ライフサイエンスコーパス: deoxyadenosine

1 ical anticancer drug cladribine (2-chloro-2'-deoxyadenosine).

2 s reductively cleaved to L-methionine and 5'-deoxyadenosine.

3 5'-deoxy-5'-(methylthio)adenosine and not 5'-deoxyadenosine.

4 interstrand cross-links with the opposing 2'-deoxyadenosine.

5 probing any target sequence containing a 2'-deoxyadenosine.

6 2'-deoxycytidine, 2'-deoxyguanosine, and 2'-deoxyadenosine.

7 2 in the presence of 2'-deoxyguanosine or 2'-deoxyadenosine.

8 arbon bond homolysis and the formation of 5'-deoxyadenosine.

9 ransfer from [octanoyl-d(15)]H-protein to 5'-deoxyadenosine.

10 zes the deglycosylation of the mismatched 2'-deoxyadenosine.

11 f 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine.

12 concluded an efficient route to 3'-amino-3'-deoxyadenosine.

13 sites located on the C5' methyl group of 5'-deoxyadenosine.

14 denine demonstrated increased sensitivity to deoxyadenosine.

15 opposing thymidine, 2'-deoxycytidine, or 2'-deoxyadenosine.

16 , where the major SAM derived products is 5'-deoxyadenosine.

17 ons formed by electron transfer from O to 2'-deoxyadenosine.

18 as improved by in situ removal of product 5'-deoxyadenosine.

19 uI provides good yields of the 8-arylated-2'-deoxyadenosines.

20 2-hydroxy-3-hydroxymethylpropan-1,3-diyl)-2'-deoxyadenosine (1,N(6)-gamma-HMHP-dA) adducts are formed

21 1-hydroxymethyl-2-hydroxypropan-1,3-diyl)-2'-deoxyadenosine (1,N(6)-HMHP-dA), in tissues of laborator

22 N1-methyl-deoxyadenosine (1-MeA) is formed by methylation of deoxy

23 Cordycepin (3'-deoxyadenosine, 1a) is a powerful trypanocidal compound

24 2-Fluorocordycepin (2-fluoro-3'-deoxyadenosine, 1b) was identified as a selective, poten

25 The deamination of 2'-deoxyadenosine, 2'-deoxyguanosine, and 2'-deoxycytidine

26 e incorporated into DNA in the form of [2H2]-deoxyadenosine (%[2H2]-dA enrichment) was determined by

27 ([3H]2-chloro-N6-methyl-(N)-methanocarba-2'-deoxyadenosine 3',5'-bis-phosphate) indicated a nearly h

28 3)H]2-chloro-N(6)-methyl-(N)-methanocarba-2'-deoxyadenosine 3',5'-bisphosphate 5 in a newly developed

29 gues of oligonucleotides by the oxidation of deoxyadenosine 3',5'-bisphosphorothioate (3) was attempt

30 ), approximately 20 microM) as well as by 2'-deoxyadenosine 3'-AMP (IC(50), approximately 2 microM),

31 ACIX was essentially insensitive to 2'-deoxyadenosine 3'-monophosphate, a known blocker of AC a

32 2-Chloro-N(6)-methyl-(N )-methanocarba-2'-deoxyadenosine-3',5'- bisphosphate (MRS2279) was develop

33 nists MRS2279 (K(i) = 13 nM), N(6)-methyl-2'-deoxyadenosine-3',5'-bisphosphate (MRS2179; K(i) = 84 nM

34 We have used RB69 DNA pol and 3-deaza-2'-deoxyadenosine (3DA), an analogue of 2-deoxyadenosine, w

35 romo)-dediazoniation of 3',5'-di-O-acetyl-2'-deoxyadenosine (4) gave the 6-[chloro (5, 63%) or bromo

36 p of 3',5'-di-O-(tert-butyldimethylsilyl)-2'-deoxyadenosine (4) occurs at C-10 of the epoxides.

37 The nonpolar isosteres of 2'-deoxyadenosine, 4-methylbenzimidazole beta-deoxynucleosi

38 ne 5'-monophosphate (T-dTMP) but not adenine-deoxyadenosine 5'-monophosphate (A-dAMP) mismatches.

