ライフサイエンスコーパス: deoxy

1 6-[(18)F]fluoro-d-fructose (6-[(18)F]FDF), 1-deoxy-1-[(18)F]fluoro-2,5-anhydro-mannitol (1-[(18)F]FDA

2 Uptake of 1-deoxy-1-[(18)F]fluoro-d-fructose (1-[(18)F]FDF), 6-deoxy

3 ibofuranuronamide (NECA) and the selective 1-deoxy-1-[6-[[(3-iodophenyl)methyl]amino]-9H-purin-9-yl]-

4 describes a stepwise optimization of DFG (1-deoxy-1-fructosylglycine) formation from glycine and glu

5 hinate intermediates can be converted into 2-deoxy-1-phosphahexopyranose and 2-deoxy-1-phosphapentopy

6 ted into 2-deoxy-1-phosphahexopyranose and 2-deoxy-1-phosphapentopyranose sugars.

7 vin D1, 5,6-epoxy-eicsatrienoic acid, and 15-deoxy-12,14-prostaglandin J2 as most predictive.

8 seven of which were new, including seven 11-deoxy-16R-hydroxy-PTM congeners.

9 2'-Deoxy-2',4'-difluoroarabinouridine (2,'4'-diF-araU) was

10 ans of individuals injected with 2-chloro-2'-deoxy-2'-(18)F-fluoro-9-beta-d-arabinofuranosyl-adenine

11 (18)F-FAC (2'-deoxy-2'-(18)F-fluoro-beta-d-arabinofuranosylcytosine) h

12 1-(2'-deoxy-2'-(18)F-fluoroarabinofuranosyl) cytosine ((18)F-F

13 te compounds-[(18)F]Clofarabine; 2-chloro-2'-deoxy-2'-[(18)F]fluoro-9-beta-d-arabinofuranosyl-adenine

14 arabinofuranosyl-adenine ([(18)F]CFA) and 2'-deoxy-2'-[(18)F]fluoro-9-beta-d-arabinofuranosyl-guanine

15 re, we show that a novel PET radiotracer, 2'-deoxy-2'-[18F]fluoro-9-beta-D-arabinofuranosylguanine ([

16 Using 2'-deoxy-2'-fluorine substituted cytidines, we show that a

17 Because 2'-deoxy-2'-fluoro (2'-F) nucleotides are not known to occu

18 at were otherwise fully modified with the 2'-deoxy-2'-fluoro and 2'-O-methyl pentofuranose chemical m

19 nthesis on templates composed entirely of 2'-deoxy-2'-fluoro-beta-d-arabino nucleic acid (FANA) and a

20 cting xeno-nucleic acid (XNA) aptamers, a 2'-deoxy-2'-fluoroarabinonucleotide (FANA) aptamer (referre

21 n a stereoselective way in six steps from 2'-deoxy-2'-fluoroarabinouridine (2'-F-araU).

22 Among tested compounds 4'-chloromethyl-2'-deoxy-2'-fluorocytidine (2c) exhibited the most promisin

23 We designed novel 4'-modified 2'-deoxy-2'-fluorouridine (2'-F U) analogues with the aim t

24 RNA octamers with (R)- or (S)-5'-C-methyl-2'-deoxy-2'-fluorouridine [(R)- or (S)-C5'-Me-2'-FU, respec

25 Herein we report the preparation of 2'-deoxy-2'-spirocyclopropylcytidine via an alternative cyc

26 r derivative that belongs to the class of 2'-deoxy-2'-spirooxetane uridine nucleotide prodrugs which

27 ls the formation of substantial levels of 2'-deoxy-2'-spirooxetane uridine triphosphate (8), a potent

28 Ac to Neu5Ac through formation of a 4-keto-2-deoxy-2,3-dehydro-N-acetylneuraminic acid intermediate a

29 2-Deoxy-2-(18)F-fluoro-d-glucose (2-FDG) with PET is unden

30 2-deoxy-2-(18)F-fluorodeoxysorbitol ((18)F-FDS) is an anal

31 9-Azido-9-deoxy-2-(e)-3-(a)-difluoro- N-acetylneuraminic acid [2(e

32 y of X-ray radiation and 15% per MBq/ml of 2-deoxy-2-[(18)F]-fluoro-d-glucose ([(18)F]FDG).

