ライフサイエンスコーパス: depressant

1 ession attenuated cocaine reward and was pro-depressant.

2 ate (GHB) is a potent central nervous system depressant.

3 ct as anesthetics, anti-epileptics, and anti-depressants.

4 rtment care than those with addiction to CNS depressants.

5 ls of THC, alcohol, stimulants, opioids, and depressants.

6 quite similar to those mediated by other CNS depressants.

7 ssion and to test the efficacy of novel anti-depressants.

8 l differences in the response to common anti-depressants.

9 e appears to be non-specific in blocking the depressant action of 2-Me-5-HT, gamma-aminobutyric acid

10 Recently, we showed that the baroreflex depressant action of ANG II in the NTS is mediated by ac

11 concentration-response relationship for the depressant action of CADO on the EPSPm more closely para

12 Although the motor-depressant action of diazepam is suppressed in alpha1(H1

13 The network depressant action of midazolam at low concentrations was

14 closely paralleled that for its presynaptic depressant action on glutamate-mediated EPSPs than that

15 The depressant action on the evoked IPSC was reduced, but no

16 The depressant actions of ethanol on central nervous system

17 but show normal sensitivity to its locomotor-depressant actions.

18 pha and IL-1beta as well as serum with known depressant activity from five patients with acute septic

19 by TNF-alpha, IL-1beta, and serum with known depressant activity from patients with septic shock.

20 Myocardial depressant activity was found to be heat stable, protein

21 Myocardial depressant activity was measured by using isolated rat l

22 e change in the mode of action of LqhIT5 (no depressant activity) by substitutions of a few amino aci

23 ncept that since this molecule produces anti-depressant activity, it could also be beneficial for pre

24 a fast contraction paralysis occurs without depressant activity.

25 resulted in elimination of serum myocardial depressant activity.

26 ere evaluated for the presence of myocardial depressant activity.

27 ts with meningococcal disease had myocardial depressant activity.

28 cally associated with central nervous system-depressant agents, including motor incoordination, anxio

29 The mechanisms of ketamine's anti-depressant and adverse effects remain poorly understood.

30 has been repurposed by physicians as an anti-depressant and by the public as a recreational drug.

31 tate except ibogaine, which has unusual anti-depressant and substance-withdrawal effects, and stabili

32 xins (LqhIT2, LqqIT2), and Buthotus judaicus depressant anti-insect toxin (BjIT2).

33 ect toxin 4 (AaIT4), Leiurus quinquestriatus depressant anti-insect toxins (LqhIT2, LqqIT2), and Buth

34 compounds, including anti-inflammatory, anti-depressant, anti-bacterial, anti-viral, anti-fungal, and

35 neuroactive drugs, including trycyclic anti-depressants, anti-convulsants, and opiates.

36 ker gene expression that correlate with anti-depressant, antipsychotic and opioid drug action on prim

37 ), but males were less likely to have used a depressant (aOR, 0.54; 95% CI, 0.47-0.62).

38 ), stimulants (aOR, 1.32; 95 CI, 1.03-1.70), depressants (aOR, 1.28; 95% CI, 1.09-1.51), opioids (aOR

39 uctural degradation, yet an intrinsic strain-depressant approach remains elusive.

40 Depressants, as a class, were detected in 2368 drivers (

41 n was a small effect of anticholinergic anti-depressants being associated with better cognitive funct

42 ally unapproved formulations for NSAID, anti-depressant/benzodiazepine, and anti-psychotic FDCs were

43 decreased for metformin (100%/75%) and anti-depressants/benzodiazepines (20%/18%), and the overall p

44 abetes (metformin), depression/anxiety (anti-depressants/benzodiazepines), and psychosis (anti-psycho

45 napproved formulations were as follows: anti-depressants/benzodiazepines, 69%; anti-psychotics, 43%;

46 (80%) approved, five (20%) unapproved; anti-depressants/benzodiazepines: 16 formulations, three (19%

47 of a highly potent insect-selective scorpion depressant beta-toxin, Lqh-dprIT(3), from Leiurus quinqu

48 are characterized to identify melting point depressants capable of rapidly denaturing double strande

49 show that a subset of central nervous system depressants cause paradoxical excitation in zebrafish.

50 cs, notably enhanced sensitivity to the anti-depressant channel blocker S-(+)-ketamine.

