ライフサイエンスコーパス: deoxynucleotide

1 formation with the phosphate group of the 2'-deoxynucleotide.

2 n kinetics for incorporation of an incorrect deoxynucleotide.

3 s of magnitude less efficiently than natural deoxynucleotides.

4 dducts by B[a]PDE following reaction with 2'-deoxynucleotides.

5 catalyzes the reduction of nucleotides to 2'-deoxynucleotides.

6 says demonstrate that both NH2Y-alpha2s make deoxynucleotides.

7 tracellular dGTP without any effect on other deoxynucleotides.

8 , catalyzes the conversion of nucleotides to deoxynucleotides.

9 14 microg/ml, whereas M1dG fell to 1.4/10(7) deoxynucleotides.

10 oration and removal of natural and unnatural deoxynucleotides.

11 nd can generate products containing up to 32 deoxynucleotides.

12 ophosphates and PP(i), with a preference for deoxynucleotides.

13 xynucleotides were not the same as for the D-deoxynucleotides.

14 s) catalyze the conversion of nucleotides to deoxynucleotides.

15 e ribonucleotide embedded within a series of deoxynucleotides.

16 the equilibrium of allosteric activation by deoxynucleotides.

17 A biosynthesis: conversion of nucleotides to deoxynucleotides.

18 e >200-fold more rapidly than other ribo- or deoxynucleotides.

19 catalyzing the conversion of nucleotides to deoxynucleotides.

20 hetic oligonucleotides containing 4'-thio-2'-deoxynucleotides.

21 reductase (RNR) converts ribonucleotides to deoxynucleotides.

22 2 have significantly reduced ability to make deoxynucleotides.

23 cytosine guanine dinucleotide-enriched oligo-deoxynucleotides.

24 ol alpha), which extends the RNA primer with deoxynucleotides.

25 NA template and extending an RNA primer with deoxynucleotides.

26 el pathway for the prebiotic synthesis of 2'-deoxynucleotides.

27 osite correct (G) and incorrect (A) incoming deoxynucleotides.

28 ency vary inversely with the accumulation of deoxynucleotides.

29 emplate duplexes with 3'-deoxynucleotide, 3'-deoxynucleotide 3'-phosphate, or 3' ribonucleotide termi

30 presence of primer-template duplexes with 3'-deoxynucleotide, 3'-deoxynucleotide 3'-phosphate, or 3'

31 2'-Deoxynucleotide 5'-tetraphosphates in which a fluorescen

32 sion of nucleoside diphosphates (NDPs) to 2'-deoxynucleotides, a critical step in DNA replication and

33 ) catalyzes the conversion of nucleotides to deoxynucleotides, a process that requires long-range rad

34 ubsequently, nodes of PCNA that incorporated deoxynucleotide analogs were observed in regions of low-

35 n cognate and near-cognate tRNAs, we made 2'-deoxynucleotide and 2'-fluoro substituted mRNAs, which d

36 e it maintains the balance between guanylate deoxynucleotide and ribonucleotide levels that is pivota

37 cluding MDA, as compared with 3.8 M1dG/10(7) deoxynucleotides and 0.07 microg/ml lipid peroxidation p

38 odified DNA probes, incorporating two pyrene deoxynucleotides and a damaged base, enable the direct,

39 in cancer cells to fuel the biosynthesis of deoxynucleotides and antioxidants and to sustain stress-

40 s) catalyze the conversion of nucleotides to deoxynucleotides and are composed of alpha- and beta-sub

41 es catalyze the conversion of nucleotides to deoxynucleotides and are composed of two subunits: R1 an

42 , enzymes that convert nucleotides (NDPs) to deoxynucleotides and are essential for DNA replication a

43 This enzyme contains approximately 30 deoxynucleotides and can cleave almost any RNA substrate

44 for counting efficiencies of labeled DNA and deoxynucleotides and illustrate the generality of this e

45 he conversion of nucleoside triphosphates to deoxynucleotides and is 100% inactivated by 1 equiv of 2

46 ) catalyzes the conversion of nucleotides to deoxynucleotides and is composed of two subunits: alpha2

47 uction of nucleoside 5'-diphosphates into 2'-deoxynucleotides and is composed of two subunits: alpha2

48 ) catalyzes the conversion of nucleotides to deoxynucleotides and is essential in all organisms.

