ライフサイエンスコーパス: derangement

1 eases, but equally able to improve energetic derangement.

2 ssion of the disease and resulting metabolic derangement.

3 minutes despite severe progressive metabolic derangement.

4 ecause additional mutations caused excessive derangement.

5 are mainly associated with severe metabolic derangement.

6 of systemic insulin resistance and metabolic derangement.

7 and transport that paralleled mitochondrial derangement.

8 lts from hyperphagia rather than a metabolic derangement.

9 oxins that cause hypoglycaemia and metabolic derangement.

10 sense microbes, tissue damage, and metabolic derangements.

11 aily dialysis can reverse many of the uremic derangements.

12 perturbations reflecting specific functional derangements.

13 en in the setting of comorbid blood pressure derangements.

14 ll tension and therefore reflect hemodynamic derangements.

15 ction of p-cresol, prevented these metabolic derangements.

16 duced oxygen consumption and ultrastructural derangements.

17 date because DKA involves multiple metabolic derangements.

18 ased MPB, and tumor resection reverses these derangements.

19 ck fat," that result in endocrine and immune derangements.

20 with further investigation of immunological derangements.

21 n of opportunistic infections, and metabolic derangements.

22 dies dealing with a broad array of metabolic derangements.

23 etween inflammation and associated metabolic derangements.

24 ias (AICs; CVID+AIC) and the causes of these derangements.

25 Assessment scores and less severe metabolic derangements.

26 chanical insult, infection, or immunological derangements.

27 HIF-1alpha pathway in burn-induced metabolic derangements.

28 eneration, and that ACVR2B/Fc prevents these derangements.

29 ional potential uses for evaluating shoulder derangements.

30 uantifying the extent of a tissue's electric derangement, (2) prospectively determining the amount of

31 s/obstruction (26.2%), metabolic/electrolyte derangements (23.1%), and anemia (12.3%).

32 ase B/mammalian target of rapamycin) pathway derangement accurately discriminates patients with NASH

33 ure elevation, insulin resistance, and lipid derangements), although these changes have not been asso

34 s frequently accompanied by severe metabolic derangements, although the mechanisms responsible for th

35 irment of cardiovascular function, metabolic derangement and accelerated ovarian ageing.

36 es do not inevitably result in neural system derangement and dementia in all individuals.

37 ctor, greater than the degree of physiologic derangement and details of medical management.

38 evidence on the mechanisms linking metabolic derangement and excessive oxidative stress to ion channe

39 Endothelial dysfunction drives vascular derangement and organ failure associated with sepsis.

40 tinamide riboside (NR) ameliorates energetic derangement and symptoms in mouse models of mitochondria

41 uscle, and Alzheimer's disease share protein derangements and attrition of postmitotic cells.

42 by a dysregulated immune response, metabolic derangements and bioenergetic failure.

43 n hypoxia can be related to microcirculatory derangements and cell edema without evidence of brain is

44 onstrated mesial or lateral frontal cortical derangements and impaired fronto-cortico-subcortical con

45 t unit allows for correction of biochemistry derangements and on-site clinical chemistry analyzers ca

46 tube placement, consequences of physiologic derangement, and human factors, including failure to rec

47 'browning response', glucose/lipid metabolic derangement, and reduced bone mass with increased bone r

48 risk for hip fracture, physiologic/metabolic derangements, and complications of anesthesia.

49 accumulation, mitochondrial gene regulatory derangements, and contractile function in MHC-PPARalpha

50 matory state, lipid transport, and metabolic derangements, and organ system effects that particularly

51 between ethnicity, NAFLD severity, metabolic derangements, and sociodemographic characteristics in a

52 Metabolic derangements are a clinically significant complication o

53 Amino acid derangements are common in severe falciparum malaria and

54 r early cardiovascular disease and metabolic derangements as compared with their uninfected peers.

55 ining reversed obesity-related mitochondrial derangements as evidenced by enhanced mitochondrial bioe

56 cations for the precorneal tear film and its derangements as well as for the histogenesis of mucus-pr

57 We speculate that microbial derangements, as indicated in our study, can demonstrate

58 To better understand metabolic derangements associated with early disease, we profiled

59 alcin is one of the drivers of the metabolic derangements associated with glucocorticoid therapy.

