ライフサイエンスコーパス: delivery

1 in epithelium, enabling epicutaneous vaccine delivery.

2 ncer cell migration through exosome-mediated delivery.

3 clearance of those proteins after pulmonary delivery.

4 apid termination of VT during radiofrequency delivery.

5 be used for tumor-targeted imaging and drug delivery.

6 impact on enrolment into community-based ART delivery.

7 n was required for 27 patients (8.8%) during delivery.

8 on with age and a strategy for enhanced drug delivery.

9 ratory air-liquid interface: the interfacial delivery.

10 ed polymers for protein conjugation and drug delivery.

11 reased risk of bleeding during pregnancy and delivery.

12 though they may be mediated by mechanisms of delivery.

13 hes lever pressing for postingestive sucrose delivery.

14 heating and enabling thermally regulated EF delivery.

15 luence on anticipatory licking before reward delivery.

16 agulation factor concentrates at the time of delivery.

17 d biomaterials in the realm of advanced drug delivery.

18 res is unique and has led to improved vector delivery.

19 that produced CS presentation, without water delivery.

20 y considered as an optimal material for drug delivery.

21 d is likely to be helpful, especially before delivery.

22 r targeted pulmonary inhalation aerosol drug delivery.

23 S100A8-A9 than from infants born by vaginal delivery.

24 lopment issues and knowledge gaps in SC drug delivery.

25 One proposed strategy to enhance delivery across endothelial or epithelial monolayers is

26 Besides sustained drug delivery, AFL-assisted powder reservoir patch delivery s

27 ugate can be considered as a promising boron delivery agent for BNCT.

28 Nanoparticle delivery also changes the biodistribution profile, resul

29 These include convection-enhanced delivery, alternative catheter delivery, and neuro-surgi

30 There were 4 vaginal deliveries and 2 cesarians.

31 ng higher costs might close, disrupting care delivery and access to care.

32 l evidence for the use of miR-30c-2*/miR-497 delivery and AURKA inhibition in the treatment of cuSCC,

33 technologies, namely, self-regulated insulin delivery and cell replacement therapies, hydrogels are e

34 effectively contribute to ecosystem service delivery and ecological intensification of agriculture i

35 We demonstrate the dual-targeted delivery and enhanced therapeutic effect of eHNP-A1-CD15

36 Coronary calcification hinders stent delivery and expansion and is associated with adverse ou

37 himeric molecules and their use for targeted delivery and for target engagement studies.

38 tions, highlighting the need for simplifying delivery and reducing current barriers to access and per

39 therapy vector because of its efficient gene delivery and relatively mild immunogenicity.

40 The efficiency of drug delivery and sensory perception is intertwined with muco

41 tin-based compartment, leading to concurrent delivery and sequential release of dual cargos toward co

42 have the potential to improve the sublingual delivery and storage stability of protein-based vaccines

43 al barriers that hinder tissue-specific drug delivery and strategies to overcome them.

44 on the barriers that impact pulmonary siRNA delivery and successful recent approaches to advance thi

45 s in a neighborhood is associated with B-CPR delivery and survival from out-of-hospital cardiac arres

46 polymer ensures the efficient intracellular delivery and the release of Cas9 RNP into 293T cells and

47 in preterm and early term provider-initiated deliveries, and to prevent perinatal adverse outcomes.

48 >=24 weeks' gestation), preterm and cesarean delivery, and neonatal unit admission in the months prec

49 tion-enhanced delivery, alternative catheter delivery, and neuro-surgically applied delivery systems

50 t, to impaired convective and diffusive O(2) delivery, and thus V O(2) , especially within fast-twitc

51 ve applications in filtration, sensing, drug delivery, and tissue engineering that often require the

52 ad range of non-cutaneous and cutaneous drug delivery applications, including multicomponent vaccinat

53 health and developed world long-acting drug delivery applications.

54 We used an in vivo local gene delivery approach to alter CaM function by directly inje

55 ed its recommendations regarding cancer care delivery around five goals: (1) promote and protect equi

56 ovides a stable nano-platform for chemo-drug delivery as well as an efficient method to solubilize hy

57 gn since nanomaterials are ideal for antigen delivery, as adjuvants, and as mimics of viral structure

58 ioning models, where cues predict reinforcer delivery at a different goal location, some animals-call

59 ly) and peaked in July each year, before SMC delivery began in August.

