ライフサイエンスコーパス: depolymerase

1 th its known role as a microtubule minus-end depolymerase.

2 om that of a bacteriophage exopolysaccharide depolymerase.

3 3 motor protein MCAK is a potent microtubule depolymerase.

4 aZ2 is thus suggested to be an intracellular depolymerase.

5 approach towards the identification of phage depolymerases.

6 crotubule array destabilization by conserved depolymerases.

7 2a is a member of the Kinesin-13 microtubule depolymerases.

8 ics and mitotic progression by regulating MT depolymerases.

9 ted motors that are proposed to be either MT depolymerases [3, 4, 8, 10, 11] or MT capping proteins [

10 s end-directed motor and a plus end-specific depolymerase--a unique combination of activities not fou

11 Extracellular depolymerase activities and expression of the correspond

12 chromosome movement and that the microtubule depolymerase activities of Kif2a, Kif2b, and MCAK fulfil

13 associated kinesin (MCAK) and inhibits their depolymerase activities.

14 tility can be uncoupled from the microtubule depolymerase activity and argue that loop5-targeting inh

15 We find that beta-CTT is necessary for Kip3 depolymerase activity but not for microtubule binding an

16 gest a model in which beta-CTT promotes Kip3 depolymerase activity by supporting a Kip3-tubulin-bindi

17 regulatory mechanism underlying precise MCAK depolymerase activity control during mitosis remains elu

18 CAK at Ser715 which promotes its microtubule depolymerase activity essential for faithful chromosome

19 This unanticipated amyloid-depolymerase activity is conserved from yeast to humans,

20 Here we demonstrate that the depolymerase activity is indispensable to control spindl

21 Finally, KIF2C depolymerase activity promotes the formation of KIF2C co

22 with a kinesin-5-mediated, length-dependent depolymerase activity that organizes chromosomes at the

23 involves fourteen putative tail fibers with depolymerase activity that provide Kp24 with the ability

24 sary and sufficient for plus-end binding and depolymerase activity, as well as by the identification

25 ability during mitosis by inhibiting MCAK MT depolymerase activity.

26 pD, a gamma-glutamyltranspeptidase with PDGA depolymerase activity.

27 ture is required for the elaboration of PDGA depolymerase activity.

28 somal passenger complex (CPC) regulate Kif2a depolymerase activity.

29 AK on residues that regulate its microtubule depolymerase activity.

30 The chitin depolymerases also had a specific pattern of activity to

31 ment end, which, when occupied, has both the depolymerase and ATPase activities.

32 ings establish a paradigm where polymerases, depolymerases and cappers together tune actin assembly.

33 l xylan esterases, poly (3-hydroxyalkanoate) depolymerases and CEs, and proteins of unknown function

34 aZ1(b), and PhaZ1(c) (putative intracellular depolymerases), as well as PhaZ2 (a hydroxybutyrate olig

35 depolymerization, also acts as a processive depolymerase at filament barbed ends.

36 duction of cell wall-degrading enzymes (wall depolymerases) by plant pathogenic fungi is under catabo

37 of a previously described variant of capsule depolymerase, CapD-CP, when delivered 24 hours after exp

38 olytic system includes three secreted chitin depolymerases (ChiA, ChiB, and ChiC), a secreted chitin-

39 c and proteomic analyses reveal 13 cellulose depolymerases complemented by seven accessory enzymes, i

40 cellular poly[D-(-)-3-hydroxybutyrate] (PHB) depolymerases degrade PHB granules to oligomers and mono

41 dation analysis using cellubiuronan-specific depolymerase demonstrated that the oligosaccharide-lipid

42 genes predicted to encode intracellular PHB depolymerases (depA and depB).

43 How different depolymerases differently remodel microtubule arrays is

44 bacter species possess a Vi antigen-specific depolymerase enzyme missing in S enterica Typhi, and we

45 sults demonstrate this phage and its capsule depolymerase exhibit specificity for capsular type K1 an

46 ersity and specificity within the kinesin-13 depolymerase family.

47 olecular weight product by a type 3-specific depolymerase from Bacillus circulans.

48 l of using the poly(3-hydroxybutyrate), PHB, depolymerase from Psuedomonas lemoignei in organic media

49 Recently an intracellular PHB depolymerase gene (phaZ1) from Ralstonia eutropha was id

50 e now report identification of candidate PHB depolymerase genes from R. eutropha, namely, phaZ2 and p

51 nome were used to identify two new candidate depolymerase genes in R. eutropha: phaZ2 and phaZ3.

52 phaZ1 was used to identify two candidate depolymerase genes in the genome of Ralstonia metallidur

53 Twinfilin, an actin uncapper and depolymerase, has not previously been linked to tissue c

54 e currently known polyhydroxyalkanoate (PHA) depolymerases have lipase activity, they do have a catal

55 The KinI kinesin MCAK is a microtubule depolymerase important for governing spindle microtubule

56 Consistently, attenuation of Klp10A MT depolymerase in patronin mutant neurons significantly re

57 e general function of kinesin-13 microtubule depolymerases in preventing ectopic, spontaneous microtu

58 kinesin-13 KIF2A is a microtubule minus-end depolymerase, in contrast to its paralog MCAK.

59 ization is controlled in part by microtubule depolymerases, including the kinesin-13 family of protei

60 Capsule depolymerase is a y-glutamyltransferase that anchors the

61 The KinI kinesin MCAK, a microtubule depolymerase, is critical for this regulation.

62 Here the authors show that the microtubule depolymerase Kif2 is localized to a cortical subdomain o

63 This study shows that the microtubule depolymerase Kif2 is localized to a cortical subdomain o

64 Here we show that the microtubule depolymerase Kif2 localizes to this subdomain of cortica

65 that Wnt signaling regulates the microtubule depolymerase KIF2A during mitosis.

