ライフサイエンスコーパス: deprotonate

1 carboxylic acid and phenol moieties, become deprotonated.

2 ic effects of bile salts by maintaining them deprotonated.

3 gap of the K-channel analog only while being deprotonated.

4 e under conditions where the side chains are deprotonated.

5 ation, which explains why the chromophore is deprotonated.

6 is more energetically favorable when E115 is deprotonated.

7 glutamate encounters the matrix channel and deprotonates.

8 A sequence of epoxide ring opening using N-deprotonated 1,2-azaborines followed by an intramolecula

9 ivities upon gas-phase reactions with doubly deprotonated 1,4-phenylenedipropionic acid (PDPA).

10 monstrated via ion/ion reactions with doubly deprotonated 1,4-phenylenedipropionic acid (PDPA).

11 A new Ru complex containing the deprotonated 2,2':6',2''-terpyridine-6,6''-diphosphonic

12 )(Cl(2) dhbq)(3)(SO(4))(2) (Cl(2) dhbq(n-) = deprotonated 2,5-dichloro-3,6-dihydroxybenzoquinone) (2-

13 obalt complexes in this study are bridged by deprotonated 3,3,3',3'-tetramethyl-1,1'-spirobi(indan)-5

14 leophilic substitution of a fluoroarene with deprotonated 3-methyl-4-piperidinenitrile giving the (3R

15 n subjected to ion/ion reactions with doubly deprotonated 4-formyl-1,3-benzenedisulfonic acid (FBDSA)

16 bute as conserved elements to the binding of deprotonated 8-HDF and allow predicting 8-HDF binding fo

17 The first triad, Thr12-Lys162-Asp90, acts by deprotonating a water molecule that subsequently binds t

18 for the negative clusters it is carried by a deprotonated acid; the same is true for the neutral clus

19 her solubility in toluene) to more uniformly deprotonate acidic components of complex mixtures by neg

20 tramethylpiperidide), a template base as its deprotonating action is dictated primarily by its 12 ato

21 deprotonated O-glucuronides and unmigrated, deprotonated acyl-glucuronides.

22 and thymine (HThy) led to hydrated salts of deprotonated adenine, [N(4444)][Ad].2H(2)O, and thymine,

23 purity (up to 98% ee) by alpha-alkylation of deprotonated alpha-aminonitriles derived by the Strecker

24 The ligation by four deprotonated amide nitrogens in macrocyclic motifs is th

25 sence of a larger population of the reactive deprotonated amides for Ar = C6F5), (3) "Cs2-I-F" cluste

26 Michael addition of the deprotonated aminonitriles to the acceptors followed by

27 II))1:((-)OCH3) can act as a general base to deprotonate an attacking solvent molecule in the case of

28 and production of an {FeNO}(8) species, the deprotonated analog of an Fe-HNO complex.

29 /2) =258 K, and treatment with base yields a deprotonated analogue [Fe(II) (HL)(2) ] (1(B) ), which s

30 yte ions (M + H)(+) in positive ion mode and deprotonated analyte ions (M - H)(-) in negative ion mod

31 (pH > 12), the dipyrrinone analogues readily deprotonate and absorption/emission profiles of the fluo

32 carboxylic acid and an amine base, which can deprotonate and protonate respectively depending on the

33 rm radical cation species, which then likely deprotonate and react with dissolved oxygen.

34 es a group with a pK(a) of 6.6 +/- 0.2 to be deprotonated and a second group with a pK(a) of 9.5 +/-

35 ndance (13)C NMR that the lipid in HAMLET is deprotonated and by chromatography that oleate rather th

36 ional movement out of the channel when it is deprotonated and by its high pKA value when it points in

37 cid is first physisorbed on bismuth and then deprotonated and chemisorbed in formate form, also on bi

38 an be redissolved, and the DMB ligand can be deprotonated and exchanged for benzene to produce the de

39 groups (carboxylic, sulfonic), which become deprotonated and negatively charged when in contact with

40 lectrons originates from the DNA bases (both deprotonated and neutral).

41 under basic conditions, the 5'-HA groups are deprotonated and the anionic hydrogel binds cationic thi

42 ion in which an analyte/indicator mixture is deprotonated and then titrated with ammonium chloride.

