ライフサイエンスコーパス: depolarization

1 PAR accumulation induced by glycine-mediated depolarization.

2 K(V) 1.2-F302L channels is more sensitive to depolarization.

3 y, we found that ALA activation promotes RIS depolarization.

4 ning voltage sensors do not translocate upon depolarization.

5 OCE) pathway and accompanied plasma membrane depolarization.

6 ed by membrane hyperpolarization rather than depolarization.

7 equency somatic bursts or strong apical tuft depolarization.

8 ed state, thereby obscuring its opening upon depolarization.

9 uced driving force, particularly during late depolarization.

10 voltage sensor domain (VSD) during membrane depolarization.

11 and ORF, but it reduces the QD fluorescence depolarization.

12 speptin neurons and estradiol increases this depolarization.

13 ects the duration of TPC1-dependent membrane depolarization.

14 in neuronal activity in response to chronic depolarization.

15 2+) leakage from the RyR and plasma membrane depolarization.

16 imulants caused SARM-dependent mitochondrial depolarization.

17 ne potential against FA-induced uncontrolled depolarization.

18 nels open upon hyperpolarization rather than depolarization.

19 the mitochondria surface upon mitochondrial depolarization.

20 ion by enhancing the amplitude of giant axon depolarization.

21 in excitable cells following plasma membrane depolarization.

22 apping that captures supra- and subthreshold depolarization.

23 sensory neurons released GABA in response to depolarization.

24 in response to neuronal differentiation and depolarization.

25 o voltage sensor stabilization upon membrane depolarization.

26 hannel Nav1.5, which is critical for cardiac depolarization.

27 but it has no effect on the SQD fluorescence depolarization.

28 tion strengthens synapses, promoting further depolarization.

29 brane permeability and to determine membrane depolarization.

30 amounts in response to K(+)-evoked membrane depolarization.

31 er [Ca(2+) ] exerts inhibitory effect during depolarization.

32 ndicating that Na-Ca exchange current caused depolarization.

33 euronal excitability by conducting K(+) upon depolarization.

34 ironmental stressors trigger plasma membrane depolarizations.

35 n to the inhibition of subthreshold membrane depolarizations.

36 v)-mediated ramp currents elicited with slow depolarizations.

37 ch neurons experience complete and prolonged depolarizations.

38 ded in future non-invasive studies of atrial depolarizations.

39 significantly more likely to have spreading depolarizations (6/7 and 10/12, respectively) than those

40 lar toxicity and vasoconstrictive effects of depolarizations act in synergy with direct ischaemic eff

41 lncRNAs are closely associated with membrane depolarization, action potential conduction, contraction

42 We identified that depolarization affected the agonist affinity for the TP

43 ansfer efficiencies measured by fluorescence depolarization allowed us to construct a two-dimensional

44 process was initiated by ischemic spreading depolarizations along with subsequent vasoconstriction,

45 ostsynaptic excitation, controlling membrane depolarization amplitude and timing via subthreshold div

46 Attenuation of ERG during coincident depolarization and ACh release leads to reduced late pha

47 induced by transient mitochondrial membrane depolarization and activation of the metalloprotease OMA

48 Inhibition of SLO2.1 leads to membrane depolarization and activation of voltage-dependent calci

49 al K(ATP) channel activity leads to membrane depolarization and an increase in action potential firin

50 spiration and induced mitochondrial membrane depolarization and apoptosis in a subset (7/11, 64%) of

51 markably, dopamine release induced by strong depolarization and asynchronous release during stimulus

52 udy determined a strong relationship between depolarization and Ca(2+) fluorescence in MCH neurons.

53 Exposure to 30 mm KCl to induce membrane depolarization and calcium influx increased expression o

54 OCHROME (dCRY) mediates electrophysiological depolarization and circadian clock resetting in response

55 a indicate that light-evoked dCRY electrical depolarization and clock resetting are mediated by disti

56 ic commentary refers to 'Brainstem spreading depolarization and cortical dynamics during fatal seizur

57 whose frequency depended on the duration of depolarization and diminished over minutes.

58 se leads to K(ATP) channel closure, membrane depolarization and electrical activity that culminates i

59 n peroxide, contributes to cellular membrane depolarization and HPV.

