ライフサイエンスコーパス: deoxygenate

1 without the need for reaction mixtures to be deoxygenated.

2 te an activated intermediate that is readily deoxygenated.

3 ymmetrical 1,2,3-triazine-1-oxides and their deoxygenated 1,2,3-triazine compounds, we report C-, N-,

4 Desymmetrization of 2-deoxygenated 4,6-dibenzylinositol was achieved using lip

5 [(ADC)Sn](2)(OC=O) is isolable but deoxygenates additional CO(2) to form [(ADC)Sn](2)(O(2)C

6 Conversion of normal deoxygenated, adult hemoglobin (HbA) in high concentrati

7 We found that the reaction of nitrite with deoxygenated AHb1 and AHb2 generates NO gas and iron-nit

8 These results demonstrate that deoxygenated AHb1 and AHb2 reduce nitrite to form NO via

9 Extensive dimerization of liganded but not deoxygenated alpha-cpbeta was observed by gel chromatogr

10 es were identified by HPLC/QToF-MS to be the deoxygenated analogs.

11 n efficiency), on par with that of the fully deoxygenated analogue.

12 etailed herein can be used to access both C4-deoxygenated and C4-oxygenated cladiellins and briarelli

13 structures of these two mutants in both the deoxygenated and CO-liganded states.

14 l coupling wherein two alcohol fragments are deoxygenated and coupled in one reaction vessel, open to

15 elementary steps by which carbon monoxide is deoxygenated and coupled, but a single metal site that c

16 alpha 103(G10) and His alpha 122(H5) in both deoxygenated and ligated hemoglobin by NMR spectroscopy.

17 re able to measure the migration velocity of deoxygenated and metHb-containing erythrocytes, exposed

18 ontrast microscopy to confirm aggregation of deoxygenated and oxygenated hemoglobins below their solu

19 The influent water was initially deoxygenated and the emissions and concentration distrib

20 Climate change is expected to warm, deoxygenate, and acidify ocean waters.

21 he synthesis of rare and unnatural branched, deoxygenated, and isomeric sugars.

22 asing H2 production over three times that of deoxygenated aqueous solutions alone.

23 hotosensitization by rose bengal (RB(2-)) in deoxygenated aqueous solutions resulting in one-electron

24 concentrations over TiO(2) under UV light in deoxygenated aqueous suspensions is described.

25 nly the ditriflate 8a gave the corresponding deoxygenated aromatic scaffold.

26 erfused for 20 min with neutrophil-depleted, deoxygenated blood in Perfadex solution.

27 lied by both the pulmonary arteries carrying deoxygenated blood originating from the right ventricle

28 of the Fontan circuit allows for shunting of deoxygenated blood to the systemic circulation.

29 was used to quantitatively measure oxy- and deoxygenated blood volume fraction at two time points: a

30 near proportional increase in oxygenated and deoxygenated blood volume fraction for healthy individua

31 lar resistance and right-to-left shunting of deoxygenated blood.

32 increases in blood volume were mainly due to deoxygenated blood.

33 imate change is heating surface waters while deoxygenating bottom waters of lakes, compressing vertic

34 lation of a C2-symmetric diol to form the C9-deoxygenated bryostatin A-ring.

35 We show that plasma from deoxygenated, but not from oxygenated, blood produces th

36 The halogenated products were deoxygenated by PCl3 or PBr3.

37 The monorhenium(VII) complex is deoxygenated by PMe2Ph to give the rhenium(V) compound (

38 o-6-deoxy hexoses, which in turn are further deoxygenated by the 2,3- and 3-dehydratases to form dide

39 thC moiety is an intermediate on the path to deoxygenated, C-C coupled products.

40 ynthetic strategy to access diverse 2- and 4-deoxygenated carbohydrates without relying on the exhaus

41 Thus, rapidly deoxygenated CDB3-bound hemoglobin alphabeta dimers reac

42 were increased in O2 compared with those in deoxygenated cells at the same free [Mg2+]i, by about 6-

43 l volume during incubation in vitro, whereas deoxygenated cells become dehydrated, and therefore more

44 K+-Cl- cotransport was minimal in deoxygenated cells but substantial in oxygenated ones.

45 Cl- cotransporter, was revealed by depleting deoxygenated cells of Mg2+.

46 ssess sickle cell deformability after mixing deoxygenated cells with buffer that was partially or ful

47 By contrast, in deoxygenated cells, although the transporter activity wa

48 s; that of the Gardos channel was greater in deoxygenated cells.

