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1 xic Tyr-123 mutants, although ribosomes were depurinated.
2 ly interfering with the capacity of StxA1 to depurinate 28S rRNA.
3 formed predominantly (> or =99%) the rapidly-depurinating 4-hydroxy estradiol (4-OHE(2))-1-N3Ade addu
4 iol (4-OHE(2))-1-N3Ade adduct and the slower-depurinating 4-OHE(2)-1-N7Gua adduct.
5 cytoplasm where, by virtue of its ability to depurinate a conserved residue within the sarcin-ricin l
6  proteins (RIPs) are RNA N-glycosidases that depurinate a specific adenine residue in the conserved s
7        Ribosome inactivating proteins (RIPs) depurinate a universally conserved adenine in the alpha-
8                           ME(1) was shown to depurinate a variety of partially denatured nucleic acid
9          Upon activation in the cytosol, RTA depurinates a single adenine from position 4324 of rat 2
10                    Ricin toxin A-chain (RTA) depurinates a single adenylate on a GAGA stem-loop regio
11                          StxA1 catalytically depurinates a well-conserved GAGA tetra-loop of 28S rRNA
12  The cytotoxin ricin disables translation by depurinating a conserved site in eukaryotic rRNA.
13 we discovered a site-specific self-catalyzed depurinating activity in short (14-18 nucleotides) DNA s
14 3,4-Q were bound to DNA in vitro to form the depurinating adduct 4-OHE1(E2)-1(alpha,beta)-N7Gua at 59
15 catechol estrogens (2-OHE2, 4-OHE2), and the depurinating adducts 4-OHE(2)-1(alpha,beta)-N7-guanine (
16 ]P can be activated to metabolites that form depurinating adducts in cells with either high peroxidas
17 ired apurinic sites derived from the loss of depurinating adducts.
18 mediates that covalently bind to DNA to form depurinating adducts.
19 of these amino acids in JIP60 activity is to depurinate adenosine in ribosomes.
20 , inhibitor screens, mechanistic analysis of depurinating agents on oligonucleotides and intact ribos
21 TA) is the catalytic subunit of ricin, which depurinates an adenine from the sarcin/ricin loop in euk
22 ngle-chain ribosomal inhibitory protein that depurinates an adenine residue in the alpha-sarcin loop
23                                 When rRNA is depurinated and translation is inhibited, the steady sta
24 nter cleft residues significantly impair the depurinating and ribosome inhibitory activity of PAP.
25 ), and (90)FND(92) substantially reduced the depurinating and ribosome inhibitory activity of PAP.
26 A resulted in greater than 3 logs of loss in depurinating and ribosome inhibitory activity.
27 t, all other purine residues in the sequence depurinate at the spontaneous background rate.
28  the loop; the 5'-G residue of the loop self-depurinates at least 10(5)-fold faster than random "spon
29 han the prokaryotic ribosomes, while PAP can depurinate both types of ribosomes.
30 pernatants were analyzed for the presence of depurinating BP-derived adducts by capillary electrophor
31 e, the sarcin-ricin loop (SRL), and were not depurinated by RTA.
32 ntitatively reacts with oxidatively modified depurinated/depyrimidinated (abasic) RNA.
33 P) has been reported to form both stable and depurinating DNA adducts upon activation by cytochrome P
34 e pathways result in formation of stable and depurinating DNA adducts, respectively.
35 elieved to include both stable and unstable (depurinating) DNA adduct formation as well as reactive o
36                                   Chemically depurinated duplex substrates representing the U5 end of
37 i and that Howardula ribosomal RNA (rRNA) is depurinated during Spiroplasma-mediated protection of D.
38 ed photoacid to effect 5'-detritylation, the depurinating effects of strong acid.
39 racterised by their ability to catalytically depurinate eukaryotic ribosomes, a modification that mak
40  bind ribosomes or depurinate them but could depurinate free RNA.
41                          We found that PAP-H depurinates fungal ribosomes in vitro and in vivo, sugge
42 nogenic aromatic hydrocarbons indicates that depurinating hydrocarbon-DNA adducts generate oncogenic
43                               Ribosomes were depurinated in yeast cells expressing the precursor form
44    Ribosomes from the P protein mutants were depurinated less than the wild-type ribosomes when treat
45             We present evidence showing that depurinated oligonucleotides react with cytosine-contain
46                               The assay uses depurinated oligonucleotides that can form a Schiff base
47 oresis can vary >100-fold if the DNA is acid depurinated prior to Southern blotting.
