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1 origin in the duplication of a gene encoding deoxyhypusine synthase.
2 were evaluated as donor substrates for human deoxyhypusine synthase.
3  a specific lysine residue (Lys329) in human deoxyhypusine synthase.
4 a) of the conserved lysine residues in human deoxyhypusine synthase.
5 slation elongation factor eIF5A, mediated by deoxyhypusine synthase.
6 e spermidine biosynthetic pathway but retain deoxyhypusine synthase.
7  erythroid progenitors, by the inhibition of deoxyhypusine synthase, abrogates erythropoiesis but not
8                               Purified human deoxyhypusine synthase also exhibited homospermidine syn
9 endently by duplication of the gene encoding deoxyhypusine synthase, an enzyme involved in the posttr
10 pusine formation by a selective inhibitor of deoxyhypusine synthase and by its depletion with RNA int
11  two sequential enzymatic steps catalyzed by deoxyhypusine synthase and deoxyhypusine hydroxylase (DO
12 se models for the hypusine-modifying enzymes deoxyhypusine synthase and deoxyhypusine hydroxylase as
13                 The reaction is catalyzed by deoxyhypusine synthase and deoxyhypusine hydroxylase.
14                                              Deoxyhypusine synthase and eIF5A are conserved throughou
15          Here, we tested the hypothesis that deoxyhypusine synthase and, secondarily, hypusinated eIF
16   We discovered that homozygous depletion of deoxyhypusine synthase and/or deoxyhypusine hydroxylase
17                            Upon depletion of deoxyhypusine synthase, and consequently of eIF-5A, cess
18 ivity, formation of different complexes with deoxyhypusine synthase, and Km values (1.5 +/- 0.2 vs. 8
19                     Although both eIF-5A and deoxyhypusine synthase are essential genes for cell surv
20                                Inhibition of deoxyhypusine synthase blocked post-transcriptional expr
21                                              Deoxyhypusine synthase catalyzes the crucial hypusine mo
22                                              Deoxyhypusine synthase catalyzes the first step in hypus
23                                              Deoxyhypusine synthase catalyzes the first step in the p
24                                              Deoxyhypusine synthase catalyzes the first step in the p
25                                              Deoxyhypusine synthase catalyzes the first step in the t
26                                              Deoxyhypusine synthase catalyzes the formation of deoxyh
27        In the initial step of this reaction, deoxyhypusine synthase catalyzes the production of NADH
28                                          The deoxyhypusine synthase competitive inhibitor N(1)-guanyl
29 is a two-step reaction involving the enzymes deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxyl
30 sination, which is catalyzed by two enzymes, deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxyl
31 s catalyzed by two enzymatic steps involving deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxyl
32                                              Deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxyl
33  two sequential enzymatic steps catalyzed by deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxyl
34  eIF5A post-translationally via two enzymes, deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxyl
35 s and Main Results: Hypusine forming enzymes-deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxyl
36 nd mouse models with inducible knockdowns of deoxyhypusine synthase (DHPS) and eIF5A to investigate t
37                                              Deoxyhypusine synthase (DHPS) is an enzyme encoded by th
38                                              Deoxyhypusine synthase (DHPS) is an enzyme that post-tra
39                                              Deoxyhypusine synthase (DHPS) uses the polyamine spermid
40 nally modified ("hypusinated") by the enzyme deoxyhypusine synthase (DHPS).
41  In-vivo inhibition of elF5A hypusination by deoxyhypusine synthase (DHS) inhibitor "GC7" was studied
42        It was recently shown that the enzyme deoxyhypusine synthase (DHS) promotes early cytokine-ind
43 copies inhibition or knockdown of the enzyme deoxyhypusine synthase (DHS).
44 f eukaryotic initiation factor 5A (eIF5A) by deoxyhypusine synthase, employing spermidine as a butyla
45 SS, we identified sequences encoding HSS and deoxyhypusine synthase from various species of the Convo
46 of transcript levels have shown that HSS and deoxyhypusine synthase have also diverged with respect t
47 s suggest a previously unrecognized role for deoxyhypusine synthase in promoting T cell proliferation
48 5A-1 and -2, respectively) as substrates for deoxyhypusine synthase in vitro.
49        N(1)-APA functions analogously to the deoxyhypusine synthase inhibitor GC7 in C. elegans and,
50  Th17, and Treg), but those treated with the deoxyhypusine synthase inhibitor GC7 showed a dose-depen
51 ctive metabolite that functions similarly to deoxyhypusine synthase inhibitors but has other unidenti
52 rwinian selection is sufficient to convert a deoxyhypusine synthase into a HSS.
53                                Inhibition of deoxyhypusine synthase may provide a strategy for reduci
54  chain of the deoxyhypusine residue prevents deoxyhypusine synthase-mediated reversal of the modifica
55 xyhypusine residue, was incubated with human deoxyhypusine synthase, NAD, and 1,3-diaminopropane, [3H
56                    This first structure of a deoxyhypusine synthase.NAD.inhibitor ternary complex und
57 t here at 2.2 A a new Form II crystal of the deoxyhypusine synthase:NAD holoenzyme grown at low ionic
58               Trypanosoma brucei encodes two deoxyhypusine synthase paralogs, one that is catalytical
59 f previous biochemical investigations of the deoxyhypusine synthase reaction mechanism.
60 ficity of this enzyme and versatility of the deoxyhypusine synthase reaction.
61 tion in the single copy gene, yDHS, encoding deoxyhypusine synthase results in the loss of viability
62                    A previous study of human deoxyhypusine synthase revealed four active sites of the
63 of human DOHH along with eIF5A precursor and deoxyhypusine synthase was required for overproduction o
64 nsion of this prozyme paradigm to the enzyme deoxyhypusine synthase, which is required for spermidine
65  differentiation by providing substrates for deoxyhypusine synthase, which synthesizes the amino acid