ライフサイエンスコーパス: delta virus

1 ding a self-cleaving ribozyme from hepatitis delta virus.

2 fic entry of hepatitis B virus and hepatitis delta virus.

3 rum titers were lower against the B.1.617.2 (Delta) virus.

4 supported the replication of hepatitis B and delta viruses.

5 n host cell entry factor for hepatitis B and delta viruses.

6 cases poorly neutralizes early pandemic and Delta viruses.

7 viruses related to coronaviruses, hepatitis delta virus and huge phages, respectively, and analysed

8 rus, human immunodeficiency virus, hepatitis delta virus, and alanine aminotransferase levels were li

9 Self-cleaving hammerhead, hairpin, hepatitis delta virus, and glmS ribozymes comprise a family of sma

10 ing RNAs: the hammerhead, hairpin, hepatitis delta virus, and in vitro-selected lead-dependent ribozy

11 Ag carriers, 42% had antibodies to hepatitis delta virus (anti-HDV).

12 mosaic virus 35S promoter and the hepatitis delta virus antigenomic ribozyme with a downstream nopal

13 In the hepatitis delta virus antigenomic ribozyme, imidazole buffer rescu

14 In the ribozyme of hepatitis delta virus antigenomic RNA, two short duplexes, P2 and

15 Hepatitis D virus (also known as hepatitis delta virus) can establish a persistent infection in peo

16 The RNA enzyme (ribozyme) from hepatitis delta virus catalyzes self-cleavage of a phosphodiester

17 el enabling functional genomics of hepatitis delta virus entry and infection.

18 Hepatitis delta virus expresses two essential proteins, the small

19 ary structure, based on a modified hepatitis delta virus genome.

20 iety of catalysts that include the hepatitis delta virus, hammerhead, X motif and Tetrahymena group I

21 Hepatitis delta virus has no FDA approved therapy and its only ava

22 Ribozymes of hepatitis delta virus have been proposed to use an active-site cyt

23 /W site) in the antigenomic RNA of hepatitis delta virus (HDV) allows two essential forms of the vira

24 Hepatitis delta virus (HDV) and cytoplasmic polyadenylation elemen

25 formation on the early kinetics of hepatitis delta virus (HDV) and hepatitis B surface antigen (HBsAg

26 small, 195-amino-acid form of the hepatitis delta virus (HDV) antigen (deltaAg-S) is essential for g

27 RNA editing of the hepatitis delta virus (HDV) antigenome at the amber/W site by the

28 Hepatitis delta virus (HDV) assembly also uses the envelope protei

29 is delta antigen (HDAg-L) mediates hepatitis delta virus (HDV) assembly and inhibits HDV RNA replicat

30 ty of data regarding the extent of hepatitis delta virus (HDV) associated health care burden in the U

31 Hepatitis delta virus (HDV) can dramatically worsen liver disease

32 omic and antigenomic RNAs of human hepatitis delta virus (HDV) can fold into a rod-like structure wit

33 The circular RNA genome of hepatitis delta virus (HDV) can fold into an unbranched rodlike st

34 The antigenomic RNA of hepatitis delta virus (HDV) can form a short duplex, P2a, in which

35 Hepatitis delta virus (HDV) causes both acute and chronic liver di

36 Hepatitis delta virus (HDV) causes the most severe form of human v

37 Infection with hepatitis delta virus (HDV) causes the most severe form of viral h

38 The two ribozymes of hepatitis delta virus (HDV) cleave faster in divalent metal ions t

39 Hepatitis delta virus (HDV) contains a circular RNA which encodes

40 Hepatitis delta virus (HDV) contains a viroid-like circular RNA th

41 Hepatitis delta virus (HDV) contains a viroid-like circular RNA th

42 Hepatitis delta virus (HDV) contains two RNA species (HDV-S and HD

43 Hepatitis delta virus (HDV) contains two types of hepatitis delta

44 -S and deltaAg-L, respectively) of hepatitis delta virus (HDV) differ only in the 19-aa C-terminal ex

45 The human pathogenic hepatitis delta virus (HDV) employs a unique self-cleaving catalyt

46 Hepatitis delta virus (HDV) encodes one protein, hepatitis delta a

47 Hepatitis delta virus (HDV) encodes two isoforms of its principal

48 Hepatitis delta virus (HDV) expresses two essential proteins with

49 ize self-cleaving ribozymes of the hepatitis delta virus (HDV) family for processing their 5' termini

50 ular genome and antigenome RNAs of hepatitis delta virus (HDV) form characteristic unbranched, quasi-

51 as 5 days after DNA copies of the hepatitis delta virus (HDV) genome or even in vitro-transcribed HD

