ライフサイエンスコーパス: deneddylation

1 es and deconjugates Nedd8/Rub1 from cullins (deneddylation).

2 ddylation) and deactivated by NEDD8 removal (deneddylation).

3 ed with substrate are normally refractory to deneddylation.

4 losome regulates CDT2 stability through CUL4 deneddylation.

5 process and ubiquitin chain elongation after deneddylation.

6 alpha stabilization independent of Cullin 2 deneddylation.

7 nt flowers without an obvious defect in CUL1 deneddylation.

8 indicating that CSN2 is essential in cullin deneddylation.

9 We conclude that the CSN and its cullin deneddylation activity are required to sustain postembry

10 IM2 exhibit reduced nuclear accumulation and deneddylation activity of the CSN toward the cullin 1 an

11 While there was no obvious influence on CSN deneddylation activity, the increase in CSN subunits and

12 suggesting that these functions require the deneddylation activity.

13 ed conformational changes are retained after deneddylation, allowing both initiation of the ubiquitin

14 ith an F-box-Skp1 complex markedly inhibited deneddylation, although the magnitude varied considerabl

15 RL complexes are controlled by cycles of CRL deneddylation and CAND1 binding.

16 ng with the ubiquitin-proteasome pathway via deneddylation and phosphorylation.

17 mpaired CSN holocomplex formation and cullin deneddylation and resulted in decreases in F-box protein

18 Although CIF causes cullin deneddylation and the generation of free NEDD8 Q40E, inh

19 ated via distinct mechanisms: the monomer by deneddylation and the tetramer by auto-ubiquitylation.

20 The RING domain is crucial for deneddylation, and works in part through conformational

21 This inhibition is independent of cullin deneddylation but mediated by the CSN-associated deubiqu

22 otes substrate adaptor release following SCF deneddylation by the COP9 signalosome (CSN).

23 Upon consumption of substrate and subsequent deneddylation, CSN can remain stably bound to the CRL an

24 and demonstrate that the cullin neddylation-deneddylation cycle is not only required to activate CRL

25 Together, these mechanisms enable a dynamic deneddylation-disassembly cycle that promotes rapid remo

26 ivo, raising the question of how neddylation/deneddylation exerts its effects.

27 quitin ligases, where neddylation as well as deneddylation, facilitated by the protease activity of t

28 It promotes cleavage of the Nedd8 conjugate (deneddylation) from the cullin component of SCF ubiquiti

29 sought to determine the role of CSN-mediated deneddylation in UPS function and postnatal cardiac deve

30 complexes known to regulate neddylation and deneddylation, including the COP9 signalosome, Nub1, and

31 onstrated that NEDP1 overexpression restored deNEDDylation, induced apoptosis, impaired tumor cell pr

32 provide evidence that cullin neddylation and deneddylation is highly dynamic, that its equilibrium ca

33 terodimer and finally activation of the CSN5 deneddylation machinery.

34 whereas selectively promoting CSN5-mediated deNEDDylation may be beneficial in all stages of atheros

35 ects of csn mutants and monitored the cullin deneddylation/neddylation ratio during embryonic and ear

36 Deneddylation of both SCF(Fbw7) and SCF(Skp2-Cks1) was f

37 -1) deneddylation, we found a dose-dependent deneddylation of Cul-1 by Ado receptor stimulation predo

38 unit of the COP9 signalosome responsible for deneddylation of Cul-1, partially reversed HPC-mediated

39 do and suppresses NF-kappaB activity through deneddylation of Cul-1.

40 ates cell cycle at the G1 phase by promoting deneddylation of Cul1.

41 r (TLR) and reactive oxygen species-mediated deneddylation of Cul3, which is essential for Cul3/Keap1

42 on inhibitor MLN4924 prominently induces the deneddylation of Cullin-1.

43 s ubiquitin-dependent protein degradation by deneddylation of cullin-based ubiquitin ligases and, the

44 tent with NEDD8 deamidation causing enhanced deneddylation of cullins by the CSN.

45 ied by subunit 5 (CSN5/Jab1), resides in the deneddylation of the CRLs that is the hydrolysis of the

46 ochemical activity intrinsic to the complex, deneddylation of the Cullin subunits from Cullin-RING ub

47 nalysis indicates that NEDP1 mutants perturb deNEDDylation of the tumour suppressor p53.

48 besides CSN and the role of neddylation and deneddylation of their substrates.

49 Csn8/CSN plays an essential role in cullin deneddylation, UPS-mediated degradation of a subset of p

50 Cul-1 deneddylation was evident in a murine model of HPC and l

51 bition of NF-kappaB through cullin-1 (Cul-1) deneddylation, we found a dose-dependent deneddylation o

52 However, deneddylation, which removes NEDD8 from cullin, does not