39 that AMP and a non-hydrolyzable AMP analog (deoxyadenosine 5'-monophosphonate, ACP) directly activat

40 deoxyribozymes that transfer the 2'-azido-2'-deoxyadenosine 5'-monophosphoryl group (2'-Az-dAMP) from

41 nucleotides (dNTP) containing biotinlated 2'-deoxyadenosine 5'-triphosphate (biotin-dATP) by terminal

42 forming a Hoogsteen base pair with incorrect deoxyadenosine 5'-triphosphate (dATP).

43 -(7-diethylaminocoumarin-3-carbonylamino)-3'-deoxyadenosine 5'-triphosphate], shows a 17-fold enhance

44 bstracts an H-atom from substrate to form 5'-deoxyadenosine (5'-Ado) and the alpha-Lys* radical (stat

45 ethionine (SAM) is converted to 5'-chloro-5'-deoxyadenosine (5'-ClDA) in a reaction catalyzed by a SA

46 ion of the non-native substrate 5'-chloro-5'-deoxyadenosine (5'-ClDA) into 5'-fluoro-5'-deoxyadenosin

47 and catalyzed formation of 0.60 equiv of 5'-deoxyadenosine (5'-dA) and 0.27 equiv of lipoylated H-pr

48 kinetics of deuterium incorporation into 5'-deoxyadenosine (5'-dA) during the reaction were followed

49 ' radical, abstracts H-4' atom from (4'R)-5'-deoxyadenosine (5'-dA) to transiently generate 5'-deoxya

50 exed with S-adenosylhomocysteine (SAH) or 5'-deoxyadenosine (5'-dAdo) and l-methionine (l-Met).

51 M) enzyme, catalyzing homolysis of SAM to 5'-deoxyadenosine (5'-dAdo) in the presence of paromamine.

52 thioadenosine (MTA), adenosine (Ado), and 5'-deoxyadenosine (5'-dAdo).

53 idenced by the transfer of deuterium into 5'-deoxyadenosine (5'-dAH).

54 eine (SAH), 5'-methylthioadenosine (MTA), 5'-deoxyadenosine (5'-DOA), and 6-amino-6-deoxyfutalosine.

55 '-deoxyadenosine (5'-ClDA) into 5'-fluoro-5'-deoxyadenosine (5'-FDA).

56 y the adenosine kinase inhibitor 5'-amino-5'-deoxyadenosine (5'A5'dAdo), indicating that the metaboli

57 MTA, SAH and 5'-deoxyadenosine (5'dADO) are product inhibitors of these

58 of two weakly cytotoxic compounds, 8-aza-2'-deoxyadenosine (5) and 8-bromo-2'-deoxyadenosine (9), ha

59 veral enzymes to release (5'S)-8,5'-cyclo-2'-deoxyadenosine [(5'S)-cdA] from dinucleotides and oligod

60 roxy-2'-deoxyguanosine, (5'-S)-8,5'-cyclo-2'-deoxyadenosine, (5'-R)-8,5'-cyclo-2'-deoxyguanosine, and

61 using miRNA as a primer and incorporating 2'-deoxyadenosine-5'-O-(1-thiotriphosphate) as a dATP alter

62 -(7-diethylaminocoumarin-3-carbonylamino)-3'-deoxyadenosine-5'-triphosph ate (deac-aminoATP), to stud

63 8-Azido-5'-aziridino-5'-deoxyadenosine (6), a novel cofactor mimic, was synthesi

64 fication and quantification of 8,5'-cyclo-2'-deoxyadenosine (8,5'-cdAdo) in DNA by liquid chromatogra

65 ng chemistry has been extended to 8-bromo-2'-deoxyadenosine (8-BrdA) and 5-iodo-2'-deoxyuridine (5-Id

66 xo-2'-deoxyguanosine (8-oxo-dG) and 8-oxo-2'-deoxyadenosine (8-oxo-dA) in diseased RPE could provide

67 ne (8-oxoG:dC) and Hoogsteen base pairs with deoxyadenosine (8-oxoG:dA).

68 operties with 8-(1- H-1,2,3-triazol-4-yl)-2'-deoxyadenosine (8-TrzdA), exhibiting a quantum yield of

69 completion than the corresponding 8-bromo-2'-deoxyadenosine (8BrdA) couplings.

70 8-Vinyl-2'-deoxyadenosine (8vdA) is a fluorophore with a quantum yi

71 , 8-aza-2'-deoxyadenosine (5) and 8-bromo-2'-deoxyadenosine (9), have been prepared.

