ライフサイエンスコーパス: depletion

1 ~50-fold reduction in viability after oxygen depletion.

2 states and no evidence of regulatory T cell depletion.

3 the proliferation defect induced by lincNMR depletion.

4 rsed the decrease in DeltaNp63alpha by FIH-1 depletion.

5 ing CRLs or CRL4s in general by RBX1 or DDB1 depletion.

6 ts and suppresses DNA damage caused by INO80 depletion.

7 lush occurred despite inositol pyrophosphate depletion.

8 to complete loss of HSC self-renewal and HSC depletion.

9 ently reduced targets for anti-Ly6G-mediated depletion.

10 ssociated with lipid isomer upregulation and depletion.

11 fects in neural crest cells (NCCs) upon emc1 depletion.

12 2 expression were unchanged upon cholesterol depletion.

13 emic-climate interaction through susceptible depletion.

14 at the midbody and is not affected by ESCRT depletion.

15 dominant negative TP53 minigene, or by TP53 depletion.

16 rescued reduction in DeltaNp63alpha by FIH-1 depletion.

17 inducible factor (HIF) signaling due to iron depletion.

18 duced fluctuations-the phenomenon of quantum depletion.

19 elopmental abnormalities observed upon dElys depletion.

20 24.5%) following statin-mediated cholesterol depletion.

21 icient zebrafish exhibit systemic macrophage depletion.

22 Fluvastatin-mediated cholesterol depletion (-27.8%) lowered VSMC migration distance on a

23 esults support a critical role for ER Ca(2+) depletion-activated Ca(2+) current in mediating Ca(2+)-i

24 ant barttin palmitoyl acyltransferase, whose depletion affected barttin palmitoylation and ClC-K-bart

25 Lama5 depletion affected LN structure with increased HEVs, upr

26 mporal lobe, and prefrontal cortex, while DA depletion affected social reward prediction encoding onl

27 We found that beta-actin depletion affects induction of several adipogenic genes

28 ce translocation frequency compared to POLD2 depletion alone.

29 CRK9 depletion also caused a loss of phosphorylation in RPB1,

30 This conditional depletion also led to a reduction of mature mycolic acid

31 to space alongside H(2) This early volatile depletion also makes it more difficult for later volcani

32 ATAD2 depletion also reduced global RNA synthesis and nascent

33 GCK-1 or CCM-3 depletion also reduced RGA-3 levels in pulses and increa

34 eling-based fMRI analyses revealed that 5-HT depletion altered social reward prediction signals in th

35 NR2F2-depletion altered the abundance of C-circles and APBs bu

36 In vivo neutrophil depletion altered the systemic and peritoneal immune mic

37 clinical responsiveness of IgG4-RD to B cell depletion and by the identification of multiple self-ant

38 these banks, and associated impacts on ozone depletion and climate change.

39 mtDNA depletion and cytochrome c oxidase-negative cells were f

40 atopoietic stem cells (HSCs), leading to HSC depletion and dysfunction and the risk of malignant tran

41 erations in ER homeostasis trigger ER Ca(2+) depletion and ER stress, which have been associated with

42 re shortening, early apoptosis leads to cell depletion and insufficient compensatory proliferation.

43 ion is promoted during oxygen and amino acid depletion and protects LRS from degradation.

44 rs ATG16L1 and ATG9 compartments by nutrient depletion and reduced the formation of ATG16L1 membrane

45 Here we investigate how depletion and selective reconstitution of the maternal g

46 kinase activation and possibly through NADPH depletion and subsequent inhibition of BMI1, an integral

47 ematical model indicates that local nutrient depletion and the resulting inhibition of proliferation

48 r) increased virus resistance to cholesterol depletion and to the surface-acting agents.

49 synthetic lethal interaction between Haspin depletion and VX-680 was mediated by the inhibition of H

50 ansgenic mice received Ad/E2TM after NK cell depletion, and they produced less HER2 IgG, demonstratin

51 Variant-specific depletion approach showed that BMP2K isoforms constitute

52 nical data have emerged from GM-CSF deletion/depletion approaches indicating that GM-CSF is a potenti

53 eir clinical use and call for different Treg depletion approaches.