60 f C-Raf is necessary for maintaining ongoing depolarization and hyperactivity, demonstrating an unexp

61 nsistent with, and contributing to, neuronal depolarization and hyperexcitability.

62 s to odors with complex temporal patterns of depolarization and hyperpolarization that can vary with

63 ongly decreased burst-induced NMDAR-mediated depolarization and impaired LTP induction.

64 hibit TRESK in native cells, leading to cell depolarization and increased excitability.

65 ERG currents, leading to membrane potential depolarization and increased input resistance, two criti

66 -activated Cl(-) conductance, causing tissue depolarization and increased smooth muscle excitability.

67 Membrane depolarization and intracellular Ca(2+) promote activati

68 deprivation (OGD) that reflect inflammation, depolarization and ischemia respectively, mimicking even

69 ronal gain and selectivity with subthreshold depolarization and linearizes the relationship between s

70 capable of light-induced selective DeltaPsim depolarization and mitochondrial autophagy.

71 CCC1 functions independently of PM depolarization and negatively regulates pathogen-associa

72 d voltage dependence, meaning it closes with depolarization and opens with hyperpolarization.

73 nd a similar receptive field structure: fast depolarization and persistent, spatially offset hyperpol

74 ice to phenylephrine, KCl-dependent membrane depolarization and phorbol 12,13-dibutyrate (PDBu).

75 tigated ethanol-induced potentiation of GABA depolarization and prevented aberrant patterns of tangen

76 tin treatment of these cells led to membrane depolarization and reduced ATP production.

77 dynamics of short term phenomena such as the depolarization and repolarization of membrane potentials

78 maximal rates of voltage change during spike depolarization and repolarization.

79 t of Yap1 in the adult mouse RPE caused cell depolarization and tight junction breakdown, and led to

80 /fissures are sufficient to induce spreading depolarizations and acute infarction in adjacent cortex.

81 ifications are a risk factor for early after depolarizations and cardiac arrhythmias.

82 they produce ramp currents, amplifying small depolarizations and enhancing electrical activity.

83 respiration, elicited mitochondrial membrane depolarization, and disrupted mitochondrial morphology.

84 uidity, intracellular calcium dysregulation, depolarization, and impaired LTP.

85 rrents in AECs, counteracted HO-induced cell depolarization, and lowered iCa(2+) concentrations.

86 evate the electrical threshold for spreading depolarization, and reduce spreading depolarization freq

87 Despite this, feedforward spiking, synaptic depolarization, and spontaneous spiking were largely nor

88 secrete IGF-1 from the cell bodies following depolarization, and that IGF-1 controls release of dopam

89 Consistent with the negative modulation of depolarization- and Ca(2+)-activated K(+) currents, dopa

90 and may represent an unexpected link between depolarization- and hyperpolarization-activated channels

91 pairing mAChR stimulation with subthreshold depolarization ( approximately 10 mV from RMPs) initiate

92 hannels responsible for alpha1-A(R)-mediated depolarization are unknown.

93 Thus, neurons that recover from spreading depolarizations are less able to function normally as el

94 r HCN channels open by hyperpolarizations or depolarizations are small differences in the energies of

95 d with iloprost showed a similar reaction to depolarization as TP receptor.

96 A spectral imaging potassium depolarization assay was designed to detect ANAP emissio

97 lar Purkinje neuron dendrites, the transient depolarization associated with a climbing fiber (CF) EPS

98 he latter is investigated using fluorescence depolarization based on detecting the mobility-dependent

99 n potential firing in control model neurons, depolarization block and cessation of action potential f

100 The reduction is unlikely due to depolarization block and persists following 7-day withdr

101 ripiprazole also removes haloperidol-induced depolarization block in MAM rats, which may underlie the

102 tion in neuroblastoma cells, which induced a depolarization block in neurons with a reduction of neur

103 In contrast, 1 h after induction of depolarization block of dopamine neurons by acute halope

104 ), aripiprazole (1 mg/kg, i.p.) reversed the depolarization block state.

105 dominant IS/NFS cells are prone to entering depolarization block, causing them to temporarily lose t

106 en following D(2) antagonist administration, depolarization block.

107 istration, suggesting that it was not due to depolarization block.