49 he conversion of nucleoside triphosphates to deoxynucleotides and is rapidly (<30 s) inactivated by 1

50 h 18:0/stearic acid) produced 6.5 M1dG/10(7) deoxynucleotides and no detectable lipid peroxidation pr

51 the availability of pure, well-characterized deoxynucleotides and not a sequence-specific pure DNA st

52 s) catalyze the conversion of nucleotides to deoxynucleotides and require dinuclear metal clusters fo

53 ficient at adding templated and nontemplated deoxynucleotides and ribonucleotides to DNA ends in vitr

54 The antisense deoxynucleotides and siRNA approach acts via removal of

55 encing in GBM cells reduced levels of NADPH, deoxynucleotides, and glutathione and increased their se

56 acteriophage-encoded RNA polymerase using 3'-deoxynucleotides as chain terminators.

57 results suggest that the potency of adenine deoxynucleotides as co-factors for APAF-1-dependent casp

58 Incorporation of site-specific 2'-deoxynucleotides, as well as phosphorothioate and methyl

59 as documented by more rapid incorporation of deoxynucleotides, associated with earlier increases in c

60 ozyme bound to an inhibitor RNA containing a deoxynucleotide at the cleavage site.

61 A polymerase Pol iota, which misincorporates deoxynucleotides at a high rate.

62 thesis of a series of derivatives containing deoxynucleotides at each position along the D5 strand.

63 variant of pol beta, K289M, misincorporates deoxynucleotides at significantly increased frequencies

64 The introduction of 3 deoxynucleotides at the 5' terminus of the 2'-methoxy an

65 binds nucleoside diphosphate substrates and deoxynucleotide/ATP allosteric effectors and is the site

66 that phage-augmented NADPH production fuels deoxynucleotide biosynthesis for phage replication, and

67 phage genes involved in the light reactions, deoxynucleotide biosynthesis, and the PPP, including a t

68 A protein, termed mitochondrial deoxynucleotide carrier (DNC), based on its ability to t

69 25A19, which encodes a nuclear mitochondrial deoxynucleotide carrier (DNC), contains a substitution t

70 The lack of deoxynucleotides causes replicative stress leading to ac

71 io of PrEP's active metabolites vs competing deoxynucleotides compared to cisgender women and men (P

72 will only occur if the gap is filled with a deoxynucleotide complementary to the wild-type or mutant

73 triphosphate (TP) levels similar to cellular deoxynucleotide concentrations can induce multilog killi

74 Bypass efficiency was proportional to deoxynucleotide concentrations equivalent to those found

75 /z 399 and 497 were observed for all four 2'-deoxynucleotides, corresponding to [(B[a]Ptriol+phosphat

76 efficient than the second, and among natural deoxynucleotides, dATP was the preferred substrate due t

77 ymes that are alone capable of generating 2'-deoxynucleotides de novo and are thus critical in DNA bi

78 vestigate allosteric activation of SAMHD1 by deoxynucleotide-dependent tetramerization and measure ho

79 Collectively, our data suggest that deoxynucleotide-dependent tetramerization contributes to

80 y, RTEL1 deficiency induces tolerance to the deoxynucleotide-depleting drug hydroxyurea, which could

81 tional Xrs2p complex leads to sensitivity to deoxynucleotide depletion and to an inability to efficie

82 However, under conditions of deoxynucleotide depletion produced by hydroxyurea treatm

83 he half-life of the assembled tetramer after deoxynucleotide depletion varies from minutes to hours d

84 operties of dimerized pentaphosphate-bridged deoxynucleotides (dicaptides) that contain reactive comp

85 ntrols the balance and level of the cellular deoxynucleotide diphosphate pools that are critical for

86 sion of nucleoside 5'-diphosphates (NDPs) to deoxynucleotides (dNDPs).

87 conversion of nucleoside 5'-diphosphates to deoxynucleotides (dNDPs).

88 n of nucleoside 5'-diphosphates (NDPs) to 2'-deoxynucleotides (dNDPs).

