ライフサイエンスコーパス: demethylate

1 much of the remainder of the genome is being demethylated.

2 e to activate Bril when the promoter becomes demethylated.

3 essential PRC2 subunit, upon HBx expression demethylate a CpG dinucleotide located adjacent to NF-ka

4 in all models, underpinned by the failure to demethylate a small group of TS cell genes.

5 logous expression of ArsI conferred MAs(III)-demethylating activity and MAs(III) resistance to an ars

6 s a 5-methylcytosine dioxygenase and its DNA demethylating activity has been implicated in pluripoten

7 anscriptome reprogramming independent of its demethylating activity to affect key cancer signaling pa

8 llular toxicity of 5-azacytidine and its DNA demethylating activity were strongly reduced after hENT1

9 ry regions of pluripotency genes that become demethylated after OSKM induction.

10 ng growth factor beta (TGF-beta) cytokine, a demethylating agent (5-azacytidine), B cell receptor eng

11 st (VDA) nor an HDAC inhibitor (HDACI) nor a demethylating agent (DAC) individually could optimally u

12 omoters of these genes; furthermore, the DNA demethylating agent 5 aza-2'deoxycytidine (5-Aza-dC) ant

13 either alone or in combination with the DNA-demethylating agent 5-aza-2'-deoxycytidine (DAC).

14 apitulated or enhanced by treatment with the demethylating agent 5-aza-2'-deoxycytidine as well as by

15 and UM-UC13), and exposure to the chromatin demethylating agent 5-aza-2'-deoxycytidine restored HSPA

16 -type mouse fibroblasts treated with the DNA demethylating agent 5-aza-2'-deoxycytidine.

17 arcinogen-transformed HBECs treated with the demethylating agent 5-aza-2'deoxycytidine revealed miR-1

18 Furthermore, the DNA demethylating agent 5-aza-2-deoxycytidine failed to upre

19 Ha, CaSki, and HeLa cells and treatment with demethylating agent 5-aza-2-deoxycytidine restored DOC2B

20 DNA-demethylating agent 5-Aza-2dC significantly restored the

21 recapitulated by a co-treatment with the DNA-demethylating agent 5-Aza-C and retinoic acid across var

22 treatment of humanized NSG mice with the DNA-demethylating agent 5-aza-cytidine distinctly enhanced t

23 In response to the chemotherapeutic and DNA-demethylating agent 5-aza-deoxycytidine (5-aza-dC), tran

24 broblasts to nanomolar concentrations of the demethylating agent 5-azacytidine increased basal expres

25 ion of the silenced allele by either the DNA demethylating agent 5-azadeoxycytidine or the SIRT1 inhi

26 Treatment with the DNA demethylating agent 5-deoxy-azacytidine does not increas

27 f the offspring because treatment with a DNA-demethylating agent alleviated exacerbation of allergic

28 Pure GuaUre-dR was found to be an effective demethylating agent and was able to induce 5azaC-dR type

29 lenic marginal zone lymphoma cell lines to a demethylating agent caused partial reversion of the High

30 The DNA-demethylating agent decitabine recovers FBXL7 expression

31 version of an adult cell by exposing it to a demethylating agent immediately followed by differentiat

32 Treatment of IDH mutant gliomaspheres with a demethylating agent partially restores insulator functio

33 o a combination of hypoxia, TGF-beta1, and a demethylating agent results in NK cells that express kil

34 Treatment of CCA cells with decitabine (demethylating agent) or butyrate (histone deacetylase in

35 we examined the therapeutic potential of the demethylating agent, 5'-aza-2'-deoxycytidine.

