ライフサイエンスコーパス: deoxyribonucleoside

1 of a halo-PAH catechol derivative with a 2'-deoxyribonucleoside.

2 se with the exception of UTP opposite purine deoxyribonucleoside.

3 amino-catechol PAH derivative with a halo-2'-deoxyribonucleoside.

4 -step' protocol for the hydrolysis of DNA to deoxyribonucleosides.

5 be produced de novo or can be salvaged from deoxyribonucleosides.

6 pes and enzymatically hydrolyzed to the free deoxyribonucleosides.

7 xture (alpha-D = 33% and beta-D = 39%) of 2'-deoxyribonucleosides.

8 iption process following the addition of the deoxyribonucleosides.

9 MS(2) fragmentation process of protonated 2'-deoxyribonucleosides.

10 which can be suppressed by exogenously added deoxyribonucleosides.

11 species/genus retains the ability to salvage deoxyribonucleosides.

12 converts a terminal ribonucleoside 3'-PO4 or deoxyribonucleoside 3'-PO4 of a primer-template to a 3'-

13 -BgCDEs with calf thymus DNA and with purine deoxyribonucleoside-3'-phosphates in vitro.

14 t ecto-5'-nucleotidase activity on ribo- and deoxyribonucleoside 5'-mono- and 5'-diphosphates with a

15 the N-glycosidic bond cleavage of purine 2'-deoxyribonucleoside 5'-monophosphates, a novel enzymatic

16 an be used to identify ribonucleoside and 2'-deoxyribonucleoside 5'-monophosphates, thereby taking a

17 the N-glycosidic bond cleavage of purine 2'-deoxyribonucleoside 5'-monophosphates.

18 7-deazaadenine, and 7-iodo-7-deazaguanine 2'-deoxyribonucleoside 5'-O-monophosphates (dNMPs) and 5'-O

19 We previously reported that pol B 8-oxo-2'-deoxyribonucleoside 5'-triphosphate insertion confounds

20 ort the mutagenic ligation of pol B 8-oxo-2'-deoxyribonucleoside 5'-triphosphate insertion products a

21 e relative concentrations of the 4 canonical deoxyribonucleoside 5'-triphosphates (dNTPs) at the repl

22 eat-sensitive 3'-protected derivatives of 2'-deoxyribonucleoside 5'-triphosphates (dNTPs) have been s

23 cies of different RNA polymerases against 2'-deoxyribonucleoside 5'-triphosphates (dNTPs).

24 rporation of fluorescently labeled dNTPs (2'-deoxyribonucleoside 5'-triphosphates) and by terminal tr

25 te-primer and noncompetitive with respect to deoxyribonucleoside 5'-triphosphates.

26 sphates (NRTI-TP) compete with endogenous 2'-deoxyribonucleosides-5'-triphosphates (dNTP) for incorpo

27 (pyrazolo[3,4-d]pyrimidin- 4-amine) N(8)-(2'deoxyribonucleoside), a deoxyadenosine analog (UB), pair

28 The most abundant 2'-deoxyribonucleoside adducts cross-linked by glyoxal are

29 rometry has been applied to the detection of deoxyribonucleoside adducts of the food-derived mutagen

30 Notably, the generally more labile 2'-deoxyribonucleosides also undergo reaction.

31 n and thus is also potentially vulnerable to deoxyribonucleoside analogs.

32 ed O6-benzyl-2'-deoxyguanosine (dBG), the 2'-deoxyribonucleoside analogue of BG, for its ability to i

33 low prediction of the mutagenic potential of deoxyribonucleoside analogues.

34 ed nucleoside derivatives, 6-fluoropurine 2'-deoxyribonucleoside and 2-fluoro-2'-deoxyinosine, by the

35 2'-Deoxyribonucleoside and its 5'-O-triphosphate were also

36 thesis of 3',5'-di-O-acetyl-6-bromopurine-2'-deoxyribonucleoside and its reaction with an arylamine i

37 aminopurine ribonucleoside, reduction to the deoxyribonucleoside and standard preparation of the 5'-0

38 f deoxyribose sugar radicals in DNA, guanine deoxyribonucleosides and deoxyribonucleotides.

39 rolase that cleaves physiological dNTPs into deoxyribonucleosides and inorganic triphosphate.