60 The applicability of this approach for drug delivery, bioimaging, and cell targeting was also demons

61 e points, enrolment into community-based ART delivery by 25 percentage points, and switching to secon

62 While efforts to perform targeted drug delivery by engineered nanoparticles have shown some suc

63 is more highly restricted by REAF and, using delivery by virus-like particles (VLPs), that Vpr alone

64 e conjugation nevertheless increases nuclear delivery ca 2.5-fold, and a non-destructive interaction

65 acts as both the "smart zipper lock" and the delivery carrier to alternately lock multiple functional

66 rformance, including distribution and tissue delivery, cellular uptake, intracellular trafficking, po

67 e of nanocarriers - which aim to address the delivery challenge.

68 These novel formulations will address drug delivery challenges and have great potential to improve

69 s, including cancer, but they also pose many delivery challenges.

70 agnoses with lowest fetal cerebral substrate delivery; "CHD-other," with other CHD diagnoses; "CHD-re

71 delivery with 16 fortnightly sessions; mixed delivery combining 12 group sessions with four home visi

72 vities, showed a twofold increase in vaginal delivery compared to CS with or without labor (adjusted

73 C-section delivery conditions indicative of the least exposure to

74 eased mortality rates, decreased health care delivery costs, and faster delivery of appropriate thera

75 hat the use of functionalised CNTs for dsRNA delivery could increase the efficacy of RNA interference

76 l instillation was used to achieve pulmonary delivery daily over 10 days to M. tuberculosis infected

77 r miniature bioelectronics is wireless power delivery deep inside the body.

78 tilation, cardiac output and systemic oxygen delivery did not differ between protocols (P > 0.05).

79 CCM delivery did not differ significantly between 2- and 3-l

80 e/ATP), but potentially limiting greater ATP delivery during increased workload.

81 The delivery efficacy of carbon dot formulations was also de

82 A clinic survey captured information on care delivery (eg, clinical services, adherence services, pat

83 ends the capabilities in targeted cargo/drug delivery, environmental remediation, and other potential

84 the development of bile acid-based oral drug delivery for ASBT-targeting, including bile acid-based p

85 ps (lab-on-a-paper) for diagnostics and drug delivery for biomedical applications.

86 anted and programmed with rate-based therapy delivery for rates >=250 beats per minute and morphology

87 kanols, fatty acids, prodrugs, and vesicular delivery for steroids have been investigated.

88 clinical outcomes within an integrated care delivery framework.

89 Effective nicotine delivery from e-cigarettes is important in consumer acce

90 uestion is how direct photochemical electron delivery from nanocrystals to MoFe protein is able to su

91 estigated the mechanism of coordinated actin delivery from the multiple polyproline tracts in formin

92 eveal the basic principles of oral bacterial delivery, from internal genetic engineering approaches t

93 larity and lower TFBUT were found in the low-delivery groups; hyposecretory (P = 0.006, P = 0.016) an

94 Fecal samples from infants born by cesarean delivery had lower levels of S100A8-A9 than from infants

95 d severity of glaucoma, PTM, or total energy delivery had no association with procedural success or I

96 Attempts to use antibodies for siRNA delivery have been reported but these strategies use eit

97 Thus, subcellular drug-delivery holds promise as a means to reduce off-target p

98 Subtypes were patients with high meibum delivery (hypersecretory and nonobvious MGD) and those w

99 nd nonobvious MGD) and those with low meibum delivery (hyposecretory and obstructive MGD).

100 Chronic disease and ageing create an O(2) delivery (i.e. blood flow x arterial [O(2) ], QO2 ) depe

101 This targeted delivery improves phenotype switching of TAMs from pro-

102 ays, they can begin to be optimized for drug delivery in a more personalized manner, entering the era

103 ional opportunity to investigate therapeutic delivery in AD and other conditions.

104 ce a task that investigates if mutual reward delivery in male rats can drive associative learning.

