ライフサイエンスコーパス: depot

1 therapy used (prednisolone or tetracosactide depot).

2 taken up by macrophages associated with the depot.

3 tified the drug content primarily within the depot.

4 r 2 was only indirectly involved as a supply depot.

5 and was related to percent body fat in each depot.

6 tion of preadipocytes and adipocytes in each depot.

7 lar hydrogel injections acting as a delivery depot.

8 lean mice, especially in the epididymal fat depot.

9 pecially formulated to self-aggregate into a depot.

10 ogeneity of white adipocytes within a single depot.

11 ic lesion and convert them as an in situ RLN depot.

12 g nanostructures to locally applied hydrogel depots.

13 lic behavior and physiology of different fat depots.

14 factor present in brown adipocytes found in depots.

15 s well as on the level of several individual depots.

16 tigens, depending on the dose of drug in the depots.

17 differentially affect specific body adipose depots.

18 white adipose tissue (WAT) in different body depots.

19 ulation and gradual release from subcellular depots.

20 adipocytes within multiple visceral adipose depots.

21 effects on atherogenic and diabetogenic fat depots.

22 ly higher in the liver compared with adipose depots.

23 ed on volume and intensity of individual BAT depots.

24 to serve as prolonged gastric resident drug depots.

25 must be boosted to establish long-acting ARV depots.

26 ophysiological contributions of visceral fat depots.

27 f the GR to its target gene promoters in fat depots.

28 th reduced fat cell size in subcutaneous WAT depots.

29 bly due to interactions with cellular copper depots.

30 gulatory mechanisms operate in different WAT depots.

31 eased thermogenic gene expression in all fat depots.

32 itoneal white adipose tissue (IWAT and RWAT) depots.

33 laterally in supraclavicular and gluteal fat depots.

34 in vivo CN recruits iron from intracellular depots.

35 nd oxygen consumption in beige and white fat depots.

36 ssion of the thermogenic gene program in fat depots.

37 nied by weight gain and expansion of adipose depots.

38 is and activity in both these adipose tissue depots.

39 er body, and dorsal versus ventral abdominal depots.

40 ncreased immune cell infiltration within the depots.

41 apacity of primary tumours to act as antigen depots.

42 ndrial function in gluteal and abdominal SAT depots.

43 sistent with metabolic activity in BA tissue depots.

44 nt in the circulation and in metabolic organ depots.

45 cess triglycerides in metabolically low-risk depots.

46 gy dissipation in white adipose tissue (WAT) depots.

47 s differ in their abundance in different fat depots.

48 pression patterns of HOX clusters in adipose depots.

49 ithin and between tissues, including adipose depots.

50 mi-continuous solid coating or as micro drug depots.

51 Gs) between subcutaneous and omental adipose depots.

52 times a day or intramuscular tetracosactide depot 0.5 mg (40 IU) on alternate days with or without v

53 s assay functions well with multiple adipose depots, a previously unattained analysis.

54 f newly synthesized lipids in adipose tissue depots, accompanied by weight gain and expansion of adip

55 The (131)I-ELP depots achieved >95% tumor regression in the prostate tu

56 tration for 25 weeks with substantial tissue depots after a single intramuscular injection in BALB/cJ

57 ous environment to form a solid drug eluting depot allowing for a high initial intratumoral drug conc

58 ling protein 1 (UCP1) in both adipose tissue depots, although these effects are much more pronounced

59 s ATBF, most strikingly in the gluteofemoral depot, an effect further augmented in the postprandial s

60 In the current study, a polymeric drug depot-anchoring hydrogel scaffold was developed for the

61 New depot and implant formulations of buprenorphine and nalt

62 was released relatively quickly from the oil depot and its carbamate bond was too stable to be used a

63 drophobicity are then disassociated from the depot and released over time to provide a depot dissolut

64 micron-sized adjuvants that creates a local depot and results in a slow release of antigen and adjuv

65 us fat tissues than in those in the visceral depot and that HSF1 is more abundant in differentiated,

66 ansion of the subcutaneous abdominal adipose depot and the development of insulin resistance.