33 uoro-2,5-anhydro-mannitol (1-[(18)F]FDAM), 2-deoxy-2-[(18)F]fluoro-d-glucose (2-[(18)F]FDG), and 6-de

34 II-mediated trapping of the glucose analog 2-deoxy-2-[(18)F]fluorodeoxyglucose.

35 Here we report a new PET probe, 2-deoxy-2-[(18)F]fluororibose ([(18)F]-2-DFR), for use in

36 2-Deoxy-2-[18F]fluoro-D-glucose (2-FDG) with positron emis

37 FDG), a substrate for SGLTs and GLUTs; and 2-deoxy-2-[F-18]-fluoro-d-glucose (2-FDG), a substrate for

38 ed in human tumor xenografts in mice using 2-deoxy-2-[F-18]fluoro-D-glucose ((18)F-FDG) PET imaging.

39 Finally, 2-deoxy-2-[F-18]fluoro-d-sorbitol ((18)F-FDS) can be easil

40 c syntheses of (-)-ADMJ and (+)-ADANJ, the 2-deoxy-2-amino analogues of (-)-1-deoxymannojirimycin and

41 The glucose analog [(18)F]fluoro-2-deoxy-2-d-glucose ([(18)F]-FDG) is commonly used in PET/

42 Two isomeric aryl 2-deoxy-2-fluoro-beta-glucosides react with a beta-glucosi

43 ycin, mannoimidazole, or 2,4-dinitrophenol 2-deoxy-2-fluoro-mannoside reveal the residues essential f

44 d and four isomers of caffeoyl-2,7-anhydro-3-deoxy-2-octulopyranosonic acid were identified for the f

45 2'-Deoxy-2-thiouridine is an effective deoxyribosylating ag

46 2'-Deoxy-2-thiouridine is produced by photoreduction of 2,2

47 Here, we demonstrate the synthesis of 2'-deoxy-2-thiouridine, and subsequently 2'-deoxyadenosine

48 n 8-azido-3,6-dioxaoctyl 4,6-O-benzylidene-2-deoxy-2-trichloroacetamido-beta-D-glucopyranoside afford

49 version of cytidine triphosphate (CTP) to 3'-deoxy-3',4'-didehydro-CTP (ddhCTP), a previously unknown

50 o catalyze the SAM-dependent formation of 3'-deoxy-3',4'-didehydro-CTP (ddhCTP), which inhibits some

51 The enzyme converts CTP to 3'-deoxy-3',4'-didehydro-CTP, which functions as novel chai

52 to synthesis of the antiviral nucleotide 3'-deoxy-3',4'-didehydro-CTP.

53 dylaldehyde using this ylide results in a 3'-deoxy-3',4'-didehydronucleotide derivative, isolated as

54 PET with 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) can be used t

55 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) is a prolifer

56 The radiotracer 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) is commonly u

57 feration is a hallmark of transformation, 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) might be supe

58 Quantitative 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) PET has poten

59 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) PET has previ

60 parametric methods for quantification of 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) PET in advanc

61 -concept study evaluating the efficacy of 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) PET to assess

62 was to investigate whether sex influences 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) uptake and ti

63 To achieve our goal, PET/CT imaging with 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) was used to m

64 performed with the PET tracers (18)F-FDG, 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT), and (18)F-fl

65 tissue proliferation uses the PET tracer 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT).

66 studies (such as the proliferation probe 3'-deoxy-3'-(18)F-fluorothymidine [(18)F-FLT]).

67 ng of cellular proliferation with PET and 3'-deoxy-3'-(18)F-fluorothymidine or 2'-(18)F-fluoro-5-meth

68 Molecular imaging with the PET tracer 3'-deoxy-3'-[(18)F]fluorothymidine ([(18)F]FLT) allows asse

69 3'-Deoxy-3'-[(18)F]fluorothymidine positron emission tomogr

70 -emission tomography (PET) imaging tracer 3'-deoxy-3'-fluorothymidine (FLT) from its impurities in a

71 Here we show that (18)F-FLT PET ((18)F- 3'-deoxy-3'-fluorothymidine positron emission tomography) r

72 sed a novel method of cell tracking using 3'-deoxy-3'-L-[(18)F]-fluorothymidine ((18)F-FLT); a clinic

73 ino esters gave the protected forms of the 3-deoxy-3-aminosphingoid base targets.

74 syntheses of a range of N- and O-protected 3-deoxy-3-aminosphingoid bases have been achieved using tw

75 decade-long reported method to access both 3-deoxy-3-fluoro- and 4-deoxy-4-fluorogalactopyranose.

