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1  a Lys-50 mutant that blocks modification by deoxyhypusine.
2 pusine or selectively to hypusine but not to deoxyhypusine.
3 educed enzyme intermediate was identified as deoxyhypusine and was shown to occur at a single locus.
4 ural (2S,9R)-hypusine, (2S,9S)-hypusine, and deoxyhypusine- and hypusine-containing peptides are desc
5 imide; KLH conjugates are also made with the deoxyhypusine- and lysine-containing hexapeptides.
6 rain with deletion of YJR070C contained only deoxyhypusine but no hypusine, indicating that YJR070C w
7 hypusine synthase catalyzes the formation of deoxyhypusine by conjugation of the butylamine moiety of
8                       Synthetic hypusine and deoxyhypusine can be generated from these reagents.
9                             The synthesis of deoxyhypusine catalyzed by this enzyme involves transfer
10 maleimide conjugates, as well as against the deoxyhypusine-containing and lysine-containing hexapepti
11 al gel analyses revealed the accumulation of deoxyhypusine-containing eIF5A [eIF5A(Dhp)] and a reduct
12 due in the eIF5A precursor protein to form a deoxyhypusine-containing eIF5A intermediate, eIF5A(Dhp).
13 isplayed a strong preference for binding the deoxyhypusine-containing form of eIF5A, over the eIF5A p
14 were determined in complex with hypusine- or deoxyhypusine-containing peptides.
15   The availability of synthetic hypusine and deoxyhypusine has made it possible to develop analytical
16            Deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxylase (DOHH) are key enzymes that ut
17                                   The enzyme deoxyhypusine hydroxylase (DOHH) catalyzes the activatio
18                                              Deoxyhypusine hydroxylase (DOHH) catalyzes the final ste
19 ization of nero, the Drosophila melanogaster deoxyhypusine hydroxylase (DOHH) homologue.
20                                              Deoxyhypusine hydroxylase (DOHH) is a novel metalloenzym
21                                              Deoxyhypusine hydroxylase (DOHH) is the enzyme catalyzin
22 sttranslational modification event requiring deoxyhypusine hydroxylase (DOHH), an enzyme that can be
23 ow that PCBP1 and PCBP2 also deliver iron to deoxyhypusine hydroxylase (DOHH), the dinuclear iron enz
24 ng enzymes-deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxylase (DOHH)-and hypusinated eukaryo
25 he enzymes deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxylase (DOHH).
26 talyzed by deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxylase (DOHH).
27  which promotes CREB-dependent expression of deoxyhypusine hydroxylase (DOHH).
28 o enzymes, deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxylase (DOHH).
29 teps catalyzed by deoxyhypusine synthase and deoxyhypusine hydroxylase (DOHH).
30  involving deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxylase (DOHH).
31                            Recombinant human deoxyhypusine hydroxylase (hDOHH) has been reported to h
32 modifying enzymes deoxyhypusine synthase and deoxyhypusine hydroxylase as well as for the cancer-rela
33 s depletion of deoxyhypusine synthase and/or deoxyhypusine hydroxylase causes lethality in adult mice
34                                              Deoxyhypusine hydroxylase is the key enzyme in the biosy
35 o enzymes, deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxylase.
36 n is catalyzed by deoxyhypusine synthase and deoxyhypusine hydroxylase.
37  on multiple cell processes, suggesting that deoxyhypusine/hypusine biosynthesis could be a promising
38 tic NOD mice that received injections of the deoxyhypusine inhibitor N1-guanyl-1,7-diaminoheptane (GC
39                                              Deoxyhypusine is a modified lysine residue.
40  novel cofactor called trypanothione and for deoxyhypusine modification of eukaryotic translation ini
41                              The hypusine or deoxyhypusine moiety was found to reside in a deep pocke
42 synthetic methods which allow access to (2S)-deoxyhypusine, natural (2S,9R)-hypusine, (2S,9S)-hypusin
43                                              Deoxyhypusine (Nepsilon-(4-aminobutyl)lysine) is the key
44     The antibodies bind to both hypusine and deoxyhypusine or selectively to hypusine but not to deox
45 thesis, as donor substrates for synthesis of deoxyhypusine (or its analog), and for synthesis of homo
46 e methods involve both the construction of a deoxyhypusine reagent in which the alpha-nitrogen protec
47 -containing eIF5A, indicating a role for the deoxyhypusine residue in binding.