72 (5'-([(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine) (a substrate analogue that transaminates

73 oxy-2(E)-decenal is a precursor of etheno-2'-deoxyadenosine, a highly mutagenic lesion found in human

74 7 exhibits very low deaminase activity on 2'-deoxyadenosine, a substrate that is readily hydrolyzed b

75 T. brucei cultivated in the presence of deoxyadenosine accumulates high levels of dATP in an ade

76 ere we show that T. brucei treated with 1 mm deoxyadenosine accumulates higher dATP levels than mamma

77 Because BcPh DEs form substantial amounts of deoxyadenosine adducts at dA, their adverse effects on h

78 n DNA polymerase eta (pol eta) encounters N6-deoxyadenosine adducts formed by trans epoxide ring open

79 anosine and N(6)-(2-hydroxyestrogen-6-yl)-2'-deoxyadenosine adducts induced by quinones of 2-hydroxye

80 For deoxyadenosine/adenosine analogues to remain intact and

81 2'-bromo-2'-deoxyadenosine, and 2'-chloro-2'-deoxyadenosine (all with beta-d-ribo configurations).

82 3'-Deoxyadenosine, also known as cordycepin, is a known pol

83 ard, 5'-(diaminobutyric acid)-N-iodoethyl-5'-deoxyadenosine ammonium hydrochloride (AAI), to generate

84 s containing adenosyl moieties, including 5'-deoxyadenosine, AMP, ADP, and methylthioadenosine, to pu

85 in- 4-amine) N(8)-(2'deoxyribonucleoside), a deoxyadenosine analog (UB), pairs with each of the natur

86 Clofarabine is the first deoxyadenosine analog that shows promise in adult and pe

87 TP and the incorporation of cordycepin, a 2'-deoxyadenosine analogue, into the 3'-terminal position.

88 Phosphoramidite-protected quadracyclic 2'-deoxyadenosine analogues qAN1 (donor) and qAnitro (accep

89 opment of additional novel C2-substituted 3'-deoxyadenosine analogues to be evaluated in development

90 f 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine analogues was designed and synthesized in

91 10-tetrahydrobenzo[a]pyrene (BaP DE-2) by 2'-deoxyadenosine and 2'-deoxyguanosine is described.

92 hyl- and 7,12-dimethyl- derivatives) with 2'-deoxyadenosine and 2'-deoxyguanosine were prepared by th

93 yethyl)methylenecyclopropane analogues of 2'-deoxyadenosine and 2'-deoxyguanosine were synthesized, a

94 Rate constants for deamination of 2'-deoxyadenosine and 2'-deoxyguanosine, which could not be

95 r than the rates of glycoside cleavage in 2'-deoxyadenosine and 2'-deoxyguanosine.

96 2'-deoxy-2-thiouridine, and subsequently 2'-deoxyadenosine and 2-deoxyribose, under prebiotic condit

97 )-etheno-2'-deoxyguanosine, 1,N(6)-etheno-2'-deoxyadenosine and 3,N(4)-etheno-2'-deoxycytidine arisin

98 al oxygen-independent salvage pathway for 5'-deoxyadenosine and 5'-methylthioadenosine in both Rhodos

99 BciD catalyzed the conversion of SAM into 5'-deoxyadenosine and BChlide c or d into BChlide e or f, r

100 llows that dissociation of methionine and 5'-deoxyadenosine and binding of a second equivalent of Ado

101 Deoxyadenosine and deoxycytidine exhibited comparable re

102 ynthesis of the purine deoxyribonucleosides: deoxyadenosine and deoxyinosine.

103 The observation of multiply deuterated 5'-deoxyadenosine and deuterated S-adenosylmethionine when

104 ic and strictly anaerobic conditions were 5'-deoxyadenosine and hydroxocobalamin, which suggested int

105 ing occurs via reaction with the opposing 2'-deoxyadenosine and is independent of O(2).

106 uires AdoMet and flavodoxin and generates 5'-deoxyadenosine and methionine, suggesting that biotin sy

107 sis of the model adducts N(6)-(1-pyrenyl)-2'-deoxyadenosine and N(2)-(1-pyrenyl)-2'-deoxyguanosine as

108 side derivatives N(6)-(6-benzo[a]pyrenyl)-2'-deoxyadenosine and N(2)-(6-benzo[a]pyrenyl)-2'-deoxyguan

109 (3))-H bond in the methyl group of N6-methyl deoxyadenosine and N6-methyl adenosine, epigenetic modif