43 readily available ethyl 4-bromocrotonate is deprotonated and trapped with Ellman imines selectively

44 veal that electron pair repulsion within the deprotonated anion is not the reason behind the lack of

45 s place from their neutral forms, from their deprotonated anionic forms, or under nucleophilic cataly

46 ference between the protonated (nonionic) or deprotonated (anionic) states.

47 In this paper, gas-phase reactions of deprotonated anions of benzene, pyridine, pyridazine, py

48 rdiolipins ionized as both singly and doubly deprotonated anions.

49 es generated in the reaction of benzyne with deprotonated arenes or heterocycles has been developed,

50 ed amino acids, the more acidic ammonium ion deprotonates as the media pH is changed from acidic towa

51 FG flip is also possible in simulations with deprotonated Asp.

52 The initial halocyclohexenone can be deprotonated at C-6 and reacted with carbon, fluorine, o

53 mo-3-methoxycyclohex-2-en-1-ones are readily deprotonated at C-6, and the resulting anions react smoo

54 rlier, while phenolic-rich sub-fractions are deprotonated at greater pH values and eluted later.

55 ng: 1) the carboxylic-rich sub-fractions are deprotonated at lower pH values and eluted earlier, whil

56 s ca. 9-10 where the thymine base is largely deprotonated at N3, one-electron oxidation of the thymin

57 approximately 9.0 and thus remains partially deprotonated at neutral pH.

58 de (3(-)) and Ru-monohydride (4(-)) that are deprotonated at nitrogen in the pincer ligand backbone.

59 LB-bound SERCA populates an E1 state that is deprotonated at residues E309 and D800 yet protonated at

60 n that the phosphate groups of GTP are fully deprotonated at the start of the hydrolysis reaction, wh

61 We find that the carboxylic acid group deprotonates at a significantly higher pH at the surface

62 oxidants in various DNA systems are known to deprotonate, at most, within a few microseconds.

63 ndeuterated and deuterated analogues and for deprotonated authentic compounds.

64 of Cu(II) involved His and the nitrogens of deprotonated backbone amide groups, resulting in either

65 one sites and (ii) species with at least one deprotonated base (in addition to several deprotonated p

66 pbz)(THF)Fe](2)(mu-MgX(2)), where sub-A is a deprotonated benzamide substrate.

67 te glutamate (Glubeta(117)) is positioned to deprotonate bound acyl-CoA and initiate carbon-carbon bo

68 ibuted to an active-site residue involved in deprotonating bound substrate, and assigned to His-120 b

69 his dangler Mn4A site and not as a partially deprotonated bridge between two metal centers.

70 N-Protected 3-alkylpyrazoles are easily deprotonated by (n)BuLi at the 5-position of the aromati

71 The results suggest that (1) alphaY190 is deprotonated by alphaK145 to strengthen the interaction

72 ith the attacking water being simultaneously deprotonated by an Mg(2+)-bound hydroxide ion.

73 uch as aconitase, which use a serine residue deprotonated by an oxyanion hole.

74 very similar energies when the head group is deprotonated by high subphase pH or exposed to relativel

75 Imidazolium cations were deprotonated by hydroxide ions, leading to carbenes form

76 c alpha-protons of sulfoxides are reversibly deprotonated by LiOtBu, and a palladium phosphine comple

77 2-siloxycyclopropanecarboxylate was smoothly deprotonated by lithium diisopropylamide and reacted wit

78 -alkynylbenzamide is predicted to be readily deprotonated by many bases, with subsequent cyclization

79 The fully hydrogenated complex, 4, is first deprotonated by OH(-) to form 5, which then releases hyd

80 chain when the physiological substrates are deprotonated by TbbTIM to form an enediolate phosphate t

81 ation, in which the hydrocarbon substrate is deprotonated by the supported M(2)CO(3) and reacts with

82 ions (VSCCs) in the nonbonding region of the deprotonated C(alpha)-atom will provide some insight on

83 Brilliant bases (e.g., deprotonating C-H bonds), nucleophiles (e.g., adding to

84 supported by observing the incorporation of deprotonated -C identical withCPh as ligands on rod-shap

85 enzyme-reactant complex contains an anionic deprotonated C4a-peroxyflavin that is stabilized by stro

86 NO(2)(-), NO(3)(-), O(2)(-)) and selectively deprotonated CA in the presence of its fragments.

87 e many enzymes with anionic side chains that deprotonate carbon acids.