105 response strategies to optimize health care delivery in parts of the world who have not yet confront

106 ique for subretinal gene replacement therapy delivery in pediatric patients exists.

107 is context, increasing extracorporeal oxygen delivery, increases the respiratory quotient of the nati

108 ocular symptoms than those with high meibum delivery, indicating the pivotal role of meibum secretio

109 (n=376 group-only intervention, n=400 mixed-delivery intervention, n=376 comparison group).

110 phagolysosomal destruction and limited drug delivery into infected cells.

111 e editing dogma for single guide RNA (sgRNA) delivery is based on the premise that 5'-and 3'-nucleoti

112 hese studies demonstrate that non-viral gene delivery is impacted by proteoglycan interactions and su

113 nt challenges remaining in the field of drug delivery is insufficient targeting of diseased tissues o

114 n complexities, especially for multiantibody deliveries, long infusion times, and production issues c

115 ry, the aHR for IHD associated with pre-term delivery (<37 weeks) was 2.47 (95% confidence interval [

116 -specific endopeptidase fused to the protein delivery machinery of diphtheria toxin.

117 Sensitivity, specificity, preterm delivery, maternal adverse effects, congenital birth def

118 A series of glucose-responsive insulin delivery mechanisms and devices have been reported to in

119 e sRNA executors of HIGS and their potential delivery mechanisms from the plant host to filamentous e

120 treatment and intrinsic variability of gene delivery methods may contribute to the variable outcomes

121 quencing is useful to compare exogenous RNAi delivery methods on peanut plants, and to analyze the ef

122 MGD (P = 0.008, P = 0.006) relative to high-delivery MGD (hypersecretory and nonobvious groups, resp

123 und in low-delivery MGD groups than the high delivery MGD groups (P < 0.01 and P < 0.006, respectivel

124 s and ocular staining were also found in low-delivery MGD groups than the high delivery MGD groups (P

125 Patients with low-delivery MGD had worse dry eye parameters and ocular sym

126 heranostic platforms taking advantage of RBC-delivery modalities.

127 ple logistic regression models (one for each delivery mode), we calculated the adjusted rates of PCS

128 ly and comprehensively transitioned its care delivery model and administrative organization to confor

129 al gene expression changes between different delivery modes can add to our understanding of how CS co

130 Immunohistochemistry reveals that PAL/HCQ co-delivery nanoparticles trigger anti-apoptotic pathway af

131 to district general hospitals by operational delivery networks.

132 noemulsions (PFCs) resulted in the efficient delivery of (19)F cargo to EpiSCs and enabled their visu

133 o the administration of a placebo, the local delivery of a clinically deployable formulation of the t

134 al treatments to overcome MDR involve the co-delivery of a Pgp inhibitor and a chemotherapeutic.

135 amic influx and clearance mechanisms prevent delivery of a uniform dose with time.

136 no notable safety concerns after subretinal delivery of an adeno-associated viral vector encoding co

137 ble, and abundant target for affinity-guided delivery of anticancer drugs.

138 ids overcome this barrier and enable topical delivery of antisense oligonucleotides capable of specif

139 eased health care delivery costs, and faster delivery of appropriate therapeutics.

140 in South Africa and Uganda, community-based delivery of ART significantly increased viral suppressio

141 for developing novel CPPs for transcellular delivery of cargo.

142 Here, we developed novel nanocarrier delivery of chemotherapy via TFR1-mediated endocytosis,

143 As a consequence of reduced delivery of cholesterol to the PM in ORP1-null cells, ch

144 e application of in situ nasal gel for brain delivery of CNS acting moieties.

145 ther surfaces may result in the preferential delivery of coarse material to channel networks that ini

146 ch 'next generation' implementation includes delivery of combinatorial cell populations exerting syne

147 Adeno-associated viral (AAV) delivery of constitutively active Pfn1 to rodents promot

148 ideo-EEG telemetry showed that AAV9-mediated delivery of CRISPRa, upon doxycycline administration, de

149 daptation of placental transport to maintain delivery of critically needed FA.

150 Intranasal delivery of CXCL10 siRNA blocked Th1 infiltration but di

151 esigned to ensure a smooth and uninterrupted delivery of desolvated particles to the plasma.