51 The fact that anti-depressants, cocaine and amphetamines can have such prof

52 nutes) of variable direction, stimulatory or depressant, depending on the ambient physiologic milieu

53 Because the tricyclic anti-depressant desipramine has been found to be effective in

54 rate depression at near-maximal respiratory depressant doses of morphine.

55 ring the effects of near maximal respiratory depressant doses of opioids in the KF may be a powerful

56 parison of different chemical classes of CNS depressant drugs on NMDA-gated currents.

57 synaptic serotonin and is the target of anti-depressant drugs.

58 Some have speculated that the depressant effect is related to long-term depression (LT

59 nodal myocytes, elevated [K+]o, augments the depressant effect of adenosine on AV nodal conduction.

60 The depressant effect of capsaicin on gustatory transmission

61 The depressant effect of high glucose was rapidly (minutes)

62 Tolerance developed to the respiratory depressant effect of morphine but at a slower rate than

63 elative lack of tolerance to the respiratory depressant effect of opioids.

64 The depressant effect of Waglerin-1 was greater at negative

65 (10 and 30muM) and Flupirtine (30muM) had a depressant effect on 4-AP-induced excitation in SG such

66 ggest that in addition to its well-described depressant effect on NMDA receptor-mediated synaptic tra

67 n 2 and 7 hours of exposure; this myocardial depressant effect persisted at 25 hours.

68 The depressant effect was due mostly to anoxic activation of

69 anding of molecular mechanisms of the mGluR4 depressant effect, we decided to identify the proteins i

70 edating patients, which can have respiratory depressant effects and reduce patient mobility.

71 the mechanisms by which exercise exerts anti-depressant effects are not fully understood.

72 Similarly, depressant effects caused by synergistic concentrations

73 ugs that are able to prevent the ventilatory depressant effects elicited by powerful opioids such as

74 ist CGP 55845A (1 microM) fully reversed the depressant effects of (-)-baclofen (5-10 microM) such th

75 These results suggest that the depressant effects of A2a receptor activation are due to

76 thine (DPCPX; 0.2 microM) fully reversed the depressant effects of both adenosine (100 microM) and CA

77 Antagonism of GABAA receptors blocked the depressant effects of CGS 21680 on neuronal firing; was

78 ed bursting frequency, and acid reversed the depressant effects of halothane, consistent with modulat

79 ical effects of the VSD patch and myocardial depressant effects of ischemia and reperfusion during su

80 increased behavioral arousal and reduced the depressant effects of isoflurane on barrel cortex somato

81 If these depressant effects of L-Phe take place in the PKU brain,

82 Consistent with the depressant effects of L-Phe, expression of NMDA receptor

83 We found that the anxiolytic and anti-depressant effects of NPS are enhanced in acute ethanol

84 ethanol reduced tolerance to the respiratory depressant effects of opioids.

85 hesis sensitizes the heart to the myocardial depressant effects of PPA and increases the risk for ven

86 its, even when repeated, suggesting that CNS-depressant effects of sedating ethanol exposures are req

87 erm potentiation (LTP) was enhanced, and the depressant effects of the metabotropic glutamate recepto

88 test also mirror the antidepressant and pro-depressant effects of these drugs in patients suggesting

89 easuring the antinociceptive and respiratory depressant effects of these ligands, we showed that the

90 Thus, after fluid loading, the cardiac-depressant effects of TNF and L-NMMA given together beca

91 Of note was that the cardiac-depressant effects of TNF and L-NMMA given together were

92 sed in the brain during hypoxia has critical depressant effects on breathing in fetal and newborn mam

93 in these analyses is consistent with strong depressant effects that account for the "zombielike" beh

94 ioral changes, such as stimulant followed by depressant effects, and (2) chronic changes in behavior,

95 gamma-hydroxybutyrate, a drug of abuse with depressant effects, primarily on the central nervous sys

96 irty drug" with broad central nervous system depressant effects, results instead support accounts pos

97 by which PACAP exerts its anxiogenic and pro-depressant effects, via the recruitment of the central C

98 e ketamine has both acute and sustained anti-depressant effects.

99 tides AQEE-30 and TLQP-62 in dHc induced pro-depressant effects.

100 in septic shock are known to have myocardial depressant effects.

101 in mice with profound central nervous system depressant effects.