76 strategy to access orthogonally protected 3-deoxy-3-fluorogalactopyranose and acetylated 4-deoxy-4-f

77 I)-OH in 8-azido-3,6-dioxaoctyl 6-O-benzyl-2-deoxy-3-O-(2,3,4,6-tetra-O-acetyl-beta-D-galactopyranosy

78 piration whereas their glycolytic flux and 2-deoxy-(3)H-glucose uptake rates were largely unaffected.

79 r flux analysis as well as their uptake of 2-deoxy-(3)H-glucose.

80 xy (34, MRS4202 (S); 55, MRS4380 (N)) and 5'-deoxy 38a (MRS4203 (S)) analogues, containing 7- and N(6

81 Propylamycin is a 4'-deoxy-4'-alkyl paromomycin whose alkyl substituent conve

82 nsport can be estimated using alpha-methyl-4-deoxy-4-(18)F-fluoro-d-glucopyranoside (Me-4FDG).

83 nsport can be estimated using alpha-methyl-4-deoxy-4-[18F]fluoro-D-glucopyranoside (Me-4FDG).

84 ranoside (Me-4FDG), a substrate for SGLTs; 4-deoxy-4-[F-18]-fluoro-d-glucose (4-FDG), a substrate for

85 oro-N-acetylglucosamine (4FGlcNAc) and UDP-4-deoxy-4-fluoro-N-acetylgalactosamine (4FGalNAc), were pr

86 ridine diphosphate (UDP)-sugar donors, UDP-4-deoxy-4-fluoro-N-acetylglucosamine (4FGlcNAc) and UDP-4-

87 oxy-3-fluorogalactopyranose and acetylated 4-deoxy-4-fluorogalactopyranose.

88 ethod to access both 3-deoxy-3-fluoro- and 4-deoxy-4-fluorogalactopyranose.

89 rhodium to generate the rhodium analogue 5'-deoxy-5'-adenosylrhodibalamin (AdoRbl).

90 f phosphoramidite derivatives of all four 5'-deoxy-5'-thioribonucleosides is described.

91 tig olefination of 2',3'-O-isopropylidene-5'-deoxy-5'-uridylaldehyde using this ylide results in a 3'

92 ed the possibility of replacement of T by 2'-deoxy-5-(hydroxymethyl)uridine (5hmU) in the genomic DNA

93 ization of deoxyuridine monophosphate (dUMP)/deoxy-5-fluorouridine monophosphate (5-FdUMP) as a subst

94 on suggested a mode of binding similar to 5'-deoxy-5-iodotubercidin and other known inhibitors.

95 ethodology leads to 5-phosphasugars with a 4-deoxy-5-phosphapentopyranose framework.

96 1-[(18)F]fluoro-d-fructose (1-[(18)F]FDF), 6-deoxy-6-[(18)F]fluoro-d-fructose (6-[(18)F]FDF), 1-deoxy

97 (18)F]fluoro-d-glucose (2-[(18)F]FDG), and 6-deoxy-6-[(18)F]fluoro-d-glucose (6-[(18)F]FDG) was studi

98 oxy-6-sulfogluconolactone (SGL) lactonase, 6-deoxy-6-sulfogluconate (SG) dehydratase, and 2-keto-3,6-

99 lves an NAD(+)-dependent SQ dehydrogenase, 6-deoxy-6-sulfogluconolactone (SGL) lactonase, 6-deoxy-6-s

100 Sulfoquinovose (SQ; 6-deoxy-6-sulfoglucose) is the polar head group of the pla

101 oxy-7-cyano-7-deazaguanine (dPreQ(0)) and 2'-deoxy-7- aminomethyl-7-deazaguanine (dPreQ(1)).

102 mediates of the same pathway, in viruses: 2'-deoxy-7-amido-7-deazaguanine (dADG), 2'-deoxy-7-cyano-7-

103 ile the firehammerviruses replace dG with 2'-deoxy-7-amido-7-deazaguanosine (dADG), noncanonical nucl

104 tablished by detecting 2'-deoxy-preQ0 and 2'-deoxy-7-amido-7-deazaguanosine in enzymatic hydrolysates

105 : 2'-deoxy-7-amido-7-deazaguanine (dADG), 2'-deoxy-7-cyano-7-deazaguanine (dPreQ(0)) and 2'-deoxy-7-

106 cleoside analogues to develop a series of 3'-deoxy-7-deazaadenosine nucleosides, and investigate thei

107 uanine base in phage genomic DNA and that 2'-deoxy-7-deazaguanine modifications protect phage DNA fro

108 this study, we identify three additional 2'-deoxy-7-deazaguanine modifications, which are all interm

