ライフサイエンスコーパス: deoxyhemoglobin

1 nitrosonium donor formed in the presence of deoxyhemoglobin.

2 d as the ratio of oxyhemoglobin to oxy- plus deoxyhemoglobin.

3 signaling can be recapitulated with isolated deoxyhemoglobin.

4 shown previously for the reaction of O2 with deoxyhemoglobin.

5 n and cleaved oxyhemoglobin twice as fast as deoxyhemoglobin.

6 , including water, lipid, oxyhemoglobin, and deoxyhemoglobin.

7 ion to NO by reaction with intraerythrocytic deoxyhemoglobin.

8 is low in areas with high concentrations of deoxyhemoglobin.

9 zymatic disproportionation, and reduction by deoxyhemoglobin.

10 ivity is inferred from local fluctuations in deoxyhemoglobin.

11 e responsible for the low oxygen affinity of deoxyhemoglobin.

12 the major source of quaternary constraint in deoxyhemoglobin.

13 activated by a nitrite reductase activity of deoxyhemoglobin.

14 o methemoglobin and reduces methemoglobin to deoxyhemoglobin.

15 are several published crystal structures for deoxyhemoglobin A (deoxy-Hb A), and it has been reported

16 focal elevations of R2*, suggesting areas of deoxyhemoglobin accumulation.

17 There was also an increase in deoxyhemoglobin after both doses of resveratrol, which s

18 ween the quaternary-T structure of wild-type deoxyhemoglobin and an ensemble of related T-like quater

19 ulted from the nitrite reductase activity of deoxyhemoglobin and deoxygenated erythrocytes.

20 BC O2 content because of competition between deoxyhemoglobin and key EMP enzymes for binding to the c

21 ic model that includes a redox cycle between deoxyhemoglobin and methemoglobin has been forwarded to

22 es have revealed a novel interaction between deoxyhemoglobin and nitrite to generate nitric oxide (NO

23 , nitric oxide (NO)-generating reaction with deoxyhemoglobin and potentially other heme proteins.

24 h few repulsive contact areas in both the T (deoxyhemoglobin) and R (oxyhemoglobin) structures; (2) t

25 determination of fractions of oxyhemoglobin, deoxyhemoglobin, and high-spin and low-spin methemoglobi

26 globin, promoting nitrite reduction to NO by deoxyhemoglobin, and releasing free NO from iron-nitrosy

27 ts of magnetic field perturbations caused by deoxyhemoglobin, and the advection and diffusion of the

28 s of proteins, lipids, non-heme tissue iron, deoxyhemoglobin, and their magnetic susceptibilities.

29 These studies suggest a vital role for deoxyhemoglobin- and deoxymyoglobin-dependent nitrite re

30 dilation elicited by aerosolized nitrite was deoxyhemoglobin- and pH-dependent and was associated wit

31 ferrous high-spin (S = 2) deoxymyoglobin and deoxyhemoglobin; and (6) ferric high spin (S = (5)/(2))

32 CO production was detected by using deoxyhemoglobin as a reporter and monitoring the appeara

33 assess tissue oxygen bioavailability, using deoxyhemoglobin as an endogenous contrast agent.

34 hemoglobin to dimers 2500-fold over that of deoxyhemoglobin, as measured by haptoglobin binding.

35 n detail the magnetic properties of oxy- and deoxyhemoglobin, as well as those of closely related com

36 ng sites on band 3, we found that docking of deoxyhemoglobin at the N terminus of band 3 displaces th

37 ts suggest that, unlike the expectation from deoxyhemoglobin-based optical imaging studies, the highe

38 s nitrite approximately 36 times faster than deoxyhemoglobin because of its lower heme redox potentia

39 he X-ray crystallographic results from human deoxyhemoglobin, beta 99Asp at the alpha 1 Beta 2 interf

40 ing (MRI), to detect differences in vascular deoxyhemoglobin between tissue compartments following st

41 hree transgenic mouse strains having mutated deoxyhemoglobin-binding sites on band 3, we found that d

42 By exploiting the paramagnetic properties of deoxyhemoglobin, BOLD magnetic resonance imaging can det

43 chrome oxidase CuA redox state and increased deoxyhemoglobin, both PL-arginine and increased by NO bl

44 Because deoxyhemoglobin, but not oxyhemoglobin, binds band 3 rev

45 results with measurements of tissue oxy- and deoxyhemoglobin concentration during oxygen deprivation

46 stroke are likely to reflect differences in deoxyhemoglobin concentration, and therefore differences