89 over saturation kinetics for all 16 possible deoxynucleotide (dNTP) incorporations and for four match

90 overed that incorporation of a complementary deoxynucleotide (dNTP) into a self-primed single-strande

91 phosphorylation, differential effects on 2'-deoxynucleotide (dNTP) pools, and differences in the aff

92 ) catalyze the rate-limiting step of de novo deoxynucleotide (dNTP) synthesis.

93 which subsequently catalyzed the addition of deoxynucleotides (dNTP) containing biotinlated 2'-deoxya

94 es were to analyze pharmacodynamic effect on deoxynucleotides (dNTPs) and to seek relationships betwe

95 se that catalyzes the sequential addition of deoxynucleotides (dNTPs) at the 3'-OH group of an oligon

96 tion of a mixture of natural and fluorescent deoxynucleotides (dNTPs) at the 3'-OH of an RNA-DNA hybr

97 preparation of the corresponding fluorinated deoxynucleotides (dNTPs).

98 strate-recognition domains of seven to eight deoxynucleotides each.

99 Terminal deoxynucleotide end-labeling (TUNEL) assays performed on

100 Terminal nick deoxynucleotide end-labeling-positive apoptotic cells (1

101 yl radical (Fe(III)2-Y*) cofactor to produce deoxynucleotides essential for DNA replication and repai

102 hen this initiation complex is supplied with deoxynucleotides, essentially all of the tRNA is used as

103 yme is comprised of a catalytic domain of 15 deoxynucleotides, flanked by two substrate-recognition d

104 s reveal a preference for guanosine/cytosine deoxynucleotides flanking the cognate CpG.

105 o RNase A pretreatment and requires all four deoxynucleotides for optimal polymerization.

106 tion of large bDNA combs containing all four deoxynucleotides for use as signal amplifiers in nucleic

107 osyl radical (Y122.) cofactor that initiates deoxynucleotide formation.

108 nt of Y731 of R2 with phenylalanine prevents deoxynucleotide formation.

109 with DNA polymerases, can excise mismatched deoxynucleotides from DNA.

110 se containing ribose; purine nucleotides and deoxynucleotides gave more methylglyoxal than did the py

111 The deoxynucleotide generated depends on the presence of all

112 double-stranded target derived from standard deoxynucleotides (i.e. beta-anomers).

113 reaks, incorporates both ribonucleotides and deoxynucleotides in a template-directed manner.

114 The presence of chloride and deoxynucleotides in a total concentration above 10 micro

115 ch catalyze the conversion of nucleotides to deoxynucleotides in all organisms, are an exemplar of ra

116 yze the de novo conversion of nucleotides to deoxynucleotides in all organisms, controlling their rel

117 s) catalyze the conversion of nucleotides to deoxynucleotides in all organisms, providing the monomer

118 s) catalyze the conversion of nucleotides to deoxynucleotides in all organisms.

119 e radical chemistry to reduce nucleotides to deoxynucleotides in all organisms.

120 to several other clinically relevant adenine deoxynucleotides in B-chronic lymphocytic leukemia extra

121 ggest that site-specific incorporation of 3'-deoxynucleotides in CpG DNA modulates immunostimulatory

122 his reversal of the polymerization reaction, deoxynucleotides in DNA are converted to deoxynucleoside

123 The duplex donor DNAs are approximately 300 deoxynucleotides in length and contain only 15 bp of the

124 s, thereby maintaining the proper balance of deoxynucleotides in the cell.

125 A pre-steady-state burst of deoxynucleotide incorporation (k(obsd) = 1.0 s(-)(1)) in

126 y for the enzymatic reaction during a single deoxynucleotide incorporation event.

127 Steady-state kinetic analyses of deoxynucleotide incorporation indicate that pol eta has

128 re is a hyperbolic dependence of the rate of deoxynucleotide incorporation on the concentration of dC

129 ved with a DNA template, the rate of correct deoxynucleotide incorporation was reduced 25-fold (5.5+/

130 Endogenous levels of deoxynucleotides increased 24 hours after ara-C infusion

131 merases are defined as such because they use deoxynucleotides instead of ribonucleotides with high sp

132 The misincorporation of non-complementary deoxynucleotides into DNA by pol alpha was substantially

133 on helix was evaluated by introducing single deoxynucleotides into each of the six positions in the h

134 epair in response to the misincorporation of deoxynucleotides into newly synthesized DNA, long before

135 f ribonucleotide 5'-diphosphates to their 2'-deoxynucleotides, is modulated by levels of its M2 subun

136 tion in a viral strategy to control cellular deoxynucleotide levels for efficient replication.

