ライフサイエンスコーパス: dentate granule cell

1 ed NR2A and NR2B hybridization densities per dentate granule cell.

2 of CA1 pyramidal cells and the dispersion of dentate granule cells.

3 in a significant increase in the density of dentate granule cells.

4 input strength and dendritic spine number in dentate granule cells.

5 ere they differentiate into neurons known as dentate granule cells.

6 down Pten in mouse neonatal and young adult dentate granule cells.

7 r KCNQ2 but was reduced approximately 50% in dentate granule cells.

8 ural evidence for axoaxonic gap junctions in dentate granule cells.

9 ne possibility is insufficient inhibition of dentate granule cells.

10 ssion, indicating a special vulnerability of dentate granule cells.

11 ribute to the low-pass filtering function of dentate granule cells.

12 ing increase in hypersynchronous activity of dentate granule cells.

13 avioral seizure, Fos labeling was evident in dentate granule cells.

14 ocalize with synaptic markers in hippocampal dentate granule cells.

15 dal neurons in CA3, and in a small number of dentate granule cells.

16 ition at physiological firing frequencies of dentate granule cells.

17 ptic inputs similar to those found in mature dentate granule cells.

18 of zinc released at mossy fiber synapses on dentate granule cells.

19 he property of being monosynaptic targets of dentate granule cells.

20 in a majority of cortical regions and in the dentate granule cells.

21 es present on soma and proximal dendrites of dentate granule cells.

22 daily seizures on P10-P25 had an increase in dentate granule cells.

23 imals also demonstrated vulnerability of the dentate granule cells.

24 aralleled by electrophysiological changes in dentate granule cells.

25 om aberrant connections formed by newly born dentate granule cells.

26 s, such as hippocampal pyramidal neurons and dentate granule cells.

27 hat are important for regulating activity of dentate granule cells.

28 assess synaptic function in Ptchd1-deficient dentate granule cells.

29 ce despite normal dendritic spine density on dentate granule cells.

30 were unchanged following COX10 removal from dentate granule cells.

31 timulation-induced activation of hippocampal dentate granule cells.

32 outons, but rather to all synapses formed by dentate granule cells.

33 ptic release of both glutamate and GABA onto dentate granule cells.

34 ant path input-output operation in epileptic dentate granule cells.

35 erved that Aplp1 mRNA is highly expressed in dentate granule cells.

36 y afferent pathway from entorhinal cortex to dentate granule cells.

37 rent altering intrinsic firing properties of dentate granule cells.

38 in regulating plasticity of the mPP onto the dentate granule cells.

39 the medial perforant path (mPP) synapse onto dentate granule cells.

40 eletion of alpha-CaMKII from newly generated dentate granule cells.

41 nificantly enhances tonic GABA inhibition in dentate granule cells.

42 of inhibitory neurotransmission measured in dentate granule cells.

43 icrodialysis, negligible GABA is detected by dentate granule cells.

44 GABA is a key regulator of adult-born dentate granule cell (abDGC) maturation so mapping the f

45 ly modified by the integration of adult-born dentate granule cells (abDGCs).

46 Hippocampal dentate granule cell abnormalities are thought to play a

47 -epileptic animals, these strongly inhibited dentate granule cells act as a gate, regulating hippocam

48 macological properties of GABAA receptors on dentate granule cells acutely isolated from hippocampi o

49 Here we find that hippocampal dentate granule cells adapt their spiking threshold to t

50 play a central role in the reorganization of dentate granule cells after entorhinal denervation in vi

51 ntaneous inhibitory postsynaptic currents in dentate granule cells after FPI, and ionotropic glutamat

52 ered action potential firing in postsynaptic dentate granule cells after single light pulses.

53 Newly generated dentate granule cells also appeared in ectopic locations

54 he strata oriens and radiatum of CA3, in the dentate granule cell and molecular layers, and in the de

55 luding increased levels of alpha4 subunit in dentate granule cells and associated functional alterati

56 ect link between the primary cilia of mature dentate granule cells and behavior will require further

57 principal neurons within the hippocampus-the dentate granule cells and CA1 pyramidal cells.

