ライフサイエンスコーパス: deprotection

1 astereoselective hydrogenation, and nitrogen deprotection).

2 ic phospholane monomers followed by oligomer deprotection.

3 tion with 800 nm light resulted in efficient deprotection.

4 er by a Mitsunobu reaction followed by final deprotection.

5 yl Thermolabile Protecting Groups in thermal deprotection.

6 r promotion of the coupling reaction and for deprotection.

7 residue under basic conditions used for Fmoc deprotection.

8 ral modification via UV irradiation or basic deprotection.

9 id-catalyzed deprotection, and amine-induced deprotection.

10 rded its 6-phospho analogue (49) after final deprotection.

11 athione could be observed upon the enzymatic deprotection.

12 of synthetic peptides prior to cleavage and deprotection.

13 atalyst, followed by S-alkylation and acetyl deprotection.

14 novel heterocyclic system 4 during attempted deprotection.

15 condensation with symmetrical diamines, and deprotection.

16 roxylation catalyzed by OsO(4) or RuO(4) and deprotection.

17 , followed by solution-phase cyclization and deprotection.

18 egulate telomere length and prevent telomere deprotection.

19 l 12 via the practical Tollens' reaction and deprotection.

20 ctly used or elaborated without the need for deprotection.

21 Routine workup leads to quantitative deprotection.

22 roup promote beta-elimination and accelerate deprotection.

23 site-selective syn-1,4-hydroxyamination and deprotection.

24 s well as numerous selective protections and deprotections.

25 (F)iCd is not stable during oligonucleotide deprotection (55 degrees C, aq NH3) and was converted to

26 tion with a fluorescent probe produces, upon deprotection, a transporter-probe conjugate that is show

27 cal caspase pathway, which promotes telomere deprotection, activates DNA damage signalling, and deter

28 ction of 16, phosphitylation/oxidation, then deprotection afforded 10, which was a full agonist in Ca

29 uccessive phosphorylation followed by global deprotection afforded bis- and monophosphorylated hexaac

30 Global deprotection afforded the target pentasaccharide to be u

31 xyl group of 3, followed by fluorination and deprotection, afforded the key intermediate 10, which wa

32 Subsequent cyclization and global deprotection affords ustiloxin D in six steps from a kno

33 d good stereoselectivities in only one step, deprotection affords water-soluble 2-thio saccharides.

34 It requires shorter reaction times for deprotection and allows us to replace Cu(OTf)(2) by CuCl

35 This approach streamlines selective deprotection and anomeric derivatization steps prior to

36 itotic arrest, resulting in mitotic telomere deprotection and cell death, thereby eliminating precanc

37 transfer (PET-RAFT) process, after which the deprotection and click reaction is triggered by UV light

38 Their one-pot deprotection and coupling with 2-thiophene carboxaldehyd

39 Efficient conditions for the subsequent deprotection and cyclization of these intermediates allo

40 ase protected maleimides are used, maleimide deprotection and Diels-Alder cycloaddition can be simult

41 A highly efficient TMSI-mediated deprotection and direct isolation method to obtain zwitt

42 manipulations and a final concomitant -OTBS deprotection and displacement of an -OMs placed next to

43 rmediates was further demonstrated through a deprotection and double-reductive amination sequence to

44 ll aging and tissue-invasiveness to telomere deprotection and heterochromatin unpacking, identifying

45 on under very mild conditions, followed by a deprotection and intramolecular double ring-closing cond

46 Following deprotection and isolation, the Fapy-dG lesion is genera

47 ions) the physicochemical constraints on SOC deprotection and microbial turnover in MIMICS, the error

48 ss of these materials was initiated by allyl deprotection and monitored by the absorbance of the PNP

49 Deprotection and reduction affords the corresponding ter

50 Deprotection and reduction of the resulting acyclic azid

51 ans isomerization of delta-azaproline during deprotection and reprotection is supported by theoretica

52 dules performing N-alkylation and arylation, deprotection, and amidation to install broad molecular d

53 monstrated: thermal cleavage, acid-catalyzed deprotection, and amine-induced deprotection.