108 d cause interneurons to more readily develop depolarization block.

109 ced cessation of cell firing, referred to as depolarization block.

110 s T226M models were also more susceptible to depolarization block.

111 membrane potential and that plasma membrane depolarization blocks cellular uptake of N-acylethanolam

112 ium, finding that cell hyperpolarization and depolarization both induce persistent static elevation o

113 POm triggered not only a stronger fast-onset depolarization but also a delayed all-or-none persistent

114 s across the entire pharynx, showing uniform depolarization but compartmentalized repolarization of a

115 nd artificial remapping of place cells under depolarization, but not under hyperpolarization, of laye

116 xidative stress, but not after mitochondrial depolarization by carbonyl cyanide m-chlorophenyl hydraz

117 RG neurons, causing increased sensitivity to depolarization by KCl, increased response to noxious TRP

118 C-1 in Pomc neurons in mice attenuates their depolarization by leptin, decreases Pomc expression and

119 We report on how depolarization can be exploited as a strategy to visuali

120 show that optogenetic-mediated mitochondrial depolarization can be well controlled to differentially

121 We show that mitochondrial depolarization can cause Ca(2+) waves and Ca(2+) alterna

122 longer latency to fire action potentials on depolarization compared with bottom 33% of weight gainer

123 Resulting depolarization conducts to SMCs, depolarizing membrane p

124 presaged gradients in both proliferation and depolarization, consistent with previous reports correla

125 Cortical spreading depolarization constricts sphincters and causes vascular

126 TRPC6-mediated Ca(2+) influx and depolarization coordinately promoted the interaction of

127 icularly applicable in systems where a large depolarization current is needed or sustained channel ac

128 henyl hydrazone (CCCP)-induced mitochondrial depolarization decreased mitochondrial mass and Mfn2 lev

129 NCLX causes mtCa(2+) overload, mitochondrial depolarization, decreased expression of cell-cycle genes

130 Thus, depolarization-dependent C-Raf and downstream ERK activi

131 nnel conductance, outward rectification, and depolarization-dependent inactivation kinetics.

132 Disinhibition and activation of C-Raf by depolarization-dependent phosphorylation are central to

133 This synergy caused membrane depolarization, destruction of the cell wall, and eventu

134 In 2.5-y-old mice, mild depolarization disappears in the skeletal muscles, diaph

135 Thus, SARM-dependent mitochondrial depolarization distinguishes NLRP3 activators that cause

136 However, the pattern of the membrane depolarization during singing, the fine dendritic and ax

137 erdepolarizations (EADs), which are abnormal depolarizations during the repolarization phase of a car

138 tronger inhibitory effect at mild and strong depolarization (e.g., -60 and +30 mV, 0.3-second pulse),

139 rce due to potassium accumulation, hair cell depolarization elicits sustained outward currents in the

140 Depolarization encodes both a neuron's action potential

141 Depolarization enhanced responses of several structural

142 n, as demonstrated by optically tracking VSD depolarization-evoked conformational rearrangements.

143 that ATRAP is involved in the generation of depolarization-evoked synaptic Ca(2+) transients.

144 The depolarization experienced by Salmonella undergoing oxid

145 The fluorescence depolarization experiments are carried out with both the

146 zed upon -50 mV repolarization after a 50 mV depolarization, fentanyl and naloxone blocked hERG curre

147 ght is based on ~15-ps initial dipole moment depolarization followed by ~50-ps repolarization into de

148 hed to yield stable, not increased, synaptic depolarization for cells near spike threshold.

149 reading depolarization, and reduce spreading depolarization frequency and amplitude.

150 TP receptor activity doubled upon depolarization from -90 to +60 mV in the presence of U46

151 Plasma membrane (PM) depolarization functions as an initial step in plant def

152 was accompanied by apoptosis, mitochondrial depolarization, generation of reactive oxygen species, a

153 tential oscillations or propagating waves of depolarization have been observed under metabolic stress

154 g firing at high rates; (ii) enhancing after-depolarizations; (iii) reducing the fast and medium afte

155 the otherwise inhibitory effects of cellular depolarization imposed by elevating extracellular [K(+)]

156 Calcium oscillations and waves induce depolarization in cardiac cells which are believed to ca

157 decreased hypoxia-induced cellular membrane depolarization in Cox4i2(-/-) PASMCs compared with wild-

158 Depolarization in respiring Salmonella mediates intense

159 utant for Ncc69 exhibit normal photoreceptor depolarization in response to a light pulse but lack the

160 nergic transmission accelerated subthreshold depolarization in response to current injection, reduced

161 ug, FTY720, decreased the higher synaptosome depolarization in SIV-infected animals.