152 Controllable, precise, and safe delivery of diagnostic biosensing devices and therapeuti

153 extrin molecular baskets enables loading and delivery of diverse chemicals, and nanoparticle coating

154 These findings demonstrate that co-delivery of Dox and Val via ISFI can avoid systemic toxi

155 sites, delivery of genes (siRNA,pDNA) and co-delivery of drugs and genes to combat drug resistance.

156 ers an average 8-fold improvement in topical delivery of drugs at diseased sites, when compared to pr

157 Here, we focus on CPP mediated delivery of drugs to the tumor sites, delivery of genes

158 The provision and delivery of EGS services is a globally and regionally im

159 Impairing astrocytic delivery of energy substrates by reducing astrocyte gap

160 fits achieved in the different plans and the delivery of four locally important water-related ecosyst

161 reaching adulthood.Conclusions: Nanoparticle delivery of FOXM1 or FOXF1 stimulates lung angiogenesis

162 diated delivery of drugs to the tumor sites, delivery of genes (siRNA,pDNA) and co-delivery of drugs

163 -IC (Myo1c) has been proposed to function in delivery of glucose transporter type 4 (GLUT4)-containin

164 Deletion of either ZF delayed the delivery of gRNA to the PM but did not prevent Gag-gRNA

165 o high-quality cancer care; (2) support safe delivery of high-quality cancer care; (3) advance polici

166 ne, whose enhanced aqueous solubility allows delivery of higher doses to mice.

167 the use of complex coacervates for sustained delivery of immunostimulatory proteins as an effective t

168 (SCM) for the controlled reconstitution and delivery of inkjet-spotted and dried detection antibodie

169 The delivery of kilohertz frequency alternating current (KHF

170 The unpredictable delivery of low intensity screams could become an essent

171 It also describes therapeutic delivery of miRNAs in different environments such as hyp

172 d tissue distribution and intracellular drug delivery of molecules, nanoparticles, and other therapeu

173 carbon/sulfur ratio is best explained by the delivery of most of Earth's volatiles from carbonaceous

174 Delivery of multiple dmAbs to a single animal led to inc

175 f a cocktail of different drugs, examples of delivery of multiple drugs from one MOF are rare, potent

176 our results show that MSC-mediated systemic delivery of oncolytic viruses is a promising strategy fo

177 e on patient-centered best practices for the delivery of oral anticancer and supportive care drugs wa

178 can play an important role in assisting the delivery of oropharyngeal swallowing exercises including

179 ardiovascular function ensure that increased delivery of oxygen, nutrients, and endocrine factors to

180 mechanism and show that it facilitates oral delivery of phage in vivo.

181 Expanding delivery of primary healthcare to urban poor populations

182 Delivery of pro-angiogenic factors has shown some benefi

183 Delivery of proangiogenic transcription factors has prom

184 Oral delivery of protein drugs is considered a life-changing

185 embrane fusion, a recent strategy for direct delivery of proteins into the cell cytoplasm.

186 vinization process is a means to enable oral delivery of proven therapeutic antibodies as well as nov

187 presents a new concept in achieving targeted delivery of radiopharmaceuticals.

188 technology has not substantially changed the delivery of rheumatology care.

189 elopment of this technology is the efficient delivery of RNAi effectors into the cell.

190 Delivery of siRNA-peptide nanoplexes co-targeting MK2 an

191 ology, but also may permit the cell-specific delivery of small molecules to improve the post-MI heali

192 at may be efficiently targeted by restricted delivery of SMN-enhancing agents to the nervous system,

193 ipheral positioning of late endosomes allows delivery of SRC proto-oncogene, nonreceptor tyrosine kin

194 The delivery of stem cells on an extracellular matrix (ECM)-

195 ing in the small bowel by viscous fibers and delivery of substrates to the colonic microbiota by more

196 Local delivery of targeted therapy by UTMD significantly reduc

197 erve that this G4 is fundamental to ensuring delivery of Task3 mRNA to distal primary cortical neurit

198 or cinnamic acid derivatives, leading to the delivery of the copper to the beta-position.

199 llowed the generation of cKOs by local viral delivery of the Cre-recombinase enzyme.

