ライフサイエンスコーパス: deprotonation

1 based on their gas-phase basicities (DeltaG(deprotonation)).

2 ults from a potential drop owing to Y191(*+) deprotonation.

3 )-casein, in response to phosphorylation and deprotonation.

4 that this residue plays a role in substrate deprotonation.

5 ion is thermodynamically more favorable than deprotonation.

6 with other processes such as radical cation deprotonation.

7 rface, activating the O-H bonds and inducing deprotonation.

8 wo Mn(II) and is enabled by a pKa 7.6 double deprotonation.

9 nvironment leading to an earlier Schiff base deprotonation.

10 stituted sulfone to override complex-induced deprotonation.

11 of side-chain triazole units via protonation-deprotonation.

12 orting the formation of radical species upon deprotonation.

13 lowed by oxidation to the tetraene and final deprotonation.

14 d Tyr-503, are positioned to facilitate this deprotonation.

15 on does not necessarily induce its concerted deprotonation.

16 orresponding to a pre-equilibrium of trypsin deprotonation.

17 action of this clamp in promoting substrate deprotonation.

18 ere reversible in the process of protonation/deprotonation.

19 The reaction is initiated by a rate-limiting deprotonation.

20 h displaces E148 and thereby facilitates its deprotonation.

21 ocking of each state achieved by protonation/deprotonation.

22 tion with visible light gated by protonation/deprotonation.

23 to proximity with protonated Glu325, causing deprotonation.

24 subject to acidic trapping and released upon deprotonation.

25 tereochemical course in the enantioselective deprotonation.

26 ieved in the subsequent slower, irreversible deprotonation.

27 awn, such as the key role of dihydroxyphenyl deprotonation.

28 onjugation and provides a site for selective deprotonation.

29 nce and promotes C-C bond formation prior to deprotonation.

30 t for the increase in surface potential from deprotonation.

31 eparately across the membrane after NH(4)(+) deprotonation.

32 nylogous 1,4-dipole was developed by in situ deprotonation.

33 tablishing minimal competing racemization by deprotonation.

34 ases in the activation barrier for substrate deprotonation.

35 After this initial deprotonation, A-1(O2') starts attacking the phosphate a

36 the hydrogen bond network to facilitate its deprotonation acting as a general base, removing an acet

37 sp(3))-H bonds prior to concerted metalation deprotonation activation.

38 and DFT calculations, a mechanism involving deprotonation, alkyne insertion, and protonolysis is pro

39 zation through a sequence of selective gamma-deprotonation/alpha-alkylation and palladium(0)-catalyze

40 O-LUMO energy gaps suggest that, after their deprotonation, an increase in the electron delocalizatio

41 -range electron transfer is coupled to donor deprotonation and acceptor protonation is reported.

42 sequence controls the extent of Schiff base deprotonation and accumulation of intermediates, and thu

43 aphthoquinones is possible to be reversed by deprotonation and application of the resulting dienolate

44 a relayed arenium cation attack followed by deprotonation and conjugate elimination.

45 ed phenytoin preceded by comparatively rapid deprotonation and decomplexation reactions.

46 complex at the air-water interface undergoes deprotonation and exists as IO(3)(-)-IONO(2) anion, wher

47 formation involving AgSO(4)-induced toluene deprotonation and formation of benzyl carbocation, follo

48 the core structure responsible for substrate deprotonation and isotopic preferences in AMT pores and

49 othermic multistep process involving initial deprotonation and nitrite elimination, hydroxide attachm

50 rface reaction constants, namely, on silanol deprotonation and on cation binding.

51 lations elucidate mechanistic details of the deprotonation and oxidation reactions mediated by CaMn(3

52 An anionic model suggests that deprotonation and polarization of this amide bond by Tbt

53 Opposite signs of the effects indicate that deprotonation and reprotonation of the Schiff base take

54 D156 exhibits a substantial KIE (>2) in its deprotonation and reprotonation, which substantiates its

55 ication of the strength of base required for deprotonation and the potential to correlate these data

56 ease of their electron-donating ability upon deprotonation and to their stabilization in alkaline sol

57 borylation to form an alpha-boryl carbanion, deprotonation, and alkoxide addition to form an "-ate" c

58 h include conformational change, protonation/deprotonation, and binding equilibria are routinely stud

59 The heat of protonation, deprotonation, and proton transfer reaction as well as t

60 minimize the Gibbs free energy for substrate deprotonation, and that the effects on reaction driving