48 s effectively catalyzed hydroxylation of the deoxyhypusine residue in the eIF5A intermediate.
49 at it can carry out the hydroxylation of the deoxyhypusine residue present in the elF5A substrate.
50 lation at the 4-aminobutyl side chain of the deoxyhypusine residue prevents deoxyhypusine synthase-me
51 iolabeled 4-aminobutyl side chain of the [3H]deoxyhypusine residue to 1,3-diaminopropane.
52                           In addition to the deoxyhypusine residue, a large portion of the eIF5A poly
53 iolabeled in the 4-aminobutyl portion of its deoxyhypusine residue, was incubated with human deoxyhyp
54 A binding in which the amino group(s) of the deoxyhypusine side chain of the substrate is primarily a
55 is a two-step reaction involving the enzymes deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxyl
56                                              Deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxyl
57  two sequential enzymatic steps catalyzed by deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxyl
58  eIF5A post-translationally via two enzymes, deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxyl
59 s and Main Results: Hypusine forming enzymes-deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxyl
60 sination, which is catalyzed by two enzymes, deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxyl
61 s catalyzed by two enzymatic steps involving deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxyl
62 nd mouse models with inducible knockdowns of deoxyhypusine synthase (DHPS) and eIF5A to investigate t
63                                              Deoxyhypusine synthase (DHPS) is an enzyme encoded by th
64                                              Deoxyhypusine synthase (DHPS) is an enzyme that post-tra
65                                              Deoxyhypusine synthase (DHPS) uses the polyamine spermid
66 nally modified ("hypusinated") by the enzyme deoxyhypusine synthase (DHPS).
67  In-vivo inhibition of elF5A hypusination by deoxyhypusine synthase (DHS) inhibitor "GC7" was studied
68        It was recently shown that the enzyme deoxyhypusine synthase (DHS) promotes early cytokine-ind
69 copies inhibition or knockdown of the enzyme deoxyhypusine synthase (DHS).
70                               Purified human deoxyhypusine synthase also exhibited homospermidine syn
71 pusine formation by a selective inhibitor of deoxyhypusine synthase and by its depletion with RNA int
72  two sequential enzymatic steps catalyzed by deoxyhypusine synthase and deoxyhypusine hydroxylase (DO
73 se models for the hypusine-modifying enzymes deoxyhypusine synthase and deoxyhypusine hydroxylase as
74                 The reaction is catalyzed by deoxyhypusine synthase and deoxyhypusine hydroxylase.
75                                              Deoxyhypusine synthase and eIF5A are conserved throughou
76          Here, we tested the hypothesis that deoxyhypusine synthase and, secondarily, hypusinated eIF
77   We discovered that homozygous depletion of deoxyhypusine synthase and/or deoxyhypusine hydroxylase
78                     Although both eIF-5A and deoxyhypusine synthase are essential genes for cell surv
79                                Inhibition of deoxyhypusine synthase blocked post-transcriptional expr
80                                              Deoxyhypusine synthase catalyzes the crucial hypusine mo
81                                              Deoxyhypusine synthase catalyzes the first step in hypus
82                                              Deoxyhypusine synthase catalyzes the first step in the p
83                                              Deoxyhypusine synthase catalyzes the first step in the p
84                                              Deoxyhypusine synthase catalyzes the first step in the t
85                                              Deoxyhypusine synthase catalyzes the formation of deoxyh
86        In the initial step of this reaction, deoxyhypusine synthase catalyzes the production of NADH
87                                          The deoxyhypusine synthase competitive inhibitor N(1)-guanyl
88 SS, we identified sequences encoding HSS and deoxyhypusine synthase from various species of the Convo
89 of transcript levels have shown that HSS and deoxyhypusine synthase have also diverged with respect t
90 s suggest a previously unrecognized role for deoxyhypusine synthase in promoting T cell proliferation
91 5A-1 and -2, respectively) as substrates for deoxyhypusine synthase in vitro.