54 substrates resulted in clean (>=95% product) deprotection, and an additional three compounds gave >=9

55 d resin, followed by the addition of folate, deprotection, and cleavage, resulted in the isolation of

56 fied Stryker reduction of the alkyne, global deprotection, and oxidation of the resulting C1 primary

57 uinoline ring, which upon further amidation, deprotection, and sulfation gave the targeted nonsacchar

58 the addition of K2CO3 in THF ensured a clean deprotection-aromatization sequence to afford the desire

59 bromo-N-arylbenzylamines undergo a one-pot N-deprotection/biaryl coupling followed by oxidation, thus

60 Difficulties with final deprotection by hydrogenation/hydrogenolysis caused by t

61 Exacerbation of mitotic telomere deprotection by partial TRF2 (also known as TERF2) knock

62 bsorbing UVA (lambda >315 nm), photochemical deprotection can be carried out with sunlight in high yi

63 o-oxazine regioisomers showed that selective deprotection can be performed.

64 Its deprotection can be successfully carried out with irradi

65 by a fragmentation, aromatization, and N-Boc deprotection cascade.

66 without the need for tedious protection and deprotection chemistry that is very common in traditiona

67 oop formation, which coincides with telomere deprotection, chromosome end-to-end fusions and inviabil

68 sulfonated near-IR fluorophore and the mild deprotection conditions allowed isolation of the product

69 Diverse deprotection conditions have been developed in conjuncti

70 ation of the free amine, under Boc- or ArSO- deprotection conditions have been examined.

71 th solid-phase oligonucleotide synthesis and deprotection conditions, with synthesis yields comparabl

72 er functions were obtained, depending on the deprotection conditions.

73 an be mitigated in specific cases using mild deprotection conditions.

74 The rate of the enzymatic deprotection could be tuned by the nature of the 4-acylt

75 for a simple coupling and 8 h for a two-step deprotection/coupling process.

76 N-terminal chain extension through N(alpha)-deprotection/coupling to yield peptide-selenoxo peptide

77 ereocontrol with a minimal use of protection/deprotection cycles.

78 This approach allowed one-pot deprotection, cyclization, and deselenization to give se

79 A tandem deprotection-cyclization reaction of 1,1-diacylcycloprop

80 esults uncover a unique response to telomere deprotection during early development.

81 oup is crucial to achieve high photochemical deprotection efficiency.

82 the styrene moiety could be exploited, after deprotection, either to directly conjugate a bioactive c

83 esultant enantiopure tetrahydropyridines and deprotection, enantiopure polyhydroxylated piperidines w

84 ional differences between BsRppH and the RNA deprotection enzymes of distantly related bacteria.

85 namic systems involving wavelength-selective deprotection, focusing on the choice and optimization of

86 ction of sequential coupling, oxidation, and deprotection followed by a single precipitation step.

87 dration then gave the desired oxazole 24 and deprotection followed by mesylation and elimination prod

88 r allowed on-column nucleobase and phosphate deprotection, followed by a mild cleavage of the acetyla

89 The rate of deprotection for a substrate that contains a carboxylic

90 ectron-withdrawing substituents, the rate of deprotection for the corresponding phenyl aryl sulfonate

91 nd our recently reported copper(II)-mediated deprotection for the synthesis of cyclic peptides.

92 Ficoll induced both protection and deprotection from HX in different regions of CBP, with t

93 % of sites that undergo either protection or deprotection from hydrogen exchange due to phosphorylati

94 ed with a Boc-protected adenine, followed by deprotection, furnished the target nucleoside FMCA (12)

95 Selective deprotection, further elongation, and stability of these

96 cutive intramolecular oxidative coupling and deprotection gave dictyodendrins F, H, and I.

97 Deprotection gave the final nucleosides, some of which s

98 imidazo-fused benzimidazoquinazolines via a deprotection-GBB reaction sequence.

99 confirmation (mass spectrometry and NMR) and deprotection, generates GalNAc-PP-Und.

100 Deprotection gives stable catechol surfaces whose adhesi

101 desulfonylation and concomitant silyl ether deprotection gives the vitamin D(3) analogue.

102 eaction mixture during coupling and N(alpha)-deprotection has become increasingly popular.