36 he CHS response in mice treated with the DNA demethylating agent, 5-aza-2'-deoxycytidine, after UVB e

37 l re-expression of ER was achieved using the demethylating agent, 5-azacytidine, and the HDAC inhibit

38 nografts were treated with decitabine, a DNA demethylating agent, and cytarabine, a frontline cytotox

39 ol on Ddo expression, treatment with the DNA-demethylating agent, azacitidine, causes increased mRNA

40 By treating neoplastic LGLs with a demethylating agent, IL-6-mediated SOCS3 expression was

41 Combining DNA-demethylating agents (DNA methyltransferase inhibitors [

42 However, the use of DNA-demethylating agents (e.g. 5-aza-2'-deoxycytidine (5aza-

43 derstanding the anti-tumor mechanisms of DNA-demethylating agents and highlight the MDA5/MAVS/IRF7 pa

44 if so, novel therapeutic strategies such as demethylating agents and probiotic adjuncts, particularl

45 garding the advantage of aerosol delivery of demethylating agents and the concept of priming tumors f

46 DNA demethylating agents are approved for some blood maligna

47 Exposure to demethylating agents caused reexpression of estrogen rec

48 ound that the endothelial cells treated with demethylating agents could significantly increase the ex

49 tic lesions justifies efforts to develop DNA demethylating agents for therapeutic benefit.

50 DNA-demethylating agents have shown clinical anti-tumor effi

51 view, we discuss the clinical development of demethylating agents in hematology, with a focus on azac

52 The potential role of demethylating agents in the management of this patient p

53 leukemic LGL survival, and suggest a role of demethylating agents in the treatment of this disorder.

54 ulmonary carcinogenesis and suggest that DNA demethylating agents may be useful for activating miR-48

55 These demethylating agents may induce T-cell attraction and en

56 In mice, demethylating agents reversed cyclophosphamide-induced b

57 Studies show that demethylating agents strongly upregulate the expression

58 zone lymphoma and optimize therapy by using demethylating agents to reverse the high-methylation phe

59 Furthermore, both demethylating agents were found to synergize with the FA

60 We examined the effects of 2 demethylating agents, 5-azacytidine and decitabine on gr

61 ls caution against the indiscriminate use of demethylating agents, such as 5-aza-2'-deoxycytidine (5-

62 cell lines and inducing resensitizaton with demethylating agents, we aimed to identify consistent me

63 rtunity for treatment of SONFH patients with demethylating agents.

64 gene, Ogg1, could be reversed by the use of demethylating agents.

65 RMS biopsies and could be reactivated by DNA-demethylating agents.

66 erapeutic options such as Syk inhibitors and demethylating agents.

67 ting this protein to develop therapeutic DNA demethylating agents.

68 al specimens and functionally verified using demethylating agents.

69 e of Chl breakdown, in vitro, but MES16 also demethylated an FCC.

70 However, promoters of these genes were demethylated and activated during retinal development.

71 s at putative regulatory regions that are CG-demethylated and activated in the adult brain and that C

72 plants has remained unclear since DNA is not demethylated and histones are retained in sperm(3,4).

73 We found that Ment was gradually demethylated and overexpressed during tumor progression

74 Here, we show that some TEs are demethylated and transcriptionally reactivated during an

75 ents were up-regulated in U251MG cells after demethylating and IFN-gamma treatments, suggesting an ef

76 d to the MMP13 promoter when the -104 CpG is demethylated, and confirmed this binding by chromatin im

77 the absence of Kdm3b, loci that must be DNA demethylated are trapped in an intermediate hydroxymethy

78 consequence of Set1C dimerism and that Jhd2 demethylates asymmetric H3K4me3.

79 e nucleolar rRNA genes are nearly completely demethylated at promoter CGs, whereas silenced genes are

80 uction, Helios(-) FOXP3(+) nTreg clones were demethylated at the FOXP3 Treg-specific demethylated reg

81 rograms at naive-associated genes and became demethylated at the loci of classically defined effector

82 Mature moDC-expanded nTregs were highly demethylated at the Treg-specific demethylation region w

83 The lysine specific demethylase 1 (LSD1) demethylates at both of these lysine residues and has be

84 he activities of Hg(II) methylating and MeHg demethylating bacteria.