60 a curtailment of the hormonal and metabolic derangements associated with high fat diet-induced obesi

61 Rather, the multiple derangements associated with indicators of brain damage

62 tration, hepatocyte apoptosis, and metabolic derangements associated with insulin resistance and impa

63 mmation and fibrosis, and improved metabolic derangements associated with NASH.

64 not VAT, is a better marker of the metabolic derangements associated with obesity.

65 Growing knowledge of the physiologic derangements associated with poor outcomes in SAH can im

66 istula, hypoxic lung diseases, and metabolic derangements associated with renal disease.

67 e potential for early detection of metabolic derangements associated with such events.

68 nd tissue glucose >4.5mM minimized metabolic derangement at the injury site.

69 otentials, and physiological and biochemical derangements at both the brain and systemic levels.

70 Black patients had more acute physiologic derangements at intensive care unit admission and longer

71 Black patients had more acute physiologic derangements at intensive care unit admission and were l

72 Sepsis elicits derangements at multiple subcellular sites involved in e

73 Emerging data support multiple derangements attending HIV coinfection, including increa

74 hypoxic-ischaemic injury, sepsis, metabolic derangements, autoimmune diseases, infections and rapidl

75 e hydroxamic acid (SAHA) corrected the VLCFA derangement both in vitro and in vivo, and inhibited the

76 for mitochondria in IR is that mitochondria derangements can cause IR, but IR does not have to invol

77 nding of CA and its response to pathological derangements can help assess the severity of stroke, gui

78 These metabolic derangements can result in structural, functional, and i

79 The significant mental and physical derangements caused by degraded metabolic, cardiovascula

80 ic myocardial infarction, and reduce cardiac derangements caused by metabolic disorders.

81 sm at recovery and (iv) subsequent metabolic derangement, cerebral NTP, PCr and inorganic phosphate (

82 addition to these metabolic and biochemical derangements, changes in the intraglomerular hemodynamic

83 characteristics, anatomic and physiological derangement, clinical treatment, and outcomes.

84 gnant prostate cells showed marked metabolic derangements compared with their benign counterparts.

85 ling-based predictions of stent-induced flow derangements correlated with spatial distribution of for

86 These data suggest that Paco(2) derangements could be potentially harmful for patients a

87 CRC has been proved to induce metabolic derangements detectable by high through-output technique

88 Findings suggest that individual blood gas derangements do not increase brain damage risk.

89 We hypothesize that metabolic derangement due to advanced shock in critically injured

90 eomic survey revealed that the mitochondrial derangements during insulin deficiency were related to i

91 paucity of data on the prevalence of Paco(2) derangements during the post-cardiac arrest period and i

92 Concussion results in profound metabolic derangements during which the brain is potentially vulne

93 olescents, and was associated with metabolic derangements, especially obesity, insulin resistance and

94 Multiple derangements exist in sepsis involving several different

95 fe model, envisaged an optimum level of gene derangement for tumor growth, but proposed that the cell

96 ffect modification of ethnicity on metabolic derangements for NAFLD severity.

97 the distinction of adaptations to metabolic derangements from adaptations to heart failure per se.

98 be related to inotropic support or metabolic derangements from chronic heart failure.

99 Although eNOS derangement has been demonstrated in experimental models

100 resultant very long chain fatty acid (VLCFA) derangement has dramatically opposing effects in astrocy

101 tricular state on ischemia-induced metabolic derangements has not been established.

102 Every blood gas derangement (hypoxemia, hyperoxemia, hypocapnia, hyperca

103 n patients experienced significant metabolic derangements, hypoxemia, or exposure to sedating medicat

104 sis-induced mitochondrial-related functional derangement, ii down-regulation of endotoxin/Toll-like r

105 nd DM, including sodium retention, metabolic derangements, impaired skeletal muscle function, and pot

106 d crucial pathogenic insights that metabolic derangement in adult-like metabolic milieu underlies ARV

107 the pathogenesis of glucocorticoid- induced derangement in BMD.

108 Derangement in bone mineral density (BMD) caused by gluc

109 une response against apoB with a progressive derangement in clinical disease.