88 g bidentate inner-sphere coordination of the deprotonated carboxylate group and hydrogen bonding thro

89 -assisted C-H activation mechanism where the deprotonating carboxylate adopts a pseudo-apical geometr

90 To determine the concentration of deprotonated carboxylates, a sample is acidified with HC

91 ge form where the metal ion interacts with a deprotonated carboxylic acid and the proton is displaced

92 l properties in the Pr form reminiscent of a deprotonated chromophore as confirmed by resonance Raman

93 nvolving semi-trapped protonated and trapped deprotonated chromophores en route to photoconversion in

94 In contrast, with deprotonated Ci1 or removal of the Ci1 glutamate side ch

95 singly deprotonated phospholipids and doubly deprotonated CL anions.

96 reactions leads to an enhancement in singly deprotonated [CL - H](-) species via proton transfer to

97 rated C1C2 structure with both E123 and D253 deprotonated closely resembles the available crystal str

98 l (1(C) ) has an S=5/2 spin state, while the deprotonated complexes [Fe(III) (L)(HL)], (1(D) ), and (

99 Deprotonated compounds with only beta-O-4 linkages, or b

100 Deprotonating cyclic alkenenitriles with LDA-CuCN avoids

101 n and characterization of three tautomers of deprotonated cytosine anions, [trans-keto-amino-N3H-H8b]

102 Only s-BuLi deprotonated dimethyl hydroxymethylphosphonamidates at t

103 naturally occurring bromide, brominates the deprotonated DMS(-) anion with a near-diffusion controll

104 A stoichiometric product with two deprotonated dppa ligands was characterized, indicating

105 state, especially when the sulfonamide NH is deprotonated, drastically raises the activation barrier

106 onversion is found to occur more readily for deprotonated dThd and its nucleotides than for N3-Me-dTh

107 r calculations suggest that an external base deprotonates either G40(N1) or possibly A-1(O2'), which

108 tagon of metal sites formed around the penta-deprotonated Etglu(5-) ligand; the chirality of N-ethyl-

109 Nucleophiles that are anionic or easily deprotonated exclusively produce cyclopentenones via Naz

110 ning are ruled out by demonstrating that E90 deprotonates exclusively in the nonconductive P(4)(480)

111 Briefly, singly deprotonated FA anions undergo charge inversion when rea

112 ion-induced dissociation (CID) of a range of deprotonated fatty acid standards was studied using line

113 Deprotonated fatty acids in contact with the cell exteri

114 e to the speciation change of Q(*-) with its deprotonated form (Q(*-)) oxidizing Fe(II) more rapidly

115 The absorption and emission spectra of the deprotonated form are bathochromically shifted by more t

116 (2+)* does not show direct DNA cleavage, the deprotonated form of 1H(2)O(2+)* does via a proton-coupl

117 )(2), where [(Mes)PDP(Ph)](2-) is the doubly deprotonated form of [2,6-bis(5-(2,4,6-trimethylphenyl)-

118 However, the deprotonated form of D46 side chain is also essential, b

119 gand classes such as beta-diketiminates, the deprotonated form of formazans, formazanates, have recei

120 hylphenyl)imidazol-2-ylidene; "IXy-H" is the deprotonated form of IXy) exhibit metallosilylene-like (

121 -dimethylphenyl)imidazol-2-ylidene-1-yl (the deprotonated form of IXy); Cp* = eta(5)-C5Me5] and Cp*Ru

122 M1M2Cl(py3tren), where py3tren is the triply deprotonated form of N,N,N-tris(2-(2-pyridylamino)ethyl)

123 1-8 and x = 0-1.5), where L(n) stands for a deprotonated form of the benzyl-substituted derivatives

124 ides an estimate of the base strength of the deprotonated form of the complex.