109 Another preQ0 derivative, 2'-deoxy-7-formamidino-7-deazaguanosine, was found in the E

110 , we found that deoxy-hydrolysis products [2-deoxy-adenosine 5'-diphosphate (dADP) and inorganic phos

111 The naturally occurring nucleotide 2-deoxy-adenosine 5'-triphosphate (dATP) can be used by ca

112 tic routes to novel analogues of ADPR and 2'-deoxy-ADPR that were modified only by removal of a singl

113 Overall, a simple novel deoxy alkyl modification of a readily available aminogly

114 t the hydroboration of methyl 2,3-O-methyl-6-deoxy-alpha-d-xylo-hex-5-enopyranoside resulted in exclu

115 The orthogonally protected deoxy amino l-sugar building blocks could be stereoselec

116 However, the unusual deoxy amino l-sugars present in the bacterial glycoconju

117 t methodology to access a variety of unusual deoxy amino l-sugars starting from readily available l-r

118 ns and oligosaccharides contain several rare deoxy amino l-sugars which are virtually absent in the h

119 Recently, we have synthesized the deoxy-analog of S-geranyluridine and showed the geranyla

120 rded the corresponding 4-O-benzoyl-6-bromo-6-deoxy analogue, which was coupled with 3,4,6-tri-O-acety

121 ends RNA 3' termini with an assortment of 2'-deoxy and 2',3'-dideoxy ribonucleotide analogs containin

122 oxidative deamination reactions of 4-amino-4-deoxy and 2-amino-2-deoxy hexopyranosides and a common m

123 ed Fe(d) spin count, indicating HS Fe(II) in deoxy and LS Fe(II) in carboxy.

124 of a 3alpha-OH was crucial: 3-acetylated, 3-deoxy, and 3-oxo analogs of 3alpha5alpha-P, as well as 3

125 is of beta-(1-->2)-C-saccharides employing 3-deoxy- and 3-C-branched glycals as hermaphroditic substr

126 ybenzyl protecting group strategy, 3-azido-3-deoxy- and 4-azido-4-deoxy-d-myo-inositol were efficient

127 of catecholic and non-catecholic 3-oxy- (and deoxy)-anthocyanidins.

128 nta-acylated species modified with 4-amino-4-deoxy-arabinose residues at both terminal phosphate grou

129 The time-course of VCF responses to ATP, 2'-deoxy ATP, 3'-deoxy ATP, Ap5A and alphabetameATP were ag

130 se of VCF responses to ATP, 2'-deoxy ATP, 3'-deoxy ATP, Ap5A and alphabetameATP were agonist dependen

131 ion (NO3 (-) ) and N(6) -(2-phenylethyl)-2'-deoxy-ATP (d-PATP), which almost completely rectifies th

132 The naturally occurring nucleotide 2-deoxy-ATP (dATP) is a myosin activator that enhances cro

133 mouse model with elevated skeletal muscle 2-deoxy-ATP (dATP) was used to study how myosin activators

134 Treatment with the DNA demethylating agent 5-deoxy-azacytidine does not increase Xi expression ahead

135 a conserved glycolipid terminus containing 3-deoxy-beta-d- manno-oct-2-ulosonic acid (beta-Kdo).

136 of a convenient 2-azido-4,6-O-benzylidene-2-deoxy-beta-d-allopyranose precursor by the corresponding

137 The 6-deoxy-beta-d-ido-heptopyranoside related to the capsular

138 t is the first successful synthesis of the 6-deoxy-beta-d-ido-heptopyranoside, which could possess in

139 3-Deoxy-beta-d-manno-oct-2-ulosonic acid (beta-Kdo) glycos

140 the synthesis of trans-1,2-, cis-1,2-, and 2-deoxy-beta-glycosides.

141 family GH105, producing the final product 4-deoxy-beta-l-threo-hex-4-enepyranosyl-uronic acid.

142 ectrophiles afforded corresponding 2-azido-2-deoxy-beta-mannosides in good yields and excellent anome

143 one-step and metal-free method for carbonyl deoxy-borylation under mild conditions.

144 iminutive analogue (+)-C(8)-desmethoxy-C(11)-deoxy-C(12)-didesmethylirciniastatin (6).