103 This synthetic route involves four steps of deprotection, imination, the key acid-promoted heterocyc

104 action sequence involves a one-pot carbamate deprotection/imine formation/aerobic oxidation to form t

105 Selective trans-isopropylidene deprotection in coupled 13, then monobenzylation gave se

106 Facile deprotection in hot butanol permits the rapid, multicomp

107 al system that mimics physiological telomere deprotection in human cells and discovered that the telo

108 undergoes selective CuAAC reaction via silyl deprotection in situ to give the ynamine click products.

109 ndary amine moieties, followed by controlled deprotection in solution.

110 Global TMS ether deprotection in the presence of oxygen and subsequent de

111 At the end of ODN synthesis, deprotection is achieved with strong bases and nucleophi

112 a phase-transfer catalyst for O-silyl ether deprotection is reported.

113 en bond by changes in pH or by photochemical deprotection is sufficient to refold a helical oligomer,

114 Telomere deprotection is therefore an epigenetic signal passed be

115 is method has been demonstrated in the final deprotection/isolation of the beta-lactamase inhibitor M

116 on products 3a, 3l, and 3p, which upon silyl deprotection-lactol oxidation were transformed to the tr

117 lished, they used a series of protection and deprotection maneuvers to modify the central portion of

118 Deprotection may be achieved under acidic conditions to

119 methanesulfonic acid has been evaluated as a deprotection method and further extended to more complex

120 The deprotection method developed is fully selective for N-a

121 This deprotection method does not perturb the common NHBoc or

122 A new, fast, mild and chemoselective deprotection method to cleave p-methoxybenzyl and 2-naph

123 Mechanistic insight into this deprotection methodology derived by linear free-energy r

124 amate with nucleophiles precludes the use of deprotection methodology that requires N-protonation for

125 Three deprotection methods are demonstrated: thermal cleavage,

126 rotecting groups permitted a one-step global deprotection (Na/NH3(l)).

127 different regions of CBP, with the greatest deprotection occurring at the edges of helices.

128 Telomere deprotection occurs during tumorigenesis and aging upon

129 p-Methoxybenzyl group deprotection of 16, phosphitylation/oxidation, then depr

130 ly reported the first general method for the deprotection of 4,4-difluoro-4-bora-3a,4a-diaza-s-indace

131 reaction schemes: (i) the chemical oxidative deprotection of a boronic ester by H2O2, (ii) a biomolec

132 ethod is the low-temperature (-78 degrees C) deprotection of a disulfanyl acetate with sodium methoxi

133 idine construction and a chemoselective Peng deprotection of a phenolic MOM ether.

134 riene via an (E,E)-ynediene, and a selective deprotection of a tris(tert-butyldimethylsilyl) ether.

135 A two-step procedure for deprotection of alkylpinacolyl boronate esters via trans

136 hi reaction conditions followed by a one-pot deprotection of all protecting groups.

137 The reaction involves an in situ deprotection of an isolable N-formylaminopyridine interm

138 ts (QDs) as photocatalysts for the reductive deprotection of aryl sulfonyl-protected phenols.

139 reaction in this multistep process involves deprotection of Boc-amino ynones and subsequent treatmen

140 Deprotection of Boc-protected products proceeded readily

141 An improved method for the deprotection of Co-complexes of cyclic enediynes using t

142 Orthogonal deprotection of diphenol functionality was also demonstr

143 2-14 steps, respectively, without protection/deprotection of functional groups, by a novel tandem dou

144 nitiation of mRNA degradation often requires deprotection of its 5' end.

145 ly, a visible light method has been used for deprotection of N-methyl-N-arylsulfonamides with Hantzsc

146 Deprotection of N-tert-butanesulfinyl-2-substituted pyrr

147 gram scale synthesis of N-acylaziridines by deprotection of N-tosylaziridines and reprotection with

148 ewly developed method for the protection and deprotection of native cysteine with a succinimide group

149 eveloping an efficient protocol for on resin deprotection of O-acetyl groups.

150 rophilic aminating agent released by in situ deprotection of O-Ts activated N-Boc hydroxylamines.