47 alert macaque demonstrate that both oxy- and deoxyhemoglobin concentrations in the frontal lobe show

48 Raman difference spectra between ligated and deoxyhemoglobin contain tryptophan and tyrosine signals

49 nsists of a decrease or an increase in local deoxyhemoglobin, corresponding to a positive (adult-like

50 Human deoxyhemoglobin cross-linked with trimesyl tris(3,5-dibr

51 view the interaction of NO with quaternary-T deoxyhemoglobin, crystallographic studies were carried o

52 However, when deoxyhemoglobin crystals are first exposed to air and th

53 The reaction of nitrite with deoxyhemoglobin (deoxyHb) results in the reduction of ni

54 rolled by O(2)-dependent competition between deoxyhemoglobin (deoxyHb), but not oxyhemoglobin (oxyHb)

55 Deoxyhemoglobin (deoxyHb), but not oxyhemoglobin, binds

56 ignal, detected in fMRI, reflects changes in deoxyhemoglobin driven by localized changes in brain blo

57 resonance imaging detects changes in tissue deoxyhemoglobin during maneuvers that affect oxygen cons

58 of rats, signal intensity ratios of oxy- vs. deoxyhemoglobin from sublingual mucosa correlated with c

59 of a targeted fluorescent agent and oxy- and deoxyhemoglobin gave functional information about tumor

60 of oxyhemoglobin HbO[Formula: see text] and deoxyhemoglobin Hb, which can be distuinguished by multi

61 s lowered the polymer solubility ("Csat") of deoxyhemoglobin (Hb) S, presumably by increasing its act

62 RS) can measure tissue oxyhemoglobin (HbO2), deoxyhemoglobin (Hb), and cytochrome oxidase (Cyt Ox), w

63 The distributions of oxyhemoglobin (HbO), deoxyhemoglobin (Hb), and total hemoglobin (THb) concent

64 Nitrite reductase activity of deoxyhemoglobin (HbA) in the red blood cell has been pro

65 ximately 0.07 Hz) was similar to the LFOs of deoxyhemoglobin (HbR) and oxyhemoglobin (HbO2) in both l

66 ) readings were responsive to the challenge, deoxyhemoglobin (HbR) trends exhibited little to no vari

67 ption contrast from oxyhemoglobin (HbO2) and deoxyhemoglobin (HbR), FOG allows label-free imaging.

68 l parameters including oxyhemoglobin (HbO2), deoxyhemoglobin (HbR), oxygen saturation (sO2), blood fl

69 ed at wavelengths absorbed preferentially by deoxyhemoglobin (HbR).

70 ing peripheral blood pulsatile variations in deoxyhemoglobin (HHb) in red visible spectrum (>600 nm),

71 ly, changes in cortical oxyhemoglobin (HbO), deoxyhemoglobin (HHb), and total hemoglobin (HbT), infer

72 les and females but the cerebral extraction (deoxyhemoglobin: HHb) remained higher after exposure in

73 Nitrite reacts with deoxyhemoglobin in an allosteric reaction that generates

74 , which is directly related to the amount of deoxyhemoglobin in blood and in turn to tissue PO2.

75 lving the reduction of nitrite back to NO by deoxyhemoglobin in RBCs.

76 blood that depends on the volume fraction of deoxyhemoglobin in red blood cells.

77 tion of the percentages of oxyhemoglobin and deoxyhemoglobin in specific skin tissue areas.

78 issue and is not dependent on reactions with deoxyhemoglobin in the pulmonary circulation.

79 One is through changes in deoxyhemoglobin in venules, i.e., blood oxygenation leve

80 The crystal structure of the mutant deoxyhemoglobin in which the beta-globin Val67(E11) has

81 Overall our data suggest that deoxyhemoglobin is the primary erythrocytic nitrite redu

82 Tissue deoxyhemoglobin levels (R(2)*) were measured by blood ox

83 relaxation (R2*) positively correlates with deoxyhemoglobin levels and was therefore used as a surro

84 showed that both 2,3-bisphosphoglycerate and deoxyhemoglobin levels rose following 5'-AMP administrat

85 s (a measure directly proportional to tissue deoxyhemoglobin levels) were significantly higher in nor

86 culate that one signaling mechanism by which deoxyhemoglobin may activate HIF-1 involves NO.

87 The findings in breast tumor images using deoxyhemoglobin (mean, 0.0782), oxyhemoglobin (mean, 0.0

88 radients of intravascular nitric oxide, with deoxyhemoglobin-mediated reduction identified as the dom

89 Because the deoxyhemoglobin-mediated WNK1 displacement from band 3 i

90 zymatic disproportionation, and reduction by deoxyhemoglobin, myoglobin, and tissue heme proteins.