49 ulation of KCC was similar in oxygenated and deoxygenated cells; that of the Gardos channel was great

50 Z)-2-phenyl-4-aryliden-5(4H)-oxazolones 1 in deoxygenated CH(2)Cl(2) at 25 degrees C with blue light

51 [Mn2(L)(mcb)(Ru((CF3)2-bpy)2)](PF6)3 (4) in deoxygenated CH2Cl2 solution results in emission charact

52 Primary alcohols can be deoxygenated cleanly and in yields of 60-95% by reductio

53 together with 11-cis-13-cis-isomers and the deoxygenated compound (3EZ,5EZ,8E)-3,7-dimethyl-9-(2,6,6

54 system was found to afford the corresponding deoxygenated compounds.

55 near-steady benzene emission at the initial deoxygenated condition, the emission was reduced by abou

56 xide by red blood cells under oxygenated and deoxygenated conditions at different hematocrit percenta

57 rmal morphology and membrane mechanics under deoxygenated conditions due to the polymerization of hem

58 ned this reaction and found that under fully deoxygenated conditions the product stoichiometry is 1:1

59 Moreover, under deoxygenated conditions, conversion to the aromatic pyri

60 2.48%, n=5) were recorded in oxygenated and deoxygenated conditions, with response times of 2s and 5

61 ding selenenic ester, is also observed under deoxygenated conditions.

62 ing and improved rheological behaviors under deoxygenated conditions.

63 L and 17-20 mg/L, and then decreased back to deoxygenated conditions.

64 c cofactor that stabilizes the low-affinity, deoxygenated conformation of the hemoglobin tetramer.

65 me in the R (oxygenated conformation) and T (deoxygenated conformation) allosteric quaternary structu

66 otophysical properties of these molecules in deoxygenated cyclohexane, including their absorption spe

67 eep CNN exhibits good performance even for a deoxygenated dataset and distinguishes the subtle differ

68 tural oligosaccharides including methylated, deoxygenated, deoxyfluorinated, as well as carboxymethyl

69 The kinetics of CO binding to the deoxygenated derivatives following rapid mixing and of C

70 hese variants as well as the tendency of the deoxygenated derivatives to dissociate into alphabeta di

71 active at high concentration (1 mM), but the deoxygenated derivatives were inactive.

72 tiomerically pure haloconduritols or certain deoxygenated derivatives with either terminal alkynes or

73 that was capable of measuring oxygenated and deoxygenated (Dhb) hemoglobin specifically in the mucosa

74 In this investigation, sickle RBCs were deoxygenated either continuously or in 15-minute cycles

75 b+) influxes were measured in oxygenated and deoxygenated equine red blood cells, whose free [Mg2+]i

76 .18x10(-6)) but lower than that of the fully deoxygenated erythrocyte (3.33x10(-6)).

77 We find that deoxygenated erythrocytes scavenge nitric oxide faster t

78 te reductase activity of deoxyhemoglobin and deoxygenated erythrocytes.

79 Scavenging and deoxygenated experiments indicate that SO(4)(*-) radical

80 Nitrite is reduced by deoxygenated ferrous hemes, such that heme deoxygenation

81 ridged peroxide) can be fully reduced to the deoxygenated form with four equivalents of cobaltocene.

82 transitions from the oxygenated form to the deoxygenated form.

83 ydroxylated (haterumalides NC and ND) and C9 deoxygenated forms (haterumalides NA, NB, and NE; via de

84 fference in magnetism between oxygenated and deoxygenated forms of the protein and, along with consid

85 Deoxygenated GbX reduces nitrite to form nitric oxide (N

86 trate significantly different oxygenated and deoxygenated haemoglobin concentration changes in users'

87 namics/oxygenation (measuring oxygenated and deoxygenated haemoglobin), and metabolism (measuring the

88 m total Hb (tHb), oxygenated Hb (oxyHb), and deoxygenated Hb (deoxyHb) concentrations.

89 ated during crystallization experiments with deoxygenated Hb (deoxyHb): one crystal type was composed

90 lly, we show that intracellular S1P promotes deoxygenated Hb anchoring to the membrane, enhances the

91 0 v 26.5 mm Hg), and the lower solubility of deoxygenated Hb S Antilles than Hb S (approximately 11 v

92 udies, indicating that the polymerization of deoxygenated Hb S can be significantly slowed by relativ

93 hreonine at beta 87 in the polymerization of deoxygenated Hb S.