110 The isotope distributions of 5'-deoxyadenosine and p-cresol were evaluated using deuteri

111 0517) to evaluate levels of adenosine and 2'-deoxyadenosine and real-time PCR to quantify TREC levels

112 nK reaction revealed that 1 equiv each of 5'-deoxyadenosine and S-adenosyl-homocysteine are produced

113 Some of the cross-links between 2'-deoxyadenosine and the oxidized abasic sites, 5'-(2-phos

114 d to the 5'-deoxyadenosyl radical to form 5'-deoxyadenosine and the pro-S hydrogen is transferred to

115 n and that one SAM (SAM1) is converted to 5'-deoxyadenosine and the second SAM (SAM2) is converted to

116 ve orientation of the C5' methyl group of 5'-deoxyadenosine and the substrate radical in vitamin B(12

117 e formation of S-adenosylhomocysteine and 5'-deoxyadenosine and the transfer of a methyl group to l-v

118 pore, oligonucleotides with 5' overhangs of deoxyadenosines and deoxythymidines up to nine bases in

119 r >> Cl for 2'-O-tosyladenosine, 2'-bromo-2'-deoxyadenosine, and 2'-chloro-2'-deoxyadenosine (all wit

120 l toward the DNA-bases 2'-deoxyguanosine, 2'-deoxyadenosine, and 2'-deoxycytidine and proteins.

121 Efficient conversions of adenosine, 2'-deoxyadenosine, and related adenine nucleosides into 6-h

122 Radical SAM enzymes produce 5'-deoxyadenosine, and SAM-dependent enzymes for polyamine,

123 ase coproducts S-adenosylhomocysteine and 5'-deoxyadenosine, and to require cobalamin.

124 ysis revealed a stoichiometric mixture of 5'-deoxyadenosine, aquocobalamin, and allylmalonyl-CoA.

125 ransferred to the GRE, and methionine and 5'-deoxyadenosine are also formed.

126 Since MTAP substrates MTA and 5'deoxyadenosine are prone to toxicities associated with a

127 ynthesis of 1,N6-ethano- and 1,N6-propano-2'-deoxyadenosine are reported in order to demonstrate the

128 neous quantification of formylglycine and 5'-deoxyadenosine as a function of time indicates an approx

129 vels of the ADA substrates, adenosine and 2'-deoxyadenosine, as well resulting dATP levels and S-aden

130 2 cofactor containing O at the 5'-end and 2'-deoxyadenosine at the 3'-end was studied by femtosecond

131 Introduction of a deoxyadenosine at the depurination site of short RNA oli

132 denosine (1-MeA) is formed by methylation of deoxyadenosine at the N1 atom.

133 (3S)-3-aminocarboxypropyl]-N-methylamino}-5'-deoxyadenosine (azaSAM) as measured by spectroelectroche

134 = 2.3 A) (2)H in the C5' methyl group of 5'-deoxyadenosine, (b) two weakly coupled (r(eff) = 4.2 A)

135 lene glycol modification or 1,N(6)-etheno-2'-deoxyadenosine base efficiently and stably halts Escheri

136 ,8-dihydrodiol-9,10-epoxide (N2-dG-BPDE); N6-deoxyadenosine-benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxi

137 es E(NADH/3'-keto-adenosine) and E(NAD(+)/3'-deoxyadenosine) but was absent for the complex E(NADH/3'

138 of thymocyte development is not adenosine or deoxyadenosine, but a phosphorylated derivative of an AD

139 DNA, as demonstrated by its conversion to 2'-deoxyadenosine by reaction with adenine, and 2-deoxyribo

140 ly protected against lower concentrations of deoxyadenosine by the ability to cleave it and use the a

141 ues, such as 10 (N6-cyclopentyl-3'-ureido-3'-deoxyadenosine), by >100-fold, while decreasing the affi

142 mined for their ability to handle 3-deaza-2'-deoxyadenosine (c3dA), an analog of 2'-deoxyadenosine la

143 ylamine derivatives of both adenosine and 2'-deoxyadenosine can be prepared via simple S(N)Ar reactio

144 ing the stereoisomeric R and S 5',8-cyclo-2'-deoxyadenosine (cdA) and 5',8-cyclo-2'-deoxyguanosine (c

145 damage products including the 8,5'-cyclo-2'-deoxyadenosine (cdA) and 8,5'-cyclo-2'-deoxyguanosine (c

146 8,5'-cyclo-2'-deoxyadenosine (cdA) and 8,5'-cyclo-2'-deoxyguanosine ge

147 nce that both (5'R)- and (5'S)-5',8-cyclo-2'-deoxyadenosine (cdA) in a CAG repeat tract caused CTG re

148 still accelerates in response to 2-chloro-2'-deoxyadenosine (Cl-dAdo).