200 Finally, in vivo delivery of the ITCH siRNA using nanoparticles to the ne

201 We demonstrate that targeted delivery of the LRRC31 gene via nanoparticles improves t

202 a late step in entry involving uncoating and delivery of the RNA genome to the cytoplasm.

203 Despite recent advances, targeted delivery of therapeutic oligonucleotide to extra-hepatic

204 ugated to bioactive compounds allow targeted delivery of therapeutics to cell types of choice based o

205 oduction of inflammatory cytokines following delivery of therapy, with symptoms ranging from mild fev

206 dynamics, enabling exquisite fine-tuning of delivery of these essential metabolites.

207 CPP have been effective for delivery of various chemotherapeutic agents used to comb

208 Results show that lentiviral delivery of Wnt6 to the amygdala ameliorates locomotor i

209 Buccal drug delivery offers a potential non-invasive means of delive

210 We found an interaction of expectancy and delivery on pain improvement following the intervention.

211 of this study was to characterize FUSIN drug delivery outcome in mice with regard to its dependency o

212 ategizing pulmonary surfactant (PS) for drug delivery over the respiratory air-liquid interface: the

213 stational age, 5-minute Apgar score, mode of delivery, parity) factors, multimorbidity was associated

214 en reactions, including light-triggered drug delivery, photodynamic therapy, and photocatalysis.

215 ted metal NPs represent a biocompatible drug delivery platform for chemotherapy resistant tumor treat

216 ate that dendrimers are a promising targeted delivery platform to achieve effective glioblastoma trea

217 s according to intervention characteristics (delivery platform, delivery timing, and health system ob

218 particle formulations, which are utilized in delivery platforms for RNA therapeutics.

219 eful for testing candidate mAbs and emerging delivery platforms prior to human trials.

220 l PEG-lipid in vitro and enabled higher mRNA delivery potency in vivo at a low dose of 0.1 mg kg(-1)

221 ndations have focused largely on health care delivery practices and occasionally on general categorie

222 nt a polymeric NP system with sustained gene delivery properties, which can be synthesized using biod

223 HD-MAP delivery resulted in enhanced humoral responses compared

224 elivery, AFL-assisted powder reservoir patch delivery showed a good safety.

225 short interval between membrane rupture and delivery) showed no evidence of association with atopic

226 e mechanism of dendrimer-mediated triptolide delivery significantly reduced triptolide-associated hep

227 ential utility of PS to open novel effective delivery strategies for inhaled drugs.

228 Transcript length (relevant to gene delivery strategies) correlated significantly with numbe

229 articularly nerve guidance conduits and drug delivery strategies.

230 omponent, termed CDTa, and a pore-forming or delivery subunit termed CDTb.

231 We developed a nucleoside triphosphate (NTP) delivery system (the TriPPPro approach), in which the ga

232 te delivery systems induced a depot (of both delivery system and antigen) at the injection site, the

233 o the targeted subretinal site using a novel delivery system and suprachoroidal approach for most par

234 d smart "all-in-one" nanoparticle-based drug delivery system capable of overcoming biological barrier

235 developed hydrogels from amnion tissue as a delivery system for ADSCs.

236 peptide-targeted EMs can be a promising drug delivery system for advanced PC.

237 rect administration procedure, suitable drug delivery system, selection of effective and safe dosage

238 using a modified vibrating mesh aerosol drug delivery system.

239 study investigated the impact of malting as delivery-system for endogenous enzymes.

240 entries as core components of nanoscale drug delivery systems (NDDSs) by making use of analytical ult

241 Functionalized drug delivery systems against malignant lung metastasis of br

242 clusive research in psychology suggests that delivery systems are one primary determinant of costs an

243 Transdermal drug delivery systems as films not only avoids first-pass met

244 Drug delivery systems based on electrospun fibers have been u

245 In this study, electrospun membrane drug delivery systems consisting of the antibiotic ciprofloxa

246 Here, recent advances in targeted exosomal delivery systems engineered by aptamer for future strate

247 Targeted exosomal delivery systems for precision nanomedicine attract wide

248 Zero-order drug delivery systems have the potential to overcome the issu

249 omedical research, providers, and healthcare delivery systems in advancing the care of patients and t

250 Similarly, whilst the particulate delivery systems induced a depot (of both delivery syste

251 amework of the state-of-the-art RBC-mediated delivery systems is explained in detail to inspire the d

252 heter delivery, and neuro-surgically applied delivery systems such as polymeric hydrogels and interst

253 Glucose-responsive insulin delivery systems that mimic pancreatic endocrine functio

254 e is an urgent need to develop improved drug delivery systems which have potential to cross impaired

255 ng and integration with biomaterials or drug delivery systems, is examined.