94 eous nitric oxide (NO) are equilibrated with deoxygenated Hb, all NO added can be accounted for in te

95 in the concentration of oxygenated (HbO) and deoxygenated (HbR) hemoglobin, holds promise to study fu

96 S (HbS), which is the concentration of fully deoxygenated HbS in equilibrium with polymer (C(SAT)), i

97 a ligand and is a good model for permanently deoxygenated heme.

98 rotocatechuic acid 3,4-dioxygenase system to deoxygenate hemoglobin solutions enzymatically.

99 ts: In Graves' disease, significantly higher deoxygenated hemoglobin (3.18 +/- 0.52 vs. 2.13 +/- 0.62

100 hemoglobin (oxy-Hb) was reduced (P<0.01) and deoxygenated hemoglobin (deoxy-Hb) showed a near signifi

101 cess, and that the reaction between GSNO and deoxygenated hemoglobin (deoxyHb) did not conform to sec

102 in (tHb), oxygenated hemoglobin (oxyHb), and deoxygenated hemoglobin (deoxyHb) were computed from the

103 Deoxygenated hemoglobin (HbR) and total hemoglobin (HbT)

104 elationships of cerebral blood volume (CBV), deoxygenated hemoglobin (Hbr), and light scatter (LS) as

105 globin (HbO2) and decreased concentration of deoxygenated hemoglobin (HHb) in the prefrontal cortex a

106 ed hemoglobin (O(2)Hb) decreased, and muscle deoxygenated hemoglobin (HHb) increased environmentally

107 entration, in comparison to COHbS, COHbA, or deoxygenated Hemoglobin A (HbA), none of which have the

108 10(-6) mm(3) s/kg for erythrocytes with 100% deoxygenated hemoglobin and 3.66 x 10(-6) mm(3) s/kg for

109 es to blood flow regulation by reaction with deoxygenated hemoglobin and tissue heme proteins to form

110 The reduction of nitrite by deoxygenated hemoglobin chains has been implicated in re

111 al hypoxia, significantly increased cerebral deoxygenated hemoglobin concentration (P < 0.01, d = 0.8

112 partial pressure of oxygen decreases and the deoxygenated hemoglobin formed reduces the nitrite regen

113 hanges in cortical oxygenated hemoglobin and deoxygenated hemoglobin inferring prefrontal activation

114 There was a 50% increase in deoxygenated hemoglobin on R0 and R8.

115 to formation of iron nitrosyl hemoglobin in deoxygenated hemoglobin preparations and a radical in ox

116 ggests that the reaction between nitrite and deoxygenated hemoglobin provides a mechanism by which ni

117 The solubility of deoxygenated hemoglobin S (HbS), which is the concentrat

118 Vaso-occlusion occurs when deoxygenated hemoglobin S polymerizes and erythrocytes s

119 Polymerization of deoxygenated hemoglobin S underlies the pathophysiology

120 derived from contributions of oxygenated and deoxygenated hemoglobin spectral signatures extracted fr

121 s at beta37 also alter the properties of the deoxygenated hemoglobin tetramer.

122 The reaction of deoxygenated hemoglobin with limited quantities of nitri

123 he presence of blood hypoxia (high levels of deoxygenated hemoglobin) in the liver and kidneys that w

124 ack to NO by the nitrite reductase action of deoxygenated hemoglobin, acidic disproportionation, or x

125 brosis, collagen, lipids, and oxygenated and deoxygenated hemoglobin, in a mouse model of steatotic f

126 functional biomarkers and tissue parameters deoxygenated hemoglobin, oxygenated hemoglobin, total he

127 d by concentration changes in oxygenated and deoxygenated hemoglobin, were assessed in the frontal co

128 and oxygenated hemoglobin, and decreases in deoxygenated hemoglobin.

129 hemoglobin and least pronounced for rapidly deoxygenated hemoglobin.

130 een this anion and the ferrous heme group of deoxygenated hemoglobin.

131 ing in considerable dissociation of even the deoxygenated hemoglobins into alphabeta dimers at microm

132 We show that deoxygenated human neuroglobin reacts with nitrite to fo

133 /unsymmetrical double-arylated products, and deoxygenated hydroarylated products could be synthesized

134 isation in cells from sickle trait patients (deoxygenated hyperosmotic sucrose solutions at pH 6) sup

135 which the amino inositol unit is cleaved and deoxygenated in a homologous fashion.

