ライフサイエンスコーパス: deoxynucleoside

1 (4)-epsilon-Cyt)] and their corresponding 2'-deoxynucleosides.

2 ates for oxidation than the corresponding 2'-deoxynucleosides.

3 xy-2'-deoxyguanosine and 8,5'-cyclopurine-2'-deoxynucleosides.

4 tics and product profile of QM reaction with deoxynucleosides.

5 e and thus explaining the specificity for 2'-deoxynucleosides.

6 and class II enzymes are highly specific for deoxynucleosides.

7 TK2 deficiency treated 1-49 months with oral deoxynucleosides.

8 riction by SAMHD1 was rescued by addition of deoxynucleosides.

9 ing deoxynucleoside triphosphates (dNTPs) to deoxynucleosides.

10 partially overcome by addition of exogenous deoxynucleosides.

11 was alleviated by the addition of exogenous deoxynucleosides.

12 The deoxynucleosides 1 and 2 demonstrate that the chemical d

13 Among 12 other TK2 patients treated with deoxynucleoside, 2 adults developed elevated liver enzym

14 thase inhibitor 5-fluorouracil (5-FU) or its deoxynucleoside, 2'-deoxy-5-fluorouridine.

15 tudies carried out on the AFB-FAPY bases and deoxynucleoside 3',5'-dibutyrates now establish that the

16 8-dihydrodiol-9,10-epoxide (B[a]PDE) with 2'-deoxynucleoside 3'-monophosphates.

17 ith these modifications, coupling of each 2'-deoxynucleoside 3'-phosphoramidite to the growing oligod

18 2'-Deoxynucleoside 5'-(alpha-P-seleno)-triphosphates (dNTPa

19 eaction, boron-modified nucleotides, i.e. 2'-deoxynucleoside 5'-alpha-[P-borano]-triphosphates, are i

20 Synthesis entails preparation of 2'-deoxynucleoside 5'-diphosphate precursors, followed by a

21 (RNR) converts nucleoside 5'-diphosphates to deoxynucleoside 5'-diphosphates and is expressed under i

22 cleoside 5'-diphosphate substrates (S) to 2'-deoxynucleoside 5'-diphosphates.

23 Reaction of 11 with 2'-deoxynucleoside 5'-monophosphates or a nucleoside 5'-mon

24 ting CD4(+) T cells by reducing the cellular deoxynucleoside 5'-triphosphate (dNTP) concentration to

25 Deoxynucleoside 5'-triphosphate analogues in which the b

26 at manganese increases the rate constant for deoxynucleoside 5'-triphosphate insertion compared to ma

27 ns required for the reaction of the incoming deoxynucleoside 5'-triphosphate with the 3'-hydroxyl in

28 duction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates and uses coenzyme B12,

29 mer extension reaction utilizing 5'-amino-5'-deoxynucleoside 5'-triphosphates generates polynucleotid

30 Two modified 2'-deoxynucleoside 5'-triphosphates have been used for the

31 on, deoxynucleotides in DNA are converted to deoxynucleoside 5'-triphosphates.

32 he incorporation of benzimidazole-derived 2'-deoxynucleoside-5'-O-triphosphates ( BENZI: TP and BIM:

33 total six crystal structures of modified 2'-deoxynucleoside-5'-O-triphosphates (dNTPs) carrying modi

34 sized base-modified benzimidazole-derived 2'-deoxynucleoside-5'-O-triphosphates on DNA polymerases wh

35 iphosphate (dSpTP) and guanidinohydantoin-2'-deoxynucleoside-5'-triphosphate (dGhTP) are reported.

36 SAMHD1 regulates cellular 2'-deoxynucleoside-5'-triphosphate (dNTP) homeostasis by ca

37 riphosphate lesions spiroiminodihydantoin-2'-deoxynucleoside-5'-triphosphate (dSpTP) and guanidinohyd

38 ) plays a critical role in the production of deoxynucleoside-5'-triphosphates (dNTPs), the building b

39 conversion of nucleoside-5'-diphosphates to deoxynucleosides-5'-diphosphates.