162 he miniature coil causes a significant local depolarization in the axon, alters activation dynamics o

163 rgy density generated in the crystals during depolarization in the high voltage mode is four times hi

164 ly, dCRY appears to mediate red-light-evoked depolarization in wild-type flies, absent in both cry-nu

165 erticilide prevented arrhythmogenic membrane depolarizations in cardiomyocytes without significant ef

166 l of Tbx5 in vivo precipitated inappropriate depolarizations in the atrioventricular (His)-bundle ass

167 Low-frequency depolarization increased nNOS S1412 phosphorylation and

168 We show that cell depolarization increases synaptic vesicle dopamine conte

169 somata abolished persistent but not initial depolarization, indicating a recurrent circuit mechanism

170 All sensors reported differences in muscle depolarization induced by a voltage-gated Ca(2+)-channel

171 Estradiol increases membrane depolarization induced by GABA(A) receptor activation in

172 ould be responsible for AP activation during depolarization induced by TCWs.

173 onduction block and reentry arising from the depolarization induced by TCWs.

174 Compared to WT, muscle strength and depolarization-induced calcium transients in RyR1Q1970fs

175 This potentiation of depolarization-induced calcium transients was blocked by

176 t each of these interactions is required for depolarization-induced phosphorylation of the CREB nucle

177 ive allosteric modulator) did not affect the depolarization-induced spike frequency in nRT neurons.

178 ices and assessed Cb1R activity by measuring depolarization-induced suppression of excitation (DSE).

179 However, CCK+ inputs undergo depolarization-induced suppression of inhibition (DSI) a

180 This endocannabinoid-mediated depolarization-induced suppression of inhibition (DSI) w

181 ese antibiotics include cell lysis, membrane depolarization, inhibition of cell wall biosynthesis, an

182 domain such that the channels now open upon depolarization instead of hyperpolarization.

183 ular excitability, amplifying small membrane depolarizations into action potentials.

184 intracellular calcium levels, mitochondrial depolarization, intracellular trypsin activation, and ce

185 It is suggested that this mitochondrial mild depolarization is a crucial component of the mitochondri

186 Fluorescence depolarization is associated with a decrease in fluoresc

187 Prolongation of ventricular depolarization is concentration-dependent with a QRS dur

188 ization whereas Kv channels are activated by depolarization is not clear.

189 that recover from hypoxia-induced spreading depolarization is not obviously abnormal when tested for

190 intracellular calcium and ATP, mitochondrial depolarization, ischaemia-sensitive leak current, and ti

191 on but also a delayed all-or-none persistent depolarization, lasting up to 1 s and exhibiting alpha/b

192 tion potential threshold; and 2) a transient depolarization leading to high-frequency plateau bursts,

193 Hair cell depolarization leads to calcium influx and activation of

194 In neurons, depolarization leads to the expression of inducible tran

195 dye showing a significantly higher baseline depolarization levels in synaptosomes of SIV(+)-infected

196 a model in which surfactin-mediated membrane depolarization maintains viability through slower oxygen

197 entials and that interventions causing acute depolarization may affect some cristae while sparing oth

198 ates, instead of ameliorating, mitochondrial depolarization-mediated cell death in HeLa cells.

199 neurons that translate wakefulness into the depolarization of a sleep-active neuron when the worm is

200 hibitory FMRP antibody into BCs, or membrane depolarization of BCs, enhances GABA release in the wild

201 2 synapses using dynamic clamp combined with depolarization of both Si3s mimicked the effects of Si1

202 A 6 mV depolarization of Bq reduced the discrepancy between the

203 heartbeat is initiated by cyclic spontaneous depolarization of cardiomyocytes in the sinus node formi

204 and generation of inward current, cause net depolarization of colonic muscles.