54 LOC-2 depletion impaired exocytosis, exocyst depletion augmented WPB exocytosis, indicating that it a

55 Morphometric analyses revealed that Treg depletion blocked plaque remodeling and contraction, and

56 ocampal cultures and their acute cholesterol depletion by methyl-beta-cyclodextrin as a tool to descr

57 er diverted to Beijing reduces cumulative GW depletion by ~3.6 km(3), accounting for 40% of total GW

58 Strong H1 depletion causes a profound de-repression of several cla

59 EZH2 depletion causes cellular cisplatin and UV hypersensitiv

60 WBP11 depletion causes centriole duplication defects, in part

61 mpetition for food production and soil-water depletion challenge the longevity of this carbon sink se

62 s near lesions showed significantly more FCD depletion compared to regions away from lesions (p<0.01)

63 normal charged tRNAGln levels despite Gln4p depletion, confirmed experimentally using tRNA Northern

64 Since MNRR1 depletion contains features of a mitochondrial disease p

65 Neutrophil depletion dampens necrosis.

66 Conversely, SLC20A2 depletion decreased phosphate uptake only slightly, most

67 HCV replication, as CRISPR-Cas9-based Mov10 depletion decreases HCV replication and infection levels

68 Consistently, AGO1 depletion decreases long-range contacts between ERalpha

69 Moreover, DINO depletion decreases sensitivity to the DNA damage-induci

70 RUSC2 knockdown phenocopied the EHD1 depletion effects.

71 functional assays, and acute in vivo myeloid-depletion experiments identify activation of IGF1R as a

72 In human cells, FACT depletion extends dCas9 residence times, delays genome e

73 s, here we analyzed the consequences of PDS5 depletion for DNA replication.

74 pid binding, sensitize the channel to PIP(2) depletion from hair cells, and alter the channel's unita

75 article density, suggesting that cholesterol depletion from the HIV-1 envelope membrane reduces virus

76 active oxygen species, S-adenosyl-methionine depletion, global hypomethylation, induction of autophag

77 With severe ion depletion gradients in the electrolyte during charging,

78 at alphaCD3 alone induced substantial T-cell depletion, impacting both conventional T cells (T(conv))

79 Although BLOC-2 depletion impaired exocytosis, exocyst depletion augment

80 Tyrosine-tRNA(GUA) depletion impaired translation of growth and metabolic g

81 cholesterol, and phytol, all show increasing depletion in (13)C over the transect from the control si

82 AF312 caused a profound CD4+ and CD8+ T cell depletion in blood and lungs but only treatment with FTY

83 ASC-1 depletion in C2C12 and in patient-derived fibroblasts an

84 rast to the role of Drosophila L(2)gl, Llgl1 depletion in cultured rat cardiomyocytes decreased Yap p

85 In vitro REEP5 depletion in mouse cardiac myocytes results in SR/ER mem

86 However, whether B cell depletion in normal adult mice has the same effect on me

87 ccess of clinical trials of selective B-cell depletion in patients with relapsing multiple sclerosis

88 Here we show that Akt3 depletion in primary endothelial cells results in decrea

89 oxicity, including mitochondrial DNA (mtDNA) depletion in several cases.

90 ished that these trends were driven by ozone depletion in the Antarctic stratosphere due to emissions

91 Similarly, in vivo analyses of PIERCE1 depletion in the KRAS mutation-related lung cancer mouse

92 Tspyl1 depletion in zebrafish mimicked the patients' phenotype

93 Store depletion induced interactions between TRPC1 and PKCdelt

94 ervables is possible within the framework of depletion interactions if the polymeric nature of IDPs a

95 Its depletion invokes a proliferation defect, triggers senes

96 activation, suggesting that sensing of iron depletion is a mechanism by which plants recognize a pat

97 These results indicate that rapid store depletion is mediated by Na(+)/Ca(2+) exchange across th

98 Although OGG1 depletion is well tolerated in non-transformed cells, we

99 e effectiveness of degrons for acute protein depletion is widely applicable in various developmental

100 the social learning process using a dietary depletion manipulation.

101 s concluded that statin-mediated cholesterol depletion may coordinate VSMC migration and adhesion to

102 We correlate stimulated-emission-depletion microscopy of proteins and synchrotron X-ray f

103 sponse and provide insight into how nutrient depletion might influence PDAC progression.

104 y consumption in comparison to commonly used depletion mode devices.