102 tOH), has stimulant, anxiolytic, ataxic, and depressant effects.

103 his neuropeptide has anti-rewarding (ie, pro-depressant) effects.

104 protein augmented the release of myocardial depressant factor by peripheral blood mononuclear cells

105 Nitric oxide is a myocardial depressant factor candidate.

106 wed that interleukin 6 is a major myocardial depressant factor in children with meningococcal septice

107 Further characterization of the myocardial depressant factor was undertaken by using cell culture s

108 tein products had properties of a myocardial depressant factor--specifically a 12-25 kDa heat-stable

109 size and had characteristics of a myocardial depressant factor.

110 Myocardial depressant factors are also released when whole blood or

111 Myocardial depressant factors are thought to cause myocyte dysfunct

112 ification and characterization of myocardial depressant factors present in meningococcal septicemia.

113 s mediated in part by circulating myocardial depressant factors.

114 cannabis), alcohol, stimulants, opioids, and depressants from January 2019 to June 2023.

115 opioids in drivers aged 55 to 64 years, and depressants in drivers aged 65 to 74 years.

116 stimulators could serve as fast-acting anti-depressants in some forms of depressive and stress-relat

117 Volatile hydrocarbon based CNS depressants including short chain alcohols and anestheti

118 A receptor (GABA(A)R) is the target of many depressants, including benzodiazepines, anesthetics, and

119 nment, dietary restriction, running and anti-depressants increase proliferation, however, stress and

120 The scorpion venom-derived excitatory and depressant insect-selective polypeptide neurotoxins modi

121 ays, both compounds had anxiolytic- and anti-depressant-like activity, with potencies up to 200-fold

122 y a significant increase in anxiety-like and depressant-like behaviors relative to wild type.

123 antagonist that previously demonstrated anti-depressant-like effects in male mice, was more efficacio

124 tration into mPFC mimics the anxiogenic- and depressant-like effects of social stress.

125 of MDD, and (ii) clinical remission to anti-depressant medications (ADMs).

126 Glucose (Tg = 30 degreesC), a very effective depressant of the phase transition temperature of freeze

127 rstanding residential mobility as a long-run depressant of voter turnout among extremely low-income a

128 dorsal hippocampus (dHc) or NAc, led to pro-depressant or antidepressant behaviors, respectively, wh

129 Unlike other presynaptic depressants, partial NaCh blockade increases paired-puls

130 -alcohols increase in central nervous system depressant potency with increasing chain length until a

131 de variety of volatile hydrocarbon based CNS depressants produce a similar inhibition of NMDA-gated c

132 mber of the beta-carbolines family with anti-depressant properties, improves mitochondrial function a

133 recently leptin has been shown to have anti-depressant properties.

134 ice, although they showed a normal locomotor depressant response to the dopamine D1 antagonist SCH-23

135 to induce less constipation and respiratory depressant side effects than opioids commonly used to tr

136 otic effects of propofol without the cardiac depressant side-effects.

137 sychological states, including stimulant and depressant states.

138 ith the presence of a circulating myocardial depressant substance with physical characteristics consi

139 with alcohol or other central nervous system depressants such as benzodiazepines, using the lowest ef

140 rlie inspiratory rhythmogenesis, respiratory depressants, such as opioids, should reduce burstlet fre

141 lly as Quaalude, is a central nervous system depressant that was used clinically as a sedative-hypnot

142 anesthetics (GAs) are central nervous system depressants that render patients unresponsive to externa

143 307/rs14259 (E197G-A>G) plays a role in anti-depressant therapy response, depression and schizophreni

144 itatory toxins in its mode of action and the depressant toxins in its primary structure.

145 Sequence comparison of LqhIT5 and known depressant toxins shows a high degree of similarity amon

146 thin hippocampus produced by stress and anti-depressant treatment that may open an avenue of understa

147 Onset kinetics for the CNS depressants was similar with tau values near 100 ms.

148 dogmatic view that BK channels act as neural depressants, we show that drug-induced slo expression en

149 fects have not been obtained with other anti-depressants which also block neonatal AS.

150 was found in favor of central nervous system depressants (WMD, -1.2 [95% CI, -1.6 to -0.8]) and antid

151 term and in favor of central nervous system depressants (WMD, -8.7 [95% CI, -11.3 to -6.0]) and anti