145 ular and electronic structures of unligated (deoxy), CO-inhibited (carboxy), and O2-bound (oxy) hemes

146 affected in both acute kidney injury and in deoxy-corticosterone acetate and sodium chloride (deoxy-

147 -corticosterone acetate and sodium chloride (deoxy-corticosterone acetate salt)-induced chronic hyper

148 Furthermore, sA3G was shown to bind a deoxy-cytidine dinucleotide near the catalytic Zn(2+), y

149 tic position, where the interactions between deoxy-cytidines and CTD loop-1 and loop-7 residues were

150 ine the catalytic function of the combined 3-deoxy-d-arabino heptulosonate-7-phosphate synthase (DAH7

151 tinctive bifunctional protein comprising a 3-deoxy-d-arabino heptulosonate-7-phosphate synthase (DAH7

152 Here, we have examined a critical enzyme, 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase (DAH7

153 ral CM and requires complex formation with 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase for h

154 hanism observed for Neisseria meningitidis 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase, the

155 Two key enzymes of the shikimate pathway, 3-deoxy-d-arabinoheptulosonate 7-phosphate synthase and ch

156 s bioactive components, including N-alpha-(1-deoxy-D-fructos-1-yl)-L-arginine (FruArg).

157 ering using tetra-O-acetyl-2-N-azidoacetyl-2-deoxy-d-galactopyranose (Ac(4)GalNAz).

158 -phenyl carbamate (PUGNAc), O-(2-acetamido-2-deoxy-D-galactopyranosylidene)amino N-phenyl carbamate (

159 l is NAD(+)-dependent and has distinct UDP-6-deoxy-d-GlcNAc-5,6-ene 4-oxidase, 5,6-reductase, and 5-e

160 probes were: alpha-methyl-4-[F-18]-fluoro-4-deoxy-d-glucopyranoside (Me-4FDG), a substrate for SGLTs

161 beta-d-galactopyranosyl-(1->3)-2-acetamido-2-deoxy-d-glucopyranoside derivatives bearing a unique azi

162 lacto-configured inhibitors O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenyl carbamate (PU

163 d to lactate production and (18)F-2-fluoro-2-deoxy-D-glucose ((18)F-FDG) uptake.

164 by labelling cells with 2'-[(18)F]-fluoro-2'-deoxy-D-glucose ((18)F-FDG).

165 c activity as measured by [18F]-2-fluoro-d-2-deoxy-d-glucose (18F-FDG) PET/CT.

166 complex 1 and is efficiently inhibited by 2-deoxy-d-glucose (2-DG) or by glucose starvation.

167 Inhibition of glycolysis with 2-deoxy-D-glucose (2-DG) reduced osteoclast formation and

168 7-nitrobenz-2-oxa-1, 3-diazol-4-yl) amino]-2-deoxy-D-glucose (2-NBDG) reports on glucose uptake and T

169 ypoglycemia and to a blunted CRR caused by 2-deoxy-d-glucose (2DG) administration.

170 tment with low doses of the glucose analog 2-deoxy-d-glucose (2DG) on ADPKD progression in orthologou

171 have either been treated or untreated with 2-deoxy-d-glucose (2DG), a pharmaceutical that targets cel

172 limidazole (NDI) with glycolytic inhibitor 2-deoxy-d-glucose (2DG).

173 TP), and an inhibitor of energy metabolism 2-deoxy-D-glucose (DeOGlc) + sodium iodoacetate (IAc), on

174 which tumor cells take up 2-[(18)F]fluoro-2-deoxy-D-glucose (FDG) is heterogeneous and influenced by

175 aphy after an injection of [(18)F]2-fluoro-2-deoxy-d-glucose before the OGTT, and the rate of glucose

176 ments of B6.Sle1Sle2.Sle3 mice with either 2-deoxy-D-glucose or metformin were sufficient to prevent

177 nd sex-matched controls using 18F-2-fluoro-2-deoxy-d-glucose PET (n = 20 per group) and voxel-based m

178 n these subjects by means of [(18)F]fluoro-2-deoxy-d-glucose Positron Emission Tomography/Computed To

179 glucose-free medium or in the presence of 2-deoxy-D-glucose upon CCCP treatment.

180 to alanine (Q282A) doubled the Km(app) for 2-deoxy-d-glucose uptake and eliminated cis-allostery (sti

181 abolites modulated (14)C-D-glucose and (14)C-deoxy-D-glucose uptake into hepatic HepG2 cells.These da

182 Overload-induced [(3)H]-2-deoxy-d-glucose uptake was not inhibited by d-fructose,

183 5 days, muscle weights and ex vivo [(3)H]-2-deoxy-d-glucose uptake were assessed.

184 Concurrent inhibition of glycolysis (2-deoxy-D-glucose, 2DG) and mitochondrial respiration (rot

185 ular metabolism, and a treatment combining 2-deoxy-D-glucose, which inhibits glucose metabolism, and

186 ity was enhanced by glucose and reduced by 2-deoxy-D-glucose-induced starvation.