85 It can also demethylate beta-catenin-encoding CTNNB1 mRNA that conta

86 Increased levels of demethylated beta-cell-derived DNA in the bloodstream ac

87 s question and determine that <2% of regions demethylated by 5-Aza-CdR treatment assume an open confi

88 In this assay methylated peptides are first demethylated by a KDM, and a protein methyltransferase (

89 Moreover, we find that m(6)Am is selectively demethylated by fat mass and obesity-associated protein

90 erally a transcriptional repression mark, is demethylated by H3K9-specific demethylases, leading to t

91 then targeted two proteins whose genes were demethylated by RG108-estrogen receptor 1 (ESR1) and cyc

92 onse to toll-like receptor ligands, TRAF6 is demethylated by the Jumonji domain protein JMJD6.

93 we found that histone H3 lysines 4 and 9 are demethylated by the lysine-specific demethylase, LSD1 an

94 limosum Instead of forming TMA, carnitine is demethylated by the newly discovered methyltransferase M

95 -resorcin[5 and 6]arenes were quantitatively demethylated by treatment with BBr3 to obtain the corres

96 With the demethylated c8-ring and with c10- and c11-rings, the de

97 The lack of a demethylating capacity may have contributed to the robus

98 thylation activity of FTO, which selectively demethylates cardiac contractile transcripts, thus preve

99 hl breakdown in Arabidopsis and specifically demethylates Chl catabolites at the level of FCCs in the

100 hritis and systemic lupus erythematosus were demethylated compared to healthy controls and favoured p

101 mice and suggests roles for Tet proteins in demethylating conserved gene enhancers during the phylot

102 In this DNA demethylated context, either deletion of the CTCF bindin

103 , we investigated the function of Gadd45b in demethylating CpG islands of representative gene targets

104 xon and TSS200 and a dominant pattern of age-demethylated CpGs at other gene regions, and by overwhel

105 atterns over gene regions for methylated and demethylated CpGs both relate to reduced gene activity d

106 Intriguingly, demethylated CpGs downstream from SALL4 TSS are within b

107 its oxidized derivatives, at the majority of demethylated CpGs, are converted to unmodified cytosines

108 of relevance to the report that selenoneine demethylates CysHgMe, thereby providing a mechanism for

109 CD8 T cells while key effector genes remain demethylated, demonstrating that memory T cells arise fr

110 nomes of the HCT116 cell line and its highly demethylated derivative, DKO1.

111 nfected individuals, CCR5 cis-regions remain demethylated, despite restoration of CD4+ counts (>/=800

112 s)(m) was found to have a higher capacity to demethylate DMHg, in comparison with dissolved sulfide.

113 therapy against this cancer, we used the DNA demethylating drug 5-aza-2'-deoxycytidine (DAC) in an ag

114 rs, and treatment of the cell lines with the demethylating drug 5-aza-2'-deoxycytidine resulted in in

115 The DNA-demethylating drug 5-Aza-2-deoxycytidine (5-azadC) induc

116 Here we show that treatment with the DNA-demethylating drug 5-Aza-deoxycytidine (AZA) restores hi

117 Early successes have been made with DNA-demethylating drugs in hematologic malignancies, and eff

118 was detectable for only 2 weeks, whereas DNA-demethylating drugs induced permanent epigenetic reprogr

119 over time after treatment with HDACi or DNA-demethylating drugs.

120 regions, and CpG shores were preferentially demethylated during erythropoiesis.

121 transcription initiation, but how H3K4me3 is demethylated during gene repression is poorly understood

122 ethylated in stem cells and gradually became demethylated during normal B-cell differentiation, sugge

123 , hox genes) is methylated, but the loci are demethylated during zygotic cleavage stages to precisely

124 protein expression correlate with the highly demethylated EBV type III latency program permissive for

125 Phosphatidylcholine (PC) bilayers were demethylated either by substitution with phosphatidyleth

126 cally, we found that miR-29b targets the DNA-demethylating enzyme, TET1, for downregulation resulting

127 ment leads to the aberrant expression of DNA demethylating enzymes and locus-specific changes to DNA

128 ne in postmitotic neurons is to functionally demethylate expressed gene bodies while retaining the ro

129 H3K27ac) are more prominent at regions that demethylate faster.

130 y in urine therefore represents a mixture of demethylated fish-derived MeHg and amalgam-derived inorg

131 asil, which explains the accumulation of 7-O-demethylated flavone nevadensin.