40 ant increases in the oxidatively damaged DNA deoxynucleoside 8-hydroxydeoxyguanosine, with the degree

41 chromatographic analysis of DNA digested to deoxynucleosides, about 60% of the Wilms tumors were fou

42 rly, Vpx-containing virus-like particles and deoxynucleosides added to the cells more than 24 h posti

43 Thus, deoxynucleoside addition partially overcomes the restric

44 ionic acid (BODIPY FL) was used to label the deoxynucleoside adducts N-(2'-deoxyguanosine-8-yl)-4-ami

45 The 2'-deoxynucleoside adducts, 1,N(2)-epsilon-dG and 1,N(6)-ep

46 linked DNA returned primarily the unmodified deoxynucleosides, along with 1-[N3-deoxycytidyl]-2-[N1-d

47 e recently reported that in the last step, L-deoxynucleoside analog diphosphates are phosphorylated b

48 ts attributed favorable phosphorylation of L-deoxynucleoside analog diphosphates by PGK to difference

49 mutations on the phosphorylation of L- and D-deoxynucleoside analog diphosphates was different from t

50 ted by 3-phosphoglycerate kinase, whereas, D-deoxynucleoside analog diphosphates were phosphorylated

51 explain the preference of PGK for L- over D-deoxynucleoside analog diphosphates, the kinetics of the

52 Among these pyrimidine deoxynucleoside analog monophosphates, D-FMAU monophosph

53 fluorescence of a set of four benzo-expanded deoxynucleoside analogs (xDNA) that maintain Watson-Cric

54 We evaluated deoxynucleoside analogs for lack of toxicity to human ce

55 "lethal mutagenesis" driven by the class of deoxynucleoside analogs represented by 5-OH-dC could pro

56 HIV-1 reverse transcriptase (RT)-specific 2'-deoxynucleoside analogs that contain a clickable triple

57 y, several L- and D-configuration pyrimidine deoxynucleoside analogs were found to be potent antivira

58 Fd4C, L-FMAU, and L-ddC were compared with D-deoxynucleoside analogs, AraC, dFdC, and D-FMAU, and D-d

59 The deoxynucleoside analogue gemcitabine is among the most e

60 Studies with deoxynucleoside analogues indicated that 3'-azido-3'deox

61 e in DMSO/THF gave the respective 2'- and 3'-deoxynucleoside analogues with beta-D-threo configuratio

62 ry of potent antiviral agents based on novel deoxynucleoside analogues with unusual bicyclic base moi

63 es of this enzyme and to study the effect of deoxynucleoside analogues, we have isolated and partiall

64 w furo[2,3-d]pyrimidin-2(3H)-one (FuPyrm) 2'-deoxynucleoside analogues.

65 ynucleoside triphosphates to the constituent deoxynucleoside and inorganic triphosphate.

66 catalyzes the hydrolysis of all dNTPs to the deoxynucleoside and tripolyphosphate, which effectively

67 he results define the acidity of oxopropenyl deoxynucleosides and highlight its importance to their r

68 n products from millimolar concentrations of deoxynucleosides and oligomers.

69 aced incorporation of (15)N into tryptophan, deoxynucleosides and pheophytin derived from chlorophyll

70 We synthesized seven propargylated 2'-deoxynucleosides and tested them for lack of cytotoxicit

71 y catalysing the hydrolysis of dNTPs into 2'-deoxynucleosides and triphosphate.

72 6-[chloro (5, 63%) or bromo (6, 80%)]purine deoxynucleosides, and 2',3',5'-tri-O-acetyladenosine (8)

73 8,5'-Cyclopurine 2'-deoxynucleosides are among the major lesions in DNA that

74 The 8,5'-cyclopurine-2'-deoxynucleosides are quite stable lesions and are valid

75 hypoxanthine and 8-aza-6-thiohypoxanthine 2'-deoxynucleosides as well as methylated 2'-deoxynebularin

76 ivation parameters for the degradation of 2'-deoxynucleosides at 25 degrees C were determined by extr

77 '-deoxyadenosine, 4-methylbenzimidazole beta-deoxynucleoside (B), and 9-methyl-1H-imidazo[4,5-b]pyrid

78 4'-C-ethynyl-2'-deoxynucleosides belong to a novel class of nucleoside a

79 As free deoxynucleosides, both dyT and dyC displayed robust fluo

80 We have focused our attention on the use of deoxynucleoside building blocks bearing non-natural base

81 specificity of the class I enzyme for purine deoxynucleosides can be traced to a loop (residues 48-62

82 es, which accept either purine or pyrimidine deoxynucleosides, class I enzymes are specific for purin

83 e incorporating the low energy C2'-endo/anti deoxynucleoside conformation.