52 Hepatitis delta virus (HDV) genome replication requires the virus-

53 d with a cDNA expressing a mutated hepatitis delta virus (HDV) genome that could only replicate by us

54 ng sequences or ribozymes from the hepatitis delta virus (HDV) genomic RNA and its complement form si

55 The genome of the human hepatitis delta virus (HDV) harbors a self-cleaving catalytic RNA

56 Hepatitis delta virus (HDV) has a circular RNA genome that replica

57 Hepatitis delta virus (HDV) has been detected in the minor salivar

58 The ribozymes of hepatitis delta virus (HDV) have so far been studied primarily in

59 Assembly of hepatitis delta virus (HDV) in infected human hepatocytes involves

60 Hepatitis delta virus (HDV) infection and spread in vivo are depen

61 Therapies for chronic hepatitis delta virus (HDV) infection are unsatisfactory.

62 Chronic hepatitis delta virus (HDV) infection causes severe liver disease

63 Hepatitis delta virus (HDV) infection is associated with fast prog

64 Hepatitis delta virus (HDV) infection of humans was first reported

65 of chronic liver disease caused by hepatitis delta virus (HDV) infection superimposed on chronic hepa

66 f 46 Italian patients with chronic hepatitis delta virus (HDV) infection were analyzed for HDV RNA by

67 rus (HBV) genotypes A to I support hepatitis delta virus (HDV) infectivity.

68 A woodchuck-derived hepatitis delta virus (HDV) inoculum was created by transfection o

69 e replication of the RNA genome of hepatitis delta virus (HDV) involves redirection of RNA polymerase

70 The genome of hepatitis delta virus (HDV) is a 1,679-nucleotide (nt) single-stra

71 Hepatitis delta virus (HDV) is a cause of acute and chronic liver

72 Hepatitis delta virus (HDV) is a circular pathogenic RNA that uses

73 Hepatitis delta virus (HDV) is a defective satellite virus that us

74 Hepatitis delta virus (HDV) is a highly pathogenic human RNA virus

75 Hepatitis delta virus (HDV) is a human hepatitis-causing RNA virus

76 The hepatitis delta virus (HDV) is a human pathogen and satellite RNA

77 Hepatitis delta virus (HDV) is a natural subviral agent of human h

78 Human hepatitis delta virus (HDV) is a natural subviral agent that uses

79 Hepatitis delta virus (HDV) is a pathogenic human virus whose RNA

80 Hepatitis delta virus (HDV) is a satellite of hepatitis B virus th

81 similarity between them.IMPORTANCE Hepatitis delta virus (HDV) is a satellite of hepatitis B virus th

82 Hepatitis delta virus (HDV) is a satellite virus of hepatitis B vi

83 Hepatitis delta virus (HDV) is a significant human pathogen that c

84 Hepatitis delta virus (HDV) is a small single-stranded RNA satelli

85 Hepatitis delta virus (HDV) is a small, defective RNA virus that c

86 Hepatitis delta virus (HDV) is a subviral human pathogen that requ

87 Hepatitis delta virus (HDV) is a subviral human pathogen that uses

88 Hepatitis delta virus (HDV) is a subviral pathogen that increases

89 IMPORTANCE Hepatitis delta virus (HDV) is a unique virus that causes severe l

90 Hepatitis delta virus (HDV) is an unusual RNA agent that replicate

91 Hepatitis delta virus (HDV) is geographically classified according

92 Hepatitis delta virus (HDV) is known to express a protein termed t

93 In a natural setting, hepatitis delta virus (HDV) is only found in patients that are als

94 Hepatitis delta virus (HDV) is responsible for the most severe for

95 Intrinsic to the life cycle of hepatitis delta virus (HDV) is the fact that its RNAs undergo diff

96 Hepatitis delta virus (HDV) is the most severe form of viral hepat

97 The self-cleaving ribozyme of the hepatitis delta virus (HDV) is the only catalytic RNA known to be

98 Hepatitis delta virus (HDV) is unique relative to all known animal

99 ations of genetic variations among hepatitis delta virus (HDV) isolates have focused principally on p

100 Most hepatitis delta virus (HDV) prevalence estimates from the United S

101 Hepatitis delta virus (HDV) produces two essential forms of the so

102 The large form of the hepatitis delta virus (HDV) protein (L) can be isoprenylated near

103 Hepatitis delta virus (HDV) replicates by a double rolling-circle

104 Hepatitis delta virus (HDV) replicates by RNA-dependent RNA synthe

105 Hepatitis delta virus (HDV) replicates its circular RNA genome via

106 Hepatitis delta virus (HDV) replication and packaging require inte

107 Hepatitis delta virus (HDV) replication involves processing and ac

108 Moderation of hepatitis delta virus (HDV) replication is a likely prerequisite i

109 mic and antigenomic ribozymes from hepatitis delta virus (HDV) requires divalent cation for optimal a

