ライフサイエンスコーパス: deoxyguanosine

1 of ribose pseudorotation in guanosine and 2'-deoxyguanosine.

2 the telomeric DNA damage mediator 6-thio-2'-deoxyguanosine.

3 anscriptional markers but positive for 8-oxo-deoxyguanosine.

4 s factors are known to attack preferentially deoxyguanosine.

5 : thymidine > deoxyuridine >> deoxyinosine > deoxyguanosine.

6 sylase activity for the excision of 8-oxo-2'-deoxyguanosine.

7 in its apo form and in complex with 8-oxo-2'-deoxyguanosine.

8 pproximately 120-fold relative to unmodified deoxyguanosine.

9 s of PNPs and is essential for catabolism of deoxyguanosine.

10 dihydroxy-5,6-dihydrothymine, mispaired with deoxyguanosine.

11 ure of a 2'-dG-II aptamer domain bound to 2'-deoxyguanosine.

12 -2'-deoxyguanosine, and (5'-S)-8,5'-cyclo-2'-deoxyguanosine.

13 ycoside cleavage in 2'-deoxyadenosine and 2'-deoxyguanosine.

14 r to those observed for 8-oxo-7,8-dihydro-2'-deoxyguanosine.

15 dition to increased urine secretion of 8-oxo-deoxyguanosine.

16 ass that most tightly bind the nucleoside 2'-deoxyguanosine.

17 -deoxyuridine, 2'-deoxyuridine, and 8-oxo-2'-deoxyguanosine.

18 were active against the hydroxylation of 2'-deoxyguanosine.

19 anosine from oxidation; and 1,N(2)-etheno-2'-deoxyguanosine, 1,N(6)-etheno-2'-deoxyadenosine and 3,N(

20 Using a fused-core silica column, 2'-deoxyguanosine (2dG) and 5-methyl-2'-deoxycytidine (5mdC

21 xycytidine (5mdC) to the internal standard 2-deoxyguanosine (2dG) in mass signal were used to quantif

22 llyl-3',5'-di-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine (3) and of the 6-amino group of 3',5'-di-

23 hes for the synthesis of 2'-C-beta-methyl-2'-deoxyguanosine (3) via 2'-radical deoxygenation.

24 llyl-3',5'-di-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine (3).

25 e and showed sigmoidal enzyme kinetics (K0.5(deoxyguanosine) = 302 +/- 12 mum; kcat = 14 min(-1)).

26 changes was the accumulation of 8-hydroxy-2'-deoxyguanosine, 4-hydroxynonenal protein adducts, and ni

27 hy/mass spectrometry to measure 8-hydroxy-2'-deoxyguanosine, (5'-S)-8,5'-cyclo-2'-deoxyadenosine, (5'

28 oumarin tags to the terminal phosphate of 2'-deoxyguanosine-5'-tetraphosphate.

29 nt with a telomere-targeting drug, 6-thio-2'-deoxyguanosine (6-thio-dG), leads to tumor regression th

30 oside analogue DNA damage mediator 6-thio-2'-deoxyguanosine (6-thio-dG).

31 8-Nitro-2'-deoxyguanosine (8-nitrodG) is a relatively unstable, mut

32 ly and nitratively damaged DNA (8-hydroxy-2'-deoxyguanosine (8-OHdG) and 8-nitroguanine (8-NO2Gua)) a

33 n urinary biomarkers of oxidant stress, 8-OH deoxyguanosine (8-OHdG) and F2-isoprostane, and measures

34 8-Hydroxy-2'-deoxyguanosine (8-OHdG) and human neutrophil elastase/al

35 this design was validated using 8-hydroxy-2'-deoxyguanosine (8-OHdG) and prostate specific antigen (P

36 er sensor for quantifying urine 8-hydroxy-2'-deoxyguanosine (8-OHdG) as a biomarker for diabetic reti

37 fluid (GCF) and salivary levels of 8-hydroxy-deoxyguanosine (8-OHdG) as a marker of oxidative deoxyri

38 on of 2'-deoxyguanosine to give 8-hydroxy-2'-deoxyguanosine (8-OHdG) as assessed by RP-HPLC (MS).

39 is presented to monitor urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) down to the pmol/L level.

