ライフサイエンスコーパス: deoxyribonuclease

1 mediated conversion from a ribonuclease to a deoxyribonuclease.

2 digestion of linear DNA by an ATP-dependent deoxyribonuclease.

3 s cleaved the inhibitor of caspase-activated deoxyribonuclease.

4 encode human and murine DNase II, the acidic deoxyribonuclease.

5 idate protein family that includes ribo- and deoxyribonucleases.

6 dtB, was shown to exhibit features of type I deoxyribonucleases.

7 le-stranded ribonuclease and single-stranded deoxyribonuclease 1 (Card1).

8 In models of FGF23 excess, renal deoxyribonuclease 1 (Dnase1) mRNA expression is downregu

9 tested the hypothesis that recombinant human deoxyribonuclease 1 (rhDNase) reduces airflow obstructio

10 int mutation (chromosome 6: 99593111) in the deoxyribonuclease 1 hypersensitivity binding site on chr

11 ctive chromatin configuration as analyzed by deoxyribonuclease 1 sensitivity.

12 l galectin [CLC]; carboxypeptidase 3 [CPA3]; deoxyribonuclease 1-like 3 [DNASE1L3]; alkaline phosphat

13 Recombinant deoxyribonuclease accelerated the lysis of coronary thro

14 Coronary NET burden and deoxyribonuclease activity are predictors of ST-segment

15 vely with ST-segment resolution, whereas CLS deoxyribonuclease activity correlated negatively with in

16 A simple colorimetric assay for deoxyribonuclease activity employing a DNA-methyl green

17 f the UL12.5 protein prevented its potential deoxyribonuclease activity from being assayed in infecte

18 Deoxyribonuclease activity was not affected by the treat

19 spase to generate a C-terminal fragment with deoxyribonuclease activity, which produced 3' hydroxyl D

20 I forms a very tight complex with actin, and deoxyribonuclease affinity columns have been utilized to

21 the sputum of CF patients in the presence of deoxyribonuclease and high-salt conditions.

22 The current CF therapy relies on inhaled deoxyribonuclease and hypertonic saline but does not add

23 TREX2 structure is the first of a dimeric 3'-deoxyribonuclease and indicates how this highly efficien

24 ne can cleave inhibitor of caspase-activated deoxyribonuclease and lead to DNA fragmentation, thus pr

25 serological responses to streptolysin O and deoxyribonuclease B.

26 ccal antibodies, antistreptolysin O and anti-deoxyribonuclease B.

27 nuclease II (DNase II) is also known as acid deoxyribonuclease because it has optimal activity at the

28 agmentation factor (DFF, a caspase-activated deoxyribonuclease (CAD) and its inhibitor (ICAD)), is ca

29 3 and 7 and the downstream caspase-activated deoxyribonuclease (CAD).

30 in a homolog cDNA encoding caspase-activated deoxyribonuclease (CAD)/DNA fragmentation factor 40 (DFF

31 for catalysis or magnesium binding in type I deoxyribonucleases did not cause chromatin disruption.

32 Deoxyribonuclease digestion of the capped fragments left

33 Mutations in a DNA helicase/deoxyribonuclease (dna2-1) or in two RNase H activities

34 Deoxyribonuclease (DNase) I has been implicated in the i

35 Additionally, deoxyribonuclease (DNase) I sensitivity mapping defined

36 Several deoxyribonuclease (DNase) I-hypersensitive sites (HS) ha

37 Deoxyribonuclease (DNase) II, which was discovered more

38 uclease degradation was tested by means of a deoxyribonuclease (DNase) protection assay.

39 We expressed neurotrophin-3 (NT3), deoxyribonuclease (DNase), or vascular endothelial growt

40 another major class of degradative enzymes, deoxyribonuclease (DNase), remains unconfirmed and not s

41 icancer drug delivery system consisting of a deoxyribonuclease (DNase)-degradable DNA nanoclew (NCl)

42 phisms (SNPs) were functionally enriched for deoxyribonuclease (DNase)-hypersensitivity sites, expres

43 ons and hypomorphic variants of the secreted deoxyribonuclease DNASE1L3 are linked to familial and sp

44 ndritic cell (DC)-specific expression of the deoxyribonuclease, DNASE1L3, is positively correlated wi

45 Both CifA and CifB are deoxyribonucleases (DNases) that elevate DNA damage in l

46 DNA-based tension sensors are vulnerable to deoxyribonucleases (DNases) which cells may express on c

47 activity of human TREX2-catalyzed 3' --> 5'-deoxyribonuclease has been analyzed in steady-state and

48 inding site that is located near a region of deoxyribonuclease hypersensitivity.