110 rmine the role and mechanism of Kupffer cell derangement in exacerbating postburn end organ damage in

111 g NAFLD with more severe liver histology and derangement in glucose and lipoprotein metabolism, which

112 ld be considered part of a multiorgan system derangement in insulin sensitivity.

113 system contributes to this as evidenced by a derangement in key autophagy markers in both mouse and h

114 (72%) of all CA patients without substantial derangement in major organ function.

115 cal and subcortical pathophysiology, while a derangement in mechanisms of motor attention may be a fe

116 on in cardiac Na(+)-based processes leads to derangement in multiple cardiac components at the level

117 A derangement in protein ubiquitination may be linked to p

118 sK(ATP) channel activation in myocyte volume derangement in response to stress.

119 Hypocalcemia is a derangement in serum calcium level due to a vast spectru

120 ion of excess fat mass can be conceived as a derangement in the balance between energy intake and exp

121 The existence of these deposits reflects a derangement in the protein homeostasis machinery.

122 ng "just right" of optimum intermediate gene derangement in tumorigenesis, and in part it is inherent

123 o target one or more of the pathophysiologic derangements in acute decompensated heart failure, denot

124 tation corrects systemic and local metabolic derangements in advanced heart failure, leading to reduc

125 Derangements in apoptosis of liver cells are mechanistic

126 n increase in secretion, or both, as well as derangements in barrier properties.

127 patocyte-specific deletion of SIRT1 leads to derangements in bile acid metabolism, predisposing the m

128 study demonstrates the presence of metabolic derangements in BKS-db before the onset of beta-cell fai

129 fied mice is a phenotype of interest because derangements in blood flow may precede detectable change

130 ir, but impaired fibrin clearance results in derangements in bone fracture repair.

131 We found substantial derangements in both neuronal excitability and short-ter

132 Derangements in both oxygenation and ventilation were co

133 PAO1 and 3O-C12-HSL induce barrier derangements in bronchial epithelial cells by lowering t

134 KD), but whether it also worsens CKD-induced derangements in calcium and phosphate homeostasis is unk

135 Derangements in calcium homeostasis occur during sepsis

136 It has been proposed that derangements in cardiac metabolism and oxidative stress

137 acellular volume fraction measures and other derangements in cardiovascular structure.

138 Chronic obesity results in derangements in cardiovascular, respiratory and metaboli

139 ue to tissue hypoperfusion, and investigated derangements in coagulation associated with this.

140 oss of circulating prothrombin, and profound derangements in coagulation function.

141 (adjusted OR: 2.22; 95% CI: 1.14, 4.33), and derangements in coagulation profile (adjusted OR: 1.91;

142 otein-2 (MECP2) gene and is characterized by derangements in cognition, behavior, motor control, resp

143 Moreover, Mkl2(-/-) ES cells exhibit derangements in cytoskeletal organization, cell adhesion

144 ability to understand and correct molecular derangements in disease, genomics and novel phenotypic a

145 out mice, investigators have determined that derangements in epithelial or innate and adaptive immune

146 nalysis of HDL-P subfractions in HF to date, derangements in HDL-P subfractions were identified that

147 The neurohormonal and catabolic derangements in HF are at the base of HF symptoms.

148 se may provide a window into the biochemical derangements in human plasma, an approach that could, in

149 ely correlates with obesity-driven metabolic derangements in humans.

150 ntestinal inflammation and ischemia, as well derangements in intestinal microcirculation.

151 We hypothesized that increasing derangements in left ventricular blood flow would relate

152 Collectively, these data demonstrate that derangements in lipid metabolism in MHC-FATP ventricles,

153 RA exhibited no derangements in liver microcirculation when compared to

154 se, obesity and metabolic syndrome represent derangements in macrophage activation with concomitant l

155 eceptors in particular, we hypothesized that derangements in metabolic regulation may accelerate reti

156 Derangements in metabolism and related signaling pathway

157 dy aimed at the fine characterization of the derangements in mitochondrial structure and function con

158 Derangements in normal cellular homeostasis at the prote

159 sulin acts to depress autophagic flux, these derangements in nutrient deprivation signaling are not a

160 Oxidative stress leads to derangements in pump function due to changes in the expr

161 Results confirmed the predicted derangements in purine metabolism, but also revealed una

162 esized that 6J mice would experience greater derangements in redox homeostasis/metabolic disease upon

163 Metabolic derangements in sepsis stem from mitochondrial injury an

164 eurotransmitter orexin modulates physiologic derangements in sepsis.