40 ith respect to environmental availability of deoxyribonucleosides and metabolic processes generating

41 well as 5-substituted uracil and cytosine 2'-deoxyribonucleosides and mono- and triphosphates were sy

42 When mixed with deoxyribonucleosides and N-protected 2'-deoxyribonucleos

43 These results support the notion that purine deoxyribonucleosides and pyrimidine ribonucleosides may

44 drolase (dNTPase), converting dNTPs into the deoxyribonucleosides and triphosphate.

45 triphosphohydrolase that converts dNTPs into deoxyribonucleosides and triphosphates.

46 steres of cytosine (2-fluoro-4-methylbenzene deoxyribonucleoside) and thymine (2,4-difluoro-5-methylb

47 stable UVA photoproduct of free 6-TG, its 2'-deoxyribonucleoside, and DNA 6-TG.

48 nomic DNA, hydrolyzing enzymatically to free deoxyribonucleosides, and derivatizing for GC-MS analysi

49 For the synthesis of 2'-deoxyribonucleosides, anion glycosylation performed with

50 ty is labeled; purine rather than pyrimidine deoxyribonucleosides are analyzed; and stable isotopes r

51 electron affinities in eV for each of the 2'-deoxyribonucleosides are as follows: 0.06, dA; 0.09, dG;

52 ionalized 8-aza-7-deazaxanthine ribo- and 2'-deoxyribonucleosides are described.

53 been evaluated for 5'-hydroxyl protection of deoxyribonucleosides as carbonates and for potential use

54 arly promising for 5'-hydroxyl protection of deoxyribonucleosides as thermolytic carbonates.

55 f 8-fluoro derivatives were obtained with 2'-deoxyribonucleosides, as compared to ribonucleosides.

56 ng sequences by replacing one or two natural deoxyribonucleosides at various positions with one or mo

57 ne and 7-deazapurin-2,6-diamine ribo- and 2'-deoxyribonucleosides by halogen atoms (chloro, bromo, io

58 approach, we show that depletion of a single deoxyribonucleoside causes reversible arrest of cells in

59 oguanine and 8-aza-7-deaza-2-aminoadenine 2'-deoxyribonucleosides decorated with fluorescent pyrene o

60 e of the glucitol (GutR), fucose (FucR), and deoxyribonucleoside (DeoR) systems of E. coli, as well a

61 The purine deoxyribonucleoside, deoxyadenosine (dA), is directly is

62 -selective prebiotic synthesis of the purine deoxyribonucleosides: deoxyadenosine and deoxyinosine.

63 hymidine can also transport other pyrimidine deoxyribonucleosides (deoxycytidine) and pyrimidine ribo

64 ides a class of stable, isolable ribo and 2'-deoxyribonucleoside derivatives that possess excellent r

65 This is the first synthesis of 8-fluoro-2'-deoxyribonucleoside derivatives.

66 The structure of the deoxyribonucleoside derived from N 6-methoxy-2, 6-diamin

67 for the quantitative analysis of the native deoxyribonucleoside dG, and MS-MS was used for the deter

68 2'-Deoxyribonucleoside dimers connected by a five-atom link

69 RNRs) are Fe-dependent enzymes that catalyze deoxyribonucleoside diphosphate (dNDP) synthesis.

70 sion of ribonucleoside diphosphates (NDP) to deoxyribonucleoside diphosphates (dNDP) and thereby prov

71 iphosphates (rNDPs) that can be converted to deoxyribonucleoside diphosphates (dNDPs) by ribonucleoti

72 ase (RNR) catalyzes the de novo synthesis of deoxyribonucleoside diphosphates (dNDPs) to provide dNTP

73 eotide reductase catalyzes the production of deoxyribonucleoside diphosphates, the precursors of deox

74 ersion of the ribonucleoside diphosphates to deoxyribonucleoside diphosphates, which are essential fo

75 CK), a rate-limiting enzyme in the cytosolic deoxyribonucleoside (dN) salvage pathway, is an importan

76 The diastereomeric spiroiminodihydantoin-2'-deoxyribonucleoside (dSp) lesions resulting from 2'-deox

77 a set of thermodynamically stable endcapped deoxyribonucleoside duplexes as a tool to elucidate the

78 The parasite is dependent on exogenous deoxyribonucleosides for DNA replication and thus is als

79 e corresponding 2'- and 3'-phosphates, while deoxyribonucleosides form 5'- and 3'-phosphates, the rat

80 es of C-6 azidopurine ribonucleosides and 2'-deoxyribonucleosides have been developed.