105 host death without mitochondrial RNA or DNA depletion; moreover, autophagy promotes survival in this

106 volunteers were randomly allocated to a 5-HT depletion (N = 24), DA depletion (N = 24), or placebo (N

107 y allocated to a 5-HT depletion (N = 24), DA depletion (N = 24), or placebo (N = 22) group.

108 Neither neutrophil depletion nor the enhancement of lung neutrophils by adm

109 Mechanistically, DEPTOR depletion not only activated both mTORC1 and mTORC2 sign

110 -transformed cells, we report here that OGG1 depletion obstructs A3 T-cell lymphoblastic acute leukem

111 DJ34-mediated c-Myc depletion occurred in a wide range of tumor cell types,

112 nolic levels, respectively, with the highest depletion occurring in those with the lowest initial con

113 nitial dark-adapted levels, with significant depletion occurring under natural levels of illumination

114 A previous genome-wide screen revealed that depletion of 14 RNA splicing factors leads to a specific

115 Here, we observe quantum depletion of a high-density exciton-polariton condensate

116 cell imaging experiments, we show that local depletion of actin-membrane links is needed for protrusi

117 mation of Gli2 and Gli3 repressors and early depletion of adenylyl cyclase III in neuroepithelial cil

118 ured keratinocyte model system, we show that depletion of alpha-catenin perturbs adherens junctions,

119 y track the dynamic change of enrichment and depletion of amino acid characters in the sequence logo

120 of pro-oxidant elements such as arsenic and depletion of anti-oxidant elements such as zinc, underpi

121 The negative depletion of antibody-tagged leukocytes enables isolatio

122 Conversely, depletion of AP factors, or AH50 less than median, impai

123 rease in p120-catenin isoform 3A; similarly, depletion of APC altered the p120-catenin protein isofor

124 e tissues whose enhancers show the strongest depletion of archaic alleles, but only brain enhancers s

125 Moreover, depletion of ATG7 markedly reduced the binding of RelA/p

126 Depletion of ATP by adding azide also results in IFT slo

127 Depletion of Axl suppressed cell intrinsic oncogenic pro

128 erefore, neural-specific exon 5 splicing and depletion of BAK1 proteins uniquely repress neuronal apo

129 Across the deglaciation period, a depletion of basin-wide soil carbon stocks was triggered

130 dundant' genes is strongly affected by rapid depletion of both factors, showing the overlapping funct

131 Depletion of CD2AP or phosphoinositide 3-kinase (PI3K) i

132 s on MM target cells as well as DARA-induced depletion of CD38high natural killer (NK) cells resultin

133 E The hallmark of HIV infection is a gradual depletion of CD4 T cells, with a progressive decline of

134 Depletion of CD4(+) T cells showed unique pathological b

135 In the absence of STAT1 signaling, however, depletion of CD8 T cells resulted in lytic infection of

136 Chemical depletion of cholesterol from HIV-1 particles inactivate

137 Upon depletion of circulating and perivascular memory T cells

138 rimary subcutaneous tumours, but resulted in depletion of circulating melanoma cells and reduced the

139 ding auditory pathway and multimodal cortex, depletion of cognitive reserve due to an impoverished li

140 ased phospho-G3BP1 and axon growth, although depletion of Csnk2a1 mRNA from PNS axons decreases regen

141 characterized by reduced microbial richness, depletion of Cutibacterium acnes, Dermacoccus and Methyl

142 ased HIV-1 replication in macrophages, while depletion of cyclin L2 decreased HIV-1 replication.

143 Genetic depletion of cyclin-dependent kinase 12 (CDK12) or selec

144 e models of breast cancer to show that while depletion of DeltaNp63 inhibits primary mammary adenocar

145 also enriched in regions of H3K18ac, and the depletion of DIGIT results in decreased recruitment of B

146 In addition, overexpression and depletion of dynamin 1 in MPCs increased and decreased t

147 Depletion of eIF5A or Tsc2 leads to metabolic re-initiat

148 Depletion of either protein increased steady-state level

149 ndent decrease in fluorescence, representing depletion of ER Ca(2+) stores, followed by a slower deca

150 e antibiotic neomycin, whereas inhibition or depletion of exosomes from the extracellular environment

151 g cGAMP production in Cgas(-/-) tumor cells, depletion of extracellular ATP, or inactivation of the A

152 Genetic and pharmacologic depletion of fibrinogen reduced astrocyte formation with

153 Imaging the depletion of fluorescently labeled bacteria provides inf

154 Importantly, depletion of FNDC3A increased the fitness of FAM46C-expr

155 mulation and destruction, and the inevitable depletion of fossil resources.