92        N(1)-APA functions analogously to the deoxyhypusine synthase inhibitor GC7 in C. elegans and,
93  Th17, and Treg), but those treated with the deoxyhypusine synthase inhibitor GC7 showed a dose-depen
94 ctive metabolite that functions similarly to deoxyhypusine synthase inhibitors but has other unidenti
95 rwinian selection is sufficient to convert a deoxyhypusine synthase into a HSS.
96                                Inhibition of deoxyhypusine synthase may provide a strategy for reduci
97               Trypanosoma brucei encodes two deoxyhypusine synthase paralogs, one that is catalytical
98 f previous biochemical investigations of the deoxyhypusine synthase reaction mechanism.
99 ficity of this enzyme and versatility of the deoxyhypusine synthase reaction.
100 tion in the single copy gene, yDHS, encoding deoxyhypusine synthase results in the loss of viability
101                    A previous study of human deoxyhypusine synthase revealed four active sites of the
102 of human DOHH along with eIF5A precursor and deoxyhypusine synthase was required for overproduction o
103  erythroid progenitors, by the inhibition of deoxyhypusine synthase, abrogates erythropoiesis but not
104 endently by duplication of the gene encoding deoxyhypusine synthase, an enzyme involved in the posttr
105                            Upon depletion of deoxyhypusine synthase, and consequently of eIF-5A, cess
106 ivity, formation of different complexes with deoxyhypusine synthase, and Km values (1.5 +/- 0.2 vs. 8
107 f eukaryotic initiation factor 5A (eIF5A) by deoxyhypusine synthase, employing spermidine as a butyla
108 xyhypusine residue, was incubated with human deoxyhypusine synthase, NAD, and 1,3-diaminopropane, [3H
109 nsion of this prozyme paradigm to the enzyme deoxyhypusine synthase, which is required for spermidine
110  differentiation by providing substrates for deoxyhypusine synthase, which synthesizes the amino acid
111  chain of the deoxyhypusine residue prevents deoxyhypusine synthase-mediated reversal of the modifica
112  a specific lysine residue (Lys329) in human deoxyhypusine synthase.
113 a) of the conserved lysine residues in human deoxyhypusine synthase.
114 slation elongation factor eIF5A, mediated by deoxyhypusine synthase.
115 e spermidine biosynthetic pathway but retain deoxyhypusine synthase.
116 origin in the duplication of a gene encoding deoxyhypusine synthase.
117 were evaluated as donor substrates for human deoxyhypusine synthase.
118                    This first structure of a deoxyhypusine synthase.NAD.inhibitor ternary complex und
119 t here at 2.2 A a new Form II crystal of the deoxyhypusine synthase:NAD holoenzyme grown at low ionic
120  enzyme-substrate intermediate formation and deoxyhypusine synthesis activity, indicating that Lys329
121 diate and that it is absolutely required for deoxyhypusine synthesis in the eukaryotic translation in
122 rison of spermidine analogs as inhibitors of deoxyhypusine synthesis, as donor substrates for synthes
123  type enzyme) suggesting that in contrast to deoxyhypusine synthesis, spermidine cleavage can occur w
124 ecently discovered the efficient reversal of deoxyhypusine synthesis.
125                        The fact that labeled deoxyhypusine was found after treatment with a reducing
126 reduction of the eIF5A-imine intermediate to deoxyhypusine was reflected by a rapid decrease in the N

 
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