ライフサイエンスコーパス: denervate

1 not disappear when the gut was extrinsically denervated.

2 By 12 h all muscle fibres were denervated.

3 hat 50% of soleus end plates were completely denervated 1-4 weeks post-partial denervation in Hb9(cre

4 adrenalectomized mice were transplanted with denervated adrenal glands to restore physiologic glucoco

5 Principal neurons that are partially denervated after brain injury remodel their synaptic con

6 Synapses eventually denervate and the muscles atrophy.

7 (Id2) and c-Myc protein contents between the denervated and control muscles, the protein content of t

8 the ipsilateral inferior oblique muscle was denervated and extirpated.

9 Denervated and fellow orbits were imaged by MRI, embedde

10 growth factor-1 was expressed vigorously by denervated and reinnervated cutaneous nerve but minimall

11 imaging can be used to differentiate between denervated and reinnervated muscles for at least 12 mont

12 fter nerve repair, and signal intensities of denervated and reinnervated muscles were measured semiqu

13 In baroreceptor denervated and vagotomized cats, the present study evalu

14 ) were recorded in anaesthetized sino-aortic denervated and vagotomized rats.

15 jected into the liver of parasympathetically denervated animals and orexin fibres were found adjacent

16 Acutely hypertensive denervated animals developed significantly less cerebral

17 In sham-denervated animals, neurons close to the border had axon

18 y function were assessed in CB intact and CB denervated animals.

19 epinephrine, had a greater pressor effect in denervated animals.

20 The denervated anterior chest skin was reinnervated by both

21 erative axonal sprouts grew into the central denervated area in a stereotypic pattern with collateral

22 l of the incised cylinder of skin, leaving a denervated area in which Schwann cells are absent.

23 Despite the very small denervated area, the injured axons consistently reshape

24 Bipolar voltages in denervated areas and (123)I-mIBG transition zones were <

25 vical ganglia, grow into the cholinergically denervated areas of the hippocampus.

26 de of the brain to extend new projections to denervated areas of the midbrain and spinal cord.

27 ojections from the undamaged hemisphere into denervated areas of the spinal cord and improves skilled

28 (123)I-mIBG denervated areas were approximately 2.5-fold larger than

29 s that induce retinal axons to innervate the denervated auditory thalamus may compete with barriers,

30 splayed smaller neuromuscular endplates that denervated before motor neuron loss, which is consistent

31 er electroporation is sufficient to rescue a denervated blastema and regenerate the distal structures

32 erentially homed to innervated compared with denervated bone.

33 in-2, which we then engrafted into partially denervated branches of the sciatic nerve of adult mice.

34 current upon repolarization, in fibres from denervated but not innervated muscle.

35 orylation and downstream signaling in the DA-denervated but not the intact striatum.

36 y, lung, skin, small intestine, stomach, and denervated, but not normal, skeletal muscle.

37 adult brain to form new connections in areas denervated by a lesion (axonal sprouting) is more widesp

38 Motor end plates denervated by axonal retraction of dying motor neurons a

39 in NT3-OE mice, touch domes were chronically denervated by resecting dorsal cutaneous nerves.

40 lamic and thalamocortical axons and are thus denervated by such injuries, yet nRT cells generally sur

41 nts sprout into cervical gray matter regions denervated by the loss of CST terminations.

42 t cardiac vagal branches but sympathetically denervated by thoracic spinal pithing, cardiac chronotro

43 The autoperfused and denervated calf muscles of the cat hindlimb were placed

44 significant manner; 2) the fine structure of denervated cells is altered; 3) cell phenotypes are diff

45 ogo-ab(atg/atg) and ngr1(-/-) CST axons into denervated cervical gray matter.

46 half of the spinal cord and recrossed to the denervated cervical hemicord below the injury.

47 ncreased their projections to the cortically denervated cervical hemicord by 1.2- to 1.6-fold.

48 endogenous molecular machinery in the stroke-denervated cervical spinal gray matter with a focus on p

49 nd then grew slowly toward the center of the denervated circle.