40 An 8-hydroxy-2'-deoxyguanosine (8-OHdG) ELISA assay was used to quantify

41 We also measured 8-hydroxy-2-deoxyguanosine (8-OHdG) levels as a marker of oxidative

42 bstrate (Gel-BSA-OHG) to adhere 8-hydroxy-2'-deoxyguanosine (8-OHdG) to the polystyrene plate and ass

43 authors examined whether urinary 8-hydroxy-2-deoxyguanosine (8-OHdG), a biomarker of global DNA oxida

44 issue sections were stained for 8-hydroxy-2' deoxyguanosine (8-OHdG), an indicator of hydroxyl radica

45 vention for assessing levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), an oxidative DNA damage biomark

46 d their levels of OS biomarkers 8-hydroxy-2'-deoxyguanosine (8-OHdG), superoxide dismutase (Cu-Zn SOD

47 d a marker of oxidative stress, 8-hydroxy-2'-deoxyguanosine (8-OHdG), were determined in these sample

48 tDNA damage is the formation of 8-hydroxy-2'-deoxyguanosine (8-OHdG), which can cause mutations when

49 peroxidation; (ii) formation of 8-hydroxy-2'-deoxyguanosine (8-OHdG); (iii) decrease in proliferating

50 peripheral blood leukocytes and 8-hydroxy-2'-deoxyguanosine (8-OHDG; an oxidative DNA damage marker)

51 nt of oxidative DNA lesions such as 8-oxo-2'-deoxyguanosine (8-oxo-dG) and 8-oxo-2'-deoxyadenosine (8

52 ly insert dAMP opposite 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-oxo-dG) during translesion DNA synthes

53 8-oxo-7,8-dihydroxy-2'-deoxyguanosine (8-oxo-dG) has high mutagenic potential a

54 VB-induced formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG) in vivo.

55 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-oxo-dG) is one of the most common oxid

56 d DNA strand breaks and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dGuo) formation) in human lung cel

57 by the comet assay) and 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-oxo-dGuo).

58 ative stress biomarkers 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and malondialdehyde were measur

59 d of deoxyribonucleotides, opposite 8-oxo-2'-deoxyguanosine (8-oxodG) are efficiently ligated and the

60 oxidation in DNA, with 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) as a major product.

61 In the presence of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) damage, many DNA polymerases ex

62 7,8-Dihydro-8-oxo-2'-deoxyguanosine (8-oxodG) is a well-known marker of oxida

63 8-Oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) is one of the major DNA modific

64 8-Oxo-2'-deoxyguanosine (8-oxodG) is one of the most important ox

65 8-Hydroxy-7,8-hydro-2'-deoxyguanosine (8-oxodG) is selectively oxidized by [Os(

66 DNA oxidation sites, and 8-oxo-7,8-dihydro-2-deoxyguanosine (8-oxodG) is the initial product.

67 idative stress, urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) is the most frequently measured

68 ion of Akt and tuberin, 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) levels, and 8-oxoG-DNA glycosyl

69 icularly in hydrolysing 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) present at 3'-end of DNA.

70 lls generates mutagenic 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-oxodG), which may initiate diseases re

71 Addition of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo) as a sacrificial reductant re

72 7,8-Dihydro-8-oxo-2'-deoxyguanosine (8-oxoG) is a major lesion that is a cons

73 mutation due to oxidative damage is 8-oxo-2'-deoxyguanosine (8-oxoG) mispairing with adenine (Ade), w

74 rom oxidative stress is 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxoG) that has ambiguous coding potent

75 The oxidized nucleotide, 8-oxo-7,8-dihydro-2-deoxyguanosine (8-oxoG), is one of the most abundant DNA

76 NA synthesis, including 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-oxoG), one of the most abundant DNA le

77 es (ROS), primarily as 7, 8-dihydro-8-oxo-2'-deoxyguanosine (8-oxoG), which is repaired by 8-oxoguani

78 major oxidative adduct 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-oxoG).

79 n [NGAL]) and oxidative stress (8-hydroxy-2'-deoxyguanosine [8-OHdG] and F2-isoprostane).

80 suitably sized cations like K(+), 8-aryl-2'-deoxyguanosine (8ArG) derivatives self-assemble into set

81 change from baseline in urinary 8-hydroxy-2'-deoxyguanosine (8OH2'dG), a marker of oxidative DNA dama

82 ed here to the determination of 8-hydroxy-2'-deoxyguanosine (8OHdG), a biomarker of oxidative stress

83 rotocol relies on the addition of 7-deaza-2'-deoxyguanosine, a dGTP analog to the PCR mixture and a n

84 comitant increase in the production of 8-oxo-deoxyguanosine, a marker for oxidative DNA damage, in hu

85 factor 2, and increased 8-oxo-7,8-dihydro-2'-deoxyguanosine, a marker of DNA damage.