81 ns using high-level ab initio methods on the deoxyribonucleosides have been performed to investigate

82 The deoxyribonucleosides have been studied to determine the

83 from lactobacilli and a 5'-monophosphate-2'-deoxyribonucleoside hydrolase from rat.

84 the neutral and anionic forms of the four 2'-deoxyribonucleosides in DNA: 2'-deoxyriboadenosine (dA),

85 purine nucleobases to anomeric 2'-fluoro-2'-deoxyribonucleosides in favor of beta-anomers generally.

86 f rN catabolic enzymes in the degradation of deoxyribonucleosides in vivo.

87 units (purine ribonucleosides and pyrimidine deoxyribonucleosides) in a unified reaction network rema

88 Deoxyribonucleoside kinases (dNKs) are important to DNA

89 In antiviral and cancer therapy, deoxyribonucleoside kinases (dNKs) are often the rate-li

90 Deoxyribonucleoside kinases (dNKs) carry out the rate-de

91 r inefficient activation through cellular 2'-deoxyribonucleoside kinases (dNKs).

92 ut independent calculations for complexes of deoxyribonucleoside kinases with various cognate ligands

93 Starting from two promiscuous deoxyribonucleoside kinases, we computationally designed

94 rsist throughout the synthesis of the purine deoxyribonucleosides, leading to a mixture of deoxyadeno

95 ritical for conversion of ribonucleotides to deoxyribonucleosides, leading to replication stress, DNA

96 oothly with the silyl-protected ribo- and 2'-deoxyribonucleosides, leading to the C-6 triazolyl produ

97 the point of having nicks with a 3'OH and 5'deoxyribonucleoside monophosphate during S phase.

98 d NDP kinase, but not dCMP hydroxymethylase, deoxyribonucleoside monophosphate kinase, or DHF reducta

99 s: dihydrofolate reductase, dCTPase-dUTPase, deoxyribonucleoside monophosphokinase, ribonucleotide re

100 could supply heart and skeletal muscle with deoxyribonucleosides needed for dNTP production by salva

101 escribe the preparation and structure of the deoxyribonucleoside of 4-fluoro-6-methylbenzimidazole, a

102 We also show that the deoxyribonucleosides of 2,6-diaminopurine and adenine ca

103 reliable means for the formation of novel 2'-deoxyribonucleosides of novel structural type from these

104 Product characterization identified the 2'-deoxyribonucleosides of spiroiminodihydantoin, 5-guanidi

105 ted electrochemically or chemically) with 2'-deoxyribonucleosides or the corresponding purine bases.

106 with deoxyribonucleosides and N-protected 2'-deoxyribonucleosides or with a model phosphorothioate di

107 achieved through incorporation of activated deoxyribonucleoside phosphoramidite 8b into the oligonuc

108 rt-butylcarboxamido)-1-propyl group into the deoxyribonucleoside phosphoramidites 1a-d is achieved us

109 pyridyl)]aminoethanol were incorporated into deoxyribonucleoside phosphoramidites 7a-d and 9, which w

110 Deoxyribonucleoside phosphoramidites functionalized with

111 hich were found as efficient as 2-cyanoethyl deoxyribonucleoside phosphoramidites in solid-phase olig

112 potential 5'-hydroxyl protecting groups for deoxyribonucleoside phosphoramidites to improve the synt

113 coupling efficiencies comparable to those of deoxyribonucleoside phosphoramidites.

114 ficiently as that achieved with 2-cyanoethyl deoxyribonucleoside phosphoramidites.

115 omparable to that of commercial 2-cyanoethyl deoxyribonucleoside phosphoramidites.

116 Here, we report that down-regulation of deoxyribonucleoside pools is another endogenous source o

117 Since this assay was selective for deoxyribonucleosides, potential interference from methyl

118 g 6-methylpyrrolo[2,3-d]pyrimidine-2(3H) one deoxyribonucleoside (pyrrolo dC), which pairs with G, wa

119 oesters, comprised of butenyl-functionalized deoxyribonucleoside repeat units, connected via 3',5'-ba

120 y phosphorylate two MRI-detectable synthetic deoxyribonucleosides ('reporter probes').