137 tetramerization contributes to regulation of deoxynucleotide levels in cycling cells, whereas in non-

138 h defects in genes involved in mitochondrial deoxynucleotide metabolism or utilization, such as mutat

139 thanol-induced alterations in methionine and deoxynucleotide metabolism.

140 atically digested to its constituent monomer-deoxynucleotide monophosphates (dNMPs), of which there a

141 ase upon Q deprivation is due to the lack of deoxynucleotides needed for DNA synthesis.

142 d (either on the base or phosphate group) 2'-deoxynucleotides of guanine, adenine, cytosine and thymi

143 Interestingly, deoxynucleotides of Pf1 DNA exhibit sugars in the C2'-en

144 Using the drug-containing and normal deoxynucleotide oligomers (21-base) annealed to M13mp18(

145 Substitution of a 3'-deoxynucleotide on the scissile strand at position -6 en

146 e DNA lesions, but readily extends from such deoxynucleotides once they have been inserted.

147 We report that LigD POL can add a deoxynucleotide opposite an abasic lesion in the templat

148 ases act sequentially: Pol iota incorporates deoxynucleotides opposite DNA lesions, and Pol zeta func

149 Pol zeta is very inefficient in inserting deoxynucleotides opposite DNA lesions, but readily exten

150 s damage, Pol iota specifically incorporates deoxynucleotides opposite highly distorting or non-instr

151 polymerase I selects its natural substrates, deoxynucleotides, over ribonucleotides by several thousa

152 s specifically insert the hydrophobic pyrene deoxynucleotide (P) opposite tetrahydrofuran (F), an sta

153 g protein-1 (SAMHD1) is a recently described deoxynucleotide phosphohydrolase controlling the size of

154 ation) and the subsequent addition of 2 or 3 deoxynucleotides (polymerization).

155 or the construction of high molecular weight deoxynucleotide polymers.

156 nvolved DNA sequencing of two closely spaced deoxynucleotide polymorphisms.

157 Also, disturbances in bacterial deoxynucleotide pools amplify 5-FU-induced autophagy and

158 Hydroxyurea also depleted deoxynucleotide pools and increased the incorporation of

159 hibit ribonucleotide reductase and decreased deoxynucleotide pools, were incorporated mainly within r

160 , there was a decline in the cellular purine deoxynucleotide pools.

161 the incorporation of matched and mismatched deoxynucleotides probably reflects the differences in th

162 It controls cell proliferation through deoxynucleotide production and metastatic propensity thr

163 The pH rate profiles of deoxynucleotide production by these F(n)()Y(356)-R2s are

164 metabolism including energy transduction and deoxynucleotide production catalyzed by ribonucleotide r

165 up a functional unit involved in energy and deoxynucleotide production for phage replication in reso

166 he possibility of an abiotic route to the 2'-deoxynucleotides provides a new perspective on the evolu

167 ) catalyzes the conversion of nucleotides to deoxynucleotides, providing the building blocks for DNA

168 s) catalyze the conversion of nucleotides to deoxynucleotides, providing the monomeric precursors req

169 The B[a]PDE plus 2'-deoxynucleotide reaction mixtures were purified using so

170 ication that is independent of checkpoint or deoxynucleotide regulation is proposed.

171 V-1 RT manifested itself during ATP-mediated deoxynucleotide removal.

172 *) enzymes that provide the balanced pool of deoxynucleotides required for DNA synthesis and repair i

173 wn for its antiviral activity of hydrolysing deoxynucleotides required for virus replication.

174 igomers containing 2-aminoquinazolin-5-yl 2'-deoxynucleotide residues are reported.

175 s they did for substrates composed solely of deoxynucleotide residues.

