletion mutation in postmortem sural nerves of patients
124 equences for a recurrent autosomal-recessive deletion mutation in revealing the genetic basis of SPG2
125 m mice lacking RGS11 (RGS11(-/-)), or with a deletion mutation in RGS7 (RGS7(Delta/Delta)), or both,
130 of alanine, while a mutant with an in-frame deletion mutation in the gene for alanine racemase lost
131 nts, Six3 protein with a naturally occurring deletion mutation in the helix 3 of the homeodomain does
132 r heterotopia, caused by an unusual in-frame deletion mutation in the meckelin C-terminus at the regi
136 (SHIV-Cs), we identified a 3-asparagine (3N) deletion mutation in the V2 loop stem of gp120 as the ma
141 27 genes, including nonsense, missense, and deletion mutations in Bcl11b, Hist1h2ac, Npy2r, Notch3,
142 ecutive days, and quantified mtDNA point and deletion mutations in bone marrow and liver using our ne
143 heterozygous missense or in-frame insertion/deletion mutations in C1R (15 families) or C1S (2 famili
144 recently been used to generate insertion and deletion mutations in Caenorhabditis elegans, but not to
146 y account for the 4.1-fold increase in mtDNA deletion mutations in DCM (P<0.05 versus nonfailing hear
147 n pathogenesis, we constructed disruption or deletion mutations in each of eight AT-encoding genes an
148 cancer tumours that have EGFR mutations have deletion mutations in exon 19 or the Leu858Arg point mut
149 e most common single-nucleotide substitution/deletion mutations in favorable histology Wilms tumors (
151 bacterium Bacillus subtilis by constructing deletion mutations in genes predicted to be involved in
155 rains, including C57BL/6J, carry nonsense or deletion mutations in Mx1 and thus a nonfunctional allel
159 We constructed and characterized in-frame deletion mutations in several FrzS domains to determine
160 glaucoma revealed clustering of missense and deletion mutations in the 5-phosphatase domain and the R
163 y missense, nonsense, frameshift, splice, or deletion mutations in the genes for p22(phox), p40(phox)
164 on of the successful attenuating capacity of deletion mutations in the guaBA operon in S. flexneri 2a
166 eport the presence of acquired insertion and deletion mutations in the NF-E2 gene in MPN patients.
167 also has an elevated level of insertion and deletion mutations in the peri-telomeric genes, which is
168 bind HIV-1 gp120, we constructed a series of deletion mutations in the repeat regions of both recepto
169 st neutron (FN) radiation was used to induce deletion mutations in the soybean (Glycine max) genome.
177 ions (IGH@-CRLF2, P2RY8-CRLF2, CRLF2 F232C), deletion/mutation in genes frequently associated with hi
178 genes were cloned, and chromosomal insertion-deletion mutations inactivating them were obtained to de
180 periodicity and linearity, reveal that while deletion mutations indicate a notable disruption in frac
181 proliferation assays with N- and C- terminal deletion mutations indicated that the central portion of
182 n of new origins is not suppressed by a greA deletion mutation, indicating an active role of DksA rat
183 he pathway (i.e. leu1Delta or leu2Delta gene deletion mutations) induced post-transcriptional up-regu
185 n, specifically, a non-temperature-sensitive deletion mutation involving 6 nucleotides in the overlap
186 ith the copresence of complex karyotypes and deletions/mutations involving TP53 demonstrated a partic
187 RNA harboring a complete 3' noncoding region deletion mutation is infectious (not merely quasi-infect
188 In chronic lymphocytic leukemia (CLL), TP53 deletion/mutation is strongly associated with an adverse
189 explored their genetic interactions with 18 deletion mutations known to cause chromosome instability
191 hat seven nontruncating missense or in-frame deletion mutations (L986F, delF1289, R1648C, F1661S, G16
193 of the 5' flanking region by progressive 5' deletion mutations localized transcription repression el
194 breast tumors, there are specific insertion/deletion mutations located close to R-loop-mediated BRCA
195 f these mutations involve either missense or deletion mutations located in a region of the proSP-C mo
197 sed frequency of chromosomal translocations, deletions, mutations, micronuclei, and decreased plating
198 utations at pre-binding sites, insertion and deletion mutations, microsatellite expansions, or tandem
201 concomitantly reduces the occurrence of "-1 deletion" mutations observed opposite the lesion at lowe
202 identified and characterized a novel exon 27 deletion mutation occurring within the EGFR carboxyl-ter
203 ozygous missense or small in-frame insertion/deletion mutations occurring within one of the helix bou
