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1 other and with an additional cell type: the delta cell.
2 vely expressed in the somatostatin-secreting delta cell.
3 2 expression and budding are delayed in ccr4 delta cells.
4 pable of increased Ty1 transposition in pmr1 Delta cells.
5 p210 level in Bcr-Abl-transduced SHP-2Delta/Delta cells.
6 ignaling was greatly decreased in SHP-2Delta/Delta cells.
7 endogenous IL-2 RNA degradation in TCR gamma delta cells.
8 in sister kinetochore coorientation in spo13 Delta cells.
9 e cells was missing in all of the above crd1 Delta cells.
10 bud6 delta cells but are proficient in kar9 delta cells.
11 lectively impaired at the bud cortex in bud6 delta cells.
12 in MMS-treated mag1 Delta rad14 Delta rad26 Delta cells.
13 otein exacerbates the defects of sid2-1 sic1 Delta cells.
14 ed for the preanaphase arrest of sid2-1 sic1 Delta cells.
15 ed tubules, similar to the phenotype of dnm1 Delta cells.
16 ions were absent in both nvj1-Delta and vac8-Delta cells.
17 unctioning islets containing alpha, beta and delta cells.
18 ducing beta cells and somatostatin-producing delta cells.
19 er than wild-type in nup188-Delta and nup170-Delta cells.
20 nificantly faster in nup188-Delta and nup170-Delta cells.
21 S-GFP nuclear localization defects of nup188-Delta cells.
22 in the pancreatic islet, especially in islet delta cells.
23 cidergic neurons in midbrain, and pancreatic delta cells.
24 ssed in alpha, beta and PP cells, but not in delta cells.
25 role that is increasingly emerging for gamma delta cells.
26 alpha beta cells, but lack mature TCR gamma delta cells.
27 yruvate kinase activity was elevated in mck1 delta cells.
28 and partially restore actin cables in mdm20 delta cells.
29 ly longer than for rats bearing C6 or C6trkA delta cells.
30 eptors were found predominantly in alpha and delta cells.
31 ne recombination in thymically derived gamma delta cells.
32 ion is a frequent occurrence in thymic gamma delta cells.
33 e opposite, beta cells surrounding alpha and delta cells.
34 atostatin secretion via cognate receptors on delta cells.
35 ed translational efficiency of mRNAs in tit1-Delta cells.
36 ce exposure of the Als3 adhesin on slr1Delta/Delta cells.
37 gene up-regulation, and slow growth of sla1-Delta cells.
38 alpha cells but substantial in OFF alpha and delta cells.
39 otein expression in mouse alpha-, beta-, and delta-cells.
40 alpha-cells, and that Kv2.2 is expressed in delta-cells.
41 ity via gap junction-dependent activation of delta-cells.
42 d almost exclusively in pancreatic beta- and delta-cells.
43 the <10% of beta-cells situated <20 um from delta-cells.
44 identity of human alpha-, beta-, gamma- and delta-cells.
45 eatic polypeptide cells but not to alpha- or delta-cells.
46 nds that limit paracrine signaling from beta/delta-cells.
47 lusive effect by AG-induced SST release from delta-cells.
48 ed of a collection of >500 alpha-, beta- and delta-cells.
49 essed at the mRNA, but not protein, level in delta-cells.
50 asse reprogramming of somatostatin-producing delta-cells.
51 glucagon(+) alpha-cells, and somatostatin(+) delta-cells.
52 ct inhibition via somatostatin released from delta-cells.
53 ucing alpha-cells and somatostatin producing delta-cells.
54 ecretion, and cross regulation of alpha- and delta-cells.
55 high glucose levels due to the inhibition by delta-cells.
56 ects that parallel those found in PLK1(Delta/Delta) cells.
57 ed oxidant-induced cell death in Fra-1(Delta/Delta) cells.
58 ss response, are dysregulated in Lmnb1(Delta/Delta) cells.
59 that this association is lost in Lmnb1(Delta/Delta) cells.
60 mune disease, may be a general one for gamma delta + cells.
61 tions of alpha-cells (5%), beta-cells (92%), delta-cells (1%), and pancreatic polypeptide cells (2%).