149 ues, such as the antineoplastic, 2-chloro-2'-deoxyadenosine (cladribine) and puromycin, a protein syn

150 M-forming enzyme SalL tolerates 5'-chloro-5'-deoxyadenosine (ClDA) analogues modified at the 2-positi

151 The nucleoside analog 2-chloro-2'-deoxyadenosine (CldAdo; cladribine) is effective in the

152 f the clinical agent cladribine (2-chloro-2'-deoxyadenosine, CldAdo), which is the drug of choice aga

153 as indicated by the phosphate dependence of deoxyadenosine cleavage in T. brucei cell extracts and i

154 iated protection is less efficient at higher deoxyadenosine concentrations.

155 We show that N6-methyl deoxyadenosine-containing oligonucleotides can be enrich

156 -deoxyguanosine (cyclo-dG) and 8,5'-cyclo-2'-deoxyadenosine (cyclo-dA) in five different strains of E

157 ells, the oxidative DNA lesion 8,5'-cyclo-2'-deoxyadenosine (CydA) induces prolonged stalling of RNA

158 site-specific N2-deoxyguanosine (dG) and N6-deoxyadenosine (dA) adducts derived from BaP 7,8-diol 9,

159 ed benzo[a]pyrene 7,8-diol 9,10-epoxide (DE) deoxyadenosine (dA) adducts of known absolute configurat

160 l stable BPQ-deoxyguanosine (dG) and two BPQ-deoxyadenosine (dA) adducts.

161 has been utilized to synthesize covalent 2'-deoxyadenosine (dA) and 2'-deoxyguanosine (dG) adducts o

162 tereomeric pairs of diol epoxide-adducted 2'-deoxyadenosine (dA) and 2'-deoxyguanosine (dG) nucleosid

163 appreciable levels in vivo by deamination of deoxyadenosine (dA) and deoxyguanosine (dG), respectivel

164 uantitatively measure low levels of DNA base deoxyadenosine (dA) and its isotopologues (e.g., dA M+1)

165 NA nucleosides and their isotopologues (e.g. deoxyadenosine (dA) M + 1, dA M + 2, dA M + 3), as well

166 of the lesion directs misincorporation of 2'-deoxyadenosine (dA) opposite it.

167 nd benzo[c]phenanthrene (BcPh) DE adducts at deoxyadenosine (dA) or deoxyguanosine (dG) bases in four

168 specific bulky, covalent adducts at N(6) of deoxyadenosine (dA) or N(2) of deoxyguanosine (dG) on We

169 e report that BP adducts at the +1 and -2 N6-deoxyadenosine (dA) positions flanking the scissile phos

170 ol 9,10-epoxide were introduced at single N6-deoxyadenosine (dA) positions within the 3'-G+5G+4G+3A+2

171 cross-link between abasic (Ap) sites and 2'-deoxyadenosine (dA) residues was recently reported, but

172 richia coli DNA polymerase I incorporated 2'-deoxyadenosine (dA) six times more frequently than 2'-de

173 When the 2'-deoxyadenosine (dA) was substituted with adenosine (A),

174 es the initial conversion of the nucleosides deoxyadenosine (dA), deoxyguanosine (dG), and deoxycytid

175 re-mutagenic lesion prone to mispair with 2'-deoxyadenosine (dA).

176 n, was used to form a volatile derivative of deoxyadenosine (dA).

177 gen atom abstraction from the N6-amine of 2'-deoxyadenosine (dA*).

178 (6)-[3-methoxyestra-1,3,5(10)-trien-6-yl]-2'-deoxyadenosine (dA-N(6)-3MeE), which were embedded in si

179 exocyclic N(6)() amino group of the central deoxyadenosine, dA(6), through trans addition at C10 of

180 Deoxyadenosine (dAdo) is a DNA breakdown product that am

181 he radical was found to be located on the 2'-deoxyadenosine (dAdo) moiety of DNA.

182 rations of extracellular adenosine (Ado) and deoxyadenosine (dAdo).

183 e findings, we are naming this new enzyme 5'-deoxyadenosine deaminase (DadD).