156 alyses stratified according to the degree of depletion of functional variation (described here as "in

157 Depletion of gB- and PC-specific ABs revealed that, in p

158 and faster cytokinetic furrowing, following depletion of GCK-1 or CCM-3.

159 Depletion of Gln4p inhibited growth, and induced a GCN4

160 However, in vivo depletion of GORASPs in metazoans has given equivocal re

161 we evaluate the impact of high-iron diets or depletion of Gpx4, an antioxidant enzyme reported as an

162 as and eastern New Mexico regions due to the depletion of groundwater.

163 ysbiotic" changes to gut microbiota, such as depletion of gut bacteria that produce short-chain fatty

164 Depletion of HIRA elicits systemic death of ALT cancer c

165 more rapid rebound of T(regs) Despite robust depletion of host T(conv) and host T(regs), donor T(regs

166 Depletion of IIS or TORC1 blocked both JH biosynthesis a

167 Depletion of IL-17A in vaccinated C57BL/6 mice prior to

168 Infection led to a 3-fold depletion of ILC3 in the colon and an increase in the le

169 alizing monoclonal antibodies or conditional depletion of Insr in myeloid cells using the Cre-loxP sy

170 in beta-cells develop diabetes due to severe depletion of insulin SG content and a defect in insulin

171 sed granularity by flow cytometry and marked depletion of intracytoplasmic granules by light microsco

172 ure of the ATP synthase leak channel by mild depletion of its c-subunit or pharmacological inhibition

173 Genetic depletion of K(v)beta1 blocked all broadening of the AP(

174 uronal cells leads not only to a nonspecific depletion of KIF1A mRNA but also to an accelerated prote

175 adation of KIF1A proteins, leading to a near depletion of KIF1A protein late in infection.

176 cervicovaginal microbiota, characterized by depletion of Lactobacillus species and increased bacteri

177 Consistent with fumC-dependent depletion of local fumarate, the DeltahemB SCV failed to

178 ly and late viral transcripts contain m(6)A, depletion of m(6)A writer METTL3 specifically impacts vi

179 omic instability was rescued by simultaneous depletion of macroH2A1.1 or alt-EJ factors, and mice def

180 cins, resulting in very large aggregates and depletion of macromolecular mucin and occurring at conce

181 Unexpectedly, depletion of macrophages in obese mice enhanced mammary

182 Co-depletion of Mdm4 and Mdm2 further impaired DNA replicat

183 tress leads to hair greying through the fast depletion of melanocyte stem cells.

184 d on the results of antibody blockage, siRNA depletion of Mincle and its adaptor spleen tyrosine kina

185 Maternal depletion of MOF acetyltransferase leading to H4K16ac lo

186 Depletion of MYC or factors important for MYC expression

187 , loss of ac4C from viral transcripts due to depletion of NAT10 inhibited HIV-1 replication by reduci

188 Depletion of Nedd4 limits the protein degradation of VDA

189 Depletion of neither Rab6A or Rab6A' isoforms alone had

190 Depletion of neutrophils or S100A8/A9 deficiency resulte

191 Degron-mediated depletion of NHR-23/NR1F1 within hermaphrodite or male g

192 Depletion of NK cells by anti-NK1.1 Abs drastically impr

193 Consistently, depletion of NK1.1(+) cells in Rag-deficient mice both p

194 Accordingly, depletion of OGG1 or APE1 leads to greater dependence of

195 late the expression of each other, such that depletion of one results in reduced expression of the ot

196 lycine-modified lipopolysaccharide (LPS) and depletion of outer membrane porin OmpT, which confers re

197 Moreover, depletion of pDCs in the murine OX40+ pDC-rich tumor mod

198 The depletion of PHF8 or PKCalpha greatly up-regulated PTEN

199 Depletion of Pol nu alone reduced mutations only for O (

200 Co-depletion of POT1B or BRD2 with TRF2 restores a canonica

201 Depletion of PP4-complex subunits increases phosphorylat

202 A depletion of proinflammatory elastase-related proteases

203 o-acid-deprived cells also leads to specific depletion of proteins containing polyglutamine tracts in

204 otype, similar to what is observed following depletion of proteins in the Rho1 pathway.