121 toradiography, and immunohistochemistry, and deoxyribonucleoside salvage activity in brain-infiltrati

122 with significant leukocyte infiltration, and deoxyribonucleoside salvage activity is present at simil

123 18)F-FAC) is a PET radiotracer that measures deoxyribonucleoside salvage and accumulates preferential

124 ((18)F-CFA), a PET radiotracer that measures deoxyribonucleoside salvage in humans, were analyzed to

125 kinase (dCK), a rate-limiting enzyme in the deoxyribonucleoside salvage metabolism and in gemcitabin

126 ively expressed, mitochondrial enzyme of the deoxyribonucleoside salvage pathway.

127 xycytidine kinase (dCK), a key enzyme in the deoxyribonucleoside salvage pathway.

128 mphocyte development critically requires the deoxyribonucleoside salvage pathway.

129 ne kinase (dCK) is a rate-limiting enzyme in deoxyribonucleoside salvage, a metabolic pathway that re

130 Most of the deoxyribonucleosides showed good cytotoxic activity, esp

131 nctionalized ribonucleosides and anomeric 2'-deoxyribonucleosides, some of them showed strong fluores

132 ((F)iCd, (F)iGd and fluorinated canonical 2'-deoxyribonucleosides) stabilize double-stranded DNA, RNA

133 pic coexpression of TS and RR or addition of deoxyribonucleosides substantially suppressed DNA damage

134 23 altered substrates, each with a single 2'-deoxyribonucleoside substitution, were synthesised and t

135 ctive centers of the enzymes responsible for deoxyribonucleoside synthesis and transfer RNA modificat

136 trityl) derivatives of 3'-(carboxymethyl)-3'-deoxyribonucleosides that are effective precursors for s

137 hagocytes from staphylococcal death-effector deoxyribonucleosides that target dCK and the mammalian p

138 A charges, which show that in the neutral 2'-deoxyribonucleosides the sum of NPA charges for every ba

139 n of 5-methyl-2'-deoxycytidine from the four deoxyribonucleosides, the four ribonucleosides, and 5-me

140 blood-brain barrier (BBB) for the pyrimidine deoxyribonucleoside, thymidine, was demonstrated.

141 reductase was bypassed, by adding exogenous deoxyribonucleosides to highly purified T cells in the G

142 Adding deoxyribonucleosides to restore dNTP pools transiently p

143 inally, dun1Delta mutants display defects in deoxyribonucleoside triphosphate (dNTP) biosynthesis und

144 tso2 mutants had reduced deoxyribonucleoside triphosphate (dNTP) levels and exhib

145 The quantification of cellular deoxyribonucleoside triphosphate (dNTP) levels is import

146 ecombination phenotype correlates with lower deoxyribonucleoside triphosphate (dNTP) levels, compared

147 t result from mutations affecting enzymes of deoxyribonucleoside triphosphate (dNTP) metabolism.

148 Deoxyribonucleoside triphosphate (dNTP) pool imbalances

149 that contributes to the control of cellular deoxyribonucleoside triphosphate (dNTP) pool sizes throu

150 Because mitochondrial and nuclear deoxyribonucleoside triphosphate (dNTP) pools are physic

151 that in Caulobacter crescentus Lon controls deoxyribonucleoside triphosphate (dNTP) pools during str

152 Alterations in deoxyribonucleoside triphosphate (dNTP) pools have been

153 the basis for marked natural asymmetries in deoxyribonucleoside triphosphate (dNTP) pools in mammali

154 Our laboratory has reported that deoxyribonucleoside triphosphate (dNTP) pools in rat tis

155 that this generates imbalanced mitochondrial deoxyribonucleoside triphosphate (dNTP) pools, which in

156 a in a pos5 deletion mutant contain abnormal deoxyribonucleoside triphosphate (dNTP) pools.

157 ions, each with a single fluorescein-labeled deoxyribonucleoside triphosphate (dNTP) species.

158 ine leukemia virus (MLV) RT that contact the deoxyribonucleoside triphosphate (dNTP) substrate are im

159 titive inhibitor of HIV-1 RT with respect to deoxyribonucleoside triphosphate (dNTP) substrate, where

160 each catalytic cycle, DNA polymerases select deoxyribonucleoside triphosphate (dNTP) substrates compl

161 s form a multienzyme complex that we call T4 deoxyribonucleoside triphosphate (dNTP) synthetase.