184 strained by the limited compatibility of the deoxyadenosine deaminase component with Cas homologs oth

185 Deuterium transfer from substrate to deoxyadenosine demonstrated that the substrate radical i

186 eoxyribonucleosides, leading to a mixture of deoxyadenosine, deoxyinosine, cytidine and uridine.

187 Deoxyguanosine, deoxyadenosine, deoxythymidine, and deoxycytidine were u

188 various aryl iodides provides 8-arylated 2'-deoxyadenosine derivatives in good yields.

189 Cob(II)alamin and 5'-deoxyadenosine derived from 5'-deoxyadenosylcobalamin ar

190 f 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine did inhibit HIV-1 growth and infectivity,

191 ulates up to approximately 0.1-0.2% of total deoxyadenosine during early embryogenesis of vertebrates

192 s report we show that 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA), a nucleoside analog that retains

193 MK-8591 (4'-ethynyl-2-fluoro-2'-deoxyadenosine [EFdA]) is a novel reverse transcriptase-

194 tiffer on going from adenosylcobalamin to 5'-deoxyadenosine, even though the 5'-carbon remains formal

195 After attaching a 25-mer poly-2'-deoxyadenosine extension to these structures, unraveling

196 the nontoxic nucleoside analogue 2-fluoro-2'-deoxyadenosine (F-dAdo) is a "subversive substrate." Pho

197 The corresponding lesions derived from 2'-deoxyadenosine, Fapy.dA and 8-oxo-dA, were not detectabl

198 P), presumably by radical addition of the 5'-deoxyadenosine followed by oxidative decarboxylation to

199 ignificant difference is the substitution of deoxyadenosine for riboadenosine at A76, which mimics th

200 DNA on the 3' or the 5' side of the adducted deoxyadenosine for the 1S- and 1R-adducts, respectively.

201 etheno-2'-deoxycytidine and 1,N(6)-etheno-2'-deoxyadenosine, formed from 2,3-epoxyaldehydes of endoge

202 enes nuclease A to generate macrophage-toxic deoxyadenosine from DNA.

203 denosine and by H atom incorporation into 5'-deoxyadenosine from solvent exchangeable site.

204 a-HOPdG) and gamma-hydroxy-1,N(6)-propano-2'-deoxyadenosine (gamma-HOPdA).

205 f alkyl- or arylthiols to 7-vinyl-7-deaza-2'-deoxyadenosine gave a series of 7-[2-(alkyl- or arylsulf

206 ified by mass spectrometry as 5'-mercapto-5'-deoxyadenosine, generated by direct attack of the 5'-deo

207 lpha were mimicked by 2-chloro-adenosine >3'-deoxyadenosine> adenosine but not by a variety of other

208 zido-5'-(diaminobutyric acid)-N-iodoethyl-5'-deoxyadenosine, has been accomplished in 10 steps from c

209 responding modifications of thymidine and 2'-deoxyadenosine have not been assessed, though significan

210 h viperin reductively cleaves SAM to form 5'-deoxyadenosine in a slow, uncoupled reaction characteris

211 adenosine of the RTA depurination site with deoxyadenosine in a small RNA stem-loop increased k(cat)

212 capable of cleaving SAM to methionine and 5'-deoxyadenosine in an uncoupled reaction (k(obs) = 0.011

213 hree times higher than those of 8-hydroxy-2'-deoxyadenosine in pig liver DNA.

214 ional effects of AP sites substituted for 2'-deoxyadenosine in the first (ap7), second (ap13) or thir

215 mino group on a nearby 2-deoxyguanosine or 2-deoxyadenosine in the opposite strand.

216 aining a catalytically inactive analog of 2'-deoxyadenosine in which a single 2'-H atom was replaced

217 [2-(alkyl- or arylsulfanyl)ethyl]-7-deaza-2'-deoxyadenosines in 45-85% yields.

218 ing tools based on directed deamination of 2-deoxyadenosines in DNA/RNA hybrids.

219 by ADAR were used to target six different 2-deoxyadenosines in the M13 bacteriophage ssDNA genome.

220 sess the efficacy of cladribine (2-chloro-2'-deoxyadenosine) in the treatment of ECD.

221 Indeed, 3'-deoxyadenosine inhibits HIV-1 proviral DNA synthesis in

222 S-adenosylmethionine into methionine and 5'-deoxyadenosine is observed during the reaction.

223 fer of (3)H to AdoMet, while no tritiated 5'-deoxyadenosine is observed.