205 on factor and expression of c-Fos induced by depolarization of cultured hippocampal neurons.

206 Depolarization of glioma membranes assessed by in vivo o

207 P2RY1 activation triggers K(+) efflux and depolarization of hair cells, as well as osmotic shrinka

208 a(2+) and activation of Ano1 channels causes depolarization of ICC-SS and LSMC, leading to activation

209 c autoreceptors, K(+) efflux, and subsequent depolarization of inner hair cells.

210 damaged phloem, activates GLRs, resulting in depolarization of membranes in the form of SWPs and the

211 ed at a lower than maximal level (i.e., mild depolarization of mitochondria).

212 ight be arresting the cell cycle at S phase, depolarization of mitochondrial membrane potential, down

213 Consequently, depolarization of one IHC triggers presynaptic Ca(2+)-in

214 uman variant (SRC-1(L1376P)), leptin-induced depolarization of Pomc neurons and Pomc expression are s

215 We show that photo-depolarization of PV+ interneurons rapidly switches from

216 euron density in FCD may lead to paradoxical depolarization of pyramidal cells.

217 , DRG neurons show hyperactivity and chronic depolarization of resting membrane potential (RMP) that

218 that SCI and one consequence of SCI (chronic depolarization of resting membrane potential) decrease s

219 ceptors from naive animals by a modest 5 min depolarization of RMP (15 mm K(+); -45 mV), reducing inh

220 echanisms that translate sleep need into the depolarization of sleep-active neurons.

221 beta-cells is driven by glucose metabolism, depolarization of the cell membrane and an influx of cal

222 MOCA1 is required for salt-induced depolarization of the cell-surface potential, Ca(2+) spi

223 s) current kinetics, including the nonlinear depolarization of the conductance-voltage (G-V) relation

224 f kidney-specific Kir4.1 knockout mice), and depolarization of the DCT membrane.

225 chondrial impairment and leading to a strong depolarization of the membrane potential and decrease of

226 ts on their electrical properties, including depolarization of the membrane potential while simultane

227 This compound caused a transient depolarization of the plasma membrane potential and indu

228 cell when presynaptic firing was paired with depolarization of the postsynaptic cell.

229 egans, we solved the presynaptic circuit for depolarization of the sleep-active RIS neuron during dev

230 oride conductance, resulting in diuresis and depolarization of the transepithelial potential.

231 This results in depolarization of the uterine smooth muscle cells and ca

232 Electrical stimuli elicit transient depolarization of the vacuole membrane that can last for

233 of mitochondria in the IS of DCs and partial depolarization of these organelles.

234 y of ENaC which resulted in the steady state depolarization of VP neurons.

235 We have also shown that subthreshold depolarizations of B21 produce widespread increases in i

236 del to simulate the effects of mitochondrial depolarization on mitochondrial Ca(2+) cycling, Ca(2+) s

237 al pathway, as demonstrated by mitochondrial depolarization, opening of mitochondrial transition pore

238 cells did not undergo mitochondrial membrane depolarization or apoptosis despite a similar attenuatio

239 uction, which, when reduced by mitochondrial depolarization or ATP synthase inhibition, eliminated lo

240 tivation of NMDA receptors in the absence of depolarization or Ca(2+) release from intracellular stor

241 s and had reduced capacity to cause membrane depolarization or death of AZ-521 cells.

242 ell volume by gating in response to membrane depolarization or hyperpolarization.

243 evoked by broad pseudo-APs can occur in the depolarization phase.

244 ter ACh application, but not by subthreshold depolarization preceding mAChR stimulation.

245 here that only very strong nonphysiological depolarization produces voltage-dependent activation of

246 nd inhibits hERG currents at mild and strong depolarization pulses by slowing activation and enhancin

247 I(Ca) depends on the repolarization but not depolarization rate of APs, being near the end of repola

248 of the threshold potential and the diastolic depolarization rate that is independent of the maximum u

249 s action potential firing by slowing maximum depolarization rate.