58 ity on synapse formation between hippocampal dentate granule cells and CA3 pyramidal neurons in cultu

59 ation at medial perforant path synapses onto dentate granule cells and dentate gyrus-dependent cognit

60 Muscarine also depolarizes dentate granule cells and elevates their rate of firing.

61 We examined synaptic inhibition of dentate granule cells and excitability of surviving GABA

62 transmitted by the mossy fiber projection of dentate granule cells and expresses an NMDA receptor-ind

63 gated altered GABAergic neurotransmission in dentate granule cells and interneurons following chronic

64 oupings (i.e., pyramidal cells as opposed to dentate granule cells and interneurons) were significant

65 ins IFT20 and Kif3A (respectively) in mature dentate granule cells and investigated hippocampus-depen

66 th recurrent seizures had greater numbers of dentate granule cells and more newly formed granule cell

67 an electrophysiology-based classification of dentate granule cells and mossy cells in mice that we va

68 stablish aberrant recurrent synapses between dentate granule cells and operate via postsynaptic kaina

69 portion of those subunits in the interior of dentate granule cells and other hippocampal neurons with

70 NR2A mRNA was higher in dentate granule cells and pyramidal cells in CA1 and sub

71 se data demonstrate that tonic inhibition in dentate granule cells and thalamic relay neurons is medi

72 hese mice show a lack of tonic inhibition in dentate granule cells and thalamic relay neurons.

73 ormation of reciprocal circuitry between the dentate granule cells and the grafted CA3 pyramidal neur

74 specialized contacts between mossy fibers of dentate granule cells and thorny excrescences (TEs) of C

75 al hilar region are known to project both to dentate granule cells and to interneurons, it is as yet

76 nduce LTP both monosynaptically for input to dentate granule cells and transsynaptically for mossy fi

77 ML), where perforant path axons synapse with dentate granule cells, and (2) the stratum lucidum (SL)

78 ionships of the hippocampal pyramidal cells, dentate granule cells, and GABAergic interneurons.

79 , decreases late rectifying K+ current(s) in dentate granule cells, and impairs memory but not other

80 t to CA3 transsynaptically via excitation of dentate granule cells, and that patterns of stimulation

81 ne density was decreased on the dendrites of dentate granule cells, and there was reorganization of i

82 ng both tonic and phasic GABAergic inputs to dentate granule cells, APP maintains excitatory-inhibito

83 In the adult mammalian hippocampus, newborn dentate granule cells are continuously integrated into t

84 chronically epileptic rats demonstrate that dentate granule cells are maximally hyperexcitable immed

85 ong-standing hypothesis that newly generated dentate granule cells are pro-epileptogenic and contribu

86 e glutamatergic cell types, including mature dentate granule cells, area CA1-3 pyramidal cells and mo

87 lobe origin, has established the hippocampal dentate granule cells as a functional barrier to invasio

88 enervation-induced synaptic scaling of mouse dentate granule cells as a model system.

89 These findings raise doubts about dentate granule cells as a source of spontaneous seizure

90 precipitate changes in tonic conductances in dentate granule cells as measured by whole-cell patch-cl

91 lasticity of retrovirally labeled adult-born dentate granule cells at different stages during their n

92 Dentate granule cell axon (mossy fiber) sprouting is a c

93 We hypothesize that sprouting of dentate granule cell axons (mossy fibers) in response to

94 Reorganization of dentate granule cell axons (mossy fibers) is a prominent

95 After epileptogenic injuries, dentate granule cell axons (mossy fibers) sprout and for

96 Aberrant reorganization of dentate granule cell axons, the mossy fibers, occurs in

97 gest in principal cells of the CA3 field and dentate granule cells but absent in CA1.

98 These neurons resembled dentate granule cells but had axon collaterals in the mo

99 mission at recurrent mossy fiber synapses on dentate granule cells but not at perforant path or assoc

100 ales and males and studied the morphology of dentate granule cells by intracellular dye filling in a

101 derate throughout, with higher expression in dentate granule cells, CA1 and CA3 pyramidal cells than

102 visual cortex, in the hippocampal formation (dentate granule cells, CA2 cells, fasciola cinereum, ind

103 Cell counting of dentate granule cells, CA3, CA1, and hilar neurons, with

104 tify that TLR4 signaling in neurons augments dentate granule cell calcium-permeable alpha-amino-3-hyd

105 Dentate granule cells communicate with their postsynapti

106 absence of neurogenesis suggests that mature dentate granule cells contribute substantially to seizur