165 ca media is severely disrupted with profound derangements in SMC morphology, cell-cell, and cell-matr

166 During sepsis, derangements in such tight regulation frequently occur,

167 f specific T cell subsets are key pathogenic derangements in systemic rheumatic diseases, and these i

168 Despite extensive metabolic derangements in T2DM mice, inhibition of a single dys-re

169 how pronounced locomotor deficits reflecting derangements in the cerebellar and basal ganglia circuit

170 f Parkinson disease (PD) is characterized by derangements in the discharge rates, bursting patterns,

171 set of HF; and (4) the pattern of metabolite derangements in the failing heart suggests bottlenecks o

172 Derangements in the host vasculature contribute to the c

173 omprehensive data on HE-associated molecular derangements in the human brain are lacking.

174 e ability of GLUT4 blockade to contribute to derangements in the other molecular pathways that influe

175 mphysema and highlights a role for metabolic derangements in the pathophysiology of emphysema.

176 The absence of major cytokeratin derangements in the squamous papillomas may be of ancill

177 of Myocd gene deletion, exhibiting profound derangements in the structure of great arteries as well

178 Mkl2(-/-) null embryos exhibit profound derangements in the tunica media of select arteries and

179 omponent in determining NSC vulnerability to derangements in their self-renewal program and, therefor

180 In this review we discuss how derangements in these developmental pathways drive cance

181 function or attenuate postprandial metabolic derangements in triglycerides, glucose, or insulin relat

182 ukED and HlgAB cause vascular congestion and derangements in vascular fluid distribution that rapidly

183 Migraine is accompanied by significant derangements in vascular function that may represent imp

184 ker also had significantly more organ system derangement, including noncardiovascular organ system fa

185 e suffer from profound cardiac and pulmonary derangement, including right ventricular strain and nonc

186 e is characterized by pathologic hemodynamic derangements, including elevated cardiac filling pressur

187 or function may result in multiple metabolic derangements, including insulin resistance.

188 e tissue inflammation, and hepatic metabolic derangements, including suppressing hepatic lipogenesis

189 These derangements increase white adipose tissue (WAT) lipolys

190 ve than saline loading to detect hemodynamic derangements indicative of HFpEF.

191 cer, hepatocellular carcinoma, and metabolic derangements induced by a high-fat diet; therefore, eluc

192 nce and related metabolic and neuroendocrine derangements induced by uDM.

193 nd characterising acute and chronic internal derangement injuries of the knee and helps guide patient

194 ment of type 2 diabetes lies a key metabolic derangement: insulin resistance (IR).

195 Admission fibrinolytic derangement is common in injured children and adults, an

196 Internal derangement is defined as an abnormal positional and fun

197 inical situation characterized by glycocalyx derangement is ischemia-reperfusion (I/R) of the whole b

198 rders, a persistent natural killer (NK) cell derangement is observed.

199 rrecting the immediately evident physiologic derangement is only the first step in the care of these

200 Among these, internal disc derangement is the most frequent type of disorder.

201 ncy leads to neurodegeneration and metabolic derangements is not known.

202 rary to methadone, its role in the metabolic derangements is not obvious.

203 lating high-fat-diet (HFD)-induced metabolic derangements is unknown.

204 involving robust recording of physiological derangements, is necessary to further advance our unders

205 In the lung, hemodynamic derangements lead to the development of abnormalities in

206 Each of these neurohormonal derangements may act through increased activity of both

207 These derangements may be further augmented in the presence of

208 uman studies suggest that systemic metabolic derangements may lead to metabolic, functional and struc

209 o evaluate whether baseline BBB permeability derangements may predict HT after recanalization therapy

210 r distributions but with greater physiologic derangement (mean Sequential Organ Failure Assessment sc

211 tion (AF) and to ascertain whether metabolic derangements might instigate this arrhythmia.

212 To characterize cellular derangements, mitochondrial bioenergetics, dynamics, end

213 on, possibly contributing to the hemodynamic derangement of acute pulmonary thromboembolism.