250 urons of LB females displayed slower maximal depolarization rates and decreased amplitudes compared w

251 The cross sections and depolarization ratios measured using broadband SRS agree

252 Linked with plasma membrane depolarization, reduced endothelial-NOS expression and d

253 This paradox arises because membrane depolarization reduces the amplitude of the action poten

254 zation, an extended ramp-like shoulder, or a depolarization reminiscent of depolarizing afterpotentia

255 es a detailed understanding of the molecular depolarization/repolarization processes responsible for

256 tamate release, was associated with stronger depolarization responses to brief (1 ms) nicotine uncagi

257 ysis of vesicles released by trains of 30 ms depolarizations revealed that most releasable vesicles r

258 ntaneous brainstem seizure-related spreading depolarization (SD) reaches respiratory nuclei in the ve

259 We postulate that brainstem spreading depolarization (SD), previously associated with lethal s

260 estigate its mechanisms, including spreading depolarization (SD), the phenomenon underlying migraine

261 a, and trauma, frequently generate spreading depolarization (SD).

262 luding increased susceptibility to spreading depolarizations (SDs) and seizures, known agents of clin

263 luorescence drops when the rhodopsin acts as depolarization-sensitive acceptor.

264 sively expose plant cells to signal specific depolarization signatures.

265 its C-terminal LZ domain resulted in loss of depolarization-stimulated NFAT signaling in rat hippocam

266 Together these findings show that neuronal depolarization stimulates enteric nNOS phosphorylation b

267 in learning and memory in which postsynaptic depolarization strengthens synapses, promoting further d

268 ayed open times that decreased with membrane depolarization, suggestive of a blocking mechanism that

269 mplex is a critical determinant of spreading depolarization susceptibility with important consequence

270 unrecognized episodes of cortical spreading depolarization that arose frequently from the peritumora

271 ient hyperpolarization followed by a delayed depolarization that triggers action potential firing.

272 e potentials (SWPs), damage-induced membrane depolarizations that activate the jasmonate (JA) defense

273 that dCRY mediates UV and blue-light-evoked depolarizations that are long lasting, persisting for ne

274 try when membrane potential was clamped with depolarization, the effect of TSPAN-7 on Ca(V) channel a

275 ading depression (CSD) is a wave of neuronal depolarization thought to underlie migraine aura.

276 creased mitochondrial membrane potential and depolarization threshold.

277 tive-going fluorescence response to membrane depolarization through rational manipulation of the nati

278 ity via a longitudinal study in mice and use depolarization time from measured data to predict the on

279 o the neurotransmitter GABA, from excitatory depolarization to inhibitory hyperpolarization.

280 ctive coupling of Ca(2+) binding and voltage depolarization to pore opening and that shared Ca(2+) an

281 ) channels that open in response to membrane depolarization to regulate cell excitability.

282 ll types, which open in response to membrane depolarization to regulate cell excitability.

283 cellular ATP levels as well as mitochondrial depolarization together with a significant reactive oxyg

284 Here we report that membrane depolarization triggered IKC intracellular signals media

285 ished by activation only at extreme membrane depolarization (V(50) ~ +75 mV), in contrast to other TP

286 many K2P channels are activated by membrane depolarization via an SF-mediated gating mechanism, but

287 otential duration, and ectopic cardiomyocyte depolarizations, were all rescued by Gata4 haploinsuffic

288 e model, electrical stimulation only induced depolarization when cells are treated with antibiotics,

289 lness is translated into sleep-active neuron depolarization when the system is set to sleep.

290 as thromboxane receptors are activated upon depolarization, whereas prostacyclin receptors are not.

291 ned fully conductive upon prolonged moderate depolarizations, whereas in wild-type hKv2.1 and hKv3.1,

292 om transitional and lateral movements during depolarization, which are coupled to opening of the chan

293 tivate, allowing them to open in response to depolarization, which can trigger a high-frequency seque

294 be limited.SIGNIFICANCE STATEMENT Spreading depolarization, which commonly accompanies cortical inju

295 sed technique for controllable mitochondrial depolarization with light.

296 consistent with previous reports correlating depolarization with proliferation.

297 store mitochondrial membrane potential after depolarization with rotenone.

298 is regulated by short pulses of the membrane depolarization without affecting the overall membrane po

299 65-Ub and mitophagic flux upon mitochondrial depolarization without USP30.

300 lso blocks SCI-induced hyperexcitability and depolarization, without direct effects on opioid respons