ライフサイエンスコーパス: densa

1 reactive COX-2 expression inthe cTALH/macula densa.

2 tly fell 2-fold in arterioles and the macula densa.

3 clustered AMACO deposition below the lamina densa.

4 low AT1R expression in arterioles and macula densa.

5 rticles permeate extensively into the lamina densa.

6 either LN or LG domains and formed a lamina densa.

7 essed in thick ascending limb and the macula densa.

8 adjusting transport downstream of the macula densa.

9 sertion or are present throughout the lamina densa.

10 in its highly specialized role in the macula densa.

11 ls appear to insert directly into the lamina densa.

12 o and stimulates NO generation at the macula densa.

13 cells of the thick ascending limb and macula densa.

14 nding limb of Henle's loop and of the macula densa.

15 the most pronounced expression in the macula densa.

16 the cortical thick ascending limb and macula densa.

17 ulation of NOS1beta expression in the macula densa affects sodium excretion and salt-sensitive hypert

18 between (a) NaCl concentration at the macula densa and (b) glomerular filtration rate or glomerular c

19 lar epithelial cells located near the macula densa and associated with the renal arterioles exhibit s

20 1)-dependent nitric oxide (NO) in the macula densa and blunting the tubuloglomerular feedback (TGF) r

21 pp38 expression, predominantly in the macula densa and cTALH.

22 morpholino-injected embryos lacked a lamina densa and lamina lucida at 24 hpf, and BM defects, such

23 primary NOS1 isoform expressed in the macula densa and regulates the tubuloglomerular feedback respon

24 tex, COX-2 expression is localized to macula densa and surrounding cortical thick ascending limb of H

25 issue separation in TBDN is below the lamina densa, and electron microscopy has revealed abnormalitie

26 d to cTALH cells in the region of the macula densa, and that dietary salt restriction increases COX-2

27 Evidence for the regulation of macula densa apical Na/H exchange by AngII was recently reporte

28 ments involves ATP release across the macula densa basolateral membrane through a maxi-anion channel.

29 esults indicate that AngII stimulates macula densa basolateral Na/H exchange via AT1 receptors and th

30 ble skin disease manifesting with sub-lamina densa blistering, erosions, and chronic ulcers.

31 i-vWFA2 autoantibodies located at the lamina densa bound to the dermal side of salt-split skin and in

32 localized to the lower lamina lucida/lamina densa by direct and indirect immunoelectron microscopy (

33 mulates COX-2 expression in cTALH and macula densa by transcriptional regulation predominantly via a

34 in glomerular tuft contractility and macula densa cell calcium handling were observed.

35 y or expression we clonally derived a macula densa cell line (MMDD1 cells) from SV-40 transgenic mice

36 ) receptor expression in the cultured macula densa cell line MMDD1.

37 Because macula densa cells also express a basolateral Na/H exchanger, t

38 Macula densa cells are renal sensor elements that detect change

39 Macula densa cells detect changes in luminal sodium chloride co

40 Macula densa cells in the distal nephron, according to the clas

41 Communication from macula densa cells to the glomerular vascular elements involves

42 odium-glucose cotransport by SGLT1 on macula densa cells triggers the production of nitric oxide, whi

43 kidney, the intracellular pH (pHi) of macula densa cells was measured with fluorescence microscopy us

44 l isoform of nitric oxide synthase in macula densa cells, reduces the constrictor effect of adenosine

45 ssed Nos1 and Avpr1a, consistent with macula densa cells.

46 Ca2+ oscillations were absent in the macula densa cells.

47 marked accumulation of elastin in the macula densa, collecting ducts, and pelvicalyceal epithelia of

48 uter medullary collecting ducts), and macula densa-containing segments.

49 mmary, these results demonstrate that macula densa COX-2 expression is oppositely regulated by AT(1)

50 Macula densa cyclooxygenase 2 (COX-2)-derived prostaglandins se

51 decreased hyperfiltration, decreased macula densa cyclooxygenase-2 expression, decreased albuminuria

52 very of fluid yet does not activate a macula densa-dependent fall in SNGFR because it blunts the TGF

53 s increases in luminal glucose at the macula densa, enhancing generation of neuronal nitric oxide syn

54 Macula densa epithelial cells displayed bright AE2 immunostaini

55 microfibrils might be present in the lamina densa, epithelial cell cultures (WISH, HaCaT, and primar

56 thelial cells at the perimeter of the macula densa exhibit spontaneous oscillations in intracellular

57 We recently found that macula densa expresses alpha-, beta-, and gamma-splice variants

58 plants (Potamogeton diversifolius and Egeria densa), followed by toxicity testing with microcosm surf

59 2B contributes to salt absorption and macula densa function in the low NaCl concentration range.

60 oscopy is providing new insights into macula densa-glomerular signaling.

61 rane appeared to be thickened and the lamina densa had an irregular appearance after treatment with C

62 embrane, as seen by a nearly complete lamina densa, hemidesmosomes, and the polarized, linear distrib

63 resence of fibrillin-1 throughout the lamina densa in the dermal-- epidermal junction.

64 showed that SGLT1 is expressed at the macula densa; in the presence of tubular glucose, SGLT1 inhibit

65 NOS1), and NOS1beta expression in the macula densa increases on a high-salt diet.

66 chloride [Cl(-)] at the level of the macula densa increases renin production and secretion, we inves

67 itric oxide synthase 1 (NOS1B) in the macula densa is a primary modulator of TGF, we evaluated its ro

68 , the GBM is irregularly swollen, the lamina densa is absent, and permeation is increased.