187 toirradiated cells even in glucose-free or 2-deoxy-D-glucose-treated conditions.

188 glycolytic inhibitor WP1122, a prodrug of 2-deoxy-d-glucose.

189 with unnatural glycosides such as 6-azido-6-deoxy-d-glucose/glucosamine to lead to beta-d-galactopyr

190 ATGU) glucose uptake with [(18) F]2-fluoro-2-deoxy-D-glucose/positron emission tomography, lipolysis

191 hioglycoside leading to the formation of a 3-deoxy-d-glycero-d-galacto-2-nonulosonic acid (KDN) deriv

192 configuration to the corresponding 2-keto-3-deoxy-D-glycero-D-galacto-nonulopyranosidonic acid (KDN)

193 affording a practical synthesis of 2-keto-3-deoxy-d-glycero-d-galactononulosonic acid (KDN) derivati

194 tion extending the d-hexose to the desired 6-deoxy-d-heptose.

195 cterial sialic acid, pseudaminic acid, and 3-deoxy-d-manno-oct-2-ulosonic acid (KDO) affords the hypo

196 tion of glycosyl dibutyl phosphates in the 3-deoxy-d-manno-oct-2-ulosonic acid (KDO) and pseudaminic

197 In plants, 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo) is a monosacchar

198 3-Deoxy-d-manno-oct-2-ulosonic acid (Kdo) is an essential

199 3-Deoxy-d-manno-oct-2-ulosonic acid (Kdo) is an essential

200 d at the non-reducing end by a beta-linked 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo) residue.

201 on of waaA resulted in increased levels of 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo) sugar in membran

202 ycero-d-talo-oct-2-ulosonic acid (KO), and 3-deoxy-d-manno-oct-2-ulosonic acid (KDO).

203 Kdo (3-deoxy-d-manno-oct-2-ulosonic acid) is an eight-carbon su

204 chain is terminated by a beta-linked Kdo (3-deoxy-d-manno-oct-2-ulosonic acid) residue added by a th

205 by interaction of anhydro-Kdo (4,7-anhydro-3-deoxy-d-manno-oct-2-ulosonic acid) with Arg343 and Asp32

206 e lipopolysaccharide pathway gene encoding 3-deoxy-d-manno-octulosonate 8-phosphate-phosphatase ident

207 , we determine the structure of the enzyme 3-deoxy-D-manno-octulosonate-8-phosphate synthase from mic

208 ng N-acetylgalactosamine (GalNAc) and beta-3-deoxy-d-manno-octulosonic acid (betaKdo).

209 l oxidant for preparation of those 2-azido-2-deoxy-d-mannoses from their corresponding thioglycosides

210 O-alkylation of various protected 2-azido-2-deoxy-d-mannoses with primary triflate electrophiles aff

211 5-Azido-5-deoxy-d-myo-inositol was inaccessible due to an unusual

212 oup strategy, 3-azido-3-deoxy- and 4-azido-4-deoxy-d-myo-inositol were efficiently synthesized.

213 eta-[1-naphtho[2,3-d]imidazol-2(3H)-one)]-2'-deoxy-d-ribofuranose and 1'-beta-[1-naphtho[2,3-d]imidaz

214 e and 1'-beta-[1-naphtho[2,3-d]imidazole]-2'-deoxy-d-ribofuranose and their use for quantifying O(6)-

215 Starting from 2-deoxy-d-ribose, the product is obtained in a 6.7% overal

216 adaptation to low folAmix by rerouting the 2-Deoxy-D-ribose-phosphate metabolism from glycolysis towa

217 DXPS catalyzes the formation of 1-deoxy-d-xylulose 5-phosphate (DXP), a branch point metab

218 d-glyceraldehyde 3-phosphate (d-GAP) into 1-deoxy-d-xylulose 5-phosphate (DXP), an essential bacteri

219 lastic 2-C-methyl-d-erythritol 4-phosphate/1-deoxy-d-xylulose 5-phosphate pathway (MEP/DOXP), and its

220 The enzyme 1-deoxy-d-xylulose 5-phosphate synthase (DXPS) is a key en

221 1-Deoxy-d-xylulose 5-phosphate synthase (DXPS) uses thiami

222 1-Deoxy-D-xylulose-5-phosphate (DXP) reductoisomerase (DXR

223 ts homologue FR900098 (2) potently inhibit 1-deoxy-d-xylulose-5-phosphate reductoisomerase (Dxr), a k

224 yl-D-erythritol 4-phosphate pathway enzyme 1-deoxy-D-xylulose-5-phosphate synthase (DXS).