256 advances for the development of ocular drug delivery systems.

257 icinoids including prodrugs, conjugates, and delivery systems.

258 uss the recent discoveries on non-viral gene delivery systems.

259 en the sclera and choroid, is an alternative delivery technique developed with the rationale of provi

260 In the 10 years following delivery, the aHR for IHD associated with pre-term deliv

261 rains stroke volume, cardiac output and O(2) delivery, thereby impairing VO2 peak and thus exercise c

262 We show that oxygen delivery through PMCs is dependent on its permeability t

263 rvention characteristics (delivery platform, delivery timing, and health system objective) and did on

264 impairing vascular permeability and glucose delivery to beta-cells.

265 electroporation protocols result in payload delivery to between 75 and 97% of living cells of three

266 For efficient and safe delivery to cancer cells, nucleic acids must generally b

267 and conserved guiding peptide targets their delivery to chloroplasts.

268 amine neuronal activation shifts from reward delivery to cue onset, and provide insight into the mala

269 , nanoparticles and ultrasound (US) enhanced delivery to develop a clinically viable therapeutic stra

270 he classical pathway-mediated immune complex delivery to follicular dendritic cells in vivo.

271 igonucleotide designed for receptor-mediated delivery to hepatocytes.

272 or tense (T) quaternary state modulates O(2) delivery to hypoxic (FME) and normoxic (LOX) human melan

273 may allow investigators to further fine-tune delivery to lymphoid organs.

274 le-that insures adequate oxygen and nutrient delivery to meet local metabolic demand.

275 d during wakefulness induced after carbachol delivery to PFC.

276 G5-MNI-Glu was used with optofluidic delivery to stimulate dopamine neurons of the ventral te

277 Efficient and specific drug delivery to the BM is an unmet need.

278 Drug delivery to the brain always remains a challenging issue

279 Effective delivery to the brain limits the development of novel gl

280 nd yield, likely via the control of nitrogen delivery to the reproductive sinks.

281 versible and conforming system for localized delivery to the sinuses.

282 ause of the difficulty in specific targeting/delivery to the tumor site.

283 ) affinity may play a role in increased O(2) delivery to the tumor.

284 twitch contractions reflecting impaired O(2) delivery-to-utilization matching.

285 nanoparticles (Np) as a membrane-traversing delivery vehicle to carry PMI for anticancer therapy.

286 nd efficiency of the nanostructure as a drug delivery vehicle.

287 , for applications as protocells, or as drug-delivery vehicles.

288 have drawn recent interest as drugs or drug-delivery vehicles.

289 Immediate intravitreal antibiotic delivery was a universal first-line therapy.

290 ed particles demonstrated that intracellular delivery was achieved in all cells in 2D cultures of a h

291 Delivery was dependent on presence of both C2C subunits

292 n-like behavior indicating its intracellular delivery was required for behavioral effect.

293 Vaginal, compared with cesarean delivery, was most strongly associated with an enrichmen

294 m placebo to fentanyl, leg VO2 , QL and O(2) delivery were greater for HFrEF during peak exercise (al

295 tors commented that their roles in programme delivery were unclear.

296 mune modulation and macrophage-mediated drug delivery, which will further enhance current tumor thera

297 rhDNase in the lungs of mice after pulmonary delivery while preserving its full enzymatic activity.

298 geting raccoons-timing and frequency of bait delivery, width of the ORV zone and proportion of hosts

299 d (1:1:1) to one of three groups: group-only delivery with 16 fortnightly sessions; mixed delivery co

300 As]) should be continued until 6 weeks after delivery, with a 3-month minimum total duration.