205 Further, depletion of PTEN and/or PTENP1 increased DU145 prolifer

206 Both depletion of Pyk2 and treatment with a Pyk2 kinase inhib

207 either deletion of the CTCF binding site or depletion of RAD21 cohesin complex protein can recover d

208 Downstream of KRAS, depletion of RalB (RAS-like proto-oncogene B) and Ikappa

209 The depletion of Rank in the mouse thymic epithelium results

210 Depletion of Raptor, the defining subunit of mTORC1, by

211 This was presumably due to depletion of reductive capacity (average values of 0.12

212 Depletion of regulatory T cells enhanced response.

213 We showed that depletion of regulatory T cells prior to infection with

214 Although depletion of Rictor, the unique subunit of mTORC2, or th

215 Depletion of RN-tre led to a punctate NMII phenotype, si

216 parable to previously observed RNAi-mediated depletion of SETD1A.

217 Depletion of SFMBT1 abolished ccRCC cell proliferation i

218 Females with oocyte-specific depletion of Snf2h are infertile and oocytes lacking Snf

219 , adrenocortical hyperplasia, and lymphocyte depletion of spleen and lymph nodes.

220 igh peak incidence consistent with the rapid depletion of susceptible individuals.

221 Here, we report that depletion of SUV420H2 leads to a near-complete loss of H

222 In addition, depletion of SUV420H2 resulted in compromised interactio

223 Further, siRNA-mediated depletion of TAK1 or RELA resulted in RPL11-dependent ac

224 Depletion of target proteins resulted in an accumulation

225 and pharmacological approaches, we show that depletion of the hyaluronic acid precursor UDP-glucuroni

226 We also observed that depletion of the hypoxia-inducible factor (HIF) genes, H

227 Depletion of the intracellular free iron content using t

228 The depletion of the m(6)A writer enzymes (METTL3 and METTL1

229 Accordingly, deletion or depletion of the N-end rule pathway ubiquitin E3 ligases

230 erentiation in the mPFC at P15, leading to a depletion of the oligodendrocyte progenitor pool in MS a

231 This disruption is correlated with depletion of the populations of upper layer neurons in t

232 corticoids synthesis, blockade of IL-17A, or depletion of the Th17 cell-inducing gut microbiota marke

233 which CAF plasticity is modulated by genetic depletion of the transcription factor Prrx1.

234 me Atlas databases with CRISPR/Cas9-mediated depletion of the zinc finger E-box binding homeobox 1 (Z

235 onocyte levels and recruitment to tumors and depletion of these cells abrogated MI-induced tumor grow

236 Because depletion of these cells might be valuable in patients w

237 of TRAF6 and p62 in the migrating front, and depletion of these proteins prevented Akt2 polarization

238 study, we examined in detail how consecutive depletion of thick filaments in individual sarcomeres wi

239 Acute depletion of TPR causes rapid and pronounced changes in

240 Here we show that depletion of transforming growth factor-beta receptor 2

241 Depletion of TREM-1 in EV-A71-infected PBMCs with peptid

242 al resealing in healthy skeletal muscle, and depletion of TRIM72 antibodies from these same serum sam

243 to chemical inhibition in plant protoplasts; depletion of two PI(4)P kinases, Stt4p and Pik1p; or seq

244 uitin, and this was reduced by inhibition or depletion of ubiquitin-activating enzymes.

245 Accordingly, upon overexpression or depletion of USP22, enrichment of cell-cycle and DNA rep

246 Depletion of USP36 results in replication stress-related

247 s of Vi-specific B cells in spleen and early depletion of Vi-specific B cells in bone marrow, resulti

248 Depletion of VPS13A or VPS13C caused a post-transcriptio

249 Depletion of XPB protein, by spironolactone treatment or

250 Depletion of YTHDF2 in HeLa cells leads to the delay of

251 ctor (Mrf), which is stabilized upon further depletion of zinc, presumably in a zinc-free form.