62 : 62.9 +/- 3.1% vs. 75.5 +/- 0.9%, P = 0.02; delta-cells: 2.8 +/- 0.5% vs. 4.4 +/- 0.4%, P = 0.05), w
63 f the Fc epsilon RI gamma-chain in TCR-gamma delta cells, a TCR-gamma delta transgenic mouse (G8) has
72 GAL10 genes is reduced in MMS-treated rad26 Delta cells and also in mag1 Delta rad14 Delta cells, wh
73 ng extracts derived from fir1 Delta and pbp1 Delta cells and from cells lacking the Fir1p interactor,
75 and Spt23p processing is suppressed in rsp5 Delta cells and in wild-type RSP5 cells upon expression
78 producing beta cells, somatostatin-producing delta cells and pancreatic polypeptide-producing PP cell
79 al regulator specifically required for islet delta cells and suggest compromised paracrine control as
81 , the ratios of bulk-sorted beta, alpha, and delta cells and their respective hormone-specific RNA-Se
82 ced in p38gamma/p38delta-deficient (p38gamma/delta(-/-)) cells and tissues without affecting TPL2 mes
83 TCR-alpha/beta+ cells but contain TCR-gamma/delta+ cells and a small population of a unique CD4+, TC
88 t consisting of two-state alpha-, beta-, and delta-cells, and analyze effects of known chemical inter
89 ls during epithelial infections, since gamma delta + cells are commonly abundant within epithelia.
93 ducing beta cells and somatostatin-producing delta cells are drastically reduced, while the numbers o
95 heterogeneity among delta cells, where most delta cells are entrained by oscillatory Ca(2+) behavior
97 beta cells and the development of TCR gamma delta cells are partially independent of the T domain.
98 pombe growth is resistant to rapamycin, sla1-Delta cells are sensitive, consistent with deficiency of
100 8alpha/beta T cells disappear, but TCR-gamma/delta cells are unaffected by the absence of beta2m.
104 eatic alpha-cells and somatostatin-producing delta-cells become insulin-expressing cells after the ab
107 ressor of the respiratory deficiency of coa2 Delta cells but lacks suppressor activity for two other
109 ted in stimulation of electrical activity in delta-cells but suppression of alpha-cell activity.
110 h pretreatment with hydroxyurea renders tel1-Delta cells (but not wild type) MMS-sensitive, demonstra
111 ta gene rearrangements occur in thymic gamma delta cells, but the frequency of in-frame rearrangement
112 in Schizosaccharomyces pombe tit1+ and tit1-Delta cells by using a beta-galactosidase codon-swap rep
113 r data provides an integrated picture of how delta cells can modulate beta cell activity under physio
114 ic progenitor cells; and (2) donor TCR gamma/delta+ cells can facilitate the alloengraftment of rigor
115 These results show that (1) host TCR gamma/delta+ cells can reject repopulating donor cells, presum
121 e pancreas shows a dramatic loss of beta and delta cells, contrasting a smaller relative loss of alph
122 juveniles display 'somatostatin-to-insulin' delta-cell conversion, involving dedifferentiation, prol
124 her, our study demonstrated adult alpha- and delta-cells could regenerate, and both self-duplication
125 iferating cell marker Ki67 showed alpha- and delta-cells could replicate, suggesting self-duplication
126 beta-cells (current density 9 pA/pF), 91% of delta-cells (current density 148 pA/pF), and 6% of alpha
127 rough recognition of autoantigens, and gamma delta-cell-deficient mice, unlike mice deficient in alph
131 coregulator during islet alpha-, beta-, and delta-cell development through Isl1-dependent and potent
132 tely one-third of HO HML alpha MAT alpha hmr delta cells die because they fail to repair the HO endon
133 at Mnx1 promotes beta-cell while suppressing delta-cell differentiation programs, and is crucial for
135 rotective immunity, while mice lacking gamma delta + cells display exaggerated intestinal damage, app
136 Mid2p colocalizes with septins, and mid2 Delta cells display disorganized, diffuse septin rings a
138 trast, we show that thymically derived gamma delta cells do not make detectable rearrangements of the
139 Of particular interest is the role of gamma delta + cells during epithelial infections, since gamma
142 ar compartment requires Nhx1p, and that nhx1 delta cells exhibit phenotypes characteristic of the "cl
144 Islet epsilon-cells produce ghrelin and delta-cells express growth hormone secretagogue receptor
148 usly developed tumors, and primary Usp3Delta/Delta cells failed to preserve chromosomal integrity.