67 s to the exacerbated IL-6 production in this depot and the low-grade systemic inflammation typically

68 distributed throughout the body in distinct depots and adipocytes make up a minority of the cells wi

69 al and molecular differences between adipose depots and depot-specific cellular mechanisms of adipose

70 HSF1 is differentially expressed in adipose depots and how its levels are regulated in fat tissues r

71 omote migration of immune cells into adipose depots and impede further angiogenesis.

72 ort that AIF1L is expressed in major adipose depots and kidney but was not detectable in liver or ske

73 Peripheral and central fat depots and lean mass were measured using standardized an

74 ion of interleukin (IL)-12 in adipose tissue depots and led to the selective proliferation and accumu

75 tial effect of GH on specific adipose tissue depots and on distinct classes of metabolically active a

76 causes sympathetic output to distant adipose depots and potentially other metabolic tissues to regula

77 the selective enlargement of epididymal fat depots and suppresses energy expenditure in a nutritiona

78 he relative mass of different adipose tissue depots and thus insulin sensitivity in obesity, and it s

79 ed the formation of DERE-involved regulatory depots and transcription inactivation of candidate tumor

80 that of preadipocytes in the scABD and scFEM depots and was related to percent body fat in each depot

81 orting vaccines from national to subnational depots, and 8 of 48 vaccine carriers (17%) used in outre

82 e MED/LC diet mobilizes specific ectopic fat depots, and exercise has an independent contribution to

83 ulin-mediated (18)F-FDG influx rates, tissue depots, and M value.

84 ), while H(2)O(2) production reduced in both depots, and mtDNA decreased in gSAT (p < 0.05).

85 luorodeoxyglucose (FDG) influx rates, tissue depots, and whole-body insulin sensitivity (referred to

86 se change in some liver markers (hemosiderin depots, apoptosis index and GPx) and blood lipids (total

87 liver histology (histopathology, hemosiderin depots, apoptosis index; (6) liver fatty acid incorporat

88 ow) preadipocytes and adipocytes in the same depot are more oxidative and less glycolytic.

89 pose-derived stem cells (ASCs) from visceral depots are compromised compared with those of ASCs from

90 aptations to cold of brown and beige adipose depots are examined using quantitative mitochondrial pro

91 = 0.49) and that adipocytes in subcutaneous depots are larger than their visceral counterparts (Pmet

92 tablished, but how these differences between depots are regulated at the molecular level remains larg

93 ther uncovered that ERalpha-bound regulatory depots are tethered to heterochromatin protein 1 (HP1) f

94 sing method under real-world conditions at a depot area and on the normal route of bus line 24 in Hel

95 At the depot area the emission factors were in the range of 0.3

96 ver PPT and demonstrate the promise of a gel depot as an IP drug delivery system.

97 In a condition of dysfunctional visceral fat depots, as in the case of obesity, alterations in adipok

98 mmunisation, GBS67-CpGODN+L formed a vaccine depot at the injection site and induced a remarkable inc

99 subcutaneously, the nano-suspension formed a depot at the injection site, inducing localized immune r

100 lymphatics with cationic liposomes forming a depot at the injection site.

101 zation usually results in the formation of a depot at the site of injection (SOI), which hinders the

102 in mildly acidic conditions, form insoluble depots at neutral pH, efficiently release soluble protei

103 sue (WAT) in both epidydmal and subcutaneous depots but not in interscapular brown adipose tissue (BA

104 at the bone tissue can serve as a gadolinium depot, but so far only bulk measurements were performed.

105 ompared with those of ASCs from subcutaneous depots, but little is known about the underlying mechani

106 ta-emissions of (131)I further stabilize the depot by introducing crosslinks within the ELP depot ove

107 We show that long-acting TAF depots can be designed as block copolymers or as homopol

108 were in decline as families left for ration depots, cattle stations, and mission settlements.

109 gression analysis demonstrated that the drug depot characteristics including volume, surface area, an

110 s showed that degradation and release of the depot coincided with the sustained TAF release.

111 f drug-loaded polymer islands acting as drug depots colocalized with adherent cells are surrounded by

112 afts was unchanged by treatment with fat/PGZ depots compared to no treatment.