225 igated the effects of Solanum lycopersicum 1-deoxy-d-xylulose-5-phosphate synthase (SlDXS), Arabidops

226 ooxygenase 2 and increases of its product 15-deoxy Delta-prostaglandin J2 as well as cyclooxygenase 2

227 ined the involvement of cyclooxygenase 2, 15-deoxy Delta-prostaglandin J2, and peroxisome proliferato

228 staglandin J2 as well as cyclooxygenase 2/15-deoxy Delta-prostaglandin J2-dependent activation of per

229 ced lung injury involves cyclooxygenase 2/15-deoxy Delta-prostaglandin J2-dependent activation of per

230 roduction of the signaling lipid molecule 15-deoxy-delta 12,14 prostaglandin J2 (15-d-PGJ2) and confe

231 (CyPGs)], Delta(12)prostaglandin J(2) and 15-deoxy-Delta(12,14)-prostaglandin J(2), act through 2 GPC

232 enously produced product of inflammation, 15-deoxy-Delta(12,14)-prostaglandin J2 (15-d-PGJ2), trigger

233 15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ2) is natura

234 evels of the cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin-J(2) that can activate

235 (specifically, the data suggest roles for 15-deoxy-Delta(12,14)-prostaglandin-J2 and lipoxin A4, both

236 ytes were used to investigate the role of 15-deoxy-Delta12,14-prostaglandin J(2) (15d-PGJ(2)) in vitr

237 12 prostaglandin J2 (Delta(12)-PGJ2), and 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2).

238 ligands (rosiglitazone, troglitazone, and 15-deoxy-Delta12,14-prostaglandin J2) decrease levels of be

239 hosphono-peramivir (6a), the dehydration and deoxy derivatives (7a and 8a) as well as their correspon

240 ments for monosaccharides, their methoxy and deoxy derivatives, disaccharides and sugar alcohols in (

241 ablished by the discovery of dynemicin A and deoxy-dynemicin A.

242 In its ferrous deoxy form, GLB-33 GD is capable of reversibly binding O

243 Comparing the properties of the deoxy forms of ATP demonstrated the importance of the 2'

244 eir glucose conjugates, generating 1-amino-1-deoxy-fructose and its derivatives.

245 y, is synthesized from an intermediate named deoxy-fructosyl-glutamine (DFG), which is also an opine

246 new metabolic chemical reporter, 6-Alkynyl-6-deoxy-GlcNAc (6AlkGlcNAc), for the identification of O-G

247 say, and glucose uptake determined through 2-deoxy glucose 6 phosphate luminescence.

248 e moiety in rhamnosylisoorientin to 4-keto-6-deoxy glucose, resulting in maysin.

249 TKIs are evaluated through 2-[(18)F]fluoro-2-deoxy-glucose ((18)FDG)-PET uptake, which is decreased i

250 py in the inflammatory phase with the drug 2-deoxy-glucose (2DG), lesions were diminished compared wi

251 h glucose and imidazolinone formation with 3-deoxy-glucosone at the guanidine side-chain.

252 8-Hydroxy-deoxy guanosine and malondialdehyde levels as markers of

253 otho, improved malondialdehyde and 8-hydroxy-deoxy guanosine levels, and also deteriorated renal func

254 DOSI images of the tissue concentrations of deoxy-hemoglobin (ctHHb), oxy-hemoglobin (ctHbO2), water

255 n reactions of 4-amino-4-deoxy and 2-amino-2-deoxy hexopyranosides and a common mechanism is formulat

256 .g., glucose/fructose, C6H12O6, keto-hexose, deoxy-hexose, (P < 0.01)), with significant downregulati

257 utational structural analysis, we found that deoxy-hydrolysis products [2-deoxy-adenosine 5'-diphosph

258 edlings or tobacco BY-2 cells with 8-azido 8-deoxy Kdo (Kdo-N3 ) followed by coupling to an alkyne-co

259 nt system (TCS) directly activates 4-amino-4-deoxy-l-arabinose (l-Ara4N) biosynthesis to result in ca

260 ArnT (undecaprenyl phosphate-alpha-4-amino-4-deoxy-l-arabinose arabinosyl transferase).

261 e attachment of the cationic sugar 4-amino-4-deoxy-l-arabinose to lipid A, a reaction catalyzed by th

262 lipid-to-lipid glycosyltransferase 4-amino-4-deoxy-L-arabinose transferase (ArnT).