50 ally invasive therapeutic avenue to exercise denervated circuitry and/or restore motor function after

51 tails rerouting a tibial nerve branch to the denervated common fibular nerve stump to reinnervate the

52 ngiotensin) II-infused mice, were reduced in denervated compared with innervated bone of Ang II-infus

53 The denervated compared with the control group had a greater

54 while infarcts in ptprs+/- littermates were denervated, confirming that CSPGs prevent sympathetic re

55 otransporter was elevated in interneurons of denervated cortex, and KCC2 deletion restored normal int

56 Microglia are specifically activated in the denervated corticospinal projection fields in this early

57 imals but not controls sprout into the party denervated cuneate nucleus.

58 protein were significantly more abundant in denervated cutaneous nerve than in denervated ventral ro

59 ixed tissues, by using time-lapse imaging of denervated dentate granule cells in organotypic entorhin

60 incised cylinder, leaving a defined zone of denervated dermis and epidermis.

61 this process and can rescue regeneration in denervated digit tips through secretion of pro-regenerat

62 uscle samples and to a variable extent other denervating disease but only minimally in acquired myopa

63 ial effects of these agents on SMA and other denervating diseases.

64 hin (PTN) was highly up-regulated in acutely denervated distal sciatic nerves, but high levels of PTN

65 riking loss of repair cells from chronically denervated distal stumps.

66 In four CB-denervated dogs, absence of hyper-/hypoventilatory respo

67 cardiac transplant recipients who possess a denervated donor heart.

68 red dorsal column (DC) sensory axons and the denervated dorsal column nuclei (DCN).

69 spared fibers in the ventral striatum to the denervated dorsal striatum at 7 weeks post-lesion, but t

70 When segmental data were further analyzed in denervated (DZ), transition (TZ), and normal (NZ) zones,

71 uscle-specific kinase (MuSK) was assessed at denervated endplates.

72 fect of preserving agrin on the stability of denervated endplates.

73 incision model, the earliest reinervation of denervated epidermis occurred by collateral sprouting fr

74 d there were no differences in heart rate in denervated ex vivo hearts, implicating parasympathetic h

75 munostaining were significantly decreased in denervated eyes after 7 days.

76 ency of stem/progenitor cells harvested from denervated eyes.

77 scripts were also significantly decreased in denervated eyes.

78 gate the role of muscle impulse activity, we denervated fast extensor digitorum longus (EDL) and slow

79 to what extent, if any, muscle fascicles of denervated feline soleus (SO) change length during stanc

80 rane resistances similar to those of control denervated fibers that remain excitable.

81 ed with slow and in innervated compared with denervated fibers.

82 motor unit remodelling, the reinnervation of denervated fibres acting to preserve muscle fibre number

83 Partially and fully denervated fibres added up to approximately 50% of the t

84 itability in SD fibres since many normal and denervated fibres retain normal excitability when depola

85 increased the action potential threshold in denervated fibres to that measured in innervated fibres,

86 size, suggesting a greater reinnervation of denervated fibres.

87 surprised that the cardiac infarct remained denervated following ischemia-reperfusion (I-R).

88 In muscles denervated for 1 week, both Na(V)1.4 and Na(V)1.5 mRNAs

89 were analyzed for the subset (n=27) who were denervated for an underlying diagnosis other than autoso

90 tions severed S-cell axons did not reach the denervated ganglion but grew close to it, independent of

91 sected mouse tibial nerve projected axons to denervated gastrocnemius muscle fibers, where they forme

92 contralateral CST axon sprouting toward the denervated gray matter of the cervical and lumbar spinal

93 ry developed similarly in the innervated and denervated groups.

94 form synaptic bouton-like structures in the denervated half of the spinal cord.

95 evealed two populations of NMJs in partially denervated Hb9(cre)NCAM(flx) soleus muscles, one with hi

96 raction between leptin and heart rate in the denervated heart is not known.

97 frequently in heart transplant patients with denervated hearts and coronary allograft vasculopathy, a

98 Transcriptional analysis of mechanically denervated hearts revealed a blunted inflammatory and im

99 Ex vivo, in isolated denervated hearts, the intrinsic heart rate was markedly

100 ute withdrawal from opioids in children with denervated hearts.

101 risk of prolonged atrioventricular block in denervated hearts.