151 The approach relies upon regioselective deprotection of per-O-trimethylsilyl-alpha-D-cholesteryl

152 ate this as a general strategy for selective deprotection of phenolic silyl ethers under neutral cond

153 The deprotection of phosphine-borane adducts was also demons

154 a 2-tosylamidoglucose derivative, selective deprotection of primary C-6 benzyloxy group, LiAlH4-medi

155 Deprotection of protected phenoylated phosphatidylcholin

156 /pyridine migratory cyclization (rather than deprotection of pyrimidine/pyridine group) using 20% NaO

157 Furthermore, loss of TPX2 or Aurora A causes deprotection of stalled replication forks upon replicati

158 Methods for the deprotection of the 2-O-phenacyl and 2-O-(methoxycarbony

159 An efficient deprotection of the 4-methoxyphenethyl group was develop

160 Subsequent deprotection of the aminooxy and N-alkylaminooxy groups

161 Deprotection of the beta-lactam nitrogen atom can be ach

162 The deprotection of the carboxylic acid function to afford t

163 made it possible to achieve partial on-resin deprotection of the completed oligosaccharide, thereby i

164 n reactions, and enabled the one-step global deprotection of the completely assembled, fully protecte

165 ion in the presence of oxygen and subsequent deprotection of the cyano ethyl phosphoester afforded th

166 Deprotection of the dimeric compounds leads to novel fam

167 substituted salicylic acids were prepared by deprotection of the ester and amide groups of ortho-benz

168 ide synthesis (SPPS), followed by orthogonal deprotection of the GlcNAc primers and site-selective se

169 ation with N-formylpiperidine and subsequent deprotection of the hydroxy groups to give novel dicarbo

170 Sequential deprotection of the N- or C-terminus of bicyclic amino a

171 Deprotection of the N-tosyl substituent within the beta-

172 ected UPy groups dimerize after photoinduced deprotection of the o-nitrobenzyl group, the BTA moietie

173 ions proceeded in very good yields (70-84%), deprotection of the oligosaccharide intermediates was ch

174 Deprotection of the pentasaccharide intermediate to give

175 ne ring into a beta-lactam moiety, and final deprotection of the phenolic hydroxyl group.

176 Deprotection of the phosphine boronate provided free amb

177 Deprotection of the poly(N-Boc-morpholin-2-one) yields a

178 Deprotection of the resultant polymers afforded poly(1,2

179 Stereoselective reduction and deprotection of the resulting 2,6-cis-6-substituted 4-ox

180 f phosphoramidite monomers and a single-step deprotection of the resulting oligoribonucleotide produc

181 r cross-coupling reactions at position 8 and deprotection of the sugar moiety gave eight derivatives

182 the stereodiscrimination and enables facile deprotection of the sulfonamide products with thioglycol

183 The successful acetal deprotection of the synthesized trans-3 bisadducts affor

184 through sequential reactions and protection/deprotection of the TFP group, substitution patterns tha

185 trobenzyl)(tritylthio)alkylamine, subsequent deprotection of the trityl moiety with TFA, and immediat

186 gies for ring-opening of the new aziridines, deprotection of the Ts group, and subsequent formation o

187 f gyration, respectively, after photoinduced deprotection of the UPy groups; a 30-60% reduction in th

188 droxy-functionalized pillar[5]arenes via the deprotection of their benzylated derivatives by catalyti

189 Subsequent deprotection of these enantiopure templates gave (-)-ADM

190 Further deprotection of these isolated compounds by use of hydro

191 Selective side-chain deprotection of three hexadecamers is also demonstrated,

192 nd to be sufficient to bring about efficient deprotection of various neutral or electron-deficient N-

193 minimizes refunctionalization and protection/deprotection operations, features the highly diastereose

194 minimizes refunctionalization and protection/deprotection operations.