86 associated with reduced (P<0.01) 8-hydroxy-2-deoxyguanosine, a marker of oxidative stress.

87 e-mediated telomere targeting agent 6-thio-2'deoxyguanosine abrogates colony growth in these late pas

88 highly mutagenic imidazole ring-opened AFB1-deoxyguanosine adduct (AFB1-Fapy-dG).

89 (TLS) DNA polymerases in bypassing the C8-2'-deoxyguanosine adduct (dG-C8-IQ) formed by 2-amino-3-met

90 hyl-3H-imidazo[4,5-f]quinolin-2-yl)amino]-2'-deoxyguanosine adduct (IQ) at the third guanine in the N

91 y demonstrated that the peroxidation-derived deoxyguanosine adduct, 3-(2-deoxy-beta-D-erythropentofur

92 eloped and validated using an O(6)-methyl-2'-deoxyguanosine adduct, which induced the expected GC-->A

93 and gamma-hydroxy-1, N(2)-cyclic propano-2'-deoxyguanosine adducts (alpha-OH-Acr-dG and gamma-OH-Acr

94 y in vivo and in vitro, forming six major MC-deoxyguanosine adducts of known structures.

95 tructural and biological impact of 8-aryl-2'-deoxyguanosine adducts, an efficient protocol is require

96 tion protocols were developed for 7-deaza-2'-deoxyguanosine affording the 7- and 8-iodo isomers.

97 The novel 2'-deoxyguanosine analog Entecavir (ETV) is a potent inhibi

98 Entecavir (ETV; Baraclude) is a novel deoxyguanosine analog with activity against hepatitis B

99 cleotides containing 7-octadiynyl-7-deaza-2'-deoxyguanosine and 5-octadiynyl-2'-deoxycytidine with un

100 f oxidative DNA damage, namely, 8-hydroxy-2'-deoxyguanosine and 8,5'-cyclopurine-2'-deoxynucleosides.

101 Plasma levels of 8-hydroxy-2'-deoxyguanosine and 8-isoprostane were examined in the co

102 Levels of plasma 8-hydroxy-2'-deoxyguanosine and 8-isoprostane were significantly high

103 on of BPDE-N(2)-dG, an adduct formed between deoxyguanosine and a diol epoxide metabolite of BaP, wit

104 DNA and the DNA lesions 7,8-dihydro-8-oxo-2'-deoxyguanosine and cyclobutane pyrimidine dimer but with

105 mitochondrial oxidative stress (8-hydroxy-2' deoxyguanosine and glutathione depletion), mitochondrial

106 en assessed, which has revealed that both 2'-deoxyguanosine and guanosine are incompatible with the P

107 increased levels of the heptanone-etheno-2'-deoxyguanosine and heptanone-etheno-2'-deoxycytidine add

108 ine as the analogues of N(7)-hydroxyethyl-2'-deoxyguanosine and N(7)-oxoethyl-2'-deoxyguanosine, resp

109 nd synthesis of N(7)-hydroxyethyl-9-deaza-2'-deoxyguanosine and N(7)-oxoethyl-9-deaza-2'-deoxyguanosi

110 Folate ester derivatives of O6-benzyl-2'-deoxyguanosine and of O6-[4-(hydroxymethyl)benzyl]guanin

111 as shown as increased levels of 8-hydroxy-2'-deoxyguanosine and p53 protein.

112 variable ability to discriminate between 2'-deoxyguanosine and riboguanosine, suggesting that a subs

113 an RSQXE motif; it was also shown to target deoxyguanosine and showed sigmoidal enzyme kinetics (K0.

114 ts two different equilibrium patterns toward deoxyguanosine and thymidine substrates.

115 dgt gene catalyses the hydrolysis of dGTP to deoxyguanosine and triphosphate.

116 mmon oxidative DNA lesions, such as 8-Oxo-2'-deoxyguanosines and UV light-induced DNA damage, faithfu

117 ced increases in damage to DNA (8-hydroxy-2'-deoxyguanosine) and proteins (nitrotyrosinylation).