61 complexes undergo dearomatization by direct deprotonation, and the dearomatized complex can react wi

62 s gave overall yields similar to that of the deprotonation approach, but were shorter and more amenab

63 that the transmetalation and the subsequent deprotonation are rate-determining in the catalytic cycl

64 g Ag salts enabling concerted C3-palladation-deprotonation, as explored by relevant experiments and s

65 Y(D) and facilitating oxidation or mediating deprotonation, as well the fate of the phenolic proton,

66 a)]2-(mu-OH)}(3+) (1) can undergo reversible deprotonation at -30 degrees C to yield {[Cu(tmpa)]2-(mu

67 Kinetic deprotonation at -75 degrees C followed by reaction with

68 Key observations support the proposed deprotonation at C4 of the nascent polyketide by the cat

69 port the changes in enthalpy and entropy for deprotonation at each site.

70 ors are readily prepared in good yields, and deprotonation at low temperature, in the presence of [Rh

71 Deprotonation at the 2-position to form a potassium enol

72 ibed by a multisquare model with Schiff base deprotonation at the lumirhodopsin I intermediate stage.

73 The second deprotonation at the propargylic position was determined

74 lts in a much higher cumulative rotation and deprotonation barrier that effectively blocks PT to the

75 tability and the pH-dependent protonation or deprotonation behavior are possible.

76 reaction pathway involving reversible alpha-deprotonation by a Cu(II)-O(t)Bu species followed by fur

77 studies, wherein we observed that substrate deprotonation by the catalyst framework was necessary to

78 stablishes that direct metal complexation or deprotonation can account for the interfacial behavior.

79 preferences in AMT pores and that decreased deprotonation capacity is associated with reduced select

80 loop that relies on the coordination-coupled deprotonation (CCD) of a hydrazone switch has been devel

81 bon atom of coordinated micro-OCS2, which on deprotonation cleaves one C-S bond and simultaneously fo

82 cleavage occurs via the concerted metalation-deprotonation (CMD) mechanism in all types of reactions,

83 e effects, typical of a concerted metalation-deprotonation (CMD) mechanism, were observed in the case

84 suggests operation of a concerted metalation-deprotonation (CMD) mechanism.

85 he meta-C-H bond in the concerted metalation-deprotonation (CMD) process.

86 ional studies support a concerted metalation-deprotonation (CMD)-type ruthenation mode and shed light

87 assistance" (AMLA) and "concerted metalation deprotonation" (CMD) concepts.

88 A second deprotonation-condensation with Asmic initiates a struct

89 with Ni(II) formed after P-ligand uptake and deprotonation could not undergo reductive elimination me

90 The deprotonation creates an anionic cyclopentadienyl unit,

91 At higher pH (>7.5), tau deprotonation decreased binding to microtubules both in

92 y show that the OER activity and the ease of deprotonation depend on orientation and follow the order

93 eld a positively charged hemiketal, which on deprotonation dissociates into acetone and tropone.

94 , a feature likely associated with NH(4) (+) deprotonation during passage, substantially transported

95 thesized from Weiss diketone by simultaneous deprotonation/electrophilic trapping of both oxo functio

96 for an initially unexpected mode of internal deprotonation enacted by the amide group, which is a cru

97 by ourselves and others) correlate well with deprotonation energies from quantum mechanical (QM) and

98 Using solid-state NMR and deprotonation energy calculations, the chemical environm

99 ilibria such as keto/enol tautomerization or deprotonation equilibria of four titratable groups.

100 ch aryl aldehyde, we enable an oxidation and deprotonation event, which generates a key imidoyl radic

101 Et(2) activates the isocyanide to facilitate deprotonation evolving to a zwitterion that traps pai-el

102 he reversibility of the concerted metalation-deprotonation exchange of eight para-substituted phenylp

103 rganocatalytic enolization through selective deprotonation followed by a [1,3]-H shift.

104 dium hydroxide may be operative and an alpha deprotonation followed by alpha elimination of the di(3-

105 arbene (NHC) to benzaldehyde triggers a fast deprotonation, followed by a second electron transfer, d

106 MT represents a compromise between substrate deprotonation for optimal selectivity and high substrate

107 ormyl-2'-deoxyuridine that are ascribable to deprotonation from the C5-methyl group of 1 are observed

108 enium salt [IMes(C(6)F(5))BH](+) followed by deprotonation gave the thioxoborane IMes(C(6)F(5))B=S.