113 and decrease in subcutaneous/peritoneal fat depots compared to non-tumor bearing control mice.

114 vo lipogenesis in both abdominal and gluteal depots, compared with obese girls with the favorable phe

115 developed an in-situ crosslinkable hydrogel depot containing paclitaxel (PTX) nanocrystals (PNC).

116 rporation in fat and to determine if fat/PGZ depots could decrease vascular hyperplasia development i

117 s MMP14 promotes the generation of white fat depots crucial for energy storage, MMP15 differentially

118 cantly less than that of the unmodified drug depots (DDs).

119 rther followed the dynamics of different fat depots (deep and superficial subcutaneous, liver, perica

120 265744 LAP administration, while the Vehicle depot did not suggesting that the active drug substance

121 These inter- and intra-depot differences in adipocytes are developmentally prog

122 he depot and released over time to provide a depot dissolution mechanism.

123 of global thermogenic metabolism in adipose depots during acute cold exposure.

124 ed, and is first detectable in white adipose depots during middle age.

125 posed of a polymeric NP which acts as a drug depot encapsulating cationic polymer/nucleic acid comple

126 d, resulting in a large subcutaneous insulin depot, estimated to be 450 units of regular insulin.

127 r related particle was a key driver for drug depot evolution.

128 Fat depots exhibit diverse responsiveness and are differenti

129 The depot expansion was associated with an increase in macro

130 are often found or are intercepted in grain depots, flour mills, and entry-exit ports, etc.

131 hat instantaneously forms a subcutaneous gel-depot following injection.

132 racellular compartments serve as a long-term depot for GalNAc-siRNA conjugates and are the major cont

133 could serve as a cell-responsive therapeutic depot for local chemotherapy.

134 tly been reshaped by the notion of skin as a depot for Na(+) accumulation in multiple cardiovascular

135 ids, converting the lysosome into a cellular depot for them.

136 are internalized into vesicles that serve as depots for delivery back to the cell surface, allowing f

137 lipid droplets (LDs) play a critical role as depots for energy-rich storage lipids.

138 0q13 DEREs were mobilized to form regulatory depots for synchronized gene expression of target loci.

139 The study suggests that amyloids may act as depots for the native form of the protein and therefore

140 ophobized in these prodrug segments to drive depot formation upon injection.

141 Development of in-situ depot-forming gel systems for intratumoral delivery of i

142 The results support the use of this depot formulation for treatment initiation and stabiliza

143 Lastly, injectable hydrogels as depot formulation were formed by stereocomplexation, and

144 a novel, weekly, subcutaneous buprenorphine depot formulation, CAM2038, to block euphorigenic opioid

145 d for separating individual PLGAs in a given depot formulation, leading to analysis of each type of P

146 PLGA polymers is critical for development of depot formulations as their properties control drug rele

147 Injectable, long-acting depot formulations based on poly(lactide-co-glycolide) (

148 been used for making injectable, long-acting depot formulations for the last three decades.

149 The difficulty in developing depot formulations stems in large part from the lack of

150 ant for further development of not only PLGA depot formulations with controllable drug release kineti

151 as been used in many injectable, long-acting depot formulations.

152 ubdomains called foci, which likely serve as depots from where SV40 gains access to the cytosol.

153 Different fat depots have distinct metabolic and inflammatory profiles

154 thods, we show that even within a single WAT depot, high Tbx15 expression is restricted to a subset o

155 entially secreted from the different adipose depots; however, their paracrine and autocrine effects o

156 ive and soluble insulin is released from the depot in a well behaved, first order fashion.

157 hite adipose tissue (scWAT) is the major fat depot in humans and is a central player in regulating wh

158 eft and right side of the visceral falciform depot in six obese dogs.

159 al potential aimed to reduce deleterious WAT depots in humans and pets.

160 to cold exposure in multiple adipose tissue depots in mice.

161 ed that Foxa3 levels are elevated in adipose depots in response to high-fat diet regimens and during

162 stromal vascular cell proliferation in both depots in the metabolically unfavorable phenotype.