118 yclo-2'-deoxyadenosine, (5'-R)-8,5'-cyclo-2'-deoxyguanosine, and (5'-S)-8,5'-cyclo-2'-deoxyguanosine.

119 its natural substrates, 2'-deoxycytidine, 2'-deoxyguanosine, and 2'-deoxyadenosine.

120 The deamination of 2'-deoxyadenosine, 2'-deoxyguanosine, and 2'-deoxycytidine led to accelerated

121 Each enzyme class (deoxycytidine, deoxyguanosine, and deoxythymidine kinases, as well as t

122 bituric acid reactive substances, 8-hydroxy--deoxyguanosine, and H2O2 and plasma thiobarbituric acid

123 hyde can result in N(6)-deoxyadenosine, N(2)-deoxyguanosine, and N(4)-deoxycytidine adducts in vitro.

124 , measured as reactive oxygen species, 8-oxo-deoxyguanosine, and protein carbonyls formation, were gr

125 ause a specificity switch from guanine to 2'-deoxyguanosine, and to impart an altered structure for a

126 N7-Alkyl-2'-deoxyguanosines are major adducts in DNA that are genera

127 binding factor, RNA polymerase II, and 8-oxo-deoxyguanosine as markers of recent incorporation, trans

128 -deoxyguanosine and N(7)-oxoethyl-9-deaza-2'-deoxyguanosine as the analogues of N(7)-hydroxyethyl-2'-

129 hesis of the cis adducts of BaP DE-2 with 2'-deoxyguanosine as well as the first synthesis of both dA

130 that C forms a non-perturbing base pair with deoxyguanosine, as designed.

131 Individual 2'-deoxyguanosines at positions dG5, dG10, dG14 and dG15 of

132 sourea, with O6-benzyl-3'-O-(gamma-folyl)-2'-deoxyguanosine being most active.

133 fer from a previously identified class of 2'-deoxyguanosine binding riboswitches, we have solved the

134 odification at these sites with N2-benzyl-2'-deoxyguanosine (BndG) blocked interaction with PKR's dsR

135 yrimidine dimers (CPDs) and BaP diol epoxide-deoxyguanosine (BPDE-dG), which are removed from the gen

136 and deaminates exclusively guanosine and 2'-deoxyguanosine but no other aminated purines, pyrimidine

137 at accurately bypasses some damaged forms of deoxyguanosine, but also generates single-base deletion

138 ers by 40% (P < 0.0002) and for 8-hydroxy-2'-deoxyguanosine by 61% (P < 0.01 compared with vehicle co

139 anosine caps, but is not adept at removing a deoxyguanosine cap.

140 9-Deaza-2'-deoxyguanosine (CdG) is a C-nucleoside and an analogue o

141 lo-2'-deoxyadenosine (cdA) and 5',8-cyclo-2'-deoxyguanosine (cdG) pairs that have been detected in ce

142 lo-2'-deoxyadenosine (cdA) and 8,5'-cyclo-2'-deoxyguanosine (cdG) tandem lesions.

143 principal DNA-AGE, N(2)-(1-carboxyethyl)-2'-deoxyguanosine (CEdG), is formed as a mixture of R and S

144 marker of oxidative DNA damage, 8-hydroxy-2'-deoxyguanosine, colocalized to mitochondria, indicating

145 aggression; more specifically, 8-hydroxy-2'-deoxyguanosine correlated with measures reflecting a his

146 lammatory molecules containing deoxycytosine-deoxyguanosine (CpG).

147 Cyclic crotonaldehyde-derived deoxyguanosine (CrA-PdG) adducts can undergo ring openin

148 cluding (5'S) diastereomers of 8,5'-cyclo-2'-deoxyguanosine (cyclo-dG) and 8,5'-cyclo-2'-deoxyadenosi

149 amido-2-iminohydantoin (d2Ih), 5',8-cyclo-2'-deoxyguanosine (cyclo-dG), and the free base guanine (Gu

150 The adduct derived from attack of 2'-deoxyguanosine (d-G) on 11, 28, is a familiar C-8 adduct

151 ance assignment at NA of a self-assembled 2'-deoxyguanosine derivative presenting two different molec

152 9-beta-D-arabinofuranosylguanine (ara-G), a deoxyguanosine derivative.

153 Specifically, two isomeric 8-aryl-2'-deoxyguanosine derivatives with a transposed pair of met

154 ct nucleotide opposite some N(2)-modified 2'-deoxyguanosine derivatives.