102 Finally, activated microglia in the denervated hippocampal stratum oriens did not migrate ex

103 hetic ingrowth occurs in the cholinergically denervated hippocampus at 4, 8 and 12 weeks post Saporin

104 rect, positive chronotropic influence on the denervated human heart.

105 ed in enteric neurons from nondenervated and denervated ileal segments of guinea pig after abdominal

106 DA-receptor antagonists in nondenervated and denervated ileal segments, but not by the AMPA-receptor

107 In the animal model, skeletal muscle is denervated in rats treated with high-dose corticosteroid

108 Restoration of substance P (SP) signaling in denervated KC-Tie2 skin prevented decreases in CD11c(+)

109 d pressure, only reduced inflammation in the denervated kidney, suggesting that this effect is pressu

110 nd calcitonin gene-related peptide (CGRP) in denervated kidneys mimicked the fibrotic response observ

111 ge infiltration/inflammation was enhanced in denervated kidneys, not explained by angiotensin II leve

112 idline crossing of CST axons into previously denervated left spinal cord.

113 lastema, capable of rescuing regeneration in denervated limbs, and its inhibition must prevent regene

114 aked beads rescued regeneration to digits in denervated limbs, and pharmacological inhibition of NRG1

115 rum-transferred arthritis was compromised in denervated limbs.

116 thelial cell transmigration being altered in denervated limbs.

117 muscles were initially innervated, but later denervated, loss of innervation in SMA may be attributed

118 (SCI) interrupts descending projections and denervates lumbar motor neurons (MNs).

119 the improvement in acanthosis and prevented denervated-mediated decreases in CD4(+) cells.

120 stem/progenitor cell markers and assessed in denervated mice versus controls by immunofluorescent mic

121 Furthermore, the denervated-mice exhibited a threefold increase in plasma

122 in and MuSK were preserved in endplates from denervated MMP3 null animals.

123 ificantly increased synaptic proteins in the denervated motoneurons.

124 d to examine differential gene expression in denervated motor and sensory pathways in rats.

125 nd clusterin (CLU) which were upregulated in denervated motor and sensory pathways, respectively.

126 calizes with AChRs at developing, adult, and denervated motor endplates.

127 enitor/stem cells and sensory nerves using a denervated mouse model of NK.

128 on was used to detect alpha7 subunit mRNA in denervated mouse muscle.

129 borative fashion to inhibit reinnervation of denervated mouse skeletal muscle and appear to act, at l

130 the vascular annulus persisted in surgically denervated mouse skin.

131 er one similar to fibres from experimentally denervated muscle (TTX resistant), and a third group int

132 inishes expression of MuRF1 and atrogin-1 in denervated muscle and confers resistance to atrophy.

133 elaxation time and gadolinium enhancement of denervated muscle develop in parallel to the development

134 usly, we demonstrated that mitochondria from denervated muscle exhibited dramatically higher Amplex R

135 Mass spectrometry of the bound proteins in denervated muscle identified many myofibrillar component

136 f the Amplex Red signal in mitochondria from denervated muscle is not derived from hydrogen peroxide.

137 Extrinsic stimulation of denervated muscle maintains the postsynaptic expression

138 he release of fatty acid hydroperoxides from denervated muscle mitochondria may be an important deter

139 bunit mRNAs was increased in the presence of denervated muscle protein extracts.

140 Dach2 overexpression in denervated muscle suppressed Mgn, nAChR, and MuSK gene i

141 xonal regeneration and maintains chronically-denervated muscle to thereby promote motor re-innervatio

142 In addition, the CK and GAPDH activity in denervated muscle was markedly reduced.

143 In denervated muscle, activation of the atrophy program req

144 alpha7* nAChRs are significantly present on denervated muscle, and that these receptors display unus

145 In denervated muscle, HDAC4 activates AP1-dependent transcr

146 In denervated muscle, insulin-stimulated phosphatidylinosit

147 th a molecular profile distinct from that of denervated muscle.

148 fibrillar and subsarcolemmal mitochondria in denervated muscle.

149 tophagy regulation and alters homeostasis in denervated muscle.

150 s the Amplex Red signal in mitochondria from denervated muscle.

151 nner in developing aneural myotubes or adult denervated muscle.

152 egulated genes in aneural myotubes and adult denervated muscle.