84 ase pairing, base stacking, or C2'-endo/anti deoxynucleoside conformations are perturbed significantl

85 uggest no significant changes in backbone or deoxynucleoside conformations.

86 The 2'-deoxynucleoside containing the synthetic base 1-[(2R,4S,

87 Diastereomeric 8,5'-cyclopurine 2'-deoxynucleosides, containing a covalent bond between the

88 minishes quickly as the concentration of the deoxynucleoside decreases.

89 d 1,N(2)-propanoguanine (PGua)] and their 2'-deoxynucleoside derivatives were not oxidized.

90 sugar chloride in a nonpolar solvent give 2'-deoxynucleoside derivatives with N9 regiochemistry and e

91 des, 3'-O-methyl-substituted nucleosides, 3'-deoxynucleosides, derivatives with 4'-C-azido substituti

92 and GTP and donates it to all nucleoside and deoxynucleoside diphosphate acceptors tested.

93 RB69 DNA polymerase and have shown that the deoxynucleoside diphosphate can be incorporated, in cont

94 talyzes nucleoside diphosphate conversion to deoxynucleoside diphosphate.

95 the conversion of nucleoside diphosphates to deoxynucleoside diphosphates (dNDPs).

96 of all the NTPs, has a low affinity for the deoxynucleoside diphosphates and cannot generate the dNT

97 le for converting nucleoside diphosphates to deoxynucleoside diphosphates, ensuring a balanced supply

98 the conversion of nucleoside diphosphates to deoxynucleoside diphosphates.

99 the conversion of nucleoside diphosphates to deoxynucleoside diphosphates.

100 conversion of nucleoside diphosphates to 2'-deoxynucleoside diphosphates.

101 Mutations that reduce the efficiency of deoxynucleoside (dN) triphosphate (dNTP) substrate utili

102 and in vivo, CpG DNA containing unnatural 3'-deoxynucleoside either within the CpG-dinucleotide or ad

103 Here we show that addition of deoxynucleosides enhanced integration and 2LTR formation

104 The 2'-fluoro-2'-deoxynucleosides examined here are valuable probes of th

105 f thymidines in A5 tracts by difluorotoluene deoxynucleoside (F), a non-polar molecule of the same si

106 e critical for phosphorylation of endogenous deoxynucleosides for DNA synthesis and exogenous nucleos

107 lication on encountering these pro-mutagenic deoxynucleosides four steps ahead of the primer-template

108 act in a concerted manner to excise oxidized deoxynucleosides from duplex DNA.

109 The syntheses of the desired deoxynucleoside generally proceed in three steps from a

110 Supplementation by deoxynucleosides improved DNA repair.

111 Interestingly, substitution of a 3'-deoxynucleoside in the 5'-flanking sequence distal to th

112 S/MS to measure multiple 8,5'-cyclopurine-2'-deoxynucleosides in a toxicologically important terrestr

113 8,5'-cyclopurine-2'-deoxynucleosides in DNA are repaired by nucleotide-excis

114 ence properties of the purine and pyrimidine deoxynucleosides in organic solvents in the presence of

115 The covalent 2'-deoxynucleoside inactivators of CD38 are powerful inhibi

116 effect of 3'-deoxy-2'-5'-ribonucleoside (3'-deoxynucleoside) incorporation into CpG DNA on the immun

117 RCA1 mutations to repair 8,5'-cyclopurine-2'-deoxynucleosides indicates the involvement of BRCA1 in n

118 Adenine deoxynucleosides induce apoptosis in quiescent lymphocyt

119 yields of the N9 isomers of beta-anomeric 2'-deoxynucleoside intermediates.

120 of the C-C and C-N bond-forming reactions of deoxynucleosides is also reported.

121 Two nonpolar deoxynucleoside isosteres containing 2,4-difluorotoluene

122 DNA shuffling of Drosophila melanogaster 2'-deoxynucleoside kinase, followed by FACS analysis, yield

123 ating that Cryptosporidium possesses another deoxynucleoside kinase.

124 Our work reveals that multiple deoxynucleoside kinases are involved in the phosphorylat

125 in T cells may be dependent on the levels of deoxynucleoside kinases.

126 n the binding of carboranyl nucleosides with deoxynucleoside kinases.

127 The capacity of adenine deoxynucleoside metabolites to activate the apoptosome p

128 eoxycytidine (dC), we hypothesized that: (1) deoxynucleosides might be the major active agents and (2

129 etailed investigations of this procedure for deoxynucleoside modification.