163 irming that these cells comprise thermogenic depots in vivo, and explain previous findings of a rate-

164 mized to establish functional brown fat-like depots in vivo.

165 PGZ was detected in the fat depot, in the external jugular vein wall and in adjacent

166 found outside classical brown adipose tissue depots, in adipocytes that are termed 'brite' (brown-in-

167 rgement of visceral and subcutaneous adipose depots indicative of both adipocyte hypertrophy and hype

168 Long-acting (LA) depot injections of nanomilled poorly water-soluble ARVs

169 ergo temperature-mediated assembly to form a depot inside the lacrimal gland.

170 The depot is a polymeric prodrug synthesized from monomers t

171 onship of marrow adipose tissue to other fat depots is complex and might play very distinct parts in

172 el, and methotrexate) from membrane-enclosed depots is described.

173 Thus, white adipose tissue, even in a single depot, is comprised of distinct subpopulations of white

174 f glucose metabolism, and in susceptible WAT depots, it can cause browning.

175 YK was present in cytoplasmic RNA processing depots known as P-bodies formed during the onset of EMT,

176 Once thought to be only inert energy storage depots, LDs are increasingly recognized as organelles th

177 o differences in white adipose tissue at the depot level and even heterogeneity of white adipocytes w

178 distribution of lipids between the major fat depots located in subcutaneous and visceral regions may

179 aging approach was used to identify the drug depot location and volumetric/physiologic changes in bot

180 minoglycans provide an immobilized chemokine depot maintaining a 'cloud' of 'solution-phase' chemokin

181 polymers are believed to serve as a protein depot, making the enzyme immediately available to fight

182 ch they approach ideality for photoactivated depot materials.

183 treatment by an implanted oxygen-generating depot may enhance the cytotoxicity of DOX against malign

184 While expansion of UCP1-expressing adipose depots may be achieved in rodents via genetic and pharma

185 among black people, and the effectiveness of depot medications.

186 Increasing evidence suggests depot medroxyprogesterone acetate (DMPA) and intravagina

187 Depot medroxyprogesterone acetate (DMPA) and vaginal dys

188 nz and rifampicin on the pharmacokinetics of depot medroxyprogesterone acetate (DMPA) are unknown.

189 Use of the injectable contraceptive depot medroxyprogesterone acetate (DMPA) is associated w

190 The hormonal contraceptive depot medroxyprogesterone acetate (DMPA) may be associat

191 Reliable contraceptives (injectable Depot Medroxyprogesterone Acetate (DMPA), implant, pills

192 To address this discrepancy, we developed a Depot medroxyprogesterone acetate (DMPA)-treated cotton

193 sion levels in HIV-uninfected women who used depot medroxyprogesterone acetate (DMPA; n = 32), the le

194 n increase in HIV risk in the ten studies of depot medroxyprogesterone acetate (pooled hazard ratio [

195 our study would merit complete withdrawal of depot medroxyprogesterone acetate needs to be balanced a

196 Depot medroxyprogesterone acetate use associated with in

197 In women using depot medroxyprogesterone acetate, adjusted pregnancy in

198 risk of HIV acquisition for all women using depot medroxyprogesterone acetate, with a smaller increa

199 ceptives (COCs) or the injectable progestins depot-medroxyprogesterone acetate (DMPA) or norethistero

200 intramuscular (IM) or subcutaneous (SC) drug depot morphology and distribution kinetics with plasma p

201 es with 56 populations and 29 adipose tissue depots/obesity indices were included in the meta-analysi

202 ned associations of different adipose tissue depots/obesity indices with insulin resistance, as measu

203 id a study of the efficacy of pazopanib with depot octreotide in patients with advanced NETs.

204 lu-PLGA) has been used in Sandostatin(R) LAR Depot (octreotide acetate for injectable suspension) app

205 e implanted into the inguinal adipose tissue depot of C57BL6 mice.