136 y of sickle cell disease; namely, that cells deoxygenated in the microcirculation are not merely unde

137 latelets were coincubated with RBCs and then deoxygenated in the presence of nitrite, export of NO bi

138 nce of human epithelial tissue as it becomes deoxygenated in vivo, we can resolve the fluorescence sp

139 erved the triplet-state lifetime of aqueous, deoxygenated indole and several indole derivatives to be

140 ients with sickle cell disease (SCD) lyse in deoxygenated isosmotic non-electrolyte solutions.

141 HbSC individuals showed progressive lysis in deoxygenated isosmotic sucrose solution at pH 7.4 to a l

142 n an in situ perfused mouse liver model with deoxygenated Krebs-Henseleit buffer followed by oxygenat

143 re we present the 2.9-A crystal structure of deoxygenated lamprey hemoglobin in an orthorhombic cryst

144 ver grafts from Lewis rats underwent HOPE or deoxygenated machine perfusion for 1 hour before implant

145 Molecular recognition using a series of deoxygenated maltose analogues was used to determine the

146 to those for simple nitric oxide binding to deoxygenated Mb and Hb.

147 After the training period, deoxygenated Mb kinetics during muscle contraction were

148 dation of ETBE by PPHA photosensitization in deoxygenated media (Lambda = 11 +/- 1).

149 nd accounts for up to 30% of the reaction in deoxygenated medium upon irradiation with polychromatic

150 e role of band 3 in mediating the oxygenated/deoxygenated metabolic transition was examined by treati

151 sis of 1-(3-alkynoxy)-9,10-anthraquinones in deoxygenated methanol leads to moderate yields (35-45%)

152 ubility behavior, and phase distributions of deoxygenated mixtures of Hb S with 70-kDa dextran, a rel

153 generation of NO. from nitrite reduction by deoxygenated myoglobin activates canonical soluble guany

154 We have shown that deoxygenated myoglobin in the heart can reduce nitrite t

155 In this study, we synthesized two bi-deoxygenated NAG, BNAG1 and BNAG2 and investigated their

156 We recently discovered that deoxygenated neuroglobin converts nitrite to nitric oxid

157 e always greater in oxygenated cells than in deoxygenated ones, and changes in free [Mg2+]i of the ma

158 .04 mM (mean +/- S.E.M., n = 5; P < 0.05) in deoxygenated ones.

159 , X=halide) demonstrate high efficiencies in deoxygenated organic solvents but do not function in air

160 cilitates the conversion of oxy-alphaHb to a deoxygenated, oxidized [Fe(III)], nonreactive form in wh

161 er oxygenated incubation or rapid oxygenated/deoxygenated (oxy/deoxy) cycling (70 seconds per cycle).

162 This effect was lost when deoxygenated perfusate was used.

163 Thus the deoxygenated permutated beta subunits generate an interm

164 Oxygenated PFE, but not deoxygenated PFE, resulted in PRU decreases to baseline

165 al additional streamlined total syntheses of deoxygenated PI analogues are reported.

166 pha(2)(P)beta(2)(S) does not polymerize when deoxygenated; pig alpha-chain completely neutralizes the

167 These reactants deoxygenate predominantly via decarbonylation (C-C cleav

168 rom beta-xylo-furanose affords exclusively a deoxygenated product; whereas, under the same reaction c

169 ed to pool blood from donors, detoxifies and deoxygenates pulmonary effluent blood, and permits exami

170 ss validation method both for oxygenated and deoxygenated RBCs.

171 texture alteration inside the oxygenated and deoxygenated RBCs.

172 sical basis of the wide variety of shapes of deoxygenated red cells from patients with sickle cell an

173 M (mean +/- s.e.m., n = 4) in oxygenated and deoxygenated red cells, respectively.

174 [Mg2+]i inhibited it, in both oxygenated and deoxygenated red cells.

175 s the radical-mediated elimination of H2O to deoxygenate ribonucleotides, an example of 'spin-centre

176 e of the pulmonary artery and aorta to guide deoxygenated right ventricular blood into the lungs and

177 en showed reduced photostability compared to deoxygenated samples.

178 K+ influx in fully deoxygenated sheep red cells showed substantial volume a

179 The rLbII was reversibly oxygenated/deoxygenated, showing that it is a functional hemoglobin

180 We found that the deformability of deoxygenated sickle cells did not regain its optimal val

181 port that increased erythrocyte S1P binds to deoxygenated sickle Hb (deoxyHbS), facilitates deoxyHbS

182 Deoxygenated sickle hemoglobin (HbS) polymerization driv

183 cell disease (SCD) is the polymerization of deoxygenated sickle hemoglobin (HbS).