149 Purification of islet beta-, alpha- and delta-cells followed by transcriptome analysis (RNA-seq)
151 xpression, because intraepithelial TCR-gamma delta cells from the zeta-deficient mice did not respond
152 methods to highly purify alpha-, beta-, and delta-cells from human fetal and adult pancreata by intr
155 ertonic stress or elevated temperature, spm1 delta cells grow as short branched filaments in which th
156 mponents of the ETS was also reduced in crd1 Delta cells grown at elevated temperatures because of re
157 Microarray analyses revealed that mds3 Delta/Delta cells had an expression profile indicative of a hy
158 FLAG-mu cells, MbetaCD treatment of HEK FLAG-delta cells had no effect on acute inhibition or sensiti
161 eased numbers of T cell receptor (TCR)-gamma/delta cells have been observed in animal models of influ
165 These results demonstrate that TCR gamma/delta cells have the capacity to cause acute lethal GVHD
168 o commit to division, the large size of ccr4 delta cells implies that they may have a size-specific p
171 lucidate the potential function of TCR gamma/delta cells in GVHD, we have used transgenic (Tg) H-2d m
176 Little is known about the role of islet delta cells in regulating blood glucose homeostasis in v
178 ng beta cells and the somatostatin-producing delta cells in the islets of Langerhans in the pancreas.
179 sponsible for the selective deficit in gamma/delta cells in these mice, since a high copy TCR-gamma t
180 he gamma delta cell clones and primary gamma delta cells in vivo showed a strong association of the T
181 that non-beta-cells such as alpha-cells and delta-cells in adults can regenerate, and that the regen
182 ular, it has not been resolved whether gamma delta cells, independent of any other T cells, can help
183 a2+]i imaging experiments, optoactivation of delta-cells induced islet-wide beta-cell [Ca2+]i transie
184 ntation (BMT) confirmed that G8 Tg TCR gamma/delta cells infiltrated GVHD target tissues (skin, liver
185 or optoinhibition of somatostatin-releasing delta-cells inhibits and stimulates electrical activity
186 The infusion of G8 Tg (H-2Td) TCR gamma/delta cells into lethally irradiated [900 cGy total body
188 of intracellular levels of arginine in btn1-Delta cells is detrimental and is suggestive that btn1-D
190 trate that the ectopic expression of Pax4 in delta cells is sufficient to induce their conversion int
192 c islets; within the islet the percentage of delta-cells is increased, while the percentage of alpha-
193 , and the resulting cold sensitivity of taz1 Delta cells, is suppressed by mutated alleles of Top2 th
195 BALB/c mice, transient depletion of all TCR-delta(+) cells just before airway challenge resulted in
196 In both models of HSV-1 infection, TCR-gamma/delta cells limited severe HSV-1-induced epithelial lesi
197 the permissive temperature, cdp1-1 and cdp1 delta cells lost chromosomes at a frequencies approximat
198 IL-2 gene expression in transgenic TCR gamma delta cells may be explained by subset-specific IL-2 gen
199 Thus, this study demonstrates that TCR-gamma/delta cells may play an important regulatory role in hum
200 nt deficiency in tRNA nuclear export in sla1-Delta cells may trigger the AAM response, we show that m
201 ce were found to be susceptible to TCR gamma delta+ cell mediated GVHD-induced lethality characterize
203 observed protection resulted from TCR-gamma/delta cell-mediated arrest of both viral replication and
204 have specifically examined whether TCR gamma/delta+ cells might be capable of eliminating BM-derived
206 e of thymic IL-7 in development of TCR gamma delta cells, newborn TCR beta-deficient (TCR beta(-/-))
208 nt with its detection in two-thirds of CHI-D delta-cell nuclei, similar to the fetal pancreas, and im
213 e, no development of graft-derived TCR gamma delta cells occurred, indicating that extrathymic IL-7 d
217 y factors secreted by neighbouring beta- and delta-cells (paracrine regulation) have been proposed to
219 s, and recent experiments confirm that gamma delta cells play a significant role in autoimmune diseas
222 findings support the conclusion that sst1.1 delta-cells possess a pro-beta identity enabling them to
225 at islets lacking endogenous Ucn3 have fewer delta cells, reduced somatostatin content, impaired soma
226 eling techniques, we demonstrated alpha- and delta-cell regeneration involved cell proliferation.