49 Employing deoxyribonuclease I (DNase I) as a model enzyme template

50 However, NET disruption with deoxyribonuclease I (DNase I) efficiently inhibited airw

51 are concentrated in regulatory DNA marked by deoxyribonuclease I (DNase I) hypersensitive sites (DHSs

52 It was demonstrated previously that deoxyribonuclease I (DNase I) is a highly active renal e

53 Bovine pancreatic deoxyribonuclease I (DNase I) is a nuclease of relativel

54 Bovine pancreatic deoxyribonuclease I (DNase I) is a well characterised en

55 Recombinant human deoxyribonuclease I (DNase I) is an important clinical a

56 Deoxyribonuclease I (DNase I) is an important enzyme tha

57 DNA (cf-mtDNA) levels in mice, and systemic Deoxyribonuclease I (DNase I) treatment attenuated RS-in

58 Although deoxyribonuclease I (DNase I) was used to probe the stru

59 Human deoxyribonuclease I (DNase I), an enzyme recently approv

60 Human deoxyribonuclease I (DNase I), an enzyme used to treat c

61 ty (71 and 63% similarity), respectively, to deoxyribonuclease I (DNase I).

62 Deoxyribonuclease I (DNaseI) hypersensitivity analyses i

63 Conjugation of recombinant human deoxyribonuclease I (rhDNase) to polyethylene glycol (PE

64 selective serine 3 cofilin kinase binds to a deoxyribonuclease I affinity column, whereas the nonspec

65 odified 3'-phosphate of oligonucleotides and deoxyribonuclease I and ribonuclease H cleavages.

66 A deoxyribonuclease I binding assay shows that the number

67 Detection of pointed ends in situ using deoxyribonuclease I binding demonstrates that this incre

68 reated wild-type MLEC were hypersensitive to deoxyribonuclease I compared with wild-type cells, demon

69 Deoxyribonuclease I footprint analysis of the minimal pr

70 tituted in vitro transcription reactions and deoxyribonuclease I footprinting assays confirmed the ab

71 Deoxyribonuclease I footprinting identified a specific s

72 We used genomic deoxyribonuclease I footprinting to map nucleotide resol

73 Deoxyribonuclease I footprinting was used to identify a

74 Deoxyribonuclease I forms a very tight complex with acti

75 The identification of a tissue-specific deoxyribonuclease I hypersensitive site approximately 3k

76 portant transcriptional regulatory elements, deoxyribonuclease I hypersensitive site mapping studies

77 Colon-specific deoxyribonuclease I hypersensitive sites (DHS) have been

78 d single nucleotide polymorphisms (SNPs) and deoxyribonuclease I hypersensitive sites (DHSs) from 112

79 locus control region (LCR) composed of five deoxyribonuclease I hypersensitive sites (HSs).

80 Analysis of transcription factor motifs in deoxyribonuclease I hypersensitive sites at cell-type-sp

81 A 3.5-kb fragment containing one of these deoxyribonuclease I hypersensitive sites, located -14 kb

82 t mutation (Hg19) in a noncoding region of a deoxyribonuclease I hypersensitivity binding site was fo

83 ility as detected by histone acetylation and deoxyribonuclease I hypersensitivity.