153 Ca2+-activated SK channels expressed only in denervated muscle.

154 the stability of AChR beta-subunit mRNAs in denervated muscle.

155 uscle activity inhibits the reinnervation of denervated muscle.

156 olemma of freshly isolated WT myofibers from denervated muscles also showed high hemichannel-mediated

157 Furthermore, denervated muscles from MMP3 null mice demonstrated grea

158 In contrast, similarly denervated muscles in Hb9(cre)NCAM(flx) mice failed to r

159 Administration of rAAV:Fst to innervated or denervated muscles increased protein synthesis, but mark

160 t of the depolarization was never present in denervated muscles obtained from mutant mice lacking the

161 x/Bcl-2 ratio was significantly increased in denervated muscles relative to control muscles.

162 gastrocnemius muscles, but only unloaded and denervated muscles showed a marked increase in Nedd4 pro

163 No Na(V)1.5 mRNA was detectable in denervated muscles stimulated electrically for 1 week in

164 In addition, denervated muscles were subjected to ex vivo stimulation

165 regulatory sequences by directly stimulating denervated muscles with pattern that mimic fast and slow

166 In chronically denervated muscles, in which both AChR stability and rec

167 sprouting of axon terminals in paralyzed or denervated muscles.

168 es administered rAAV:Fst, but not in treated denervated muscles.

169 airing the longitudinal growth of neonatally denervated muscles.

170 icroRNA-206 and -21 were the most induced in denervated muscles.

171 rest was correlated with a greater volume of denervated myocardium (defect of the positron emission t

172 +/- 11% of LV; p = 0.001) reflecting viable, denervated myocardium.

173 is required to sustain muscle by preventing denervated myofibers from undergoing myofibrillar disorg

174 Denervated myofibers showed up-regulation of Panx1 and d

175 tes a degenerative process that converts the denervated nerve from a suppressive environment to one t

176 digestion of inhibitory CSPGs in the distal denervated nerve using sustained lentiviral-mediated cho

177 CSPGs for up to 45 weeks in the chronically denervated nerve.

178 ces the regeneration-promoting properties of denervated nerve.

179 essential to promote axonal growth into the denervated nerve.

180 tory factors such as CSPGs accumulate in the denervated nerve.

181 PTN mRNA were not maintained in chronically denervated nerves.

182 ing response that reinnervates the partially denervated neural lobe (NL) after unilateral lesion of t

183 sprout collaterals to reinnervate previously denervated neuromuscular junctions concurrently with exp

184 e as they regenerate and ultimately reoccupy denervated neuromuscular synaptic sites to learn what ch

185 uronal loss by providing extra excitation of denervated neurons, is the most relevant form of adaptiv

186 Collectively, these findings indicate that denervated neurotrophic ulcers are associated with poor

187 muscles extended disorganized processes from denervated NMJs and failed to initiate or guide nerve te

188 ia is significantly impaired, with increased denervated NMJs and fragmentation of acetylcholine recep

189 routs and to adopt a phagocytic phenotype on denervated NMJs in SOD1(G37R) mice.

190 In denervated NMJs, the recycling of AChRs is significantly

191 aptic activity because they were inserted at denervated NMJs.

192 ffect was observed using muscle samples from denervated (non-ALS) control patients.

193 ) into the cuneate nucleus of rats partially denervated of forepaw dorsal column axons was examined.

194 ecially dense LC innervation, is selectively denervated of LC input or is ablated by the cell-specifi

195 We denervated one carotid body (CB) and used extracorporeal

196 e in living, anesthetized mice either muscle denervated or high-fat fed.

197 d the structure of the cells that form them, denervated or repair Schwann cells, remains obscure.

198 Denervated orbital layer (OL) fiber cross sections were

199 duced clusters at a level similar to that at denervated original endplates.

200 cted from a cohort of 76 ALS patients and 17 denervated patients.

201 receptor density, and endplate morphology in denervated plantaris muscles in wild-type and MMP3 null

202 atients, with unpleasant sensory symptoms in denervated posterior cervical segments occurring in 14.