66 Mechanistically, DDA3 interacts with the MT depolymerase Kif2a in an MT-dependent manner and recruit

67 regions of the kinesin-13 family microtubule depolymerases Kif2a and mitotic centromere-associated ki

68 localization and binding to the microtubule depolymerase Kif2b, and for NuMA binding to dynein.

69 During mitosis, the microtubule depolymerase KIF2C, the tumor suppressor BRCA2, and the

70 even when challenged by a known microtubule depolymerase, kinesin-13 MCAK.

71 rates for kinesin translocase motors and for depolymerase kinesins.

72 kinesin (Cin8, class Kin-5), together with a depolymerase (Kip3, class Kin-8) or minus-end-directed k

73 s dynamically unstable ipMTs outward, the MT depolymerase KLP10A acts at the poles to convert ipMT sl

74 n patronin, which antagonizes the kinesin-13 depolymerase KLP10A at spindle poles, thereby switching

75 depletion of the pole-associated microtubule depolymerase KLP10A increased spindle microtubule densit

76 irectly by localizing the pole-associated MT depolymerase KLP10A.

77 gh the actions of the Kinesin-13 microtubule depolymerase, leading to a sparse interphase microtubule

78 Bacteriophage depolymerases, leveraged by these viruses to circumvent

79 or a polar "pulling-in" mechanism in which a depolymerase localized at kinetochore fiber minus ends m

80 Kip3p (kinesin-8), a MT depolymerase, may be implicated, but other molecular det

81 The MT depolymerase MCAK (mitotic centromere-associated kinesin

82 lished a direct link between the microtubule depolymerase MCAK and Aurora B kinase.

83 mulator (ICIS), which stimulates the related depolymerase MCAK, can reactivate Kif2a after Aurora B i

84 s microtubules by inhibiting the microtubule depolymerase MCAK.

85 on and catalytic activity of the microtubule depolymerase MCAK.

86 Despite extensive study, the kinesin-8 depolymerase mechanism remains under debate.

87 oes cause mislocalization of the microtubule depolymerase mitotic centromere- associated kinesin and

88 The microtubule depolymerase mitotic centromere-associated kinesin (MCAK

89 rora B kinase and the kinesin-13 microtubule depolymerase mitotic-centromere-associated kinesin (MCAK

90 show that Klp10A also acts as a microtubule depolymerase on centriolar microtubules to regulate cent

91 s caused accumulation of MCAK, a microtubule depolymerase, on the spindle, indicating misregulation o

92 odulate plus-end MT dynamics by acting as MT depolymerases or as MT plus-end capping proteins.

93 ly, via selective binding of polymerases and depolymerases, or mechanically, because k-fiber microtub

94 cemic lactides has been studied with the PHB-depolymerase (P. lemoignei) in organic solvents.

95 The selectivity of the PHB-depolymerase (P. lemoignei) to catalyze the propylation

96 ism, specifically targeting phasin phaP1 and depolymerase phaZ3 and phaZ5 genes.

97 ltifunctional motor protein with microtubule depolymerase, plus-end motility, and antiparallel slidin

98 H16_B1672 also showed interaction with both depolymerase promoters in vivo and in vitro suggesting a

99 ncy by the kinetochore-associated kinesin-13 depolymerase promotes metaphase chromosome oscillations;

100 onstrate that Kif2a may act as a microtubule depolymerase, regulating microtubule dynamics, spindle a

101 ivities underlie the functional dichotomy of depolymerases, resulting in either large-scale destabili

102 lts, we propose that ExsH is a succinoglycan depolymerase secreted by a Type I secretion system compo

103 date a heretofore-unrecognized human amyloid-depolymerase system that could have applications in vari

104 ure of one CE1 gene of A. muscaria matched a depolymerase that degrades the carbon storage molecule p

105 reminiscent of MCAK, which is a microtubule depolymerase that is believed to be a key component of t

106 for ~0.2 to 0.5 s, acting as a nonprocessive depolymerase that likely removes one or both terminal ac

107 their bacterial host and many phages produce depolymerases that hydrolyze biofilm extracellular polym

108 propose that the conversion of KIF2A from a depolymerase to a stabilizer is driven by both the inhib

109 Moreover, the ability of the PHB-depolymerase to catalyze the solventless polymerization

110 acis can be treated with recombinant capsule depolymerase to enzymatically remove the capsule and pro

111 ux, and the chromokinesin KLP3A inhibits the depolymerase to suppress flux, thereby coupling ipMT sli

112 cetonitrile-d(3)) on the activity of the PHB-depolymerase toward propylation of L-lactide was studied

113 Thus, the depolymerase twinfilin acts as a pro-formin pro-polymeri

114 tion of one target, a kinesin-13 microtubule depolymerase, underlies a major phenotype associated wit

115 Each chitin depolymerase was detected in culture supernatants of chi

116 The gene-encoding capsule depolymerase was identified.

117 The depolymerases were modular in nature and contained glyco

118 taphase and metaphase are set by microtubule depolymerases, whereas oscillation and breathing periods

119 2a is a member of the kinesin-13 microtubule depolymerases, which tightly regulate microtubule dynami

120 relies on the kinesin-13 MCAK, a microtubule depolymerase whose activity in vitro is suppressed by al

121 The kinesin-13 MCAK is a potent MT depolymerase with a complex subcellular localization, ye