205 lls containing intact wild-type genomes or a deletion mutation of the COX2 gene gave rise to populati
206 genomic editing, we discovered that a small deletion mutation of the Mel1a melatonin receptor (mtnr1
207 otide 'TAG' sequences incorporated into each deletion mutation of the yeast knockout collection, allo
211 these genes in pathogenesis, large in-frame deletion mutations of bcaA and bcaB were constructed in
212 ation has negative genetic interactions with deletion mutations of both capping protein subunits and
213 that 18.3% of relapse cases had sequence or deletion mutations of CREBBP, which encodes the transcri
214 We generated isogenic MCF10A cell lines with deletion mutations of genes encoding cohesin subunits SM
215 viruses and was sensitive to specific glycan deletion mutations of HIV-1 glycoproteins, indicating th
222 ial myosin-II heavy-chain gene (myo2-E1) and deletion mutations of the other myosin heavy-chain genes
226 iver and tumour tissue revealed insertion or deletion mutations of the tumour suppressor genes, inclu
232 tightly linked to deletion of DDX3Y and that deletions/mutations of USP9Y can be transmitted from one
233 on immunogenicity and the efficacy of a sopB deletion mutation on two Salmonella enterica serovar Typ
234 f the cadherin point mutation W2A and domain deletion mutations on C-cadherin binding signatures.
237 efit was also observed in patients with TP53 deletion, mutation, or both and in patients with unmutat
238 functions in a virus-specific mode, and its deletion, mutation, or replacement by the same subdomain
240 in mouse embryos, including indel (insertion/deletion) mutations, point mutations, large deletions, a
241 y identified 2 patients with novel insertion/deletion mutations predicted to result in mRNA nonsense-
244 letion mutations and no insertions, giving a deletion mutation rate of 1.2 x 10(-9) (95% confidence i
248 ration (STGD3), with a five base-pair (5 bp) deletion mutation resulting in the loss of 51 carboxy-te
249 reaction driven by dithiothreitol, the 43-51 deletion mutation retained 85% and C43A/C51A 112% of the
250 ype that results from the p.epsilonDeltaF266 deletion mutation revealed by the coinheritance of the l
253 ptional activity mediated by the PR NTD, and deletion mutations showed that a region (amino acids 327
255 nstable conformation, whereas the C-terminal deletion mutation stabilized the Fas conformation, and b
257 ere further grouped as deletion or insertion-deletion mutations, substitution mutations, insertion or
258 te the properties of this subdomain, a small deletion mutation (targeting aspartic acid 346 and glyci
259 fication had significantly more EGFR exon 19 deletion mutations than adenocarcinomas with disomy, and
265 utations were identified, including two 2-bp-deletion mutations, the first non-nonsense mutations ide
267 vivo was investigated by combining in-frame deletion mutations to generate all possible double, trip
268 e sites could allow single base insertion or deletion mutations to occur, and stringent DNA groove mo
269 Previous studies had utilized insertion and deletion mutations to show that portions of the MLD are
271 n induces an especially high frequency of -2 deletion mutations; vulnerability to these mutations is
274 er number of microsatellite expansion versus deletion mutations was observed, and expansion rates of
277 ological role of LdTyrRS in Leishmania, gene deletion mutations were attempted via targeted gene repl
278 ysiological role of ASNA in Leishmania, gene deletion mutations were attempted via targeted gene repl
281 addition, compound heterozygous missense and deletion mutations were found in three additional unrela
285 ound in high CRLF2 expressors, whereas IKZF1 deletions/mutations were distributed across the full coh
286 ght independent alleles, with frameshift and deletion mutations) were created in C3H and C57BL/6J bac
287 ingle nucleotide polymorphisms and insertion/deletion mutations when our Weiss (n = 4) and Nigg (n =
288 ique to a given line, except for a single-nt deletion mutation which occurred independently in two li
290 tection confirmed specific genomic insertion/deletion mutations with 99.5% penetrance in sorted cells
291 Each gene has a coding sequence insertion/deletion mutation within the SC species that produces a
294 t contained frameshift, point, insertion, or deletion mutations within rdxA, possibly revealing genet
295 f HDAC6, stop/gain insertion in MORF4L1, and deletion mutations within SWI/SNF complex component SMAR
299 made a collection of truncation and in-frame deletion mutations within the VP1/2 gene (UL36) and exam