203 synaptic transmission in the normal and the denervated PrV of neonatal rats in an in vitro brainstem

204 model of critical illness myopathy in which denervated rat skeletal muscle is treated with corticost

205 model of critical illness myopathy in which denervated rat skeletal muscle is treated with corticost

206 sion of the mGluR5 antagonist MTEP in the DA-denervated rat striatum attenuated the activation of ERK

207 ion were induced in the striatum of dopamine-denervated rats naive of chronic drug administration.

208 In the healthy SI of the denervated rats, increases in fMRI responses were concor

209 ses of fMRI responses in SI were observed in denervated rats.

210 adult subventricular zone (SVZ) of dopamine-denervated rats.

211 dual restoration of synaptic function in the denervated region, as revealed by extracellular microele

212 ded axon and Schwann cell migration into the denervated region, perhaps acting as scaffolding for axo

213 Some of the severely denervated regions had remaining Schwann cells, as judge

214 ction of inflammation in the sympathetically denervated regions.

215 afts of cutaneous nerve or ventral root were denervated, reinnervated with cutaneous axons, or reinne

216 hed in chronically decentralized SCG but not denervated SCG, suggesting the preganglionic origin.

217 Following nerve injury, denervated Schwann cells (SCs) convert to repair SCs, wh

218 Denervated Schwann cells act as a "transient target" by

219 nal path, providing compelling evidence that denervated Schwann cells actively direct regenerating ax

220 eneration and atrophic changes that occur in denervated Schwann cells and target muscle with proximal

221 nteraction in the Remak bundles of partially denervated Schwann cells and unmyelinated axons, or the

222 Denervated Schwann cells distal to the lesion site secre

223 rst 50 days following nerve transection, the denervated Schwann cells in the dermis were easily ident

224 show here that medium conditioned by primary denervated Schwann cells or the Schwannoma cell line RN2

225 first demonstration that repair capacity of denervated SCs can be efficaciously enhanced without alt

226 n SCs but not impede transdifferentiation of denervated SCs to regeneration-promoting repair SCs.

227 ated with high-dose corticosteroids (steroid-denervated; SD), and muscle fibers become inexcitable de

228 cle is treated with corticosteroids (steroid-denervated; SD).

229 cle is treated with corticosteroids (steroid denervated; SD).

230 hat were significantly upregulated in either denervated sensory or motor pathways were identified and

231 s and upregulation of receptors on partially denervated serotonergic targets in the spinal cord.

232 d that corticospinal fibers sprouting to the denervated side of the cord following pyramidotomy conta

233 ed substantial axon outgrowth to the largely denervated side of the spinal cord and restored normal m

234 om neurons in the intact hemisphere into the denervated side of the spinal cord compared with either

235 of these neurons to form connections on the denervated side of the spinal cord, and improves perform

236 rom the intact CST across the midline to the denervated side.

237 s system in vivo in mice and in vitro in the denervated sinus node.

238 hich SK channel activity in the T-tubules of denervated skeletal muscle causes a local increase in K+

239 Hyperexcitability in denervated skeletal muscle is associated with the expres

240 eraction with Fn14 promoter are repressed in denervated skeletal muscle of mice.

241 ut also diminishes the expression of Fn14 in denervated skeletal muscle.

242 revented the inducible expression of Fn14 in denervated skeletal muscle.

243 , regenerating and uninjured axons grew into denervated skin and competed with one another for territ

244 models can be used to study reinnervation of denervated skin in man in different injury models and ha

245 at sound sensory function is provided to the denervated skin of the residual limb when connected to a

246 ons to sprout collateral axons into adjacent denervated skin, indicating a critical role for intact I

247 d the capacity of injured axons to grow into denervated skin.

248 ns reinitiated growth, they were repelled by denervated skin.

249 ngs suggest that myofascial linkages between denervated SO and its active synergists might affect its

250 ked reduction in midorbital cross section in denervated SO muscles, with anterior shift of SO mass pr

251 RI as early as 5 weeks after denervation, as denervated SO volume shifted anteriorly.

252 tory reinnervation was explored by partially denervating soleus muscles in mice lacking presynaptic N

253 hemisphere are capable of sprouting into the denervated spinal cord after TBI and EPO treatment, whic

254 ived axons extending from the graft into the denervated spinal cord also triggered local host neurona

255 ances axonal sprouting and rewiring into the denervated spinal cord which may facilitate functional r

256 mous contribution from Nf1-/- neurons in the denervated spinal cord.