155 tochondria has the function of recycling the deoxyguanosine derived from endogenous dGTP degraded by

156 8-Substituted 7-deaza-2'-deoxyguanosines destabilize canonical (aps) DNA as well

157 esize covalent 2'-deoxyadenosine (dA) and 2'-deoxyguanosine (dG) adducts of benzo[a]pyrene (BaP) seri

158 Deoxyguanosine (dG) adducts of the PAH benzo[a]pyrene (B

159 e limit of quantification (LOQ) of the major deoxyguanosine (dG) adducts of these carcinogens ranged

160 lysis of oxygen (O)-linked biaryl ether 8-2'-deoxyguanosine (dG) adducts produced by phenolic toxins

161 electronic properties of C(8)-heteroaryl-2'-deoxyguanosine (dG) adducts with C(8)-substituents consi

162 yntheses of all three epimeric lesions of 2'-deoxyguanosine (dG) and liquid chromatography-tandem mas

163 te characterization of four novel stable BPQ-deoxyguanosine (dG) and two BPQ-deoxyadenosine (dA) addu

164 .) ) has long been believed to react with 2'-deoxyguanosine (dG) generating 2'-deoxyguanosin-N1-yl ra

165 hazardous air pollutant, reacts readily with deoxyguanosine (dG) in DNA to produce cyclic 1, N2-propa

166 (benzyl, naphthyl, anthracenyl, and pyrenyl)-deoxyguanosine (dG) modified phosphoramidite building bl

167 oxide-adducted 2'-deoxyadenosine (dA) and 2'-deoxyguanosine (dG) nucleosides.

168 bonucleoside (dSp) lesions resulting from 2'-deoxyguanosine (dG) or 8-oxo-7,8-dihydro-2'-deoxyguanosi

169 s spectrometry confirmed that 100% of the 2'-deoxyguanosine (dG) residues are replaced by modified ba

170 FdC was quantitated and reported relative to deoxyguanosine (dG) since dG is the complementary base f

171 DNA showing a preference for reaction at 2'-deoxyguanosine (dG) sites.

172 Four-electron oxidation of 2'-deoxyguanosine (dG) yields 5-guanidinohydantoin (dGh) as

173 sion of the nucleosides deoxyadenosine (dA), deoxyguanosine (dG), and deoxycytidine (dC) into their m

174 Like 2'-deoxyguanosine (dG), CdG should form a stable base pair

175 vo by deamination of deoxyadenosine (dA) and deoxyguanosine (dG), respectively, and can miscode.

176 pon oxidation of the heterocyclic ring in 2'-deoxyguanosine (dG), the initial electrophilic intermedi

177 favored one-electron oxidation product of 2'-deoxyguanosine (dG), the most readily oxidized native nu

178 cognize guanine/hypoxanthine, adenine, or 2'-deoxyguanosine (dG).

179 ents that form adducts at the N2-position of deoxyguanosine (dG).

180 Platinum-modified 2'-deoxyguanosine, dG, and several dinucleotide fragments,

181 n ranged from 57% to 89% and steady-state 2'-deoxyguanosine (dGuo) concentration median was 1.8 micro

182 However, if deoxyguanosine (dGuo) is limited in host tissue, the enz

183 lpha)-acetyllysine methyl ester (Lys) and 2'-deoxyguanosine (dGuo) was used to study structural aspec

184 containing CpG (unmethylated deoxycytidylyl-deoxyguanosine dinucleotide) motifs activate endosomal T

185 cid and synthetic unmethylated deoxycytidine-deoxyguanosine dinucleotides, which mimic bacterial DNA,

186 al X-ray analysis of 7-iodo-5-aza-7-deaza-2'-deoxyguanosine displayed intermolecular iodo-oxygen inte

187 and dose-dependent increase in 8-hydroxy-2'-deoxyguanosine DNA adducts consistent with cumulative RO

188 y of bulky and potentially carcinogenic N(2)-deoxyguanosine DNA adducts in human cells.

189 ich is related to HSV1-TK and phosphorylates deoxyguanosine, does not accept acyclic guanine analogue

190 -deoxyguanosine (dG) or 8-oxo-7,8-dihydro-2'-deoxyguanosine (dOG) oxidation have generated much atten

191 In fact, addition of deoxyguanosine during the 5-FC incubation reverses the d

192 ning the genotoxic lesion 1, N (2)-etheno-2'-deoxyguanosine (epsilonG), paired to dC.