162 to common antibiotics, is a homo-tetrameric deoxyribonucleoside triphosphate (dNTP) triphosphohydrol

163 SAMHD1, a dGTP-regulated deoxyribonucleoside triphosphate (dNTP) triphosphohydrol

164 g the a-B phosphodiester bond of an incoming deoxyribonucleoside triphosphate (dNTP).

165 NA, replacing the error with the appropriate deoxyribonucleoside triphosphate (dNTP).

166 Deoxyribonucleoside triphosphate accumulation at G1/S wa

167 Thus, deoxyribonucleoside triphosphate accumulation, like the

168 hange that occurs after binding a correct 2'-deoxyribonucleoside triphosphate and, in the present wor

169 ibonucleotides, mainly due to its defects in deoxyribonucleoside triphosphate binding, and is also a

170 in, with well defined functions in ribo- and deoxyribonucleoside triphosphate biosynthesis and more r

171 nfection of Escherichia coli, the enzymes of deoxyribonucleoside triphosphate biosynthesis form a mul

172 e level and requires a divalent cation and a deoxyribonucleoside triphosphate effector.

173 cent, and the former one was converted to 2'-deoxyribonucleoside triphosphate for enzymatic synthesis

174 lymerase beta (pol beta) selects the correct deoxyribonucleoside triphosphate for incorporation into

175 e brain but also in the small intestine, and deoxyribonucleoside triphosphate imbalance was observed

176 Deoxyribonucleoside triphosphate levels increased severa

177 n of deoxyribonucleotide-synthesizing genes, deoxyribonucleoside triphosphate levels, and replication

178 animals have normal mitochondrial ribo- and deoxyribonucleoside triphosphate levels, suggesting that

179 vated levels of nucleotides cause unbalanced deoxyribonucleoside triphosphate pools and, in turn, pat

180 Deoxyribonucleoside triphosphate pools in mammalian mito

181 hway increases mtDNA copy number by altering deoxyribonucleoside triphosphate pools through the activ

182 causes a differential depletion of the four deoxyribonucleoside triphosphate pools, suggesting that

183 Balanced pools of deoxyribonucleoside triphosphate precursors are required

184 ces cerevisiae, mouse, and human all possess deoxyribonucleoside triphosphate pyrophosphohydrolase ac

185 ductase, the rate-limiting enzyme in de novo deoxyribonucleoside triphosphate synthesis.

186 tate domain-containing protein 1 (SAMHD1), a deoxyribonucleoside triphosphate triphosphohydrolase tha

187 SAMHD1 is a nuclear deoxyribonucleoside triphosphate triphosphohydrolase tha

188 Enzymatic synthesis of the azole carboxamide deoxyribonucleoside triphosphate was based on ATP as the

189 oportion, rather than the absolute amount of deoxyribonucleoside triphosphate, was critical for mitoc

190 y of ribonucleotides in DNA is determined by deoxyribonucleoside triphosphate/ribonucleoside triphosp

191 the rate-limiting enzyme in the synthesis of deoxyribonucleoside triphosphates (dNTPs) and essential

192 DNA pol eta (hpol eta) can incorporate both deoxyribonucleoside triphosphates (dNTPs) and ribonucleo

193 Intracellular concentrations of the four deoxyribonucleoside triphosphates (dNTPs) are closely re

194 When ERT was driven by addition of deoxyribonucleoside triphosphates (dNTPs) at high concen

195 rature-shift and release, and starvation for deoxyribonucleoside triphosphates (dNTPs) by treatment w

196 The synthesis of 2'-deoxyribonucleoside triphosphates (dNTPs) either by clas

197 Current methods for measuring deoxyribonucleoside triphosphates (dNTPs) employ reagent

198 the rate-limiting step in the production of deoxyribonucleoside triphosphates (dNTPs) for DNA synthe

199 zymes required to maintain adequate pools of deoxyribonucleoside triphosphates (dNTPs) for DNA synthe

200 ses (RNRs) are required for the synthesis of deoxyribonucleoside triphosphates (dNTPs) from ribonucle

201 ynthesis of ribonucleoside triphosphates and deoxyribonucleoside triphosphates (dNTPs) from the corre

202 the rate-limiting step in the production of deoxyribonucleoside triphosphates (dNTPs) required for r

203 rate-limiting enzyme in the biosynthesis of deoxyribonucleoside triphosphates (dNTPs) that are essen

204 transcriptase called telomerase, which uses deoxyribonucleoside triphosphates (dNTPs) to extend telo

205 os requires large amounts of DNA precursors (deoxyribonucleoside triphosphates (dNTPs)).