176 r DNA replication, but 2) upon addition of a deoxynucleotide results in the conversion of the incorpo

177 oside diphosphate reductase with 2'-azido-2'-deoxynucleotides results in appearance of EPR signals fo

178 ric oligonucleotides composed of a five-base deoxynucleotide sequence flanked by chemically modified

179 nse oligonucleotides composed of a five-base deoxynucleotide sequence flanked on either side by chemi

180 e, PCR competent and able to copy repetitive deoxynucleotide sequences six to seven times more faithf

181 t of each nucleotide in the tetraloop with a deoxynucleotide showed a 16-fold increase in k(cat) for

182 The method provides deoxynucleotide-specific detection, accurate measurement

183 restores A site binding, it appears that the deoxynucleotide substituted complexes are impaired in th

184 fects in tRNA selection with the multiple 2'-deoxynucleotide substituted mRNA.

185 A set of deoxynucleotide substituted versions of this tRNA has be

186 expanded set of misacylated tRNAs and two 2'-deoxynucleotide-substituted mRNAs are used to demonstrat

187 45 different tRNAs, each containing a single deoxynucleotide substitution covering the upper half of

188 Only four individual deoxynucleotide substitutions blocked splicing activity:

189 ertiary stabilization is increased by single deoxynucleotide substitutions in the exon mimic at every

190 Our results show that multiple 2'-deoxynucleotide substitutions in the mRNA substantially

191 without significantly affecting affinity for deoxynucleotide substrate (K(d)(-dNTP)).

192 ining juxtaposed dC and 5'-phosphorylated dT deoxynucleotides (substrate 1) yielded kcat and kcat/Km

193 '-substituted terminators and compared to 2'-deoxynucleotide substrates (dNTPs).

194 transferase activity, HP could use all four deoxynucleotide substrates, but TTP was clearly favored

195 ings with other nucleoside analogs or normal deoxynucleotides such as dGTP.

196 leoside 5'-diphosphates to the corresponding deoxynucleotides supplying the dNTPs required for DNA re

197 n of replication origin firing, promotion of deoxynucleotide synthesis and replication fork restart,

198 at the sample solution components (chloride, deoxynucleotides, template DNA) and injection conditions

199 P (residues 283-341) bound to a 21-base pair deoxynucleotide that encompasses the canonical 8-base pa

200 ymphoid development and aberrant pools of 2'-deoxynucleotides that are substrates for TdT in lymphoid

201 NR) catalyze the reduction of nucleotides to deoxynucleotides through a mechanism involving an essent

202 ditions that permitted polymerization of one deoxynucleotide to primers containing either 3'-penultim

203 ct stages, i.e., the attachment of the first deoxynucleotide to RT (initiation) and the subsequent ad

204 NA-DNA junction (formed upon attachment of a deoxynucleotide to the RNA primer).

205 ic DNA polymerase alpha, adding a stretch of deoxynucleotides to the RNA primer before handoff to Pol

206 arious time points using an in situ terminal deoxynucleotide tranferase-mediated dUTP nick-end labeli

207 Pancreata were analyzed by terminal deoxynucleotide tranferase-mediated dUTP nick-end labeli

208 gly, Dpo1 also displays a competing terminal deoxynucleotide transferase (TdT) activity unlike any ot

209 Cell apoptosis was evaluated by terminal deoxynucleotide transferase dUTP nick end labeling stain

210 was obtained by double staining for terminal deoxynucleotide transferase nick end labeling (TUNEL) an

211 tion assay using biotin-16-dUTP and terminal deoxynucleotide transferase showed that TopoIIbeta media

212 human V(D)J recombination, whereas terminal deoxynucleotide transferase, Artemis, and DNA-dependent

213 GATA-3, but did not express Pax-5, terminal deoxynucleotide transferase, or CD3epsilon.

214 situ end-labeling of nicked DNA by terminal deoxynucleotide transferase, with measurements of cellul

215 grammed cell death, demonstrated by terminal deoxynucleotide transferase-mediated deoxyuridine tripho

216 histological injury, the number of terminal deoxynucleotide transferase-mediated deoxyuridine tripho

217 ating hepatocyte apoptosis with the terminal deoxynucleotide transferase-mediated deoxyuridine tripho

218 e aminotransferase levels, positive terminal deoxynucleotide transferase-mediated deoxyuridine tripho