193 N(2)-Furfuryl-deoxyguanosine (fdG) is carcinogenic DNA adduct that ori

194 ne (MeFapy-dG) arises from N7-methylation of deoxyguanosine followed by imidazole ring opening.

195 Substituting deoxyguanosine for G, to eliminate this hydrogen bond, r

196 osine from nitrosative deamination; 8-oxo-2'-deoxyguanosine from oxidation; and 1,N(2)-etheno-2'-deox

197 purified and tested by replicating DNA past deoxyguanosine (G) or 8-oxoG.

198 stigated the 10S (+)-trans-anti-[BP]-N(2)-2'-deoxyguanosine (G*) adduct in double-stranded DNA.

199 cts, such as gamma-hydroxy-1,N(2)-propano-2'-deoxyguanosine (gamma-HOPdG) and gamma-hydroxy-1,N(6)-pr

200 at TiO(2) nanoparticles induced 8-hydroxy-2'-deoxyguanosine, gamma-H2AX foci, micronuclei, and DNA de

201 lo-2'-deoxyadenosine (cdA) and 8,5'-cyclo-2'-deoxyguanosine generated in DNA by both endogenous oxida

202 on of a series of C8-arylamine adducts of 2'-deoxyguanosine has been examined.

203 enal-derived DNA-adduct, heptanone-etheno-2'-deoxyguanosine (HepsilondGuo) from 2.41 +/- 0.35 to 6.31

204 acted with deoxycytidine, deoxyadenosine, or deoxyguanosine in vitro to form covalent adducts with a

205 thyl-deoxyCytidine, 2,6-Diaminopurine or Iso-deoxyGuanosine) in place of the standard T, C, A or G to

206 A minor groove on the 3'-side of the modifed deoxyguanosine, in the DB[a,l]P-derived adduct the DB[a,

207 Deoxyguanosine is a weaker substrate than deoxyinosine,

208 yrene (BaP DE-2) by 2'-deoxyadenosine and 2'-deoxyguanosine is described.

209 inding pocket is distorted, and the adducted deoxyguanosine is in a syn conformation, exposing its Ho

210 Deoxyguanosine kinase (dGK) is an essential rate-limitin

211 can be phosphorylated inside mitochondria by deoxyguanosine kinase (dGK) or degraded in the cytosol b

212 uranosyl-guanine ([(18)F]F-AraG)-for dCK and deoxyguanosine kinase (dGK), a dCK-related mitochondrial

213 athway, encoded by the nuclear gene encoding deoxyguanosine kinase (DGUOK).

214 ucleotide reductase, thymidine kinase 2, and deoxyguanosine kinase by siRNA transfection to examine h

215 current findings implicate these effects on deoxyguanosine kinase in the causal mechanism.

216 ertension in a subset of patients and lowers deoxyguanosine kinase levels in vitro; the current findi

217 rare homozygous p.N46S mutation in DGUOK, a deoxyguanosine kinase required for mitochondrial DNA rep

218 in [N(2)-methyl-(1,3-dimethoxyanthraquinone)-deoxyguanosine, LdG] embedded DNAs utilizing phosphorami

219 The 8,5'-cyclo-2'-deoxyguanosine lesion (cdG) has been recently reported t

220 by incomplete repair of closely spaced 8-oxo-deoxyguanosine lesions, whereas the cytotoxicity of amin

221 staining assay and by measuring 8-hydroxy-2'-deoxyguanosine levels and, as a genetic instability endp

222 logical and functional changes, 8-hydroxy-2'-deoxyguanosine levels in total DNA, mtDNA deletions, and

223 extracts and by increased serum 8-hydroxy-2'-deoxyguanosine levels in vivo in rats.

224 Furthermore, the N(2)-ethylidene-2'-deoxyguanosine levels increased in both Aldh2-knockout m

225 H2 sharply diminished the N(2)-ethylidene-2'-deoxyguanosine levels.

226 Oxidation of deoxyguanosine/lysine mixtures with Na2IrCl6 or sulfate

227 on was performed on both the malondialdehyde-deoxyguanosine (M(1)dG) adduct and the O(6)-carboxymethy

228 N7-Methyl-2'-deoxyguanosine (m7dG) is the predominant lesion formed b

229 ylation is the genotoxic lesion N7-methyl-2'-deoxyguanosine (m7dG).