130 on of an array of endogenously generated DNA deoxynucleosides modifications.

131 We investigated the safety and efficacy of deoxynucleoside monophosphate and deoxynucleoside therap

132 ide effect profiles and clinical efficacy of deoxynucleoside monophosphate and deoxynucleoside therap

133 slippage and dNTP stabilization followed by deoxynucleoside monophosphate incorporation and extensio

134 it is also found that transcripts containing deoxynucleoside monophosphates (dNMPs) are more poorly e

135 We administered deoxynucleoside monophosphates and deoxynucleoside to 16

136 Because we observed rapid catabolism of the deoxynucleoside monophosphates to deoxythymidine (dT) an

137 ent and hydrolysis of the modified DNA to 2'-deoxynucleosides, N(2)-BPDE-dG adducts formed at the [(1

138 Derivatives of the 2'-deoxynucleoside of furo[2,3-d]pyrimidin-2(3H)-one with l

139 The oxidized lesions observed include the 2'-deoxynucleosides of 8-oxo-7,8-dihydroguanine (dOG), spir

140 nst varicella-zoster virus (VZV) shown by 2'-deoxynucleosides of furo[2,3-d]pyrimidin-2(3H)-one and r

141 Surprisingly, deoxynucleosides of the packaged DNA genome of Pf3 adopt

142 thesized and used in the preparation of four deoxynucleoside phosphoramidites 28 and 65-67, plus the

143 A triester method for the synthesis of deoxynucleoside phosphorodithioate dimers is described.

144 ch of seven contiguous 3',5'-linked oligo-2'-deoxynucleoside phosphorothioate linkages in the center

145 thioate linkages gives 2',5'-linked oligo-3'-deoxynucleoside phosphorothioate ODNs that exhibit signi

146 roviruses/cell in memory or naive cells, and deoxynucleoside pools were equally limiting.

147 Fluorescent deoxynucleosides possessing the modified bases 6-(2-benz

148 able reactions at the C-2 position of purine deoxynucleosides proceed with less sensitivity to the li

149 its dA N1 adduct yield a similar profile of deoxynucleoside products when treated with an equimolar

150 nversion, for which this fluorine-labeled 2'-deoxynucleoside proved to be a powerful sensor.

151 and 9-methyl-1H-imidazo[4,5-b]pyridine beta-deoxynucleoside (Q), were used to examine the importance

152 oxycytidine kinase (dCK) is to phosphorylate deoxynucleosides required for DNA synthesis, with the ex

153 he 3'-hydroxyl group from potent anti-VZV 2'-deoxynucleosides results in loss of the VZV activity, bu

154 Incorporation of 3'-deoxynucleosides results in the formation of 2'-5'-inter

155 Long-chain derivatives at C6 in the 2'-deoxynucleoside series showed virus-encoded nucleoside k

156 e NO.-induced deamination rate constants for deoxynucleosides, single- and double-stranded oligonucle

157 substrate, were more modestly affected by 2'-deoxynucleoside substitution.

158 INTERPRETATION: Our studies demonstrate that deoxynucleoside substrate enhancement is a novel therapy

159 Adenine deoxynucleosides, such as 2-chloro-2'-deoxyadenosine (2C

160 Adenine deoxynucleosides, such as 2-chlorodeoxyadenosine (2CdA)

161 Both pyrimidine and purine deoxynucleoside sugar puckers are perturbed by the phena

162 (ii) Ethidium binding converts deoxynucleoside sugar puckers from the C2'-endo to the C

163 The stability of dX as a 2'-deoxynucleoside (t(1/2) = 3.7 min at pH 2; 1104 h at pH

164 modified bases including 8,5'-cyclopurine-2'-deoxynucleoside tandem lesions were identified and quant

165 The other adenine deoxynucleosides tested displayed comparable DNA-damagin

166 fficacy of deoxynucleoside monophosphate and deoxynucleoside therapies for TK2 deficiency.

167 fficacy of deoxynucleoside monophosphate and deoxynucleoside therapies.

168 by secretion of deoxycytidine, but not other deoxynucleosides, through equilibrative nucleoside trans

169 inistered deoxynucleoside monophosphates and deoxynucleoside to 16 TK2-deficient patients under a com

170 beta was completely antagonized by providing deoxynucleosides to bypass the block in ribonucleotide r

171 dation of any hydrocarbon with the purine 2'-deoxynucleosides to date.