184 ls (RBCs) stiffened by polymerized fibers of deoxygenated sickle hemoglobin.

185 kinetics of changes in the deformability of deoxygenated sickle red blood cells when they are expose

186 s in vivo, and transnitrosation reactions of deoxygenated SNO-Hb are proposed as a mechanism leading

187 ow oxygen tension if this were to occur from deoxygenated SNO-Hb.

188 ge of 3-5 in the air-saturated and partially deoxygenated solution are examined here.

189 While the use of deoxygenated solutions represents a partial remedy, it i

190 following excitation of the Ru complexes in deoxygenated solutions, the radiative (k(r)) and nonradi

191 Deoxygenated SS RBCs caused a persistent 1.5-fold PRU in

192 r obstruction was induced by the infusion of deoxygenated SS RBCs into ex vivo preparations with or w

193 ely 30% increase in solubility for the fully deoxygenated state, along with a significant increase in

194 denaturation, pentacoordinate in the ferrous deoxygenated state, and oxygen-avid.

195 In the deoxygenated state, polymerization of HbS leads to sickl

196 ty generated by hemoglobin S polymers in the deoxygenated state.

197 ling human hemoglobin between oxygenated and deoxygenated states.

198 Staurosporine (2 microM) inhibited deoxygenated-stimulated K+ influxes, but not those stimu

199 Interaction with AE1 promotes the deoxygenated structure in SNO-haemoglobin, which subserv

200 emoglobin [from the R (oxygenated) to the T (deoxygenated) structure] that releases the NO group.

201 e ability of Tyl1a and TylB to process a C-2 deoxygenated substrate and a CDP-linked substrate was al

202 the established chemical reduction routes to deoxygenate such oxo precursors produce tons of reagent

203 near physiological temperatures to occur in deoxygenated sucrose solutions at pH 7.4.

204 deoxy-beta-D-threo-hexopyranose) is a highly deoxygenated sugar component of several important natura

205 al sediment matrix consisting of pH-buffered deoxygenated sulfidic agar.

206 presented here suggest that the successively deoxygenated sulfur and nitrogen species produced during

207 imited by the binding of the first CO to the deoxygenated T state of the protein.

208 s a large effect on the beta subunits in the deoxygenated T state, but very little effect on the alph

209 rous variables besides the properties of the deoxygenated T state.

210 s increasingly difficult for subunits in the deoxygenated T-state tetramer to assume higher oxygen af

211 xchange rates were found to be higher in the deoxygenated-T than in ligated-R state.

212 exanes while tertiary silanes give partially deoxygenated tetraol and triol products.

213 Attempts were made to deoxygenate the 9,10-dimesylate, ditosylate, and ditrifl

214 While the condensation steps deoxygenate the alcohol components, the dehydrogenations

215 oposed where trialkylphsophine chalcogenides deoxygenate the oleic acid or phosphonic acid surfactant

216 the microcirculation, including 1 capable of deoxygenating the sRBC environment to monitor changes in

217 Triplet C ((3)P) atoms will deoxygenate to give CO plus CH(2) ((3)B(1)) as the major

218 ate in the synthesis of (-)-citrinadin A was deoxygenated to generate a dehydroxy compound that was e

219 cessing to fuels and chemicals or chemically deoxygenated to hydrocarbons.

220 both terminal and internal vicinal diols are deoxygenated to olefins in good yield.

221 paced to increase workload and perfusate was deoxygenated to study the effects of myocardial hypoxia.

222 sulting amino alcohol was alkylated and then deoxygenated using a Lewis acid and Et(3)SiH to give the

223 l-3,5-bisphosphate (PI3,5P2), and a range of deoxygenated versions are reported.

224 further demonstrated a stronger increase in deoxygenated versus oxygenated hemoglobin, suggesting a

225 Although mono-alcohols cleanly deoxygenate via dehydration under many conditions, polyo

226 ia characterised by diel fluctuations of hot-deoxygenated water coupled with tidally driven persisten

227 For deoxygenated water, T(2) is 3388 ms, water at ambient at

228 on and postprocessing of black phosphorus in deoxygenated water.

229 ries between 0.2 mM (oxygenated) and 0.6 mM (deoxygenated), well above the measured [Mg2+]i(1/2).

230 formation of long chains of hemoglobin when deoxygenated within capillary beds, resulting in sickle-