252 Consequently, depletion of ZNF281 impairs the efficiency of the NHEJ r

253 ased prevalence of Clostridium species and a depletion of, for example, Eubacterium spp and Ruminococ

254 y CGAS or STING knockdown, mitochondrial DNA depletion or mitochondrial outer membrane permeabilizati

255 ssion was observed upon siRNA-mediated IKBKE depletion or pharmacological inhibition due to inhibited

256 owth in mouse xenografts, compared with MEK5 depletion or radiation alone.

257 it has been suggested that purine nucleotide depletion, or accumulation of other toxic purine interme

258 ction by PRC2 enzymatic inhibitor or genetic depletion partially rescues gene expression and NPC func

259 ayed the opposite expression pattern and its depletion perturbed septation.

260 thin HSV-1-infected corneas, and CD4(+) cell depletion promoted reinnervation of HSK corneas with sen

261 We find that either high-iron diets or Gpx4 depletion promotes 8-OHG release and thus activates the

262 hat addition of hgbRNA depletion to the rRNA-depletion protocol for library preparation from blood RN

263 d-type kinetics, arguing that global histone depletion rather than DSB movement is rate limiting for

264 urther genetic analyses indicated that dElys depletion re-activates the Dorsal (NF-kappaB) pathway du

265 sed immunotherapeutic strategies: macrophage depletion, recruitment inhibition, and macrophage reeduc

266 Upon RPM depletion, red pulp fibroblasts transiently produced the

267 Microglial depletion reduces the odor responses of developing, but

268 Gln4p depletion reduces this sequestration capacity, allowing

269 respectively, triggers electron accumulation/depletion regions at the heterosurface and consequently

270 is provided that statin-mediated cholesterol depletion remodels total vascular smooth muscle cell cyt

271 TAM depletion-repletion experiments in a 4T1 mouse model add

272 Strikingly, reintroduction of BRCA1 or 53BP1 depletion restored HR and rescued the ability of cells t

273 In response to ER stress, FORCP depletion results in decreased apoptosis.

274 rmore, aimB appears to be essential, and its depletion results in decreased cell width and increased

275 Nek8445 depletion results in short flagella, aberrant ventral di

276 levels to partially restore HR, whereas KAT5 depletion rewires double strand break repair by promotin

277 ER calcium depletion robustly activates the unfolded protein respon

278 Steady O(2) depletion shows good quantitative correlation with the s

279 Interestingly, DDX5 depletion specifically reduced intracellular succinate,

280 itative super-resolution stimulated emission depletion (STED) microscopy, we demonstrate that in livi

281 cluding super-resolution stimulated emission depletion (STED), photoactivated localization microscopy

282 g-term, high-resolution (stimulated emission depletion) STED nanoscopy.

283 peptides followed by chemical enrichment or depletion strategies to facilitate their detection via m

284 hich correlated with the efficacy of the CD8 depletion strategy.

285 Ab depletion studies showed neuritis still developed in the

286 taplasia was evaluated, including eosinophil depletion studies using anti-IL5/anti-CCR3 treatment.

287 ometastases triggered by natural killer cell depletion suggests a dynamic interplay between developme

288 fluorescence imaging and stimulated emission depletion super-resolution microscopy were performed in

289 We identified a robust response to SAM depletion that is highlighted by preferential cytoplasmi

290 We find that addition of hgbRNA depletion to the rRNA-depletion protocol for library pre

291 protein synthesis were unaffected by nsun-1 depletion, translation of specific mRNAs was remodeled l

292 SMC5/6 depletion triggers a CHEK2-p53 DNA damage response, as c

293 B cell depletion via anti-CD20 antibodies is a highly effective

294 Strikingly, iron depletion was more pronounced in MDR cells due to the Pg

295 slation that included aaRS recharging, Gln4p depletion was simulated, confirming slowed translation.

296 ent from reefs in several nations, and shark depletion was strongly related to socio-economic conditi

297 nd phosphorylation of TRPC1 induced by store depletion were both reduced by pharmacological inhibitio

298 approach was to utilize differential B-cell depletion with anti-CD20 to retain B cells whose presenc

299 Furthermore, targeting EZH2 for depletion with DZNep strongly sensitizes SCLC cells and

300 We also found that ACK1 depletion with short hairpin RNA decreased EGFR degradat