172 hosphorolysis in 6-oxypurine nucleosides and deoxynucleosides to form purine and alpha-D-phosphorylat

173 Addition of deoxynucleosides to the medium increased intracellular d

174 ly protected 5'-O-(4, 4'-dimethoxytrityl)-2'-deoxynucleosides to yield 3'-O-phosphinoamidite reactive

175 ed oligomers were 5 times more reactive than deoxynucleosides toward N2O3.

176 iomarker of disease severity and response to deoxynucleoside treatment in patients with thymidine kin

177 ion, we show evidence of clinical benefit of deoxynucleoside treatment, especially when treatment is

178 the 110-to-115 loop region, which may affect deoxynucleoside triphosphate (dNTP) binding and polymera

179 upport catalysis, and Ca(2+), which supports deoxynucleoside triphosphate (dNTP) binding but not cata

180 Residue 272 is located within the deoxynucleoside triphosphate (dNTP) binding pocket of DN

181 er of the HBV reverse transcriptase (RT)-DNA-deoxynucleoside triphosphate (dNTP) complex, based on th

182 onocytic cells by reducing the intracellular deoxynucleoside triphosphate (dNTP) concentrations.

183 Analogues were examined both as incoming deoxynucleoside triphosphate (dNTP) derivatives and as t

184 ate of misincorporation is high because of a deoxynucleoside triphosphate (dNTP) imbalance.

185 dTTP is the most abundant deoxynucleoside triphosphate (dNTP) in the cell despite

186 Here, we investigated the pre-steady-state deoxynucleoside triphosphate (dNTP) incorporation kineti

187 can be explained by decreased sensitivity to deoxynucleoside triphosphate (dNTP) inhibition of the nu

188 uently in resting cells, likely due to lower deoxynucleoside triphosphate (dNTP) levels and the prese

189 Samhd1(-/-) cells have elevated deoxynucleoside triphosphate (dNTP) levels but, surprisi

190 anscriptase (RT) mutants or limited cellular deoxynucleoside triphosphate (dNTP) pools.

191 alleviated by SML1 deletion, which increases deoxynucleoside triphosphate (dNTP) pools.

192 ble interaction between SOS and the cellular deoxynucleoside triphosphate (dNTP) pools.

193 The presence of complementary 2'-deoxynucleoside triphosphate (dNTP) shifts the equilibri

194 not contact the DNA template or the incoming deoxynucleoside triphosphate (dNTP) substrate, is locate

195 I (KF) as a function of the concentration of deoxynucleoside triphosphate (dNTP) substrate.

196 zing the template-directed polymerization of deoxynucleoside triphosphate (dNTP) substrates onto the

197 SAMHD1 is a deoxynucleoside triphosphate (dNTP) triphosphohydrolase

198 anscriptase with a DNA template:primer and a deoxynucleoside triphosphate (dNTP), and the crystal str

199 a dideoxy-terminated primer and an incoming deoxynucleoside triphosphate (dNTP), does not form the c

200 Moreover, we show that binding of a deoxynucleoside triphosphate (dNTP), in the absence of a

201 h the catalytic residues of RT, the incoming deoxynucleoside triphosphate (dNTP), or the primer-templ

202 in reverse transcriptase (RT) that alter the deoxynucleoside triphosphate (dNTP)-binding pocket, incl

203 ast to previous suggestions that Dpo4 uses a deoxynucleoside triphosphate (dNTP)-stabilized misalignm

204 he presence or in the absence of an incoming deoxynucleoside triphosphate (dNTP).

205 ents associated with binding of the incoming deoxynucleoside triphosphate (dNTP).

206 metal exchange-inert Rh(III) derivative of a deoxynucleoside triphosphate (Rh.dTTP).

207 ts of the purine substrates ADP and GDP, the deoxynucleoside triphosphate allosteric effectors dGTP a

208 radical-containing (R2) enzyme subunits and deoxynucleoside triphosphate allosteric effectors.

209 f S phase by transcribing genes required for deoxynucleoside triphosphate and DNA synthesis.

210 m our laboratory have shown that the natural deoxynucleoside triphosphate and the NNRTI can simultane

211 constants of transitions that lead to strong deoxynucleoside triphosphate binding prior to chemistry.