230 henanthriplatin binds more effectively to 5'-deoxyguanosine monophosphate than to N-acetyl methionine

231 G-->A mutations at N(2)-(1-carboxyethyl)-2'-deoxyguanosine (N(2)-CEdG) and N(2)-carboxymethyl-2'-deo

232 es the formation of N(2)-(1-carboxyethyl)-2'-deoxyguanosine (N(2)-CEdG) as the major stable DNA adduc

233 nosine (N(2)-CEdG) and N(2)-carboxymethyl-2'-deoxyguanosine (N(2)-CMdG) sites.

234 DNA to form adducts, including N(2)-ethyl-2'-deoxyguanosine (N(2)-Et-dG).

235 ribonucleotides, the DNA adduct N (7)-methyl deoxyguanosine (N(7) -CH(3) dG) is one of the most abund

236 n for 48 hours were evaluated for (E)-alpha-(deoxyguanosine-N(2)-yl)-tamoxifen (dG-N(2)-TAM) adduct f

237 idence has shown that N2-(1-carboxyethyl)-2'-deoxyguanosine (N2-CEdG) is a major marker for AGE-linke

238 We prepared N7-methyl-2'-deoxyguanosine (N7mdG)-containing DNA using a transition

239 (dPer) recognizes in DNA the O(6)-benzyl-2'-deoxyguanosine nucleoside (O(6)-Bn-dG), formed by exposu

240 ses in bypassing major-groove O (6)-alkyl-2'-deoxyguanosine (O (6)-alkyl-dG) and minor-groove N (2)-a

241 O (6)-alkyl-2'-deoxyguanosine (O (6)-alkyl-dG) lesions are among the mo

242 eous quantification of O(6)-carboxymethyl-2'-deoxyguanosine (O(6)-CMdG), O(6)-methyl-2'-deoxyguanosin

243 '-deoxyguanosine (O(6)-CMdG), O(6)-methyl-2'-deoxyguanosine (O(6)-MedG), and N(6)-carboxymethyl-2'-de

244 O(6)-Methyl-2'-deoxyguanosine (O(6)-MeG) is a ubiquitous DNA lesion, fo

245 ding bulky O(6)-[4-oxo-4-(3-pyridyl)but-1-yl]deoxyguanosine (O(6)-POB-dG) lesions.

246 ons of O(6)-[4-(3-pyridyl)-4-oxobut-1-yl]-2'-deoxyguanosine (O(6)-POBdG) as well as O(2)- and O(4)-[4

247 e (M(1)dG) adduct and the O(6)-carboxymethyl-deoxyguanosine (O(6)CMdG) adduct to demonstrate the appl

248 arly evolution of life, 8-oxo-7,8-dihydro-2'-deoxyguanosine (O) may have functioned as a proto-flavin

249 analogue of the abundant promutagen 8-oxo-2'-deoxyguanosine (OdG).

250 o-2H-oxal-5-one (Z) and 8-oxo-7,8-dihydro-2'-deoxyguanosine (OG) in double stranded DNA.

251 8-Oxo-7,8-dihydro-2'-deoxyguanosine (OG), a prevalent product of oxidative st

252 tissue, to oxidize E2 in the presence of 2'-deoxyguanosine or 2'-deoxyadenosine.

253 with the exocyclic amino group on a nearby 2-deoxyguanosine or 2-deoxyadenosine in the opposite stran

254 d templates or DNA lesions, such as 8-oxo-2'-deoxyguanosine or cyclobutane pyrimidine dimer, even in

255 nucleobase, specifically 8-(4'-phenylethynyl)deoxyguanosine, or EG, have been investigated.

256 measures the lifetime cerebral 8-hydroxy-2'-deoxyguanosine (oxo8dG) levels and the activity of the D

257 The modified base 8-oxo-7,8-dihydro-2'-deoxyguanosine (oxoG) is a common DNA adduct produced by

258 have synthesized for the first time the 6-Se-deoxyguanosine phosphoramidite and incorporated it into

259 ss (urinary malondialdehyde and 8-hydroxy-2'-deoxyguanosine, plasma fibrinogen, and white blood cells

260 y 6 and 24 hours, the number of 8-hydroxy-2'-deoxyguanosine-positive cells were approximately 59% (P

261 The number of 8-hydroxy-2'-deoxyguanosine-positive cells were decreased before UV i

262 ation in oxidative stress (i.e., 8-hydroxy-2-deoxyguanosine) prior to sleep onset was correlated to L

263 th the oxidative damage markers 8-hydroxy-2'-deoxyguanosine (r = 0.53, P < 0.001) and prostaglandin F

264 ine nucleoside phosphorylase did not improve deoxyguanosine recycling by dGK in WT cells.