107 ppocampal adult neurogenesis, and adult-born dentate granule cells contribute to the pathologic retro

108 Single spikes in dentate granule cells, controlled intracellularly, gener

109 Inputs from dentate granule cells converge on the hilus, and excitat

110 The mossy fiber (MF) axons of the dentate granule cells convey strong excitatory drive to

111 These differences in the properties of dentate granule cells correlated positively with age but

112 Dentate granule cell death occurred at 6 h post-TMT as d

113 of varied [GABA] onto nucleated patches from dentate granule cells demonstrated a deactivation rate o

114 outing of hippocampal mossy fiber axons onto dentate granule cell dendrites creates a recurrent excit

115 al afferents (part of the perforant path) to dentate granule cells, dentate mossy fiber inputs to CA3

116 We found the following: (1) Aged female dentate granule cells deprived of gonadal steroids long-

117 ales deprived short-term; however, aged male dentate granule cells deprived of gonadal steroids long-

118 In patients with temporal lobe epilepsy some dentate granule cells develop basal dendrites.

119 Silenced dentate granule cells develop with input-specific decrea

120 evealed that, unlike CA1 neuron populations, dentate granule cell (DGC) ensembles activated by learni

121 The dentate granule cell (DGC) layer is often abnormal in hu

122 romote seizures.SIGNIFICANCE STATEMENT Adult dentate granule cell (DGC) neurogenesis is altered in ro

123 Dentate granule cell (DGC) neurogenesis persists through

124 Dentate granule cell (DGC) neurogenesis persists through

125 pocampal cultures, with a major focus on the dentate granule cell (DGC) population, to explore the si

126 the integration and functions of adult-born dentate granule cell (DGCs) are poorly understood.

127 d modulation of GABA(A) receptors present on dentate granule cells (DGCs) acutely isolated from epile

128 us subregion of the hippocampus give rise to dentate granule cells (DGCs) and astrocytes throughout l

129 tand how monosynaptic inputs onto adult-born dentate granule cells (DGCs) are altered in experimental

130 h CA3 interneurons peak when adult-generated dentate granule cells (DGCs) are approximately 4 weeks o

131 Newborn dentate granule cells (DGCs) are continuously generated

132 New dentate granule cells (DGCs) are continuously generated,

133 Newborn dentate granule cells (DGCs) are generated in the hippoc

134 morphology was studied in human hippocampal dentate granule cells (DGCs) by intracellularly-injectin

135 were recorded from CA1 pyramidal neurons and dentate granule cells (DGCs) by voltage clamp technique.

136 Adult-born dentate granule cells (DGCs) contribute to learning and

137 During limbic epileptogenesis in vivo the dentate granule cells (DGCs) exhibit increased expressio

138 knockout mice in which the vast majority of dentate granule cells (DGCs) fail to develop - including

139 Most dentate granule cells (DGCs) generated in response to an

140 nit mRNAs simultaneously in individual human dentate granule cells (DGCs) harvested during hippocampe

141 Dentate granule cells (DGCs) have a single, complex, api

142 from retrovirus-labeled newborn hippocampal dentate granule cells (DGCs) in acute mouse brain slices

143 clamp recordings from visualized hippocampal dentate granule cells (DGCs) in slices that were prepare

144 the developing dendrites of adult-born mouse dentate granule cells (DGCs) in vivo and found that they

145 osteroid sensitivity of GABA(A) receptors on dentate granule cells (DGCs) is diminished; the molecula

146 normally integrated, adult-born, hippocampal dentate granule cells (DGCs) is hypothesized to contribu

147 systems-based mechanisms by which adult-born dentate granule cells (DGCs) modulate pattern separation

148 nce of striking morphological alterations in dentate granule cells (DGCs) of FTD patients and in a mo

149 uency of inhibitory postsynaptic currents in dentate granule cells (DGCs) recorded from epileptic ani

150 tate gyrus (DG) of rodents generates newborn dentate granule cells (DGCs) throughout life.

151 transformation of GABAergic action occurs in dentate granule cells (DGCs), located at the first stage

152 Local application of FGF22 on the axons of dentate granule cells (DGCs), which are presynaptic to C

153 The continuous addition of new dentate granule cells (DGCs), which is regulated exquisi

154 inhibitory postsynaptic currents (sIPSCs) in dentate granule cells (DGCs).