263 y-L-fuconate via dehydratase, (iii) 2-keto-3-deoxy-L-fuconate cleavage to pyruvate and L-lactaldehyde

264 dehydrogenase, (ii) dehydration to 2-keto-3-deoxy-L-fuconate via dehydratase, (iii) 2-keto-3-deoxy-L

265 on the conversion of an L-rhamnose into a 6-deoxy-L-talose residue at a late stage of the synthetic

266 and 6-deoxy-l-talose residues in which the 6-deoxy-l-talose residues are variably replaced with O-ace

267 heteropolymer with repeating d-glucose and 6-deoxy-l-talose residues in which the 6-deoxy-l-talose re

268 We found that the 2-azido-2-deoxy moiety is more beta-directing than its C-2-O-benzy

269 high spin (HS, S = 2) pentacoordinated domed deoxy-myoglobin (deoxyMb) form upon ligand detachment fr

270 polymerase (NmSiaD(W)) identified 4-azido-4-deoxy-N-acetylmannosamine (ManNAc4N(3)) and 6-azido-6-de

271 cetylmannosamine (ManNAc4N(3)) and 6-azido-6-deoxy-N-acetylmannosamine (ManNAc6N(3)) as suitable chem

272 the nonselective 1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-d-ribofuranuronamide (NECA) and the s

273 he suicide substrate arabinosyl-2'-fluoro-2'-deoxy NAD(+) (F-araNAD(+)), dimeric F-araNAD(+), to indu

274 and regulates appearance of the free ferrous deoxy-NGB, which is the redox active form of the protein

275 articular, deamination of adenine moiety in (deoxy)nucleoside triphosphates, resulting in formation o

276 alysis proved better suited for generating 2-deoxy O-glycosides, significantly broadening the scope o

277 inkages by an engineered polymerase using 3'-deoxy- or 3'-O-methyl-NTPs as substrates.

278 chimeric oligoribonucleotides containing 2'-deoxy- or arabinonucleotides are effective templates for

279 The resulting 3'-aminooxy deoxy- or ribo-oligonucleotides were conjugated to vario

280 The resemblance of the 3'-deoxy pacidamycin moiety with the synthetic anti-retrovi

281 Structural analogs of PCer (1- or 3-deoxy-PCer) were also associated with palmitoyl lyso-PC,

282 This was established by detecting 2'-deoxy-preQ0 and 2'-deoxy-7-amido-7-deazaguanosine in enz

283 in situ; reductive N-methylation then gave 3-deoxy-(+)-preussin B as the major diastereoisomeric prod

284 B, the C(2)-epimer of (-)-preussin B, and 3-deoxy-(+)-preussin B have been developed, using the dias

285 lds (from phenylacetaldehyde) were 19% for 3-deoxy-(+)-preussin B over seven steps, 8% for the C(2)-e

286 In contrast, paromamine is reduced to a deoxy product when incubated with AprD4/AprD3/NADPH.

287 a nucleotide antiporter and prefers various (deoxy-) purine nucleotides as substrates.

288 nt homo-oligomer DNA sequences containing 10 deoxy-ribonucleotides of thymine, adenine, cytosine, or

289 cues damage-stalled replication by inserting deoxy-ribonucleotides opposite DNA damage sites resultin

290 rate efficiently promoted the formation of 2-deoxy S-glycosides in the presence of thiols, probably b

291 zoyl-4,6-O-di-tert-butylsilylidene-2-azido-2-deoxy-selenogalactoside, biotinylated oligo-alpha-(1 ->

292 how also high efficiency of phenyl 2-azido-2-deoxy-selenogalactosides as glycosyl donors.

293 ipids including ceramide phosphoinositol and deoxy-sphingolipids.

294 The 6-deoxy sugar l-rhamnose (l-Rha) is found widely in plant

295 e shown to possess clusters of rhamnose, a 6-deoxy sugar with non-polar characteristics.

296 us sensu lato group produce CDP-3-C-methyl-6-deoxy sugars for the formation of cereose-containing gly

297 into the roles of the uncommon 3-C-methyl-6-deoxy sugars in cell-surface recognition and host-pathog

298 The first examples of iminosugar-type 2-deoxy(thio)glycoside mimetics are reported.

299 The synthesis of four l-2'-deoxy-threose nucleoside phosphonates with the natural n

300 yzes synthesis of the sole de novo source of deoxy-thymidylate.

301 cells were briefly labeled with 5-ethynyl-2'-deoxy-uridine, and nuclei were subjected to two-paramete