109 chemical processes, yet the barrier for its deprotonation has never been measured.

110 for positioning the Cys-aldimine for Calpha deprotonation, His-123 acts to protonate the Ala-enamine

111 n the coupling between multidrug binding and deprotonation in MdfA, but the mechanistic basis for thi

112 an those attributable to the C5-methyl group deprotonation in NMe-1.

113 tyryl)phenols 2a-9a were synthesized, and by deprotonation in solution, the solvatochromic phenolates

114 ntially the alpha-amino radical is formed by deprotonation, in contrast to the formation of iminium i

115 Pathways to deprotonation, including whether the singlet or triplet

116 Deprotonation is also obligatory for turnover, however.

117 eprotonates the nucleophilic 3'-OH, and this deprotonation is concerted with the phosphoryl transfer.

118 This deprotonation is facilitated by the coordination of the

119 is larger than in wild-type VAO, suggesting deprotonation is impaired in these variants.

120 ies reveal that the initial site of catalyst deprotonation is not the H2IMes ligand, as the cyclometa

121 ion followed by aryl migration and reductive deprotonation is presented as a new reaction sequence in

122 We now show that the formerly unwanted deprotonation is the likely initiation pathway in the ca

123 After deprotonation, it extends toward the entire molecule, in

124 rium isotope effect and that glycolate alpha-deprotonation itself was only partially rate-limiting.

125 e-crystal X-ray diffraction study, the first deprotonation leads to a monoanionic dicarbollide ion th

126 Subsequent deprotonation leads to the isolation of the correspondin

127 al carboxylate-assisted concerted metalation/deprotonation mechanism.

128 s proposed that the C-H cleavage occurs by a deprotonation mechanism.

129 vity against alkali cations via an NH(4) (+) deprotonation mechanism.

130 , cofacial bis-dipyrrin) were synthesized by deprotonation/metalation with mesitylcopper (CuMes; Mes:

131 the C-2 position of an imidazolium salt, the deprotonation occurred at the C-5 position, affording im

132 ich indisputably indicates that the proposed deprotonation occurs during the isomerization of U to Ps

133 The deprotonation of 4- tert-butylcyclohexanone and cyclohex

134 nomethyl-5-lithiotetrazole, generated by the deprotonation of 4-(N-tetrazolylmethyl)morpholine with L

135 Specifically, we explore the protonation/deprotonation of 4-mercaptobenzoic acid as a function of

136 rataphenanthrene anion is easily accessed by deprotonation of a 9,10-dihydro-9-boraphenanthrene and i

137 the cytoplasmic half-channel and subsequent deprotonation of a Glu residue at a luminal half-channel

138 the coupling process occurs by rate-limiting deprotonation of a hydrazine-bound arylpalladium(II) chl

139 e amino acid substrate is facilitated by the deprotonation of a key glutamate residue (E115) located

140 .7) important for catalysis, consistent with deprotonation of a metal-bound water nucleophile.

141 ule can be accessed by the sequential double deprotonation of a mono-nido-carboranyl imidazolium zwit

142 uperoxide reacts with substrate activated by deprotonation of a phenol group at position 4 of the sub

143 imental and computational examination of the deprotonation of a series of benzhydryl cations has been

144 uirement for a strong base suggests that the deprotonation of a six-coordinate Ru species is integral

145 ch a catalysis acts as a general base in the deprotonation of a water molecule involved in the cleava

146 rbon bond-forming processes that involve the deprotonation of a weakly acidic C-H pro-nucleophile usi

147 nature of the CF(3) group should facilitate deprotonation of adjacent hydrogens, the propensity of t

148 e which indicates proton release through the deprotonation of all oxygen groups bonding to Pb.

149 Deprotonation of alphaY190 by a nearby lysine strengthen

150 terionic quinine-derived entity generated by deprotonation of an ammonium salt with the anionic react

151 nism of enamine formation via intramolecular deprotonation of an iminium carboxylate intermediate.

152 yne intermediates are generated by ortho-C-H deprotonation of aryl(mesityl)iodonium salt with a comme

153 l pH that are caused by activation and thiol deprotonation of beta-subunit cysteines.

154 rate through a glycal intermediate formed by deprotonation of C2'.