195 Derivatization of the products by tert-butyl deprotection or N-deoxygenation was demonstrated.

196 monomer addition requiring purification and deprotection (or other functional group activation) step

197 l methylenation, a boron tribromide promoted deprotection, ortho- to para- naphthoquinone spiroketal

198 A intermediate to implement a chemoselective deprotection/oxidation sequence to access the requisite

199 molecules, and thus, applying a wet-chemical deprotection/oxidative acetylene coupling protocol exclu

200 Postsynthetic modification, postsynthetic deprotection, postsynthetic exchange, postsynthetic inse

201 eful for biological applications because the deprotection process can be initiated by illumination wi

202 oxidation-state adjustments, protection and deprotection processes, and purification procedures that

203 g(alpha-aminoacyl)benzotriazoles followed by deprotection produced unprotected depsides useful for th

204 A deprotection protocol involving ethanethiolate exchange

205 le coupling reactions through protection and deprotection protocols to synthesize these (NN) biradica

206 esis of BCP-containing dithianes which, upon deprotection, provide access to BCP analogues of medicin

207 of the N-O bond of the oxazepinones and Boc-deprotection provided 2-substituted 2,3-dihydropyridin-4

208 cted adenosine derivative followed by global deprotection provides a concise synthesis of the respect

209 rent postsynthetic strategies: postsynthetic deprotection (PSD) and postsynthetic exchange (PSE).

210 IPDMS < TES < TBS, etc.), the deprotection rate can be optimized so that all reaction

211 ts in an increase or decrease in the thermal deprotection rate.

212 ed by an intramolecular version of the boron deprotection reaction can be applied to access the first

213 loying microwave irradiation, protection and deprotection reaction times are dramatically reduced.

214 uction of the core eravacycline structure, a deprotection reaction was developed, allowing for the is

215 The deprotection reaction was performed in the presence of o

216 atly improves the yield of the photochemical deprotection reaction, compared with the corresponding o

217 Herein lies a detailed examination of the deprotection reaction, with a view to optimization and g

218 suggest that the superoxide anion drives the deprotection reaction.

219 ediate and isolated pure following efficient deprotection reactions that involved metal-dissolving co

220 mino terminal dendrons, combining protection/deprotection reactions with copper-catalyzed azide alkyn

221 ove to be important to the efficiency of the deprotection reactions, as shown in the photo reactions

222 es several approaches to supplant H(2)S as a deprotection reagent in favor of a safer and more conven

223 oss is not accompanied by increased telomere deprotection, recombination, or T-circle release.

224 l siloxy-crotylation 3a-3o, which upon silyl deprotection-reduction deliver 1,4-diols 5a-5o with exce

225 iomer (LAB) and subsequent one-pot catalytic deprotection-reductive amination.

226 ay is engaged through non-canonical telomere deprotection, regulated by TRF2, Aurora B and ATM.

227 ay free from any functional group protection/deprotection requirements.

228 human cells and discovered that the telomere deprotection response is functionally distinct from the

229 ation, hydroxyl group-assisted in situ N-Boc-deprotection, selective deoxygenation of the xanthate es

230 A straightforward deprotection sequence enables conversion of the protecte

231 as a one-pot Rieche formylation/cyclization/deprotection sequence to efficiently construct the tricy

232 enylglycine, a 1-pot activation/displacement/deprotection sequence to introduce the aminooxy function

233 % after a 30 min microwave-assisted coupling-deprotection sequence.

234 e ester in the 1-pot activation/displacement/deprotection sequence.

235 e finally obtained after four- and five-step deprotection sequences, respectively.

236 observation of single ribozymes after photo-deprotection showed that the precleaved folded state is

237 oreover, long acid exposure times during the deprotection step degrade sequences with high A content

238 In both biological realms, this deprotection step is catalyzed by members of the Nudix h

239 eomers as documented here, but the reductive deprotection step is not compatible with dCTP or the bro

240 te yields are linked to the N-tosylaziridine deprotection step, while acylation with N-hydroxysuccini

241 )F-fluoride ion activation step to the final deprotection step.

242 provides selectivity that avoids protection-deprotection steps and presents unique options for struc

243 procedures, including a number of protection/deprotection steps and purifications.

244 oups, and therefore no formal protection and deprotection steps are required.

245 developed method circumvents protection and deprotection steps as well as tedious ion-exchange and c

246 Further deprotection steps have been successfully applied, leadi

247 owed by the need for multiple protection and deprotection steps owing to the large number of similarl

248 ng groups were chosen to limit the number of deprotection steps required to obtain the final derivati

249 gy, free of coupling reagents and protection/deprotection steps, for the synthesis of oligo(2-hydroxy

250 mes are required for both the protection and deprotection steps, generally resulting in low deprotect

251 avoid the need for additional protection and deprotection steps.