224 Deoxyadenosine is preferentially incorporated opposite C

225 also consistent with the contention that 5'-deoxyadenosine is the sole mediator of hydrogen transfer

226 za-2'-deoxyadenosine (c3dA), an analog of 2'-deoxyadenosine lacking the minor groove electron pair.

227 mumol/L (normal value, <1.5 mumol/L) and 2'-deoxyadenosine levels of 0.7, 2.7, and 2.4 mumol/L (norm

228 xtinction, the DNA modification N6-methyl-2'-deoxyadenosine (m6dA) accumulates along promoters and co

229 A novel DNA modification, N-6 methylated deoxyadenosine (m6dA), has recently been discovered in e

230 f 5'-(((Z)-4-amino-2-butenyl)methylamino)-5'-deoxyadenosine (MDL 73811), but not pentamidine, berenil

231 er membrane protein Ag43 in E. coli requires deoxyadenosine methylase (Dam) and OxyR.

232 hylated template DNA, which is essential for deoxyadenosine methylase (Dam)- and OxyR-dependent phase

233 Mutants in deoxyadenosine methyltransferase (dam) from many Gram-ne

234 activation is associated with loss of the 5'-deoxyadenosine moiety from the active site, precluding r

235 -yloxymethyl]-phosphonic acid) is a dAMP (2'-deoxyadenosine monophosphate) analog that maintains its

236 eoside monophosphate (uridine monophosphate, deoxyadenosine monophosphate, and adenosine monophosphat

237 syntheses of authentic N(6)-carboxymethyl-2'-deoxyadenosine (N(6)-CMdA) and N(4)-carboxymethyl-2'-deo

238 osine (O(6)-MedG), and N(6)-carboxymethyl-2'-deoxyadenosine (N(6)-CMdA).

239 re, although formaldehyde can result in N(6)-deoxyadenosine, N(2)-deoxyguanosine, and N(4)-deoxycytid

240 mmune function and less elevated erythrocyte deoxyadenosine nucleotides than his 4-year-old affected

241 oxyguanosine (OG) or an 8-oxo-7,8-dihydro-2'-deoxyadenosine (OA) nucleotide and Escherichia coli sing

242 rred from the methyl group of SAM2 to the 5'-deoxyadenosine of SAM1 and the other two hydrogens of th

243 ir of 7,8-dihydro-8-oxo-2'-deoxyguanosine-2'-deoxyadenosine (OG*A) mismatches in DNA.

244 ionarily conserved and were enriched in poly-deoxyadenosine or poly-deoxythymidine sequences.

245 ound that LGE(2) reacted with deoxycytidine, deoxyadenosine, or deoxyguanosine in vitro to form coval

246 xsA, reveals that OXT-A is derived from a 2'-deoxyadenosine phosphate in an OxsB-catalysed ring contr

247 ibitor of adenosine kinase, the major thymic deoxyadenosine phosphorylating enzyme, or with bcl-2 tra

248 ntroduced at single N2-deoxyguanosine and N6-deoxyadenosine positions within the 3'-G(+5)G(+4)G(+3)A(

249 conformational preferences of the 8-aryl-2'-deoxyadenosine products have been determined by detailed

250 3'-Amino-3'-deoxyadenosine proved to be 7-fold more potent at the H2

251 nificant accumulation of (5'R)-8,5'-cyclo-2'-deoxyadenosine (R-cdA) and (5'S)-8,5'-cyclo-2'-deoxyaden

252 enzyme able to reductively cleave SAM to 5'-deoxyadenosine radical and is competent in FeMo-co matur

253 5-methyl-2'-deoxycytidine and N(6)-methyl-2'-deoxyadenosine) representing epigenetic marks, and a str

254 Conversion of NETs to deoxyadenosine requires two enzymes, nuclease and adenos

255 or adenylate cyclase inhibitors, H89 and di-deoxyadenosine, respectively, indicating a cAMP-mediated

256 oxyadenosine (R-cdA) and (5'S)-8,5'-cyclo-2'-deoxyadenosine (S-cdA) in liver DNA of neil1(-/-) mice t

257 olites S-adenosylhomocysteine, adenosine, 5'-deoxyadenosine, S-methyl-5'-thioadenosine, methionine, a

258 age in T. brucei cell extracts and increased deoxyadenosine sensitivity in TbMTAP knockdown cells.

259 en C2'-endo and C2'-exo conformations at the deoxyadenosine site moves the 3'- and 5'-phosphorus atom

260 ence of a more flexible ribosyl group at the deoxyadenosine site.