212 e effect of mutations in the YXDD motif, the deoxynucleoside triphosphate binding site, the thumb dom

213 ismatched nucleotides from the ternary E.DNA.deoxynucleoside triphosphate complex and by the use of s

214 ccur in a fully assembled DNA polymerase-DNA-deoxynucleoside triphosphate complex with two canonical

215 relatively inactive except when the cellular deoxynucleoside triphosphate concentrations are high, as

216 Thus, rather large increases in fidelity of deoxynucleoside triphosphate insertion and mispair exten

217 previously shown to increase the fidelity of deoxynucleoside triphosphate insertion.

218 r results suggest that motif B influences RT-deoxynucleoside triphosphate interactions at multiple st

219 PCR was performed with a deoxynucleoside triphosphate mixture which resulted in t

220 d by the direct interaction of CD81 with the deoxynucleoside triphosphate phosphohydrolase SAMHD1.

221 Taken together, these findings support deoxynucleoside triphosphate pool depletion as the prima

222 ponse to genotoxic stress by maintaining the deoxynucleoside triphosphate pools necessary for error-p

223 Quantification of deoxynucleoside triphosphate pools showed that hydroxyur

224 DNA stability is by modulating mitochondrial deoxynucleoside triphosphate pools.

225 repair of DNA require equilibrated pools of deoxynucleoside triphosphate precursors.

226 ion by the lentivirus vector was improved by deoxynucleoside triphosphate pretreatment of the vector

227 oredoxin, a primer-template, and an incoming deoxynucleoside triphosphate reveals a putative hydrogen

228 ring the balance between DNA replication and deoxynucleoside triphosphate synthesis in the case of nd

229 than the Exo mutants, converted the incoming deoxynucleoside triphosphate to its monophosphate, indic

230 1 has been identified as the first mammalian deoxynucleoside triphosphate triphosphohydrolase (dNTPas

231 A new study shows that host deoxynucleoside triphosphate triphosphohydrolase (dNTPas

232 SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase and a n

233 The deoxynucleoside triphosphate triphosphohydrolase SAMHD1

234 Upon binding a correct deoxynucleoside triphosphate, alpha-helix N of DNA polym

235 , potentially involving rearrangement of the deoxynucleoside triphosphate-binding pocket residues.

236 titutions near the polymerase active site or deoxynucleoside triphosphate-binding site of HIV-1 RT in

237 omplex formation in the presence of the next deoxynucleoside triphosphate.

238 P, XTP, dXTP, or 6-hydroxylaminopurine (HAP) deoxynucleoside triphosphate] into nucleic acids is prev

239 catalyzes the hydrolysis of nucleoside- and deoxynucleoside-triphosphate (NTP) substrates by nucleop

240 d expression, decreasing the availability of deoxynucleoside triphosphates (dNTP) and thus HIV-1 reve

241 large number of nucleoside analogues and 2'-deoxynucleoside triphosphates (dNTP) have been synthesiz

242 ave functional roles in the interaction with deoxynucleoside triphosphates (dNTPs) and DNA.

243 cellular enzyme that depletes intracellular deoxynucleoside triphosphates (dNTPs) and inhibits the a

244 4), NL4-3 virions, incubated with or without deoxynucleoside triphosphates (dNTPs) and/or the polyami

245 Normal deoxynucleoside triphosphates (dNTPs) could still be inc

246 Synthesis of deoxynucleoside triphosphates (dNTPs) is required for bo

247 The deoxynucleoside triphosphates (dNTPs) of these bases are

248 t cell type contains a very low level of the deoxynucleoside triphosphates (dNTPs) required for provi

249 phosphohydrolase that degrades intracellular deoxynucleoside triphosphates (dNTPs) to a lower level t

250 (SAMHD1) is a triphosphohydrolase converting deoxynucleoside triphosphates (dNTPs) to deoxynucleoside

251 apped DNA 5.5-fold, and increases the Km for deoxynucleoside triphosphates (dNTPs) twofold.

252 icted infection by hydrolyzing intracellular deoxynucleoside triphosphates (dNTPs), lowering their co

253 , is impaired due to limited availability of deoxynucleoside triphosphates (dNTPs), which are needed

254 reactions lacking one of four complementary deoxynucleoside triphosphates (dNTPs).

255 emplating base from a pool of four different deoxynucleoside triphosphates (dNTPs).