48 nvestigated to improve the ionization of the depurinated product and assay reproducibility.
49 ns was prepared to test for their ability to depurinate prokaryotic and eukaryotic ribosomes.
50 ovide the first evidence that the ability to depurinate ribosomes and inhibit translation does not al
51                                 PAPn did not depurinate ribosomes and was non-toxic when expressed in
52                           However, it cannot depurinate ribosomes in a translation-independent manner
53 cytotoxicity without altering the ability to depurinate ribosomes in trans and inhibit translation.
54 hese results demonstrate that the ability to depurinate ribosomes in trans in a catalytic manner is r
55  only during their translation and could not depurinate ribosomes in trans in a translation-independe
56 tic activity toward the SRL allows Stx2A1 to depurinate ribosomes, inhibit translation, and exhibit c
57 ion mutants was lost before their ability to depurinate ribosomes.
58 iminated its cytotoxicity and the ability to depurinate ribosomes.
59                                       Stx2A1 depurinated ribosomes and inhibited translation at a sig
60                 Several nontoxic RTA mutants depurinated ribosomes and inhibited translation to the s
61                                       Stx2A1 depurinated ribosomes at a higher level in vivo and was
62                         The RTA mutants that depurinated ribosomes but did not kill cells were not ab
63      The mutant proteins isolated from yeast depurinated ribosomes in vitro, indicating that they wer
64                                These mutants depurinated ribosomes only during their translation and
65 with ribosomes and does not get processed on depurinated ribosomes, thereby inhibiting the UPR.
66  I) ribosome-inactivating protein (RIP) that depurinates ribosomes at the alpha-sarcin/ricin loop of
67 ive-site mutant of PAP (PAPx) which does not depurinate rRNA, we present evidence that double-strande
68                    Using a PAP variant which depurinates rRNA, inhibits translation but does not dest
69  Appearance of the apurinic site in the self-depurinating stem-loop was confirmed by digestion of pla
70                           The detection of a depurinated substrate was enhanced by using a more effic
71 is required for PAP to bind to ribosomes and depurinate the 25 S rRNA, suggesting that it is located
72 hat PAP binds to the ribosomal protein L3 to depurinate the alpha-sarcin/ricin loop and binding of PA
73                  We demonstrate that PAP can depurinate the rRNA in trans in a translation-independen
74 mericana, is characterized by its ability to depurinate the sarcin/ricin (S/R) loop of the large rRNA
75 n A chain (RTA), which binds to the stalk to depurinate the sarcin/ricin loop (SRL).
76  Stxs bind the ribosomal P-stalk proteins to depurinate the sarcin/ricin loop on the eukaryotic ribos
77 2 interactions work together allowing RTA to depurinate the SRL at a much higher rate on the intact r
78 P1 and P2 proteins of the ribosomal stalk to depurinate the SRL in yeast.
79 ; ricin A-chain is an RNA N-glycosidase that depurinates the adenosine at position 4324 and alpha-sar
80                                        Ricin depurinates the eukaryotic ribosomes more efficiently th
81 ng protein (RIP) that binds to ribosomes and depurinates the highly conserved alpha-sarcin/ricin loop
82 PAP) is a ribosome-inactivating protein that depurinates the highly conserved alpha-sarcin/ricin loop
83          Ricin inhibits protein synthesis by depurinating the alpha-sarcin/ricin loop (SRL).
84 he acceptor site groove prior to binding and depurinating the GAGA tetra-loop.
85 e capped by binding to the cap structure and depurinating the RNAs downstream of the cap.
86    Ricin holotoxin did not bind ribosomes or depurinate them but could depurinate free RNA.
87 nder physiologically relevant conditions and depurinate to release an alkylated nucleobase in a proce
88 ce that PAP is associated with ribosomes and depurinates tobacco ribosomes in vivo by removing more t
89 e yeast, ribosomes from mak8-1 cells are not depurinated when PAP expression is induced in vivo, indi
90                     That residue is uniquely depurinated with a rate some 5 orders of magnitude faste
91 purination kinetics demonstrated that Stx2A1 depurinates yeast and mammalian ribosomes and an RNA ste
92                 The ribosomes are eventually depurinated, yet cytotoxicity and loss of viability are