206 ng drug levels and targeted an intracellular depot of ciprofloxacin to the alveolar macrophage compar

207 Additionally, the presence of a depot of large tubular organelles in the cytoplasm sugge

208 ession (AS; two injections of every-3-months depot of luteinizing hormone-releasing hormone agonist)

209 eciprocally regulated in white and brown fat depots of diet-induced obesity and leptin-deficient ob/o

210 we create materials that form photoactivated depots of insulin without the need for polymers, by link

211 e polarization in the subcutaneous white fat depots of microbiota-depleted animals.

212 ncreases cAMP levels in subcutaneous adipose depots of obese mice, promoting the synthesis and secret

213 trast, sustained local delivery via hydrogel depots of required axon-specific growth factors not pres

214 ipocytes are located mainly in dedicated BAT depots of rodents and infants, beige adipocytes sporadic

215 Wnt6, a known anti-adipogenic factor, in fat depots of the mouse.

216 iferase emission was detected from major fat depots of transplanted mice.

217 mones or treatments with chemicals, specific depots of WAT undergo a browning process, characterized

218 t the particulate delivery systems induced a depot (of both delivery system and antigen) at the injec

219 ncluded changes in total-body fat and muscle depots on dual-energy X-ray absorptiometry (DXA), whole-

220 o assess the effect of different ectopic fat depots on left ventricular (LV) function in subjects wit

221 r vein was used to assess effects of PGZ/fat depots on vascular hyperplasia development.

222 We previously described the photoactivated depot or PAD approach that allows for the light control

223 er, associations of different adipose tissue depots or/and obesity indices with insulin resistance ha

224 pot by introducing crosslinks within the ELP depot over 24h.

225 Depot parenteral corticosteroids are not recommended for

226 een non-reactive secretory protein molecular depots patterned at the plasma membrane.

227 rough charge-charge interaction, and 2) this depot platform enabled long-term, controlled release ove

228 Here we present a novel nanoparticle depot platform for on-demand drug delivery using a far u

229 Here, we describe an injectable depot platform that exploits a new mechanism for both fo

230 ranslationally stabilized cellular NF-kappaB depot potentially confers a survival advantage to CD5(hi

231 in-releasing hormone analogues, danazol, and depot progestagens are associated with a higher incidenc

232 similar composition to the commercial Lupron Depot(R) (LD).

233 Risperdal Consta(R) (Risperidone) and Lupron Depot(R) (Leuprolide acetate, LA) were selected as model

234 s also predictive of the RLD product, Lupron Depot(R)(.) This work highlights the feasibility of deve

235 propose that these foci act as mRNA storage depots rather than mRNA decay facilities.

236 lf-assembling peptide (RADA16)-modified drug depots (RDDs) were prepared and anchored to a RADA16 hyd

237 on close to the tumor, the oxygen-generating depot reacts with the interstitial medium to produce oxy

238 age infiltration and edema in and around the depot region and was correlated to plasma drug concentra

239 macrophages were shown to be present in the depot region of the GSK1265744 LAP injected gastrocnemiu

240 the muscle microcirculation, that local PVAT depots regulate insulin-stimulated muscle perfusion and

241 ytes had higher formation rates in the scFEM depot relative to the scABD.

242 g implants (ISFIs) form a solid drug-eluting depot, releasing drug for an extended period of time aft

243 rdial fat compared with other adipose tissue depots remains uncertain.

244 id fluxes in the abdominal and gluteofemoral depot, resulting in the fat distribution changes associa

245 The ELP depots retained greater than 52% and 70% of their radioa

246 VIS imaging of rhodamine labeled homopolymer depots showed that degradation and release of the depot

247 tissue damage, or collagen deposition around depot site, suggesting exceptional biocompatibility of t

248 rafficking to the GSK1265744 LAP and Vehicle depot sites.

249 aried secretome that targets distant adipose depots, skeletal muscle, and the nervous system.

250 ular emphasis on the embryonic patterning of depot-specific adipocyte lineages and adipocyte differen

251 12-weeks of exercise training; and examined depot-specific associations with body fat distribution a

252 and blood parameters did not affect total or depot-specific BAT activity.

253 cular differences between adipose depots and depot-specific cellular mechanisms of adipose expansion.