132 ites examined, the -104 CpG was consistently demethylated following treatment of human articular chon

133 Herein, we report the first synthesis of a demethylated form of cholesterol (18,19-di-nor-cholester

134 ALKBH5 demethylates FOXM1 nascent transcripts, leading to enhan

135 d a higher proportion of CD4(+) T cells with demethylated Foxp3 and a specific expansion of CD4(+) CD

136 Irrespective of a fully demethylated FOXP3 locus, Tregs of subjects with dAIH ar

137 CD127CD25CD45RA Treg cells had a stable TSDR demethylated FOXP3 phenotype after expansion whereas CD4

138 In epiblast cells, TET1 demethylates gene promoters via hydroxymethylation and m

139 TET2 and EBNA2 function cooperatively to demethylate genes important for EBV-driven B-cell growth

140 ignaling pathways, whereas those enriched in demethylated genes after decitabine treatment included p

141 The number of demethylated genes was greater (P < 0.05) in tumor biops

142 n of many gene promoters and upregulation of demethylated germline genes.

143 chrome P450 system, GcoAB, was discovered to demethylate guaiacol (2-methoxyphenol), which can be pro

144 with core cardiac transcription factors and demethylates H3K27 residues in cardiac genes.

145 er molecular analyses demonstrate that JMJD3 demethylates H3K27me3 along the gene bodies, paving the

146 JD3 activates bivalent gene transcription by demethylating H3K27me3 and promoting transcriptional elo

147 Here, we show that KDM5B, which demethylates H3K4, is important for ES cell differentiat

148 y identifies a crucial function for KDM5A in demethylating H3K4 to allow ZMYND8-NuRD to operate withi

149 JMJ17 specifically demethylated H3K4me1/2/3 via conserved iron-binding amin

150 a, does not have the intrinsic capability to demethylate H3K4me2.

151 o the chromatin of OPEN STOMATA 1 (OST1) and demethylated H3K4me3 for the regulation of OST1 mRNA abu

152 In this study, we show that KDM5B, which demethylates H3K4me3, plays an integral role in regulati

153 of KDM4A-D histone demethylases selectively demethylates H3K9 and H3K36 and is implicated in key cel

154 interactions, and in the second role, JMJD1A demethylates H3K9 di-methylation.

155 The histone lysine demethylase 3A (KDM3A) demethylates H3K9me1 and H3K9Me2 to increase gene transc

156 PHF8 demethylates H3K9me1, H3K9me2 and sustains H3K4me3 to pr

157 KDM7A and UTX demethylate H3K9me2 and H3K27me3, respectively, and are

158 Thus, by demethylating H3K9me2, JMJD1C alters chromatin accessibi

159 Lysine-specific demethylase 4A (KDM4A) demethylates H3K9me3 at promoters marked by H3K4me3 in a

160 LSD1 demethylates HIF1alpha at lysine (K) 391, which protects

161 LSD1 demethylates histone H3 Lys4, an epigenetic mark for act

162 B-dependent manner, where KDM6B specifically demethylates histone H3 lysine 27 dimethyl.

163 specific demethylase 1 (LSD1; ref. 5), which demethylates histone H3 on Lys 4 or Lys 9 (H3K4/K9), is

164 (lysine [K]-specific demethylase 5A), which demethylates histone H3 on Lys4 (H3K4), as a pRB-interac

165 e-specific demethylase 1 (Lsd1/KDM1a), which demethylates histone H3 on Lys4 or Lys9 (H3K4/K9), is an

166 ulate cellular processes by hydroxylating or demethylating histone and non-histone targets.

167 breast cancer cell invasion and apoptosis by demethylating histone and the non-histone protein p53, r

168 tones, indicating that this HDM is unable to demethylate histones during steady-state conditions.