155 Observations support the deprotonation of carboxyl groups with low acid dissociat

156 observed over pH ranges attributable to the deprotonation of carboxylic acids and phenols.

157 e pH-dependent increase in absorption due to deprotonation of carboxylic acids and phenols.

158 iolate to the GSSG-disulfide followed by the deprotonation of Cys56-thiol by Glu47-carboxylate and (i

159 lence bond calculations of the TIM-catalyzed deprotonation of DHAP and GAP by both wild-type TIM and

160 .994) and beta = 0.74 (R(2) = 0.995) for the deprotonation of DHAP and GAP, respectively.

161 The deprotonation of differently substituted propargyl xylos

162 d kinetic activation (DeltaG( )) barriers to deprotonation of dihydroxyacetone phosphate (DHAP) and d

163 changes that accompany the substrate-evoked deprotonation of E26T/D34M/A150E.

164 Deprotonation of E90 and successive pore hydration are c

165 rom 20 ns to 5 ms is incompatible with early deprotonation of E90.

166 which themselves were prepared by Hoppe-Beak deprotonation of ethyl 2,4,6-triisopropyl-benzoate with

167 8 kcal/mol smaller than for OMPDC-catalyzed deprotonation of FUMP to form the vinyl carbanion interm

168 irectly initiate this polymerization through deprotonation of gamma-BL to generate reactive enolate s

169 idea that Arg302 (helix IX) is important for deprotonation of Glu325.

170 in the blood; this pH change would result in deprotonation of Glu8 to release the hormone peptide fro

171 ange in the cellular milieu acts through the deprotonation of glutamate 8 to release the hormone from

172 is attributable to a chemical reaction, the deprotonation of glutamic acid 148 (E148).

173 Compound I, and in mediating stereospecific deprotonation of H-3re of the substrate.

174 n of precursor salts to give neutral NHCs or deprotonation of heterocyclic mesomeric betaines to give

175 heterocyclic salts and (ii) anionic NHCs by deprotonation of heterocyclic mesomeric betaines.

176 i) neutral N-heterocyclic carbenes (NHCs) by deprotonation of heterocyclic salts and (ii) anionic NHC

177 esign of selective transformations involving deprotonation of high-energy intermediates.

178 ich reveal gradual refolding and concomitant deprotonation of higher charge state ions in the course

179 rough the channel, including the protonation/deprotonation of His37, are explicitly considered using

180 l as a function of pH were controlled by the deprotonation of hydrated sulfur dioxide, SO2.H2O, which

181 equires inert atmosphere and strong base for deprotonation of imidazolium precursors or the use of sp

182 These catalysts mediate the deprotonation of imines and direct the 2-azaallyl anions

183 ace charge resulting from the protonation or deprotonation of insulating mineral oxides is highly loc

184 rgies, which are significantly enhanced upon deprotonation of iodine acids, indicating that these hal

185 were passivated with polybases to induce the deprotonation of its methylammonium ions (MA(+)).

186 g and transmembrane helices H5 and H6, while deprotonation of its protonated Schiff's base triggers t

187 hemical reactions describing protonation and deprotonation of macromolecules, as well as self-ionizat

188 H(2) (18) O in an ion trap reveal the facile deprotonation of multiple water molecules via hydroxylat

189 Deprotonation of N-(aryloxy)imines generates a delocaliz

190 We report the enantioselective, lateral deprotonation of ortho-protected or functionalized terti

191 terocyclic carbene (NHC) formation either by deprotonation of precursor salts to give neutral NHCs or

192 ctions depends on the following factors: (1) deprotonation of pro-R or pro-S-H, (2) equilibration of

193 As a proof-of-concept, deprotonation of propanal by the chiral bases 9-11 is pr

194 ed pathway that involves photoionization and deprotonation of radical cation, followed by homolytic c

195 manner, is effective for the regioselective deprotonation of sensitive diazines in hydrocarbon solut

196 issolution of solid doxorubicin, protonation/deprotonation of soluble doxorubicin, and passive transp

197 romatic substitution, catalyzed by enzymatic deprotonation of substrate, in single-component hydroxyl

198 cent to silica is sensitive to the degree of deprotonation of surface silanol groups.

199 e antibiofilm effect via the protonation and deprotonation of TAs.

200 e of continuous-flow methods has allowed the deprotonation of TFPO and subsequent zincation at higher

201 -CH2. presumably arising at copper oxidation/deprotonation of the 1-NMe2 group.