256 of a 13/20mer primer/template (D) to detect deoxynucleoside triphosphates (N)-dependent conformation

257 Upon the addition of deoxynucleoside triphosphates and a polymerase, concatem

258 erize efficiently with low concentrations of deoxynucleoside triphosphates and seems to be able to ex

259 d d4TMP, even when relatively high levels of deoxynucleoside triphosphates are present in the reactio

260 work by depleting the pool of intracellular deoxynucleoside triphosphates but has also been reported

261 , suggesting that demethylation of alkylated deoxynucleoside triphosphates by AlkB could have biologi

262 Other deoxynucleoside triphosphates could also inhibit the upt

263 Other nucleoside triphosphates or deoxynucleoside triphosphates could not substitute for A

264 vels of dNTPs to maintain a balanced pool of deoxynucleoside triphosphates in the cell.

265 NA polymerases catalyze the incorporation of deoxynucleoside triphosphates into a growing DNA chain u

266 racellular enzyme that specifically degrades deoxynucleoside triphosphates into component nucleoside

267 e (RNAP) for ribonucleoside triphosphates vs deoxynucleoside triphosphates inverted question mark(kca

268 magnesium, potassium, sodium, Tris ions, and deoxynucleoside triphosphates on melting profiles of dup

269 2 microM, had no detectable activity against deoxynucleoside triphosphates or other typical Nudix hyd

270 y with different primers and compositions of deoxynucleoside triphosphates to differentially monitor

271 stimulated triphosphohydrolase that converts deoxynucleoside triphosphates to the constituent deoxynu

272 converting ribonucleoside triphosphates and deoxynucleoside triphosphates to their respective diphos

273 drolyze all eight of the canonical ribo- and deoxynucleoside triphosphates to their respective monoph

274 The Km of deoxynucleoside triphosphates was determined with a modi

275 m wild-type enzyme under conditions in which deoxynucleoside triphosphates were not limiting.

276 g sequences, under conditions where primers, deoxynucleoside triphosphates, and enzyme are not limiti

277 th various triggers, including S100 cytosol, deoxynucleoside triphosphates, detergents, NaCl, and buf

278 in the presence of a normal concentration of deoxynucleoside triphosphates, leading to a high toxicit

279 hydrolase that depletes the cellular pool of deoxynucleoside triphosphates, thereby preventing revers

280 leoside triphosphatase preferring pyrimidine deoxynucleoside triphosphates.

281 The drugs directly or indirectly decrease deoxynucleoside triphosphates.

282 osine polyphosphates, sugar nucleotides, and deoxynucleoside triphosphates.

283 nt for the binding of nucleoside analogs and deoxynucleoside triphosphates.

284 -based approach with 15N- and/or 13C-labeled deoxynucleoside triphosphates.

285 he conversion of nucleoside triphosphates to deoxynucleoside triphosphates.

286 eration of a wide variety of nucleoside (and deoxynucleoside) triphosphates (NTPs) from their cognate

287 een proposed that SAMHD1 is a dGTP-dependent deoxynucleoside triphosphohydrolase (dNTPase) that restr

288 HD domain-containing protein 1 (SAMHD1) is a deoxynucleoside triphosphohydrolase (dNTPase) with a nuc

289 Its deoxynucleoside triphosphohydrolase activity regulates c

290 The deoxynucleoside triphosphohydrolase SAMHD1 restricts ret

291 HD domain-containing protein 1 (SAMHD1) is a deoxynucleoside triphosphohydrolase that restricts the r

292 inoquinoline- and 2-aminoquinazoline-based C-deoxynucleosides (TRIPsides) that are designed to be inc

293 en condensed with appropriately protected 2'-deoxynucleosides using 4,5-dicyanoimidazole to yield the

294 Ts catalyze N-glycosidic bond cleavage of 2'-deoxynucleosides via a covalent 2-deoxyribosyl-enzyme in

295 Substitution of G620 with a 2'-deoxynucleoside was expected to inhibit the reaction, in

296 ion of lipophilic alkyl furano pyrimidine 2'-deoxynucleosides, we now report that 2',3'-dideoxy sugar

297 Sites of derivatization of adduct deoxynucleosides were established primarily by nuclear m

298 Suitably protected versions of the deoxynucleosides were prepared for oligonucleotide synth

299 the expanded adenine, we tested a formamide deoxynucleoside, which Leonard proposed as a shortened t

300 Pretreatment of HLFs with deoxynucleosides, which increase cellular dNTP pools, en