169 Pectin methylesterases (PMEs) demethylate homogalacturonan (HG), and the majority of H

170 that inflammasome-related genes are rapidly demethylated in both monocyte-to-macrophage differentiat

171 CD56(bright) NK cells and are progressively demethylated in CD56(dim) NK cells as they mature and ac

172 Dnmt3b activity, the majority of which were demethylated in Dnmt3b-/- lymphomas, but not in Dnmt3b-/

173 The TSDR is selectively demethylated in ex vivo Tregs purified from secondary ly

174 These sequences are, however, demethylated in Foxp3(+) Treg by mechanisms as yet unkno

175 e, also upregulated in HBV-mediated HCCs, is demethylated in liver tumors at CpG dinucleotides flanki

176 rich Foxp3 intronic cis-element specifically demethylated in mature Tregs, helps maintain immune home

177 enhancer region at -5.8 kb was significantly demethylated in OA samples compared with control samples

178 In summary, the -104 CpG is demethylated in osteoarthritic cartilage, correlating wi

179 P-responsive element site, was significantly demethylated in patient-derived compared with normal con

180 er the first recombination step were largely demethylated in pro-, pre-, and mature B cells.

181 ggested that the paternal genome is actively demethylated in the zygote while the maternal genome und

182 ion is established, as CNS2 is thought to be demethylated independently of Foxp3 expression.

183 as identified from an environmental MAs(III)-demethylating isolate, Bacillus sp. MD1.

184 The enzyme demethylated its natural substrate eburicol and the plan

185 TET1 binds and demethylates its own promoter and the promoter of homeob

186 sterase PME-1 limits the activity of PP2A by demethylating its catalytic subunit.

187 An additional class of demethylated loci mapped to Alu elements across the geno

188 At actively demethylated loci, 5mCs were processed to unmodified cyt

189 LSD1 can demethylate lysine at specific histone positions to repr

190 These enzymes demethylate lysine residues in histones in a methylation

191 t LSD1 positively regulates FOXA1 binding by demethylating lysine 270, adjacent to the wing2 region o

192 FTO preferentially demethylates m(6)Am rather than N(6)-methyladenosine (m(

193 The observation that AlkB can demethylate m6A in vitro suggests a role for AlkB in reg

194 dm6ACRISPR specifically demethylates m6A of targeted mRNA such as cytochrome b5

195 encodes the ArsI C-As lyase, S. putrefaciens demethylated MAs(III) to As(III).

196 (1)H and (13)C NMR of both EAPB0203 and its demethylated metabolite (EAPB0202) to the corresponding

197 -specific demethylase 1, also known as KDM1) demethylates mono- and dimethylated H3K4 in peptide subs

198 y important roles in gene expression through demethylating mono-, di-, or trimethylated lysines.

199 DM1A) acts as a transcriptional repressor by demethylating mono/dimethylated histone H3 lysine 4 (H3K

200 ation assays, which demonstrated that HR can demethylate monomethylated or dimethylated histone H3 ly

201 methylase 3A (KDM3A) binds to PGC-1alpha and demethylates monomethylated lysine (K) 224 of PGC-1alpha

202 resents a molecular switch as methylated and demethylated MTA1 nucleate NuRD or NURF complexes with o

203 is required for the NuRD repressor complex, demethylated MTA1 recognizes the bivalent histone H3K4-A

204 s pretreatment with Escherichia coli AlkB to demethylate N(1)-methyladenosine (m(1)A), N(3)-methylcyt

205 FTO demethylates N6-methyladenosine, a potential regulatory

206 y of dioxygenases have a general function in demethylating nucleic acids.

207 Lysine-specific demethylase 1 (LSD1) demethylates nucleosomal histone H3 lysine 4 (H3K4) resi

208 requires the corepressor protein, CoREST, to demethylate nucleosome substrates.

209 eosome, explaining its essential function in demethylating nucleosome substrates.

210 n within the FOXP3 locus that is selectively demethylated only in bona fide Tregs (Treg-specific deme

211 which uncovered hundreds of loci that became demethylated only when hENT1-mediated transport was acti

212 mediated stimulation of Sox2 expression, and demethylating p53 protein and consequently, modulating i

213 thylation, KDM3A promotes chemoresistance by demethylating p53.