202 Although deprotonation of the alpha-hydroxyalkyl radical has been

203 nipulation of the products is facilitated by deprotonation of the amines to enable carbon-sulfur bond

204 cate that Asp-678 is involved in the initial deprotonation of the amino group of glycine, enabling nu

205 Deprotonation of the As-H bonds in 2 by nBuLi produces [

206 In GtCCR2, deprotonation of the Asp-96 homolog is required for cati

207 and-cooperation pathway in which an internal deprotonation of the benzylic position by the eta(1)-CO2

208 ural MFM-300(V(IV)), [V(IV)2O2(L)], in which deprotonation of the bridging hydroxyl groups occurs.

209 tructure suggests sequential protonation and deprotonation of the c-ring, with ATP-hydrolysis-driven

210 hydroxyl radical adduct of dG as well as by deprotonation of the corresponding radical cation.

211 carbodicyclopropenylidene (2) is accessed by deprotonation of the corresponding triafulvene cycloprop

212 Heterolysis of the Si-H bond, deprotonation of the heteroarene, addition of the hetero

213 displacements, the second of which requires deprotonation of the indole nitrogen in Trp during its a

214 or 2,6-di-tert-butyl-4-methyl-pyridine, the deprotonation of the initial adducts became faster, whic

215 currently facilitating carbide formation via deprotonation of the initial carbon radical.

216 re is presented based on the STM tip-induced deprotonation of the inner protons of individual macrocy

217 e electrophiles followed by rate-determining deprotonation of the intermediate ammonium ions.

218 We found that double deprotonation of the ligand is essential and excess base

219 roups in GLP-1 suggest it is the protonation/deprotonation of the N-terminus that is responsible for

220 Upon deprotonation of the NH group, a C6F5-substituted formaz

221 es provide evidence that rearomatization via deprotonation of the pentahydro-beta-carbolinium ion int

222 as well as 4 equiv of methane, 2 equiv from deprotonation of the phosphine and 2 equiv from C-H bond

223 H-dependent electrochemistry associated with deprotonation of the phosphonic acid groups.

224 Selective deprotonation of the pro-S P-phenyl ring of 5 was ascert

225 monstrated to have a shielding effect during deprotonation of the protein.

226 cm(-1) The first contribution corresponds to deprotonation of the proton release complex (PRC), a com

227 trinsic gas-phase basicities (GB, DeltaG for deprotonation of the protonated base) and proton affinit

228 base) and proton affinities (PA, DeltaH for deprotonation of the protonated base) of six lipids repr

229 nt possibilities for selectivity-determining deprotonation of the radical cation intermediate.

230 in an L-like intermediate that precedes the deprotonation of the retinylidene Schiff base (i.e., for

231 sins, opening of the channel occurs prior to deprotonation of the Schiff base.

232 g nucleophilic attack of CTQ, as well as the deprotonation of the substrate-oxidized CTQ adduct, whic

233 s the oxidation product, reasonably due to a deprotonation of the sulfide radical cations.

234 between CTA(+) and -COO(-) (derived from the deprotonation of the terminal carboxyl group of MHA).

235 Deprotonation of the thiol gives a protonated amine that

236 dard-state Gibbs free energy of reaction for deprotonation of the weak alpha-carbonyl carbon acid sub

237 es) undergo migratory ring expansion through deprotonation of their benzylic urea derivatives with li

238 Deprotonation of these salts gave the corresponding neut

239 Deprotonation of thioureas by sodium, potassium or imida

240 Subsequent deprotonation of this monoanion leads to the first N-dic

241 Here we report that the deprotonation of ureas generates a class of versatile ca

242 = (5)/(2) form to an S = (7)/(2), form upon deprotonation of W1.

243 ing affinity of Mn(2+/3+) and facilitate the deprotonation of water to form a proposed mu-hydroxo bri

244 role of confined water in the oxidation and deprotonation of Y(D).

245 Gas-phase acidities (DeltaG and DeltaH for deprotonation) of neutral phospholipids are also evaluat

246 Alternate scenarios, such as catalyst deprotonation or the in situ formation of a neutral chir

247 etwork usually exhibit volume expansion upon deprotonation or volume contraction when being heated.

248 ism, the initial C-H activation step via the deprotonation pathway is reversible and the nucleophile

249 ivation process via the concerted metalation-deprotonation pathway, which is slightly more feasible t

250 s, presumably through a concerted metalation-deprotonation pathway.