257 otes sprouting of uninjured CST axons to the denervated spinal cord.

258 Thus, the stroke-denervated spinal gray matter, in particular its interme

259 ing on the de-afferented red nucleus and the denervated spinal motoneurons (p<0.05).

260 relays to restore supraspinal regulation of denervated SPNs, thereby contributing to cardiovascular

261 nsitization to D1R-activated excitability in denervated striatal MSNs.

262 s showed diminished spine density in totally denervated striatal regions in parkinsonian mice.

263 ntralateral corticostriatal neurons into the denervated striatum after ischemic cortical lesions.

264 ates of dopamine (DA) neurons grafted to the denervated striatum are extremely poor (5-20%).

265 hat D1-dependent ERK1/2 activation in the DA-denervated striatum depends on a complex interaction bet

266 olecular and motor responses in the dopamine-denervated striatum may prompt the development of new th

267 of dopamine as false neurotransmitter in the denervated striatum of PD patients with LIDs.

268 hese dopamine receptor genes in the dopamine-denervated striatum of rodents to reveal whether their o

269 fter stereotactic delivery into the dopamine-denervated striatum of the 6-OHDA-lesioned rat, sustaine

270 signature induced by L-DOPA in the dopamine-denervated striatum that is dependent on ERK and associa

271 terestingly, in old rats BDNF protein in the denervated striatum was significantly lower than that me

272 n levels of BDNF and GDNF were higher in the denervated striatum when compared to the intact striatum

273 nsatory increase of these two factors in the denervated striatum while no compensatory increase is ob

274 In the dopamine (DA)-denervated striatum, L-DOPA activates DA D(1) receptor(D

275 es were strongly upregulated in the dopamine-denervated striatum, resulting in a synergistic activati

276 es ERK activation in medium spiny neurons in denervated striatum.

277 nism underlying the activation of ERK in the denervated striatum.

278 the eye, where, sporadically, patients with denervated sympathetic fibers develop chronic inflammati

279 nternalized nAChRs into fully functional and denervated synapses was promoted by both direct muscle s

280 hat axons restore synaptic connectivity with denervated targets several centimeters from the site of

281 is the restoration of axonal connectivity to denervated targets.

282 CNS, axons must be stimulated to extend into denervated territory and, critically, must form function

283 hat treatment with the AI 4-OH-A essentially denervates the zebrafish trunk skeletal muscles, most li

284 Denervating the striatum of its dopaminergic inputs in a

285 ary flow reserve (CFR) in volunteers and in (denervated) transplant recipients.

286 The carotid sinus nerves were surgically denervated under general anaesthesia in 4- and 12-week-o

287 thetic nerve discharge (SND) of baroreceptor-denervated, urethane-anesthetized cats.

288 undant in denervated cutaneous nerve than in denervated ventral root, but that PTN protein was more a

289 t, but that PTN protein was more abundant in denervated ventral root.

290 nd in vivo, and this binding is increased in denervated versus innervated muscles.

291 kin 4; and fewer myofibroblast infiltration (denervated vs intact: 1.2 +/- 0.2 vs 3.2 +/- 0.6 cells/v

292 e infiltration of macrophages was increased (denervated vs intact: 112 +/- 8 vs 76 +/- 9 cells/visual

293 percentage of M2 macrophages was decreased (denervated vs intact: 31 +/- 4 vs 57 +/- 9%; p < 0.05, n

294 architecture; decreased collagen deposition (denervated vs intact: COL1alpha1, 19.1 +/- 2.2 vs 22.0 +

295 atched sham-operated and carotid sinus nerve denervated Wistar rats.

296 sity in rat hearts that have been chemically denervated with 6-OHDA, suggesting that HED retention is

297 morphologies on post-synaptic spines in the denervated Wld(S) striatum indicating an enhanced plasti

298 kines (TNF-alpha and IL-1beta) were found in denervated WT but not Cx43/Cx45-deficient muscles.

299 presence of de novo dendritic spines in the denervated zone suggests that the postlesion environment

300 neurons showed reduced complexity within the denervated zone, but dendritic spines still formed in th