125 , which corresponds to its reaction with the deprotonated form of the substrate, and kobs2, which cor

126 inhibitor isoeugenol is predominantly in its deprotonated form when bound to wild-type VAO, but predo

127 ndicators that involve only a protonated and deprotonated form, a third species, arising from the the

128 tablished by releasing the ligands, in their deprotonated form, from the protein using collision-indu

129 groups (COO(-) and some amine groups in its deprotonated form, NH2) of cysteine attached on the gold

130 e >200-fold higher than the signals from the deprotonated form, offering better sensitivity for targe

131 resonance energy transfer from protonated to deprotonated form.

132 s absorption spectra, most dramatically when deprotonated forming nitrophenolates.

133 nd characterized by UV-vis in protonated and deprotonated forms by reduction of previously isolated a

134 pK(a) of 7.6 so that both its protonated and deprotonated forms equilibrate at physiological conditio

135 the hydroxylamines deriving from neutral and deprotonated forms of 4-carboxy-TEMPO have been measured

136 opy discriminates between the protonated and deprotonated forms of the carboxylic acid buffer, and th

137 ic or neutral pH has revealed protonated and deprotonated forms of the iminoquinone that are accompan

138 rbitals were analyzed for the protonated and deprotonated forms.

139 hydroxyl group, which is hydrogen-bonded to deprotonated G40, concurrent with G40(N1) moving closer

140 ectroscopy, we demonstrate that the isolated deprotonated GFP chromophore can be trapped in the first

141 raction between the membrane surface and the deprotonated Glu134 residue of the rhodopsin-conserved E

142 with beta-lactams, hindering its function to deprotonate Glu166 and the initiation of the deacylation

143 0Ala were inactive in vitro, consistent with deprotonated-Glu214 and protonated-His230 serving as a g

144 to allow electrospray-generated ions of the deprotonated glucose molecules to be monitored at their

145 dy, gas-phase ion-molecule reactions between deprotonated glucuronide metabolites and BF(3) followed

146 inter-channel distance exerts a force on the deprotonated glutamate, resulting in net directional rot

147 mass spectrometer in the negative ion mode, deprotonated glyceollin precursors yield a diagnostic ra

148 The peak at m/z 337 corresponds to deprotonated glyceollins, whereas the others represent m

149 egions included polyunsaturated fatty acids, deprotonated glycerophospholipids, and sphingolipids.

150 valuated for a series of singly and multiply deprotonated glycopeptides from the model glycoprotein k

151 In brief, deprotonated GSL anions, [GSL-H](-), and terpyridine-mag

152 FT investigation provide indication that the deprotonated guanidine involved in such a catalysis acts

153 ctive site catalytic nucleophile Ser241 as a deprotonated hemiketal, but also to Cys269 through the p

154 ues were used to examine the halogenation of deprotonated heterocycles by perfluoroaryl and perfluoro

155 r the spin state transition of hemes through deprotonated histidine (e.g. Cytochrome c).

156 Theory to be very sensitive to the amount of deprotonated-imine character in the wave function, such

157 E90 becomes deprotonated in P(480) and stays deprotonated in the C=N

158 zation is averted because the heterocycle is deprotonated in situ.

159 E90 becomes deprotonated in P(480) and stays deprotonated in the C=N-syn cycle.

160 flux as His37 is dynamically protonated and deprotonated in the conduction cycle.

161 is observed that stronger acids (i.e., fully deprotonated in the droplets) yielding anions with highl

162 protonated in the inward-occluded state and deprotonated in the inward-open state is further confirm

163 e residues, Tyr7, was previously shown to be deprotonated in the neutron crystal structure at pH 10.

164 group has been measured to be 6.3 and hence deprotonated in the range of maximal enzyme activity.

165 u-oxo bridges of the Mn(4)O(5)Ca cluster are deprotonated in the S(2) state.

166 n bond change in D --> K transition and (ii) deprotonates in K --> M transition.