155 cteristics of the principal cells of the DG, dentate granule cells (DGCs).

156 Unlike arcuate neurons, dentate granule cells did not express the endogenous POM

157 Hippocampal dentate granule cells directly excite and indirectly inh

158 Prolonged dentate granule cell discharges produce hippocampal inju

159 rtex, the feed-forward inhibitory control of dentate granule cell discharges was compromised, and the

160 synaptic GABAA receptor-mediated currents in dentate granule cells display slower rise and decay kine

161 Our results reveal that deletion of Pten in dentate granule cells dysregulates synaptic plasticity,

162 nutrition significantly alters modulation of dentate granule cell excitability (i.e., PPI values usin

163 sure of the type and degree of modulation of dentate granule cell excitability elicited by stimulatio

164 al protein malnutrition on the modulation of dentate granule cell excitability in freely moving rats

165 , reducing inhibitory efficacy and enhancing dentate granule cell excitability.

166 Dentate granule cells exhibit exceptionally low levels o

167 We found that adult-born dentate granule cells exhibit tortuous, yet highly stere

168 For example, hippocampal dentate granule cells expressed Kv3.3 subunits specifica

169 lation model another neuroplastic change for dentate granule cells following seizures: hilar basal de

170 Dentate granule cells following trauma showed enhanced a

171 In many persons with temporal lobe epilepsy, dentate granule cells form an interconnected synaptic ne

172 mossy fiber en passant boutons of adult-born dentate granule cells form initial synaptic contacts wit

173 ocampal mossy fibers, which are the axons of dentate granule cells, form powerful excitatory synapses

174 Experiments were performed in dentate granule cells from control rats and rats with te

175 Recordings in dentate granule cells from delta subunit-deficient mice

176 In dentate granule cells from juvenile rats polysynaptic fe

177 changes in the pharmacological properties of dentate granule-cell GABAA receptors occurred during the

178 Postnatal development of hippocampal dentate granule cell gamma-aminobutyric acidA (GABAA) re

179 Cs) in the dentate gyrus receive inputs from dentate granule cells (GCs) and project back to GCs loca

180 Newly generated dentate granule cells (GCs) are relevant for input discr

181 for a novel, highly detailed active model of dentate granule cells (GCs) replicating a wide palette o

182 ns between perforant path (PP) afferents and dentate granule cells (GCs), a circuit involved in memor

183 in early, developmentally born, hippocampal dentate granule cells (GCs).

184 tify systematically the relative position of dentate granule cells generated at different ages.

185 2-immunoreactive principal cells, including dentate granule cells, hilar mossy cells, and hippocampa

186 eptogenesis may involve gradually developing dentate granule cell hyperexcitability caused by neuron

187 t differences in the intrinsic properties of dentate granule cells (i.e., input resistance, time cons

188 ogical development and mispositioning of new dentate granule cells in a cell-autonomous fashion.

189 tion of CA3 pyramids with sparing of CA1 and dentate granule cells in all age groups.

190 udies have established a role for adult-born dentate granule cells in discriminating between similar

191 or epilepsy research, and the involvement of dentate granule cells in early seizure events continues

192 al investigators have shown the existence of dentate granule cells in ectopic locations within the hi

193 Here we show that in rat dentate granule cells in ex vivo hippocampal slices, ton

194 inhibitory postsynaptic currents (IPSCs) in dentate granule cells in in vitro slices prepared from b

195 port chain of mitochondria, from hippocampal dentate granule cells in mice does not affect low-freque

196 primary cultures of rat hippocampal neurons, dentate granule cells in mouse organotypic slices, and l

197 res of rat hippocampal and cortical neurons, dentate granule cells in mouse organotypic slices, and l

198 n a moderate decrease in the number of adult dentate granule cells in null mice and an increase in th

199 s, by using time-lapse imaging of denervated dentate granule cells in organotypic entorhino-hippocamp

200 r elicited GABAergic inhibitory responses in dentate granule cells in pilocarpine-treated mice but no

201 mentary electrophysiological recordings from dentate granule cells in SE-treated slices demonstrated

202 ury on the perisomatic inhibitory control of dentate granule cells in the adult rat, with special ref

203 mRNA: cerebellar granule cell precursors and dentate granule cells in the hippocampus.