254 tivity, enhanced energy expenditure, and fat depot-specific cellular remodeling toward lowered energy

255 accumulation and metabolic disease risk and depot-specific differences is well established, but how

256 structure with distinct types of adipocyte, depot-specific differences, a biologically significant e

257 correlated with increased ROS in an age- and depot-specific manner and is mechanistically linked to m

258 rown adipogenesis in iBAT and further define depot-specific mechanisms of BA recruitment.

259 Depot-specific responses might lead to differential fatt

260 d adipose tissue on systemic metabolism, and depot-specific responses to exercise training.

261 This finding might point to depot specificity of glucocorticoid responses and insuli

262 role of secreted proteins from small tissue depots such as islets of Langerhans, which are required

263 highway, an immune sanctuary, and a storage depot supporting tumor growth and drug resistance.

264 When loading MK2i, 1) the HT depot surface gained high MK2i-loading efficiency throug

265 mic multi-tRNA synthetase complex (MSC) is a depot system that regulates non-translational cellular f

266 and both long-acting implants and injectable depot systems are being developed to improve patient adh

267 med using the "smile-and-fill," fanning, and depot technique with an optional touch-up at the 2-week

268 onse reveals that TAMs serve as a local drug depot that accumulates significant vehicle from which DN

269 presents the first long-term, drug-releasing depot that can be administered as a traditional eye drop

270 Here, a dual bioresponsive gel depot that can respond to the acidic pH and reactive oxy

271 se that crystalline guanine is the elusive N depot that mitigates the negative consequences of episod

272 Marrow adipose tissue is a dynamic depot that probably exists as both constitutive and regu

273 nitinib microparticles self-aggregate into a depot that remains localized and maintains therapeutic l

274 ), was encapsulated in RDDs (V-RDDs) as drug depot that was then anchored to the hydrogel.

275 tissue is composed of anatomically distinct depots that mediate several important aspects of energy

276 s suggest that, even within a single adipose depot, there may be distinct subpopulations of adipocyte

277 Regardless of fat depot, there was a positive relation between AT APOM exp

278 ulations or the transplantation of brown fat depots, these methods are difficult to use for human cli

279 Adipose tissue is distributed in depots throughout the body with specialized roles in ene

280 e enriched in PATs compared to other adipose depots throughout the body, with the majority of them be

281 (21%) transporting vaccine from subnational depots to health facilities and 14 of 48 vaccine carrier

282 olic switch in liver, kidney cortex, and fat depots toward decreased mitochondrial fatty acid beta-ox

283 cine model, pharmacokinetics of PGZ from fat depots transplanted perivascular to jugular vein were as

284 were observed to significantly change in WAT depots up to 6 hours post exposure.

285 visceral fat is only one of many ectopic fat depots used when the subcutaneous adipose tissue cannot

286 om the abdominal (scABD) and femoral (scFEM) depots using an 8-week incorporation of deuterium ((2)H)

287 tory cells predominantly in visceral adipose depots [visceral adipose tissue (VAT)] rather than in su

288 The GSK1265744 LAP depot volume increased rapidly by day 2 in the IM inject

289 The IM depot volume increased rapidly to a maximum volume at 2d

290 Interestingly, the released OVA from amyloid depot was found to exhibit biophysical characteristics o

291 ssed by HPLC/MS/MS, and retention of the fat depot was monitored by MRI.

292 ng-based method for quantification of tissue depots was feasible for determining adipose tissue volum

293 sceral and subcutaneous white adipose tissue depots was unchanged upon cold acclimation.

294 flammatory responses in Reverbalpha(-/-) WAT depots were associated with tonic elevation of A20 prote

295 Tissue depots were quantified by using water-fat separated MR i

296 es in mitochondrial function in multiple SAT depots when investigating the pathophysiology of insulin

297 ficiently release soluble protein from these depots when irradiated, and leave behind only small easi

298 The homopolymer depots with p(Alkyl-TAFMA) exhibited sustained TFV and T

299 hours) in both BAT and the subcutaneous WAT depots, with the most striking change being observed in

300 ccurately target the inguinal adipose tissue depot without damaging the probe.