214 These demethylated PC anions fragment upon ion trap collision-

215 Subsequent collisional activation of the demethylated PC anions produces abundant fatty acid carb

216 -induced dissociation (CID) of the resulting demethylated PC product anions allows for the determinat

217 intenance of PD-1 surface expression and the demethylated PD-1 promoter were not a result of residual

218 m distribution of cellulose microfibrils and demethylated pectin coincides with spatial differences i

219 n increased accumulation of less stretchable demethylated pectin in the apical wall, whereas MeSA did

220 l wall stiffness through local enrichment in demethylated pectin, whereas subsequent increase in lobe

221 hen exposed to TAC and maintenance of a TSDR demethylated phenotype following in vitro expansion.

222 s CD4CD127CD25CD45RA Treg cell lost the TSDR demethylated phenotype.

223 L-Dopa also enhanced demethylated PP2A amounts in the liver.

224 In contrast, demethylated PP2A is preferentially distributed in non-r

225 yl-l-methionine, the transmethylation of the demethylated precursor of vitamin K is strictly dependen

226 emethylation is occurring in the culture and demethylates preferentially the lighter Hg isotopes of M

227 tcB and related proteins in E. limosum might demethylate proatherogenic quaternary amines and contrib

228 adenosylmethionine (SAM), and increasing the demethylated product S-adenosylhomocysteine (SAH).

229 successive N-demethylation of the IPU mono-N-demethylated product.

230 e cleavage of the urea side chain of the IPU demethylated products; a distinct aniline dioxygenase ge

231 sed at the onset of and during senescence to demethylate promoter, gene body or 3' UTR regions to act

232 8 T cells identified effector molecules with demethylated promoters and poised for expression.

233 Our results indicate that only a minority of demethylated promoters are associated with nucleosome re

234 l type and silent in the other tend to share demethylated promoters, while methylation differences be

235 n vivo metabolite of Pz-1 is its less active demethylated pyrazole analogue.

236 Recombinant CYP82E4, CYP82E5v2, and CYP82E10 demethylated (R)-nicotine 3-, 10-, and 10-fold faster th

237 se 1 (LSD1) upregulates hypoxia responses by demethylating RACK1 protein, a component of hypoxia-indu

238 -1/0 pituitary cells with a combination of a demethylating reagent and a histone deacetylase inhibito

239 These results indicate that this DNA-demethylating reagent is a promising therapeutic approac

240 were treated with 5-aza-2'-deoxycytidine, a demethylating reagent.

241 the methylation status of the Treg-specific demethylated region (TSDR) have remained unchanged.

242 of demethylation of the Foxp3 Treg-specific demethylated region (TSDR) in circulating CD4(+) T cells

243 anced the demethylation of the Treg-specific demethylated region (TSDR) in the mouse Foxp3 gene and t

244 epigenetic differences in the Treg-specific demethylated region (TSDR) of Foxp3 and were more stable

245 Demethylation analysis of the Treg-specific demethylated region (TSDR) provides a more accurate asso

246 n, or methylation state of the Treg-specific demethylated region (TSDR) within the FOXP3 locus associ

247 NA methylation analyses of the Treg-specific demethylated region (TSDR) within the FOXP3 locus.

248 ds on DNA demethylation at the Treg-specific demethylated region (TSDR), a conserved, CpG-rich region

249 hin the FOXP3 gene, called the Treg-specific demethylated region (TSDR), is considered the hallmark o

250 d by a completely demethylated Treg-specific demethylated region and showed alloantigen-specific supp

251 methylated regulatory T cell (Treg)-specific demethylated region Foxp3 gene are considered natural Tr

252 3 expression are characterized by a specific demethylated region in the FOXP3 gene (Treg-specific dem

253 By using demethylation of the Treg-specific demethylated region in the FOXP3 gene as a marker for nT

254 thylation-specific PCR using a Treg-specific demethylated region in the FOXP3 gene.

255 cells with a demethylated Treg-cell-specific demethylated region in the Foxp3 locus downregulated Fox

256 cells retained a demethylated Treg-specific demethylated region in the FOXP3 promoter, maintained ac

257 Assessment of regulatory T cell-specific demethylated region methylation status in 1-month biopsy

258 tion of CpG regions within the Treg-specific demethylated region of KO versus WT Tregs, suggesting th

259 with lower methylation at the Treg-specific demethylated region of the FOXP3 gene.