204 ll proliferation and neuronal development of dentate granule cells in the hippocampus.

205 ate gyrus, with the most profound effects on dentate granule cells in the innermost portion of the gr

206 at the dynamic dispersion of newly generated dentate granule cells in the neurogenic zone is a requir

207 hologic and electrophysiologic properties of dentate granule cells in the young adult rhesus monkey (

208 nt conservation of both form and function in dentate granule cells in these two species, despite the

209 ll patch-clamp recordings were obtained from dentate granule cells in transverse hippocampal slices i

210 -lasting GABAergic inhibition of hippocampal dentate granule cells in vivo and in vitro.

211 ssy cells are significantly more active than dentate granule cells in vivo, exhibit spatial tuning du

212 ediated currents are particularly evident in dentate granule cells in which they play a major role in

213 These findings suggest that dentate granule cells in young and adult animals express

214 eling reveal a high degree of abnormality in dentate granule cells, including heterotopic localizatio

215 tide-containing hippocampal interneurons and dentate granule cell inhibition were investigated at dif

216 lso protected the animals from the scattered dentate granule cell injury observed in non-medicated an

217 rves mainly to facilitate the recruitment of dentate granule cells into population bursts.

218 Mossy fiber sprouting by the dentate granule cells is a well-characterized manifestat

219 Axon sprouting in dentate granule cells is an important model of structura

220 ime to our knowledge, that the population of dentate granule cells is disconnected from other regions

221 control of migration and cell positioning of dentate granule cells is not clear.

222 nstead reflects an abnormality of developing dentate granule cells is unknown.

223 d whole-cell GABAR currents from hippocampal dentate granule cells isolated acutely from control rats

224 mpal neurons in vitro and in vivo Adult-born dentate granule cells lacking Trim9 similarly exhibited

225 increases in BDNF mRNA were detected in the dentate granule cell layer (73.4%), region CA1 (28.1%),

226 0-microm-thick hippocampal neuron-generating dentate granule cell layer (DGCL) consistently within a

227 This leads to malformation of the dentate granule cell layer and excess cell death.

228 hippocampus, FG-positive interneurons of the dentate granule cell layer and hilus were detected in nu

229 Interneurons located near the border of the dentate granule cell layer and the hilus were studied in

230 els in the hippocampal pyramidal cell layer, dentate granule cell layer and throughout the cortex and

231 The injections of biocytin into the dentate granule cell layer labeled neurons in a Golgi-li

232 comparing field potentials recorded from the dentate granule cell layer of hippocampal brain slices f

233 The dentate granule cell layer of the rodent hippocampal for

234 -associated cells that did not innervate the dentate granule cell layer, and these synapses demonstra

235 ubtle changes in neuronal density within the dentate granule cell layer.

236 subgranular zone along the hilar side of the dentate granule cell layer.

237 responses recorded in the CA1 pyramidal and dentate granule cell layers in response to afferent stim

238 eletion of alpha-CaMKII from newly generated dentate granule cells led to an increase in dendritic co

239 tic responses and dynorphin to disappear via dentate granule cell loss, failed neurogenesis and poor

240 Reduced inhibition of dentate granule cells may contribute.

241 The up-regulation of I(A) in dentate granule cells might have protective effects.

242 hing for candidate ligands that may regulate dentate granule cell migration, we found that SDF1, a ch

243 expressed in patterns that suggest a role in dentate granule cell migration.

244 lant assay showed that it directly regulates dentate granule cell migration.

245 status epilepticus significantly attenuated dentate granule cell neurogenesis after seizures.

246 er status epilepticus, essentially abolished dentate granule cell neurogenesis but failed to prevent

247 stigate the effects of prolonged seizures on dentate granule cell neurogenesis in adult rats, and to

248 These results indicate that dentate granule cell neurogenesis in the mature hippocam

249 that prolonged seizure discharges stimulate dentate granule cell neurogenesis, and that hippocampal

250 , as well as their potential relationship to dentate granule cell neurogenesis, is unknown.

251 hese findings support the hypothesis that in dentate granule cells NMDA receptors are increased, and

252 Furthermore, new dentate granule cell number, morphology and excitatory s

253 d whether status epilepticus-induced HBDs on dentate granule cells occur in the pilocarpine model of

254 ta subunits within GABAergic synapses on the dentate granule cells of CIE rats.