110 Hepatitis delta virus (HDV) requires host RNA editing at the viral

111 Replication of the genome of hepatitis delta virus (HDV) requires RNA-directed RNA synthesis us

112 The hepatitis delta virus (HDV) ribozyme and HDV-like ribozymes are se

113 goribonucleotide substrate for the hepatitis delta virus (HDV) ribozyme and investigated the pH depen

114 RNA transcripts: one encodes a 3'- hepatitis delta virus (HDV) ribozyme and the other, used in combin

115 d magnesium hydrate in crystals of hepatitis delta virus (HDV) ribozyme and to follow the effects of

116 While the hepatitis delta virus (HDV) ribozyme can undergo self-cleavage in

117 The hepatitis delta virus (HDV) ribozyme catalyzes a self-cleavage rea

118 The hepatitis delta virus (HDV) ribozyme is a self-cleaving RNA enzyme

119 The hepatitis delta virus (HDV) ribozyme is a self-cleaving RNA that r

120 bozyme related in structure to the hepatitis delta virus (HDV) ribozyme occurs in a number of mammals

121 p II intron domain 5-domain 6, and hepatitis delta virus (HDV) ribozyme RNA constructs.

122 The Hepatitis Delta Virus (HDV) ribozyme self-cleaving activity in 20

123 forms of the cis-cleaving genomic hepatitis delta virus (HDV) ribozyme show a divalent metal ion bou

124 The hepatitis delta virus (HDV) ribozyme uses a cytosine to facilitate

125 The hepatitis delta virus (HDV) ribozyme uses the nucleobase C75 and a

126 The Hepatitis Delta Virus (HDV) ribozyme was the first RNA enzyme prop

127 Well-ordered crystals of a genomic hepatitis delta virus (HDV) ribozyme, a large, globular RNA, were

128 In the hepatitis delta virus (HDV) ribozyme, site-specific self-cleavage

129 In the case of the hepatitis delta virus (HDV) ribozyme, there are three high-resolut

130 t structure similar to that of the hepatitis delta virus (HDV) ribozyme.

131 The hepatitis delta virus (HDV) ribozymes are self-cleaving RNA sequen

132 ctures proposed for the cis-acting hepatitis delta virus (HDV) ribozymes contain four duplex regions,

133 Hepatitis delta virus (HDV) ribozymes employ multiple catalytic st

134 biochemically related to the human hepatitis delta virus (HDV) ribozymes.

135 Hepatitis delta virus (HDV) RNA forms an unbranched rod structure

136 ation for the ribozyme activity of hepatitis delta virus (HDV) RNA in infected cells is unknown.

137 ite in the antigenomic sequence of hepatitis delta virus (HDV) RNA is 33-nt downstream of the poly(A)

138 Hepatitis delta virus (HDV) RNA replicates in the nuclei of virus-

139 When the hepatitis delta virus (HDV) RNA was released by treatment of viral

140 A replication and transcription of hepatitis delta virus (HDV) RNA, generating a full-length (1.7-kb)

141 models of the replication of human hepatitis delta virus (HDV) RNA, it is generally assumed that circ

142 1,679-nucleotide (nt) unit-length hepatitis delta virus (HDV) RNAs in the livers of two HDV-infected

143 The hepatitis delta virus (HDV) S-HDAg and L-HDAg antigens are the two

144 Hepatitis B virus (HBV) and hepatitis delta virus (HDV) share the HBV envelope proteins.

145 irected mRNA constructs containing hepatitis delta virus (HDV) target sequences.

146 bitor, and phase III candidate for hepatitis delta virus (HDV) therapy, for further follow-up.

147 -mediated RNA-editing event allows hepatitis delta virus (HDV) to express two essential proteins, the

148 Hepatitis delta virus (HDV) uses a host-encoded RNA-editing activi

149 Hepatitis delta virus (HDV) uses genomic and antigenomic ribozymes

150 d changes in hepatitis B virus and hepatitis delta virus (HDV) viral loads (VL) during tenofovir-cont

151 Efficient assembly of hepatitis delta virus (HDV) was achieved by cotransfection of Huh7

152 study assessed the epidemiology of hepatitis delta virus (HDV) within the University of Utah UHealth

153 gs are currently available against hepatitis delta virus (HDV), a defective virus leading to the most

154 Infection by the hepatitis delta virus (HDV), a satellite of the hepatitis B virus

155 ication of the RNA genome of human hepatitis delta virus (HDV), a series of linear RNAs containing HD

156 Hepatitis delta virus (HDV), a single-stranded RNA virus, bears a

157 rimary human hepatocytes either by hepatitis delta virus (HDV), a subviral agent that uses HBV envelo