251 catalyst initiation via a beta-H elimination/deprotonation pathway.

252 on analyses of the transition structures for deprotonation predicted using density functional theory

253 bilities in two studies: (A) the protonation/deprotonation process for a pH-sensitive imidazoline spi

254 level showed that the stereoselective ortho deprotonation process fulfills the features of the CIPE

255 coordination/decoordination and protonation/deprotonation processes appeared reversible, thus consti

256 to either the dealkylation product 4 or the deprotonation product, triazaalkene 5, depending on the

257 We measure the deprotonation/protonation barriers of 0.36 eV and find t

258 lyst-substrate complex via a cyclometalation deprotonation provides a five-membered nickelacycle inte

259 The deprotonation rate constant decreases with decreasing wa

260 It was found that the deprotonation rate constant kd decreases with decreasing

261 The deprotonation rate constant of radical-cations (k(H)) of

262 um intermediates formed in the course of the deprotonation reaction provided new structural insights

263 the stereochemistry-determining step is the deprotonation reaction, and a model based on a deprotona

264 o a single lower charge state via sequential deprotonation reactions with a proton scavenging reagent

265 Deprotonation results in silyl dienes with yields from 5

266 e accessed from its borinic acid by a simple deprotonation/sequestration sequence.

267 Under the conditions optimized for lysine deprotonation, SETD3 has weak lysine methylation activit

268 61K mutation in proximity to the protonation/deprotonation site is considered.

269 The deprotonation site of p-hydroxybenzoic acid upon electro

270 on of the three-membered ring is the favored deprotonation site.

271 ges, the number of Cu(I) or Cu(II) ions, the deprotonation sites, and likely Cu(I/II) coordination of

272 cess in which enantioinduction occurs in the deprotonation step (Scheme 11 ).

273 s catalyst: it participates as a base in the deprotonation step and is recovered unchanged from the r

274 the catalyst-mediated alpha-tosyloxy ketone deprotonation step to form an enantiodiscriminant oxy-al

275 as MgCl2 and dicyclohexylmethylamine for the deprotonation step, an excellent functional group tolera

276 ting the Schiff base reorientation after the deprotonation step.

277 sults showed that both isomers exhibited two deprotonation steps.

278 he cage promotes spontaneous pro-nucleophile deprotonation, suggesting acidity enhancement equivalent

279 or a broad range of substrates with variable deprotonation susceptibility, such as tetramic and tetro

280 e human rhodopsin exhibited more Schiff base deprotonation than bovine rhodopsin, which could arise f

281 Deprotonation then occurs on the mus timescale and corre

282 dation of Y(373) by coupled ET to WH(*+) and deprotonation then proceeds in ~800 ps, without any sign

283 (cosubstrate)-PKMT-substrate complex, lysine deprotonation through dynamic water channels, and a nucl

284 (2) with three protons has the potential of deprotonation to form energetic salts.

285 The deprotonation to give the organolithium was optimized by

286 onic tetrads, consistent with faster forward deprotonation to the C terminus.

287 a trigonal bipyramidal concerted metalation-deprotonation transition state is presumable.

288 lize the oxocarbenium ion that forms and the deprotonation transition state.

289 h the common portions of decarboxylation and deprotonation transition states that lead to formation o

290 Deprotonation usually occurs as an unwanted side reactio

291 al and computational results have shown that deprotonation was enhanced for precursors containing rad

292 By protonation/deprotonation, we modulate the electronic conductivity o

293 Structural consequences of deprotonation were revealed via analysis of a monoanioni

294 rted reaction involving coordinated Tyr ring deprotonation where Cu(II) coordination enables formatio

295 e H(+) electrochemical gradient (microH+) is deprotonation, whereas in the presence of microH+, the l

296 he activation step is enabled by a pKa > 8.6 deprotonation, which is assigned to Mn(II)-bound H2O; it

297 Tf (X = Cl (1), F (4); OTf = CF3SO3) undergo deprotonation with KO(t)Bu to afford the trans-halide-al

298 Subsequent deprotonation with LiN(SiMe3 )2 affords the fluoroalkyny

299 fluorobenzenesulfonimide enabled via in situ deprotonation with lithium 2,2,6,6-tetramethylpiperidine

300 rising given that t-AmylOH is a byproduct of deprotonation with t-AmylOK, as well as the fact that it