255 Dentate granule cells of p35-deficient mice also demonst

256 amma-aminobutyric acidA receptors present on dentate granule cells of rats with temporal lobe epileps

257 week-old pups and in the hilar border of the dentate granule cells of the 3-week-old animals.

258 butyric acid type A receptors (GABA(A)Rs) in dentate granule cells of the hippocampus has been associ

259 ss of circuit integration of newly-generated dentate granule cells of the hippocampus has been presum

260 required for structural synapse formation in dentate granule cells or for Shh-dependent neuronal prec

261 ed by increased binding of Egr3 to GABRA4 in dentate granule cells, our findings support a role for E

262 luding embryonic piriform cortical cells and dentate granule cell precursors.

263 inate in a discrete band on the dendrites of dentate granule cells, produced a two-stage alteration i

264 ntate stem cells and absolutely required for dentate granule cell production.

265 ain x-irradiation to eliminate proliferating dentate granule cell progenitors in adult rats.

266 ages, there was a reduction in the number of dentate granule cell progenitors in the dentate ventricu

267 However, its role in the function of mature dentate granule cells remains unknown.

268 Genetic ablation of AKAP7 specifically from dentate granule cells results in disruption of MF-CA3 LT

269 SnRNA-seq of mouse dentate granule cells reveals large-scale changes in the

270 y the rate of dendritic outgrowth of newborn dentate granule cells, single injections of 5-bromo-2-de

271 d by two different TRPV1 shRNAs expressed in dentate granule cells, strongly supporting a functional

272 ical variables obtained from epileptic human dentate granule cells studied in slices with hippocampal

273 rization current (IsAHP) was also reduced in dentate granule cells, suggesting that KCNQ channels mig

274 ng-term potentiation (LTP) at perforant path-dentate granule cell synapses in ovariectomized female r

275 tions in synaptic plasticity at both CA1 and dentate granule cell synapses, and impaired spatial cogn

276 tiation (LTP) is deficient at perforant path-dentate granule cell synapses.

277 g-term potentiation at medial perforant path-dentate granule cells synapses in FX mice.

278 es have shown that BDNF has acute effects on dentate granule cell synaptic transmission, and other st

279 In dentate granule cells, the calcium binding ratio (kappa)

280 ral lobe epilepsy is recurrent excitation of dentate granule cells through aberrant sprouting of thei

281 roliferative zone that continues to generate dentate granule cells throughout life.

282 These data suggest that the response of rat dentate granule cells to aging and estradiol is sexually

283 he axonal mossy fiber bundle projecting from dentate granule cells to CA3 pyramidal neurons.

284 ologically isolated delta receptors in mouse dentate granule cells to explore IPSCs.

285 ntrol of the Thy1.2 promoter, the ability of dentate granule cells to form the SA and to homeostatica

286 ine the contribution of newly differentiated dentate granule cells to the network changes seen in thi

287 ously opening GABA(A)Rs, therefore, maintain dentate granule cell tonic currents in the face of low e

288 manently marked activated mature hippocampal dentate granule cells using conditional Fos-TRAP mice.

289 Unexpectedly, tonic inhibition in dentate granule cells was maintained in the epileptic mi

290 hyrin, and their subcellular distribution on dentate granule cells was studied by means of confocal l

291 NA amplification (aRNA) techniques in single dentate granule cells, we demonstrate that expression of

292 possessed fewer dendritic branches, whereas dentate granule cells were hypertrophic and formed spiny

293 In the present study, rat hippocampal dentate granule cells were recorded using gramicidin per

294 mono- and di-synaptic GABAergic inputs onto dentate granule cells were reversibly depressed by exoge

295 eover, an increase in gamma-H2AX was seen in dentate granule cells, which are resistant to cell death

296 of direct, monosynaptic entorhinal input to dentate granule cells, which expresses an NMDA receptor-

297 imary cilia in the memory function of mature dentate granule cells, which may result from abnormal mo

298 be used to label large cohorts of adult-born dentate granule cells with excellent time resolution.

299 (2) Aged female dentate granule cells with long-term estrogen replacemen

300 (3) Aged female dentate granule cells with short-term estradiol replacem