252 en requiring inefficient stepwise protection-deprotection strategies and prefunctionalization protoco

253 l reactivity, coupling reactions, protection/deprotection strategies, and procedures for separation a

254 NH-sulfoximines providing improved (global) deprotection strategies, which is illustrated in the syn

255 ly important molecule employed in protection-deprotection strategies.

256 tachment, allowing for a facile introduction/deprotection strategy increasing the synthetic practical

257 ane-based dendrons via a combined protection/deprotection strategy starting from different adamantane

258 ucted to date, enabled by a silyl protection/deprotection strategy that provided access to a kinetica

259 An operationally simple in situ protection/deprotection strategy that significantly expands the sco

260 eating is exploited in a chemical protection/deprotection strategy to allow selective regions of a na

261 e manner without implementing protection and deprotection strategy under mild reaction conditions.

262 deletion of CTC1 does not result in telomere deprotection, suggesting that mammalian CST is not invol

263 upling with activated dCMP and photochemical deprotection, the individual diastereomers of beta,gamma

264 Since the product requires no subsequent deprotection, the protocol provides an easy, convenient

265 Hydrogenolytic N-deprotection then gave the corresponding dihydroconduram

266 Protodestannylation and global deprotection then yield these sterically encumbered and

267 After global deprotection, these oligosaccharides were coupled with c

268 nitiation with a protected thiol gives, upon deprotection, thiol-terminated transporters which can be

269 his group renders the protein inactive until deprotection through a bioorthogonal Staudinger reductio

270 ng for the isoxazole ring opening and global deprotection to be achieved in one pot.

271 latter underwent a Swern oxidation and then deprotection to give 1.HBr.

272 18)F-fluorobenzoate conjugation, followed by deprotection to give 4-(18)F-T140 that was exclusively l

273 tive N3-alkylation followed by the SEM-group deprotection (trans-N-alkylation) allows for regioselect

274 e reaction mixture with pyridine followed by deprotection under basic conditions with tetrabutylammon

275 he hydroxyl group, spontaneously underwent N-deprotection under the reaction conditions and regiosele

276 Global deprotection using Birch metal dissolving conditions did

277 delic acid as a chiral auxiliary, with final deprotection using H(2)/Pd.

278 The half-life for the nonenzymatic deprotection varied from 0.57 to 35 h depending on the e

279 A detailed study of diphenylmethane deprotection via acid hydrolysis as well as a key lacton

280 In all cases, the photochemical deprotection was accomplished in high yields (>80%).

281 Using the new Dim-Dmoc protection, deprotection was achieved under mild oxidative condition

282 Regioselective 5-O-deprotection was also successfully performed over the (1

283 The crude product after deprotection was collected from the chip and purified on

284 of the ester function during oligonucleotide deprotection was explored and the corresponding C(6') am

285 s a suitable substrate for gamma-GT-mediated deprotection was identified.

286 The scope of thermolytic, N-Boc deprotection was studied on 26 compounds from the Pfizer

287 Acid-mediated dendrimer deprotection was successful, and the resulting carboxy-t

288 Final deprotection was successfully achieved by Pearlman's hyd

289 upport bound alkyne-oligonucleotide prior to deprotection was the most efficient "click conjugation"

290 ediated (18)F-fluorodeboronation followed by deprotection, was achieved on an Eckert & Ziegler Modula

291 Deprotections were accomplished via exchange with good n

292 Orthogonal maleimide and thiol deprotections were combined with thiol-maleimide couplin

293 ucleophilic radiofluorination and subsequent deprotection with a yield of 28% +/- 15%, a specific act

294 Furthermore, deprotection with dilute hydrochloric acid in ethanol in

295 Deprotection with LiAlH4 allowed isolation of the indivi

296 nsient active-site block, and its subsequent deprotection with light.

297 By taking advantage of a selective and rapid deprotection with tetrazine, highly reactive "masked" cy

298 ureido nitrogen are applied for simultaneous deprotections with the Boc and (t)Bu groups.

299 Global deprotection yielded the 3-aminopropyl ligand, which was

300 protection steps, generally resulting in low deprotection yields.