84 Deoxyribonuclease I protection assays confirmed the pres

85 iple histone marks and Pol II, as well as in deoxyribonuclease I sensitivity and nucleosome positioni

86 lease A) and six acidic proteins (myoglobin, deoxyribonuclease I, beta-lactoglobulin A, beta-lactoglo

87 nalised with dornase alfa (recombinant human deoxyribonuclease I, DNase), demonstrating DNA degradati

88 They belong to nine different proteins (deoxyribonuclease I, enolase, hen egg-white lysozyme, hu

89 i to digestion with micrococcal nuclease and deoxyribonuclease I, indicating that chromatin structure

90 ous ATP-actin structures from complexes with deoxyribonuclease I, profilin, and gelsolin, monomeric A

91 However, removal of SWI/SNF left a deoxyribonuclease I-hypersensitive site specifically at

92 cs of regulatory DNA, we mapped >1.3 million deoxyribonuclease I-hypersensitive sites (DHSs) in 45 mo

93 l protein (CLC); carboxypeptidase A3 (CPA3); deoxyribonuclease I-like 3 (DNASE1L3); IL-1beta (IL1B);

94 markers acetyl-H4 and H4K20m, and regions of deoxyribonuclease I-sensitive chromatin compared with co

95 Gel-shift and deoxyribonuclease-I footprinting assays revealed four DN

96 Myeloid-cell-specific, deoxyribonuclease-I-hypersensitive sites localized to th

97 a, which was abrogated by preincubation with deoxyribonuclease-I.

98 acute liver failure plasma with and without deoxyribonuclease-I.

99 We have previously implicated deoxyribonuclease II (DNase II) as an endonuclease respo

100 Deoxyribonuclease II (DNase II) has been implicated in d

101 Deoxyribonuclease II (DNase II) is also known as acid de

102 previously cloned and ubiquitously expressed deoxyribonuclease II (DNase II).

103 Acid endonucleases of the deoxyribonuclease II (DNase II, EC 3.1.22.1) family have

104 of a highly positively charged enzyme, acid deoxyribonuclease II (EC 3.1.22.1), by glycosaminoglycan

105 not exhibit the approximately 100-base pair deoxyribonuclease II repeat characteristic of condensed

106 Deoxyribonuclease IIalpha (DNase IIalpha) is an acidic e

107 ibes the cloning of this cDNA, which we term deoxyribonuclease IIbeta (DNase IIbeta) and comparison o

108 e active site is structurally congruent to a deoxyribonuclease, making an unexpected link in the evol

109 o mitigate the effect of NETs by secreting a deoxyribonuclease (Nb-DNase II) to degrade the DNA backb

110 a mutation in the RTH1/RAD27 gene encoding a deoxyribonuclease needed for removal of excess nucleotid

111 nes encoding IgA proteases, mitogenic factor deoxyribonucleases, nickel/cobalt uptake and cobalamin b

112 e I was originally identified as a 5' --> 3' deoxyribonuclease present in fractionated extracts of Sc

113 letal integrity and DNA repair, and activate deoxyribonucleases, producing cell death with morphologi

114 p), a subunit of RNA polymerase II, Rad2p, a deoxyribonuclease required in DNA repair, and Rnt1p (RNa

115 Daily recombinant human deoxyribonuclease (rhDNase) is an established but expens

116 terase preparation is free of any detectable deoxyribonuclease, ribonuclease, and nucleotidase activi

117 triggers of NETosis, activity of endogenous deoxyribonuclease, ST-segment resolution, and infarct si

118 Amino acid similarity analyses of known GAS deoxyribonucleases suggest that Sda1 may be a chimeric p

119 r analogous to the PB1 and caspase-activated deoxyribonuclease superfamily of protein interaction dom

120 ase-3 target caspase-activated DNase (CAD, a deoxyribonuclease that catalyzes DNA fragmentation) to a

121 TREX1 is a 3'-deoxyribonuclease that degrades single- and double-stran

122 erpes simplex virus type 1 (HSV-1) encodes a deoxyribonuclease that is frequently referred to as alka

123 erpes simplex virus type 1 (HSV-1) encodes a deoxyribonuclease that is frequently referred to as alka

124 Trex2 is a keratinocyte-specific 3'-deoxyribonuclease that participates in the maintenance o

125 pe II restriction endonucleases (REases) are deoxyribonucleases that cleave DNA sequences with remark

126 ntrapleural tissue plasminogen activator and deoxyribonuclease therapy can potentially improve outcom

127 trapleural tissue plasminogen activator plus deoxyribonuclease therapy vs surgical decortication.

128 n of the actin filament destabilising agents deoxyribonuclease type 1 (DNase 1; 50 microg ml-1) or cy