167 C pair residue Asp(196) (Asp(156) in CrChR2) deprotonates in N --> O transition.

168 The Wheland intermediate is deprotonated intramolecularly in a 1,2-shift but also in

169 The analytes were mostly detected as the deprotonated ion [M - H](-).

170 n the structure of the DMPC bilayer than the deprotonated/ionized form, considering similar membrane

171 rs were measured for dissociation of gaseous deprotonated ions (at the -7 charge state) of complexes

172 ing method to distinguish the protonated and deprotonated ions of metabolites from the adduct and fra

173 lision-induced dissociation performed on the deprotonated ions of the protein-carbohydrate complexes.

174 ycan ligands are readily released, as intact deprotonated ions, from GBPs in the gas phase using coll

175 tly from mouse brain tissue as intact doubly deprotonated ions.

176 th cuprous precursors from the corresponding deprotonated ligand.

177 of lophine peroxide is due to emission from deprotonated lophine.

178 In our model, a fraction of the deprotonated M-intermediate of the anti-cycle may be pho

179 howed that FAD can exist in the gas phase as deprotonated (M = C27H31N9O15P2) and protonated forms (M

180 alized with mixed monolayers of hydrophilic (deprotonated mercaptoundecanoic acid, MUA) and hydrophob

181 Only deprotonated N-glucuronides and deprotonated, migrated acyl-glucuronides form the two di

182 ioxaborale (MW of 88 Da) only in the case of deprotonated, migrated acyl-glucuronides.

183 s of H2O and CH2O were also observed for all deprotonated model compounds, which involve a previously

184 ining the fragmentation pathways for several deprotonated model compounds.

185 that 2-AA-labeled glycan generated dominant deprotonated molecular anions with much fewer and low-in

186 e two intestinal microbiota metabolites with deprotonated molecular weights of [M-H]-165/121 and 193/

187 nd to effectively identify the protonated or deprotonated molecule ([M + H](+) or [M - H](-)) while b

188 were confirmed by exact mass search of their deprotonated molecule [M-H](-) and its MS(4) fragmentati

189 In negative ion mode, the deprotonated molecule was observed ([M - H](-) at m/z 39

190 Only deprotonated N-glucuronides and deprotonated, migrated a

191 e lowest pKa value of naringenin, indicating deprotonated naringenin as the main reactant.

192 proximately 2.5 x 10(2) M(-1) s(-1)) and the deprotonated, negatively charged form (k(ox,P(-)), 3.4 x

193 The deprotonated NO(-) complex resulted to be more stable, w

194 by increasing its acidity and by biasing the deprotonated nucleophile into conformations conducive to

195 These product ions were not observed for deprotonated O-glucuronides and unmigrated, deprotonated

196 t gaseous carboxylic acids RCOOH(g) begin to deprotonate on the surface of water significantly more a

197 to UVPD mass spectra of GPL cations, UVPD of deprotonated or formate-adducted GPLs yields diagnostic

198 ied in the S2 state as an exchangeable fully deprotonated oxo bridge [Perez Navarro, M.; et al.

199 involving the 2-hydroxyallyl cation and its deprotonated oxyallyl cation have been performed.

200 e S(1)(paipai*) state of the methyl ester of deprotonated para-coumaric acid - a model chromophore fo

201 er to the two carboxylate moieties in doubly deprotonated PDPA to yield [PE - H](-) anions.

202 lities of NETD for the elucidation of doubly deprotonated peptide anions.

203 , ammonium, ammonia, and both protonated and deprotonated peroxynitrite (selectivity coefficients of

204 8 residue stabilizes the structures with the deprotonated phenolic ring in the I- and B-forms.

205 th excess electrons localized exclusively at deprotonated phosphate backbone sites and (ii) species w

206 ne deprotonated base (in addition to several deprotonated phosphates).

207 d by negative ion ESI generating both singly deprotonated phospholipids and doubly deprotonated CL an

208 lycolate)(6)(dabco)(3)] where glycolate is a deprotonated polyatomic alcohol (ethylene glycol, EgO(2)

209 ates, and internally by fluorides or a penta-deprotonated polyol.

210 s is partially due to a back-reaction of the deprotonated Pr chromophore at pH 9 after photoexcitatio

211 partners properly, K661 is predicted to get deprotonated prior to substrate binding and to act as an

212 , thus ensuring that the target atom N(3) is deprotonated prior to the methyl transfer.