158 role in the replication scheme of hepatitis delta virus (HDV), allowing the virus to produce two fun

159 Interestingly, a human pathogen, hepatitis delta virus (HDV), also replicates via a rolling circle

160 The hepatitis delta virus (HDV), an infectious human pathogen affectin

161 The hepatitis delta virus (HDV), an infectious human pathogen and sate

162 As for hepatitis delta virus (HDV), another cause of liver disease, no ef

163 of human hepatitis B virus (HBV), hepatitis delta virus (HDV), requires only the envelope proteins f

164 tigenomic RNA strands of the human hepatitis delta virus (HDV), where they serve a crucial role in pa

165 No specific therapy exists for hepatitis delta virus (HDV), which can cause severe liver disease.

166 g an RNA-dependent RNA polymerase, hepatitis delta virus (HDV), which contains a circular RNA of 1.7

167 ficulties can be circumvented with hepatitis delta virus (HDV), which needs the HBV large envelope pr

168 ilar to those observed for HBV and hepatitis delta virus (HDV), which shares the same L, M, and S.

169 We show that large hepatitis delta virus (HDV)-like ribozymes are activated by periph

170 Patients transplanted for hepatitis delta virus (HDV)-related cirrhosis are reported to have

171 the breadth and specificity of the hepatitis delta virus (HDV)-specific T-cell response in patients a

172 ly 20 million are co-infected with hepatitis delta virus (HDV).

173 a is the only treatment option for hepatitis delta virus (HDV).

174 Two classes of pathogenic RNAs (hepatitis delta virus in animals and viroids in plants) are copied

175 Activity of the two ribozymes from hepatitis delta virus in monovalent salts was examined and compare

176 e useful therapeutic agents for treatment of delta virus infection.

177 inical management of patients with hepatitis delta virus infection.

178 Replication was similar for Omicron and Delta virus isolates in human nasal epithelial cultures.

179 The hepatitis delta virus large antigen (lHDAg) is a virally encoded p

180 Delta virus neutralization also increased, from 192 to 1

181 tly regulates NTCP-dependent hepatitis B and delta virus particle entry.

182 The two forms of the hepatitis delta virus ribozyme are derived from the genomic and an

183 sense) of the NS gene joined to a hepatitis delta virus ribozyme at its 3' end.

184 erase promoter at the 5' end and a hepatitis delta virus ribozyme at the 3' end.

185 (18)O kinetic isotope effects for hepatitis delta virus ribozyme catalysis that reveal a dissociativ

186 The hepatitis delta virus ribozyme catalyzes an RNA cleavage reaction

187 promoter and upstream of the human hepatitis delta virus ribozyme domain, we inserted a complete cDNA

188 In contrast, a linear form of the delta virus ribozyme expressed as part of an unprocessed

189 ecular dynamics simulations on the hepatitis delta virus ribozyme in the product form and assessed co

190 The hepatitis delta virus ribozyme is a small, self-cleaving RNA with

191 ase promoter and the autocatalytic hepatitis delta virus ribozyme of a transcription plasmid, pBR 322

192 NA plasmid containing a cis-acting hepatitis delta virus ribozyme to control 3' cleavage.

193 f the plasmid, a cDNA encoding the hepatitis delta virus ribozyme was added to the 3' end of the FMDV

194 seP and an artificial trans-acting hepatitis delta virus ribozyme were expressed as the exon portion

195 om the antigenomic sequence of the hepatitis delta virus ribozyme with the P2 and P3 stems from the r

196 RNAs, the hairpin ribozyme and the hepatitis delta virus ribozyme, and that the shifts are likely to

197 n yellows virus pseudoknot and the hepatitis delta virus ribozyme, despite distinct structural contex

198 For the hepatitis delta virus ribozyme, we predict several nonnative stems

199 T7 RNA polymerase and cleavage by hepatitis delta virus ribozyme.

200 Hepatitis delta virus ribozymes have been proposed to perform self

201 normal; after several years, both hepatitis delta virus RNA and serum HBsAg became undetectable.

202 The two ribozymes found in hepatitis delta virus RNA form related but non-identical secondary

203 The unusual structure of hepatitis delta virus RNA has previously been shown to enhance its

204 itis B surface antigen (HBsAg) and hepatitis delta virus RNA.

205 ein complexes (RNPs) formed by the hepatitis delta virus RNAs and protein, HDAg, perform critical rol

206 gen, it was partially defective in hepatitis delta virus RNP incorporation.

207 and consider situations where the B1.617.2 (delta) virus strain is dominant and parts of the populat

208 pe proteins, hepatitis B virus and hepatitis delta virus use the sodium/taurocholate cotransporting p