206 lls is far greater than the concentration of deoxyribonucleoside triphosphates (dNTPs), and this pool

207 xhibit a surprising tolerance for analogs of deoxyribonucleoside triphosphates (dNTPs), despite the e

208 ailability of adequate and balanced pools of deoxyribonucleoside triphosphates (dNTPs), the building

209 phates (rNTPs) are much higher than those of deoxyribonucleoside triphosphates (dNTPs), thereby influ

210 g four distinguishable fluorescently labeled deoxyribonucleoside triphosphates (dNTPs).

211 When all deoxyribonucleoside triphosphates and a template bearing

212 The NTPase activity with deoxyribonucleoside triphosphates as substrate is higher

213 We report a series of 2'-deoxyribonucleoside triphosphates bearing dicarba-nido-u

214 enzymatic degradation of excess primers and deoxyribonucleoside triphosphates before the primer exte

215 bonucleoside diphosphates, the precursors of deoxyribonucleoside triphosphates for DNA synthesis.

216 talyzes ATP-dependent synthesis of ribo- and deoxyribonucleoside triphosphates from the cognate dipho

217 in vivo ATP-dependent synthesis of ribo- and deoxyribonucleoside triphosphates from the corresponding

218 been developed to measure concentrations of deoxyribonucleoside triphosphates in individual, day 14

219 gene 32 protein helps to recruit enzymes of deoxyribonucleoside triphosphates synthesis to DNA repli

220 that adenylate kinase can meet a demand for deoxyribonucleoside triphosphates that increases by up t

221 hydrolysis of all eight canonical ribo- and deoxyribonucleoside triphosphates to their corresponding

222 Finally, 3' deoxyribonucleoside triphosphates were able to inhibit R

223 -limiting enzyme in the de novo synthesis of deoxyribonucleoside triphosphates, and control of mitoch

224 dGTP is the best substrate among the deoxyribonucleoside triphosphates, and GTP is the best a

225 oside triphosphates almost as efficiently as deoxyribonucleoside triphosphates, and, unlike analogous

226 In addition, nonphysiological deoxyribonucleoside triphosphates, such as 3'-azido-3'-d

227 atural permeability of the HIV-1 envelope to deoxyribonucleoside triphosphates, the substrates for DN

228 ase active on all of the canonical ribo- and deoxyribonucleoside triphosphates.

229 reduction of ribonucleoside triphosphates to deoxyribonucleoside triphosphates.

230 iscriminate between ribo-, dideoxyribo-, and deoxyribonucleoside triphosphates.

231 the presence of calf thymus DNA and the four deoxyribonucleoside triphosphates.

232 extracellular milieu, such as polyamines and deoxyribonucleoside triphosphates.

233 ted endothelial cell stores of aspartate and deoxyribonucleoside triphosphates.

234 Hydrolysis of the oligonucleotide to its 2'-deoxyribonucleosides upon exposure to snake venom phosph

235 The imidazole (Im) deoxyribonucleoside was chosen as a highly Ag(I) -specif

236 one metabolites of carcinogenic PAHs with 2'-deoxyribonucleosides were investigated and compared.

237 Base-modified ribo- and 2'-deoxyribonucleosides were potent inhibitors of T8.

238 s of the 7-iodinated isoguanine ribo- and 2'-deoxyribonucleosides were solved by the action of aceton

239 -2,6-diamine or 7-deazapurine-2,6-diamine 2'-deoxyribonucleosides were used.

240 e) and thymine (2,4-difluoro-5-methylbenzene deoxyribonucleoside) were synthesized and hybridized to

241 gives similar recoveries for all five major deoxyribonucleosides when compared to the older protocol

242 rystal structure of TbTUT4 with the bound 2' deoxyribonucleoside, which provides the structural basis

243 Substitution of deoxyribonucleosides with a C3 or C4 alkyl-linker was fo

244 orientation incorporating 2'-fluorinated 2'-deoxyribonucleosides with canonical nucleobases or 2'-de