213 tive at increasing the extent of charging of deprotonated protein ions in negative ionization mode ES

214 has been proposed to serve as a transiently deprotonated proton donor.

215 Most significantly, we find that a deprotonated pyridine nitrogen on PLP precludes formatio

216 ive charges on carboxylate or amide group of deprotonated quinolone or sulfonamide, respectively, may

217 dized to manganese(III) and two of the three deprotonated radicals (NITIm(-)) are reduced to their di

218 Finally, two types of deprotonated radicals are identified: on the one hand, (

219 The deprotonated receptor [L(2)](-) is distinctly emissive (

220 Q-photobeta(2), where the side chain remains deprotonated, recovered photochemical enzymatic turnover

221 sol state show that naphthylic -OH of 1 gets deprotonated, resulting in C-C bond rotation that plays

222 wo states per cycle, the late M- (M2) with a deprotonated retinal Schiff base and the consecutive gre

223 at proton transfer from protonated ligand to deprotonated RNA within salt bridges initiates loss of t

224 PLP remained as an internal aldimine with a deprotonated Schiff base.

225 Acting as a chain-propagating species, the deprotonated semiquinone radical (SQ(*) (-)) generated f

226 nner sphere complexes at negatively charged, deprotonated silanol sites is appropriate.

227 es on the cationic surfactant headgroups and deprotonated silanol sites on the pore walls.

228 re related to (i) the rapid oxidation of the deprotonated species compared to the protonated species

229 At pH 7, the 5-methyl deprotonated species is found; however, at pH ca. 9, N3-

230 investigated reactions using protonated and deprotonated species of PFOA and SO(4)(*-) and showed th

231 of all analogues, in both the protonated and deprotonated species, were explored by using quantum-mec

232 sition between protonated state (NH(+) ) and deprotonated state (N).

233 essential effects on host cells when in the deprotonated state and when presented in the context of

234 ylalanine at the surface transition to their deprotonated state at bulk pH values lower than the mole

235 om the extent of charge stabilization of the deprotonated state by the protein environment.

236 membrane fragments in protonated and partly deprotonated state has been mapped by means of atomic fo

237 n the active site cysteine is converted to a deprotonated state prone to oxidation.

238 observed stabilization of the protonated or deprotonated state.

239 lowers the pK(a) of Asp85 by stabilizing its deprotonated state.

240 atio of signal intensities of protonated and deprotonated states being a reliable pH marker (accuracy

241 l polyene chain, for both the protonated and deprotonated states that represent the dark and photoact

242 d characterized in both their protonated and deprotonated states.

243 es between neutral (protonated) and charged (deprotonated) states depending on external pH.

244 The alpha-alkylation of deprotonated Strecker products derived from primary amin

245 a brucei brucei (TbbTIM) acts as the base to deprotonate substrate to form an enediolate phosphate tr

246 iated by triplet dioxygen and its binding to deprotonated substrate and only thereafter a spin state

247 ectron reduction potential, measured for the deprotonated substrate both inside and outside the prote

248 o modulate the alphaC-H bond strength of the deprotonated substrate to facilitate the oxidation.

249 e begins with a bidentate chelate binding of deprotonated substrate to the Ni.

250 N atoms are open to oxidative attack in the deprotonated substrate while an internal hydrogen bond h

251 sulfonate retention from singly- and doubly-deprotonated sulfopeptide anions.

252 he intermediacy of sulfenate anions, and the deprotonated sulfoxide was determined to be the resting

253 chanisms were tested by examining additional deprotonated synthetic model compounds.

254 plexes [((t)Bu-PNP*)Ir(H)2] (2) ((t)Bu-PNP*, deprotonated (t)Bu-PNP ligand) and [((t)Bu-PNP)Ir(H)] (3

255 omplexes [((t)BuPNP*)Ir(R)(OH)] ((t)BuPNP* = deprotonated (t)BuPNP ligand), in a process which utiliz

256 hods indicate that P.A. anion binds as the N-deprotonated tautomer (PhSO(2)NOH(-)) to [Fe(II)(N3PyS)]

257 led exposure to molecular oxygen efficiently deprotonates terminal alkyne moieties of 1,3,5-tris(4-et

258 hat the intermediates are more fibrillar and deprotonated than the monomers, whereas they are less or

259 hich in turn serves as the catalytic base to deprotonate the 4'-hydroxyl of the DSMP substrate.