91 "inverted" hemodynamic response (increasing deoxyhemoglobin, negative BOLD) with early signs of oxyg

92 ion, a process by which the NO formed in the deoxyhemoglobin-nitrite reaction that binds to other deo

93 tem, based on the paramagnetic behavior that deoxyhemoglobin or methemoglobin containing RBCs experie

94 In addition to the proposed role of deoxyhemoglobin, our findings suggest that the nitrite r

95 Levels of deoxyhemoglobin, oxyhemoglobin, total hemoglobin, and mi

96 hosphate dehydrogenase, phosphofructokinase, deoxyhemoglobin, p72syk protein tyrosine kinase, and hem

97 in and cytochrome oxidase and an increase in deoxyhemoglobin (PA redox state, PL-arginine did not att

98 cific region and is related to the amount of deoxyhemoglobin present.

99 ounds as well as those of deoxymyoglobin and deoxyhemoglobin, previously studied, have a negative sig

100 monstrated that the reaction of nitrite with deoxyhemoglobin produces a hybrid intermediate with prop

101 Single-kidney deoxyhemoglobin (R2*, reciprocal to blood relaxation) an

102 ive concentrations of both oxyhemoglobin and deoxyhemoglobin, rather than either species alone.

103 hysical and chemical analysis of the nitrite-deoxyhemoglobin reaction has revealed unexpected chemist

104 to the heme groups of crystalline wild-type deoxyhemoglobin ruptures the Fe-proximal histidine bonds

105 We have refined the crystal structure of deoxyhemoglobin S (beta Glu6-->Val) at 2.05 A resolution

106 The deoxyhemoglobin S (deoxy-HbS) double strand is the funda

107 cs of nucleation-dependent polymerization of deoxyhemoglobin S (HbS) are important in governing wheth

108 Polymerization of intraerythrocytic deoxyhemoglobin S (HbS) is the primary molecular event t

109 le cell disease depends on polymerization of deoxyhemoglobin S into rod-like fibers, forming gels tha

110 with nucleation-dependent polymerization of deoxyhemoglobin S into stiff, rodlike fibers that deform

111 x steps related to both the primary event of deoxyhemoglobin S polymerization and the many resultant

112 Although direct chemical inhibition of deoxyhemoglobin S polymerization has proven difficult, s

113 s have been designed to reduce the extent of deoxyhemoglobin S polymerization.

114 Use of deoxyhemoglobin-sensitive MRI sequences enabled visualiz

115 ctral peak height to the sum of the oxy- and deoxyhemoglobin spectral peak heights.

116 he alpha1beta2 interface of the quaternary-T deoxyhemoglobin tetramer.

117 ctural properties and ligand affinity of the deoxyhemoglobin tetramer.

118 d unexpected chemistries between nitrite and deoxyhemoglobin that may contribute to and facilitate hy

119 al activity, and (3) the initial increase in deoxyhemoglobin that precedes an increase in blood volum

120 phic studies were carried out on crystals of deoxyhemoglobin that were exposed to gaseous NO under a

121 acts at a nearly diffusion-limited rate with deoxyhemoglobin to form iron-nitrosyl-hemoglobin, which

122 ing studies reveal that hydroxyurea oxidizes deoxyhemoglobin to methemoglobin and reduces methemoglob

123 eric reaction that generates NO and oxidizes deoxyhemoglobin to methemoglobin.

124 by exposing crystals of wild-type or mutant deoxyhemoglobins to oxygen.

125 rmine tissue concentration of oxyhemoglobin, deoxyhemoglobin, total hemoglobin, tissue hemoglobin oxy

126 Deoxyhemoglobin was generated by predeoxygenation (nitro

127 hat depended on the paramagnetic property of deoxyhemoglobin was used.

128 re absolute concentrations of oxyhemoglobin, deoxyhemoglobin, water, and lipid in tumor and normal br

129 The reaction of deoxyhemoglobin with nitric oxide (NO) or nitrite ions (

130 suggest that the rapid reactions of oxy- and deoxyhemoglobin with nitric oxide are the fundamental ca

131 The reaction of deoxyhemoglobin with nitrite was characterized in the pr

132 ed to cause a transient increase in vascular deoxyhemoglobin with several imaging techniques and stim

133 ess reveals a higher volume/surface ratio of deoxyhemoglobin, with a positive Delta G(W) also in favo