232 t, when receptor synthesis is shut off, akr1 delta cells retain the ability to mate longer than do AK
233 VAC1, and subcellular fractionation of vac1 delta cells revealed a striking change in the fractionat
237 of INO80 complexes from arp5 Delta and arp8 Delta cells shows that protein complexes remain intact b
239 vation of beta-cell G(i/o)-GPCRs and NKAs by delta-cell somatostatin secretion slowed Ca(2+) oscillat
246 sed Sst(-/-) mice to investigate the role of delta-cell SST in the regulation of insulin and glucagon
251 LN2, CLN3, and SWI4 reduces the size of ccr4 delta cells, suggesting that ccr4 delta cells have a G(1
252 , rescues filamentation defects of hir1Delta/Delta cells, suggesting that Hir1 impacts the early phas
253 olar growth similar to that observed in tea1 Delta cells, suggesting that Shk1 and Tea1 may regulate
254 maintain expression of FAS1 in nmt1-451Dino2 Delta cells suggests the existence of another transcript
255 is ring structures, or cycles, of alpha and delta cells surrounding beta cell clusters or the opposi
256 genic mice, only a small proportion of gamma/delta cells survived as long-lived cells; most of these
257 st to TCR transgenic mice, most of the gamma/delta cells surviving in ATx normal mice had a rapid tur
258 -cell analysis revealed that individual cac1 delta cells switch from transcriptionally "off" to trans
260 his inhibition is somatostatin released from delta cells that are clustered with beta cells in pancre
261 d gene conversions both in Rad+ and in rad50 delta cells that cannot initiate normal meiotic DSBs.
262 rthritis contain a large proportion of gamma delta cells that proliferate in response to the causativ
263 egulated between T2D and ND alpha, beta, and delta cells that were undetectable in paired whole islet
265 s are transcriptionally close to a subset of delta-cells that we identified in control islets and tha
266 glucose level, beta-cells decreasing it, and delta-cells the precise role of which still needs identi
267 for two E2 activities, i.e., ubc4 delta ubc5 delta cells, the receptor was found to be substantially
268 Since PDX-1 is highly enriched in beta and delta cells, these results suggest that this factor play
269 o constitutive endocytosis exhibited by akr1 delta cells, they are competent to carry out ligand-medi
270 contain a secretory machinery, enabling the delta cell to reach a large number of beta cells within
272 has been suggested by the inability of plo1 Delta cells to septate and the prolific septation follow
273 uced binding (P=0.0004) of MiaPaCa-MUC4-NIDO(Delta) cells to the fibulin-2 coated plates compared wit
276 us studies, we found that budding yeast swe1 Delta cells undergo premature entry into mitosis, leadin
279 riptomes of FACS-purified alpha-, beta-, and delta-cells using bulk RNA-sequencing have facilitated o
280 lp1r expression include pancreatic beta- and delta-cells, vascular smooth muscle, cardiac atrium, gas
281 tivation of the beta-cells propagates to the delta-cells via gap junctions, and the consequential sti
282 on the turnover and lifespan of murine gamma/delta cells was obtained by administering the DNA precur
283 d no effect on AHR, and depletion of all TCR-delta(+) cells was no more effective than depletion of V
285 e proportion of islets composed of beta- and delta-cells was reduced in the transgenic mice compared
286 e whether such plasticity was also shared by delta cells, we generated and characterized transgenic a
289 ive alpha cells, and somatostatin-containing delta cells were found scattered throughout the human is
291 te-passage Mre11(ATLD1/ATLD1) Tert(Delta)(/)(Delta) cells were as short as those from Tert(Delta)(/)(
293 ulin receptors in the somatostatin-secreting delta-cells, when insulin-induced somatostatin secretion
294 considerable functional heterogeneity among delta cells, where most delta cells are entrained by osc
295 d26 Delta cells and also in mag1 Delta rad14 Delta cells, whereas a very severe reduction in transcri
296 CR alpha beta receptor and not the TCR gamma delta cells, which exclusively express CD8 alpha alpha.
297 f endocrine cells, primarily alpha, beta and delta cells, which secrete glucagon, insulin, and somato
298 required for development of thymic TCR gamma delta cells, while peripheral IL-7 was sufficient for de
299 hosphotyrosine accumulates on Cdc28 in cdc55 delta cells whose spindles have been depolymerized, and
300 arrest is maintained in the majority of bub3 Delta cells, yet they die, suggesting that Bub3p is esse