265 The deoxyguanosine released by SAMHD1 from dGTP can be phosp

266 ucts, base propenal or malondialdehyde, with deoxyguanosine residues in DNA.

267 pomethylating dinucleotide of decitabine and deoxyguanosine resistant to degradation by cytidine deam

268 ethyl-2'-deoxyguanosine and N(7)-oxoethyl-2'-deoxyguanosine, respectively.

269 which was validated as a second class of 2'-deoxyguanosine riboswitch (called 2'-dG-II).

270 asurement of the level of S(6)-methylthio-2'-deoxyguanosine (S(6)mdG) in DNA of cells treated with th

271 ) method and measured the level of 6-thio-2'-deoxyguanosine ((S)dG) and S(6)mdG in genomic DNA of fou

272 lyl residues on the properties of 7-deaza-2'-deoxyguanosine, such as fluorescence, sugar conformation

273 e for N(2)-(trans-methylisoeugenol-3'-yl)-2'-deoxyguanosine, the major adduct of methyleugenol (1.7-2

274 xylation of benzoate and hydroxylation of 2'-deoxyguanosine to give 8-hydroxy-2'-deoxyguanosine (8-OH

275 The Michael addition of deoxyguanosine to HNE yields four diastereomeric exocycl

276 ith hydrogen replacing the amino group in 2'-deoxyguanosine, to further characterize the structural a

277 tT protein in Escherichia coli removes 8-oxo-deoxyguanosine triphosphate (8-oxo-dGTP) and 8-oxo-guano

278 Intracellular deoxyguanosine triphosphate (dGTP) increase was very mod

279 Specifically, we find that intracellular deoxyguanosine triphosphate (dGTP) levels positively cor

280 N(2) -Alkyl-2'-deoxyguanosine triphosphate (N(2) -alkyl-dGTP) derivativ

281 pool by the enzymatic hydrolysis of 8-oxo-2'-deoxyguanosine triphosphate and from genomic DNA by 8-ox

282 In human DKD, increased urine 8-oxo-deoxyguanosine was associated with rapid DKD progression

283 8-hydroxy-2'-deoxyguanosine was only increased in mitochondrial DNA.

284 The O(6)-carboxymethyl-2'-deoxyguanosine was previously detected in isolated DNA u

285 Similarly, UV-induced formation of 8-oxo-deoxyguanosine was reduced by PAF and 5-HT receptor anta

286 iquid chromatography analysis of 8-hydroxy-2-deoxyguanosine, we measured oxidative DNA damage in the

287 DNA damage represented by N(2)-ethylidene-2'-deoxyguanosine were higher in the oesophagus of Aldh2-kn

288 Levels of 8-hydroxy-deoxyguanosine were increased in periodontal lesions of

289 ne and oxidative marker 7,8-dihydro-8-oxo-2'-deoxyguanosine were increased moderately in glyoxalase 1

290 The gamma-folate esters of O6-benzyl-2'-deoxyguanosine were more potent alkyltransferase inactiv

291 - derivatives) with 2'-deoxyadenosine and 2'-deoxyguanosine were prepared by these methods.

292 ropane analogues of 2'-deoxyadenosine and 2'-deoxyguanosine were synthesized, and their antiviral act

293 xGua) concentrations, including 8-hydroxy-2'-deoxyguanosine, were assessed in 8,793 older adults in a

294 for deamination of 2'-deoxyadenosine and 2'-deoxyguanosine, which could not be determined directly b

295 tually resected; and (iii) BPh adducts at N2-deoxyguanosine, which intercalate via the minor groove,

296 ts selective and high-affinity binding of 2'-deoxyguanosine, which is consistent with its occurrence

297 oxidized nucleoside is 8-oxo-7,8-dihydro-2'-deoxyguanosine, which is found both in DNA (8-oxo-G) and

298 through its ability to provide intracellular deoxyguanosine, which is readily converted by the DeoD p

299 e template base (dG) or 7,8-dihydro-8-oxo-2'-deoxyguanosine with a significant propeller twist.

300 The DNA adduct 1,N(2)-etheno-2'-deoxyguanosine, with a larger stacking surface than cano