219 Positive TUNEL (in situ terminal deoxynucleotide transferase-mediated dUTP nick end label

220 Terminal deoxynucleotide transferase-mediated dUTP nick end label

221 ssessed by activation of caspase-3, terminal deoxynucleotide transferase-mediated dUTP nick end-label

222 Positive terminal deoxynucleotide transferase-mediated dUTP nick end-label

223 ng areas of infarcted myocardium by terminal deoxynucleotide transferase-mediated dUTP nick end-label

224 s their apoptosis was quantified by terminal deoxynucleotide transferase-mediated dUTP nick-end label

225 Apoptosis assessed by terminal deoxynucleotide transferase-mediated dUTP nick-end label

226 died, and apoptosis was detected by terminal deoxynucleotide transferase-mediated dUTP nick-end label

227 optosis are time-consuming (as with terminal deoxynucleotide transferase-mediated dUTP nick-end label

228 ion, and apoptosis by Annexin V and terminal deoxynucleotide transferase-mediated dUTP nick-end label

229 nohistochemistry), apoptotic rates (terminal deoxynucleotide transferase-mediated dUTP nick-end label

230 lografts were examined by using the terminal deoxynucleotide transferase-mediated dUTP nick-end label

231 d interleukin (IL)-10 proteins, and terminal deoxynucleotide transferase-mediated dUTP nick-end label

232 and apoptosis was measured using a terminal deoxynucleotide transferase-mediated dUTP nick-end label

233 Terminal deoxynucleotide transferase-mediated dUTP nick-end label

234 e dead tumor cells were swollen and terminal deoxynucleotide transferase-mediated dUTP nick-end label

235 let cell apoptosis was evaluated by terminal deoxynucleotide transferase-mediated dUTP nick-end label

236 cardiomyocytes determined with the terminal deoxynucleotide transferase-mediated dUTP nick-end label

237 and neoplastic pituitary tissues by terminal deoxynucleotide transferase-mediated dUTP nick-end label

238 activated caspase-3, phiphilux, and terminal deoxynucleotide transferase-mediated dUTP nick-end label

239 Finally, terminal deoxynucleotide transferase-mediated dUTP nick-end label

240 We demonstrate by terminal deoxynucleotide transferase-mediated dUTP-biotin nick-en

241 mal transport activity, implying that failed deoxynucleotide transport across the inner mitochondrial

242 Our data indicate that mitochondrial deoxynucleotide transport may be essential for prenatal

243 tested if the drim2 gene also encodes for a deoxynucleotide transporter in the fruit fly.

244 o acid that lies above the nucleobase of the deoxynucleotide triphosphate (dNTP) and is expected to p

245 RNA template-DNA primer duplex and incoming deoxynucleotide triphosphate (dNTP) at 3.0-A resolution.

246 primer, and DNA template in the presence of deoxynucleotide triphosphate (dNTP) complementary to the

247 Deoxynucleotide triphosphate (dNTP) concentrations have

248 se controlling the size of the intracellular deoxynucleotide triphosphate (dNTP) pool, a limiting fac

249 -121.6-fold lower binding affinity (K(d)) to deoxynucleotide triphosphate (dNTP) substrates than HIV-

250 n Arg668 and the ring oxygen of the incoming deoxynucleotide triphosphate (dNTP) using a combination

251 he 3'-OH on the sugar moiety of the incoming deoxynucleotide triphosphate (dNTP), we examined how thi

252 compounds are competitive inhibitors of the deoxynucleotide triphosphate (dNTP).

253 cation blocker alpha-amanitin, NTPs (but not deoxynucleotide triphosphate [dNTPs]) templated at downs

254 lon nor theta influenced the Km of alpha for deoxynucleotide triphosphate and only slightly decreased

255 ginine 67 are functionally equivalent to the deoxynucleotide triphosphate binding residues arginine 5

256 These agents cause imbalances in deoxynucleotide triphosphate levels and the accumulation

257 whose products supply the mitochondria with deoxynucleotide triphosphate pools needed for DNA replic

258 de reductase and the consequent depletion of deoxynucleotide triphosphate pools result in a cellular

259 r the removal of HAP from purine pools, from deoxynucleotide triphosphate pools, and from DNA, and we

260 lls into S-phase under conditions of altered deoxynucleotide triphosphate pools, particularly an incr

261 Mus81 enables survival of deoxynucleotide triphosphate starvation, UV radiation, a

262 nterococcus faecalis is a distant homolog of deoxynucleotide triphosphate triphosphohydrolases (dNTPa

263 th protonation of the gamma-phosphate of the deoxynucleotide triphosphate(dNTP) via a solvent water m

264 ernary complex of enzyme*gapped DNA*dNTP (2'-deoxynucleotide triphosphate).

