ライフサイエンスコーパス: demethyl

1 nhibitor Ro-31-8220, or the calcium chelator demethyl-1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraac

2 anilino)-4-desoxypodophenazine (13) and 4'-O-demethyl-2'',3''-dichloro-4beta-(4-'''-nitroanilino)-4-

3 3 (4-hydroxymethyl ivermectin), and M6 (3"-O-demethyl, 4-hydroxymethyl ivermectin) were obtained by c

4 18-20, 26), 4-alpha-disubstituted-anilino-4'-demethyl-4-desoxypodophyllotoxin (27), 4-beta-trisubstit

5 otoxin (25), 4-beta-disubstituted-anilino-4'-demethyl-4-desoxypodophyllotoxins (18-20, 26), 4-alpha-d

6 studies, several new 4-beta-substituted 4'-O-demethyl-4-desoxypodophyllotoxins bearing mono-, di-, or

7 )anilino]-4-desoxypodophyllotoxin (21), 4'-O-demethyl-4beta-(-)-(4' '-camphanamido-anilino)-4-desoxyp

8 Among these, 4'-0-demethyl-4beta-(4'''- nitroanilino)-4-desoxypodophenazin

9 The target compounds include 4'-O-demethyl-4beta-[(4' '-(benzimidazol-2' '-yl)anilino]-4-d

10 hyl-desoxypodophyllotoxin (22, 23), and 4'-O-demethyl-4beta-[4' '-(benzimidazol-2' '-yl)amino]-4-deso

11 strain produced 6-deoxyerythronolide B and 2-demethyl-6-deoxyerythronolide B.

12 ocyclines, 7-fluoro-9-pyrrolidinoacetamido-6-demethyl-6-deoxytetracycline (17j, also known as TP-434,

13 tibacterial agents, 7-fluoro-9-substituted-6-demethyl-6-deoxytetracyclines ("fluorocyclines"), access

14 The analogues are iso-FAD (8-demethyl-6-methyl-FAD), 6-amino-FAD (6-NH(2)-FAD), 6-bro

15 the bicyclic isorhodopsin analogue, while 5-demethyl-8-methylisorhodopsin more closely followed nati

16 etinal (a 6-s-trans-bicyclic analogue), or 5-demethyl-8-methylretinal.

17 describes the synthesis of deamidobleomycin demethyl A(2) (3) and deamido bleomycin A(2) (4), as wel

18 pha-demethylation of obtusifoliol and its 24-demethyl analog 4alpha-,4alpha-dimethylcholesta-8,24-die

19 (11) and several 4beta-anilino-2-fluoro-4'-O-demethyl analogues were synthesized and evaluated in bot

20 thyl visual pigments and could explain why 5-demethyl artificial pigments regenerate so slowly.

21 pletely discounted, it is unlikely that this demethyl-ation reaction involves RNA cofactors or ribozy

22 The stability of 5-demethyl Batho, even though the C8-hydrogen of the polye

23 nd its application to the total synthesis of demethyl calamenene, a potent cytotoxic agent against hu

24 toxin (27), 4-beta-trisubstituted-anilino-4'-demethyl-desoxypodophyllotoxin (22, 23), and 4'-O-demeth

25 NB506), camptothecin-(para)-4beta-amino-4'-O-demethyl Epipodophyllotoxin (W1), and camptothecin-(orth

26 ), and camptothecin-(ortho)-4beta-amino-4'-O-demethyl Epipodophyllotoxin (W2)] on cleavable complex f

27 Except for the sugar, 4'-demethyl epipodophyllotoxin is identical to etoposide, e

28 eries of 4beta-[(4' '-benzamido)-amino]-4'-O-demethyl-epipodophyllotoxin derivatives (11-23) were des

29 so show that lobe period can be reduced when demethyl-esterification of pectins increases under condi

30 rified form that later can be differentially demethyl esterified by pectin methyl esterase (PME) to s

31 alls and exhibited high activities mediating demethyl-esterified homogalacturonan degradation.

32 thylation of the C-31 hydroxyl group of 31-O-demethyl-FK506 and FK520.

33 The gene encoding 31-O-demethyl-FK506 methyltransferase, fkbM, was isolated fro

34 n MA6548 yielded a mutant that produced 31-O-demethyl-FK506, confirming the involvement of the isolat

35 nd resulted in the formation of 9-deoxo-31-O-demethyl-FK506.

36 mectin metabolites in humans (i.e., M1 (3"-O-demethyl ivermectin), M3 (4-hydroxymethyl ivermectin), a

37 inal intermediate in the pathway, converting demethyl-Q to Q.

38 responding to the second O-methylation step, demethyl-Q(3) and Q(3), have been chemically synthesized

39 Both yeast and rat Coq3p recognize the demethyl-Q(3) precursor as a substrate.

40 urthermore, the absorption spectrum of the 9-demethyl retinal regenerated pigment exhibits a band bro

41 roteins expressed in COS cells with 11-cis 9-demethyl retinal, where the 9-methyl group on the polyen

42 stitution of the triple mutant with 11-cis-9-demethyl retinal.

43 Certain cis-isomers, 11-cis-13-demethyl-retinal and 9-cis-C17 aldehyde, were also activ

44 ) of SAM, and creatine (methyl-GAA) and SAH (demethyl-SAM) are produced.

45 d account for the unexpected blue shift of 5-demethyl visual pigments and could explain why 5-demethy