261 series of duplex DNA substrates containing a deoxyadenosine stereospecifically modified by a covalent

262 rst native fluorination enzyme, 5'-fluoro-5'-deoxyadenosine synthase, from this organism.

263 analyzing the mode of action of 5'-fluoro-5'-deoxyadenosine synthase, the only known enzyme capable o

264 a duplex DNA containing an alpha-anomeric 2'-deoxyadenosine:T base pair.

265 her turnover number (kcat) and Km values for deoxyadenosine than for the regular substrate, methylthi

266 gene product catalyzes the conversion of 5'-deoxyadenosine to 5'-deoxyinosine as its major product b

267 we observe the 3'-hydroxyl of the conserved deoxyadenosine to be close to one of the two divalent me

268 thymine radical abstracts a hydrogen from 5'-deoxyadenosine to regenerate the 5'-deoxyadenosyl radica

269 the polyadenylation inhibitor cordycepin (3' deoxyadenosine) to inhibit inflammation as well as to re

270 lity contained truncations in the regulatory deoxyadenosine tract element (DATE) of the HGF gene prom

271 east poly(A) polymerase (PaP) to incorporate deoxyadenosine triphosphate (dATP) at the 3'-OH of an RN

272 plexes with either GS-9148-diphosphate or 2'-deoxyadenosine triphosphate (dATP), and a post-incorpora

273 nitrobenzyl group to the N(6)-position of 2'-deoxyadenosine triphosphate (dATP), which, upon incorpor

274 show that the metazoan protein IRBIT forms a deoxyadenosine triphosphate (dATP)-dependent complex wit

275 phocyte apoptosis by being phosphorylated to deoxyadenosine triphosphate (dATP).

276 onformation nucleotide North-methanocarba-2'-deoxyadenosine triphosphate (N-MC-dATP).

277 tion of the 7-(ferrocenylethynyl)-7-deaza-2'-deoxyadenosine triphosphate was optimised in terms of a

278 nce of metal ions (Pb(2+)), small molecules (deoxyadenosine triphosphate) and nucleic acids homologou

279 ormation at a physiological concentration of deoxyadenosine triphosphate.

280 ve dinucleosides composed of adenosine or 2'-deoxyadenosine units joined by flexible linkers were stu

281 Consistently, we find deoxyadenosine upstream from the most abundant genomic r

282 f the hydroxyl groups leading to 8-fluoro-2'-deoxyadenosine using TASF in methylene chloride demonstr

283 al method for efficient N(6)-arylation of 2'-deoxyadenosine via copper-catalyzed direct coupling with

284 netic isotope effect for the formation of 5'-deoxyadenosine was 0.76 +/- 0.02, which suggests a late

285 The Km for 5'-deoxyadenosine was found to be 14.0 +/- 1.2 muM with a k

286 he basal compartment, whereas that for (14)C-deoxyadenosine was from the basal to the apical compartm

287 In each case, no detectable arylation of 2'-deoxyadenosine was noted.

288 plicability in that only N(6)-(1-pyrenyl)-2'-deoxyadenosine was prepared by this method; on the other

289 ase IV (Endo IV) to efficiently incise alpha-deoxyadenosine was used as a tool to determine the confi

290 hich the cationic adduct was mismatched with deoxyadenosine, was refined using molecular dynamics cal

291 umol/L); the mean levels of adenosine and 2'-deoxyadenosine were respectively 12.0- and 27.6-fold hig

292 nases are involved in the phosphorylation of deoxyadenosine when ADA is absent, and suggests an alter

293 effects associated with the formation of 5'-deoxyadenosine when glutamate mutase was reacted with [5

294 e effect associated with the formation of 5'-deoxyadenosine when the enzyme is reacted with [5'-(3)H]

295 that DadD is involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5

296 pears to have a high binding affinity for 2'-deoxyadenosine, which explains the mandatory requirement

297 za-2'-deoxyadenosine (3DA), an analogue of 2-deoxyadenosine, which has the same HB pattern opposite T

298 escapes these defenses by converting NETs to deoxyadenosine, which triggers the caspase-3-mediated de

299 butyldiphenylsilyl 5'-protected 8-ethynyl-2'-deoxyadenosine with the corresponding bromoanthraquinone

300 Pd/Cu-mediated direct arylation of 2'-deoxyadenosine with various aryl iodides provides 8-aryl