265 ed because the reaction lacked the requisite deoxynucleotide triphosphate.

266 nus to the alpha-beta bridging oxygen of the deoxynucleotide triphosphate; this neutralizes the evolv

267 ested to play an important role in supplying deoxynucleotide triphosphates (dNTP) for DNA repair duri

268 Deoxynucleotide triphosphates (dNTPs) are essential for

269 ductase (RNR) supplies the balanced pools of deoxynucleotide triphosphates (dNTPs) necessary for DNA

270 tial event in the HIV-1 life cycle, requires deoxynucleotide triphosphates (dNTPs) to fuel DNA synthe

271 -limiting enzyme in the de novo synthesis of deoxynucleotide triphosphates (dNTPs), is a potential ta

272 etroviral RNA into DNA by depleting cellular deoxynucleotide triphosphates (dNTPs).

273 to detect the template-dependent binding of deoxynucleotide triphosphates by DNA polymerases.

274 ype oligonucleotides were mixed with various deoxynucleotide triphosphates in the presence of Sr(2)(+

275 ent with the high ratio of ribonucleotide to deoxynucleotide triphosphates in tissues, and that riboa

276 bstrate was observed in reactions containing deoxynucleotide triphosphates required to make full-leng

277 in myeloid cells by hydrolyzing the cellular deoxynucleotide triphosphates to a level below that whic

278 orrelated with a rapid decrease in available deoxynucleotide triphosphates.

279 novel checkpoint responsive to low levels of deoxynucleotide triphosphates.

280 e show that SAMHD1 contains a dGTP-regulated deoxynucleotide triphosphohydrolase.

281 Deoxynucleotide triphosphohydrolases (dNTPases) play a c

282 to catalyze the conversion of nucleotides to deoxynucleotides under aerobic conditions, and recent st

283 to purine precursors, which would lead to 2'-deoxynucleotides upon desulfurization.

284 reductase (RNR) catalyzes the production of deoxynucleotides using complex radical chemistry.

285 P at the 3'-terminus and the adjacent normal deoxynucleotide was cleaved by DNA polymerase epsilon, t

286 The rate of excision of the 3'-terminal deoxynucleotide was similar, with both primers resulting

287 concentration of salts (chloride and di- and deoxynucleotides) was decreased below 10 microM using ge

288 The deoxynucleotides were characterized via steady-state kin

289 In 2 of 14 mutant integrants sequenced, deoxynucleotides were deleted from either the U5 or U3 t

290 acid determinants of the action of PGK for L-deoxynucleotides were not the same as for the D-deoxynuc

291 ver, 3'-terminal dAMP and subsequently other deoxynucleotides were readily excised from DNA in a dist

292 pol gamma in vitro as efficiently as natural deoxynucleotides, whereas AZT-TP, 3TC-TP, and CBV-TP wer

293 8,5'-Cyclopurine-2'-deoxynucleotides, which are strong blocks to mammalian D

294 Substitution of the 3'-deoxynucleotide with a ribonucleotide, 2'-methoxyethyl n

295 on in DNA indicates that the substitution of deoxynucleotide with ribonucleotide abolishes the need f

296 pol eta has a low fidelity, misincorporating deoxynucleotides with a frequency of about 10(-2) to 10(

297 yses and find that hPoltheta misincorporates deoxynucleotides with a frequency of about 10(-3) to 10(

298 oli can initiate reduction of nucleotides to deoxynucleotides with either a Mn(III)2-tyrosyl radical

299 obes containing 2'-O-methylnucleotides or 2'-deoxynucleotides with regard to their use in assays for

300 e couple the reduction of ribonucleotides to deoxynucleotides with the oxidation of formate to CO2.