260 and hence E3 ligases require a mechanism to deprotonate the amino group at physiological pH to produ

261 esidues D567 and E491 are general bases that deprotonate the epsilon-amino group of lysine substrate,

262 re, the base should be anionic to be able to deprotonate the neutral palladium-amine complex and/or e

263 and produces OH(-) ions, which subsequently deprotonate the PAA on AgNPs, change the surface charge,

264 NaOt-Bu was found to deprotonate the phenol product and to prevent formation

265 on of arenynes, the esters in the tether can deprotonate the Wheland intermediate, thus avoiding more

266 diate catalysis: a guanosine that we propose deprotonates the 2'-hydroxyl of the nucleotide 5' to the

267 in which His-257 acts as a general base that deprotonates the acceptor residue, which subsequently pe

268 dered insulating by solvent immersion, which deprotonates the hydroxylated LAO surface; interface con

269 the transient Al horizontal lineNTol species deprotonates the methyl group of the NacNac ligand.

270 a reaction where a Mg(2+)-coordinated water deprotonates the nucleophilic 3'-OH, and this deprotonat

271 hich lysine-180 acts as a catalytic base and deprotonates the reactive hydroxyl group of caffeoyl-CoA

272 served His447 is not the catalytic base that deprotonates the substrate in ChOx.

273 neral base for activating the nucleophile by deprotonating the 2'-hydroxyl to initiate the reaction (

274 lycal formation was efficiently prevented by deprotonating the hydroxyl group in position 2 of the gl

275 tes nucleophilic attack of the propeptide by deprotonating the Thr1 hydroxyl group and that both resi

276 Given the high energy cost of deprotonating the tryptophan at the indole nitrogen, thi

277 Results showed that with the D2.50 residue deprotonated, the M3 receptor is bound by an allosteric

278 intensity upon either fully protonating, or deprotonating, the fibrils at pH = 0 or 14, respectively

279 In agreement, calculations predict that the deprotonated thymine base has a lower energy barrier (ca

280 azole side chain of the histidine residue is deprotonated to afford Zn-imidazolate chains, with bondi

281 roducts show remarkable stability and may be deprotonated to form enolates with useful reactivity for

282 rdinated water near the substitution site is deprotonated to form OH(-) for charge compensation upon

283 forms a phenylacetylene adduct that is then deprotonated to give product.

284 thalpically favored form with tyrosine bound deprotonated to the Cu(II) active site.

285 e GtCCR2 retinylidene SB chromophore rapidly deprotonates to the Asp-85 homolog, as in BR.

286 Michael addition of the deprotonated tosylamides to the activated alkynes and su

287 ion and release are also accomplished by the deprotonated transporter.

288 the radical site in the benzene ring of the deprotonated triradical to generate the conventional DMD

289 heme compound I intermediate to the reactive deprotonated tyrosine, forming Tyr(*).

290 relatively low pKa value, N-Cl-DCAM tends to deprotonate under typical drinking water pH conditions,

291 The FnYs are deprotonated under biological conditions, undergo oxidat

292 N-methylritonavir is expected to be readily deprotonated under physiologic conditions to yield a thi

293 with beta-O-4 linkages, were evaporated and deprotonated using negative-ion mode ESI in a linear qua

294 m cations enable carbonate ions (CO3(2-)) to deprotonate very weakly acidic C-H bonds (pKa > 40), gen

295 complexes Mn4 O4 (H2 O)n (+) (n=1-7) contain deprotonated water with a maximum of four dissociatively

296 systems, because tyrosine Z is oxidized and deprotonated, whereas plastoquinone B is reduced and pro

297 if the KR2 counterions, D116 and D251, were deprotonated, which was only observed under alkaline con

298 ppaO')][B(C6 F5)4], 4[B(C6 F5)4], was simply deprotonated with the strong base K(N(SiMe3 )2 ) to give

299 show that, at the air-water interface, HMSA deprotonates within a few picoseconds and results in the

300 he otherwise fully protonated chromophore to deprotonate without additional major structural changes.