260 s a predominantly demethylated Treg-specific demethylated region of the FOXP3 locus.

261 rying highly demethylated Treg cell-specific demethylated region that configures committed Tregs stab

262 hylation of the CpG islands in Treg-specific demethylated region, CTLA-4 exon 2, and glucocorticoid-i

263 were demethylated at the FOXP3 Treg-specific demethylated region, indicative of Treg lineage stabilit

264 lated only in bona fide Tregs (Treg-specific demethylated region, TSDR) represents a reliable method

265 ated region in the FOXP3 gene (Treg-specific demethylated region, TSDR).

266 HD showed a fully demethylated Treg-specific-demethylated region.

267 ion factors, are frequently localized in the demethylated regions of the promoters of numerous ripeni

268 at demethylation may cause regain of PRC2 in demethylated regions.

269 +)CD127(-)FOXP3(+) T cells with a persistent demethylated regulatory T cell (Treg)-specific demethyla

270 Besides a localization tendency to DNA demethylating sites, MBD3 experiences a concurrent trans

271 ts also maintained their effector-associated demethylated status but acquired TEM-associated programs

272 panded with TAC, the marked loss of the TSDR demethylated status highlights the potential for loss of

273 However, native GcoAB has minimal ability to demethylate syringol (2,6-dimethoxyphenol), the analogou

274 ing the first two years of flooding, and net demethylating systems afterward.

275 accumulated in the nucleus and bound to and demethylated TCF4-associated histone H3K9 by interacting

276 ing important biomarker classes, such as C10 demethylated terpanes, alphaalphaalpha-steranes, and mon

277 ope systematics and co-occurrence with other demethylated terpenoids suggest a mechanistic connection

278 xpression of COX-2, suggesting an ability to demethylate the promoter.

279 and the Msk1 kinase, which can respectively demethylate the repressive H3K9me3 mark and phosphorylat

280 cate the presence of an enzyme activity that demethylates the C13(2)-carboxymethyl group present at t

281 entified that in vitro MINA53 preferentially demethylates the histone substrate, H3K36me3 and that in

282 DME demethylates the maternal MEDEA (MEA) promoter in endosp

283 tion of the HERVs in patients; meanwhile DNA-demethylating therapy causes a small and heterogeneous e

284 e levels of H3K56me3, suggesting that dKDM4A demethylates this heterochromatic mark to facilitate rep

285 r elements that are evolutionarily young are demethylated to a milder extent compared to older elemen

286 the Helios-positive subset, carrying highly demethylated Treg cell-specific demethylated region that

287 Treg cells with a demethylated Treg-cell-specific demethylated region in t

288 (-) nTreg were characterized by a completely demethylated Treg-specific demethylated region and showe

289 Remaining FOXP3+ cells retained a demethylated Treg-specific demethylated region in the FO

290 T cells (Tconv), and possess a predominantly demethylated Treg-specific demethylated region of the FO

291 olated Treg cells during GVHD showed a fully demethylated Treg-specific-demethylated region.

292 found that JMJD3 and KIAA1718 collaborate to demethylate trimethylated H3K27 (H3K27me3) on a subset o

293 The m1A demethylated tRNA is more sensitive to angiogenin (ANG)

294 mosome, germline-specific genes) only become demethylated upon entry of PGCs into the gonads.

295 stability and expression, which was able to demethylate usp28 promoter, reduced USP28 expression, fi

296 n 5,168 CpGs (39% age-methylated and 61% age-demethylated) which were characterized by high concentra

297 thoxy-substituted benzo[c]phenanthrenes were demethylated with BBr3 and oxidized to the o-quinones wi

298 genome-wide significance of FWER <0.05, 86% demethylated with increasing age.

299 We hypothesize that fish-derived MeHg is demethylated within the body, causing mass-dependent fra

300 on of adipogenesis and osteoblastogenesis by demethylating Wnt10a gene and upregulating its expressio