69 a change in NaCl concentration at the macula densa, is likely initiated by the generation of a vasoac

70 P consumed in active transport by the macula densa leads to formation of adenosine, which causes glom

71 ause of the presence of NKCC2A in the macula densa, maximum tubuloglomerular feedback responses were

72 Macula densa (MD) cells detect changes in distal tubular sodium

73 Macula densa (MD) cells express COX-2 and COX-2-derived PGs app

74 Macula densa (MD) cells of the juxtaglomerular apparatus (JGA)

75 f) colocalize in renal tubules and in macula densa (MD) cells which modulate glomerular filtration ra

76 ronal nitric oxide synthase (nNOS) in macula densa (MD) cells, experiments were performed in anesthet

77 The macula densa (MD) is a distinct cluster of approximately 20 spe

78 A were shown to be coexpressed in the macula densa (MD) segment of the mouse TAL.

79 pends on Na-K-2Cl co-transport in the macula densa (MD), but it is less clear whether Na,K-ATPase is

80 a minority renal cell type called the macula densa (MD).

81 cell granules and exhibit an altered macula densa morphology.

82 Here, we tested the hypothesis that macula densa neuronal nitric oxide synthase (NOS1) is upregulat

83 cellular uptake of L-arginine limits macula densa nitric oxide generation and actions on tubuloglome

84 hich was prevented with inhibitors of macula densa nitric oxide synthase (NOS).

85 Furthermore, macula densa NO production was similar in the isolated perfused

86 I) blockers correlated with increased macula densa NOS-I immunoreactivity.

87 d SNGFR through a mechanism involving macula densa NOS.

88 f SGLT1 prevented the upregulation of macula densa NOS1 and attenuated inhibition of TGF in diabetic

89 Diabetic mice had upregulated macula densa NOS1, inhibited TGF and elevated GFR.

90 Macula densa NOS1B plays a critical role in the control of rena

91 Macula densa NOS1B was upregulated during pregnancy, resulting

92 RUPP resulted in a downregulation in macula densa NOS1B, enhanced TGF, decreased GFR, and hypertensi

93 uterine perfusion pressure (RUPP) on macula densa NOS1B/NO levels, TGF responsiveness, GFR, and BP i

94 utero epidermal blisters beneath the lamina densa of the basement membrane and also in renal agenesi

95 at size-dependent permeation into the lamina densa of the GBM and the podocyte glycocalyx, together w

96 areas of the lamina rara interna and lamina densa of the GBM in npnt-knockdown zebrafish models.

97 rticles show that permeation into the lamina densa of the GBM is size-sensitive.

98 edominant distribution outside of the lamina densa of the glomerular basement membrane.

99 hat it had blunted the effects of the macula densa on SNGFR.

100 autocrine factors of endothelial and macula densa origins.

101 It also suggests that the altered macula densa phenotype is related to the activity of the renin-

102 tic plants: Azolla caroliniana Willd, Egeria densa Planch., and Myriophyllum simulans Orch.

103 dded Ag or Cu metal mass was found in Egeria densa plant tissue, with the remainder primarily in the

104 ls that were within 100 microm of the macula densa plaque using four-dimensional multiphoton microsco

105 ck ascending loop of Henle (TALH) and macula densa, providing the error signal for tubuloglomerular f

106 ing luminal NaCl concentration in the macula densa region of the nephron stimulates renin secretion,

107 changes in NaCl concentration in the macula densa region of the nephron, thereby serving as an impor

108 icited by elevations in [NaCl] in the macula densa region of the nephron.

109 Macula densa-selective NOS1 knockout attenuated the diabetes-in

110 cuss recent advances in understanding macula densa sensing and suggest these cells, in addition to sa

111 us, our findings demonstrate that the macula densa SGLT1-NOS1-TGF pathway plays a crucial role in the

112 glomerular feedback through increased macula densa sodium and chloride delivery, leading to afferent

113 Compared with control mice, mice with macula densa-specific knockout of all nitric oxide synthase 1 i

114 iveness, GFR, and BP in wild-type and macula densa-specific NOS1 knockout (MD-NOS1KO) mice.

115 In macula densa-specific NOS1 knockout mice, glucose had no effect

116 ent (Akita) diabetes in wild-type and macula densa-specific NOS1 knockout mice.

117 densa, TGF, and GFR in wild-type and macula densa-specific NOS1 knockout mice.

118 ble to rescue the abnormality seen in macula densa structure.

119 The persistence of ENMs in E. densa suggests that chronic exposures, or food web trans

120 ail grazing on biofilm growing on the Egeria densa surface led to a transfer of Au from macrophytes t

121 Particles traversing the lamina densa tend to accumulate upstream of the podocyte glycoc

122 ation, nitric oxide production in the macula densa, TGF response, and GFR during the early stage of i

123 bular glucose on NO generation at the macula densa, TGF, and GFR in wild-type and macula densa-specif

124 ular calcium dynamics in cells of the macula densa, the observation was made that tubular epithelial

125 at pregnancy upregulates NOS1B in the macula densa, thus blunting TGF, allowing the GFR to increase a

126 pt distal tubular fluid flow past the macula densa, thus minimizing tubuloglomerular feedback-depende

127 nt, Ag(0) and CuO ENMs were persistent in E. densa tissues for up to 9 and 6 months, respectively.

128 es tubuloglomerular feedback from the macula densa to increase GFR.

129 ntext of signal transduction from the macula densa to the mesangial cells and afferent arteriolar smo

130 st in part, through direct effects on macula densa transport processes.

131 n increases in luminal glucose at the macula densa upregulate the expression and activity of NOS1 via

132 TEM confirmed that the lamina densa was partly or completely absent along the anterior

133 d anchoring fibril connections to the lamina densa were more numerous compared with the composite mod

134 th basement membrane proteins and the lamina densa were retained at the BMZ throughout healing.