214 evidence for inherited predisposition to and derangement of apoptosis and inflammation in lesional de

215 at mithramycin causes hepatotoxicity through derangement of bile acid disposition; results also sugge

216 nmental repressive signals, based in part on derangement of cell cycle checkpoints governed by cilia

217 Derangement of circulatory flow affects many vital organ

218 A systemic derangement of CXC chemokines in maternal and fetal circ

219 Derangement of either step can lead to mispatterned CA s

220 We assessed whether, in obesity, derangement of energetics and diastolic function is furt

221 is to liver cancer through cytokine-mediated derangement of gender-specific cellular metabolism.

222 ion, abnormal epidermal differentiation, and derangement of intercellular junction proteins.

223 rtal hypertension (PH), a pathophysiological derangement of liver cirrhosis, is characterized by hype

224 ith biliary colic, pancreatitis, unexplained derangement of liver function tests, and/or dilated CBD

225 r static strains lowered mortality (p<0.01), derangement of lung mechanics (p<0.01), and arterial oxy

226 remia is a complex metabolic state marked by derangement of many signaling molecules and metabolic in

227 ion in tumor samples from mice revealed that derangement of metabolites were a reflection of coordina

228 b) How derangement of multiple, cell-specific, molecular proces

229 , MYPT1 deficiency may not cause significant derangement of smooth muscle contractility because the e

230 m patients revealed pathways associated with derangement of specific metabolic pathways that are indi

231 f the population, of which 70% have internal derangement of the disc.

232 Increasing severity of cirrhosis causes derangement of the hematopoietic niche and loss of HSCs,

233 animals develop cataracts associated with a derangement of the lens capsule basement membrane and al

234 Derangement of the nuclear factor kappaB (NF-kappaB) pat

235 deadly disease characterized by considerable derangement of the proinflammatory, anti-inflammatory an

236 the Ts65Dn mouse model for DS was caused by derangement of the Shh pathway due to overexpression of

237 elops in Alzheimer disease (AD) owing to the derangement of the sleep-wake cycle regulation pathways.

238 ther by a genetically determined, functional derangement of the systemic brain maturation that is age

239 Derangement of these localization motifs may lead to cys

240 Derangement of these sensory-motor circuits is implicate

241 Derangement of these trafficking mechanisms underlies th

242 nance of a highly sensitive "set point," the derangement of which may lead to the development of key

243 device (LVAD) reverses some of the metabolic derangements of advanced heart failure.

244 te infusion favorably attenuates hemodynamic derangements of cardiac failure that develop during exer

245 t of exercise capacity and is accompanied by derangements of contractile state and VAC.

246 Despite the acute derangements of critical illness, both acute and chronic

247 Furthermore, the major pathophysiological derangements of heart failure and a preserved ejection f

248 r the future is to determine how more subtle derangements of ion channel function, which arise from t

249 ked beta-cell death, loss of beta-cell mass, derangements of islet architecture, and impaired glucose

250 Measurements of histopathology derangements of lung samples and studies of intrapulmona

251 CI, Mandarano et al. illuminate bioenergetic derangements of ME/CFS T cell subsets.

252 uct that represents the end-manifestation of derangements of multiple physiologic systems leading to

253 e used a transgenic mouse model to show that derangements of myotonic dystrophy are reversed by a mor

254 sm render it particularly susceptible to the derangements of the diabetic state.

255 dispersed cells exhibit virtually identical derangements of their dendritic structures.

256 y a vital role in the normal hemostasis, and derangements of their function can lead to hemorrhage or

257 n prevents the deadly metabolic and clinical derangements of type 1 diabetic mice.

258 epsis, and hemorrhage that present as severe derangements of vital signs.

259 and metabolism than adaptive RVH, and these derangements often involve the left ventricle.

260 n in the AD, CfaE G168D exhibited structural derangements only in the adjoining PD compared with CfaE

261 zures due to acute brain injury or metabolic derangements, or unprovoked seizures that are the initia

262 chromoplexy may induce considerable genomic derangement over relatively few events in prostate cance

263 xcretion (p = 0.01), more extreme laboratory derangement (p < 0.0001) and marginally increased diasto

264 ontrols indicate increased risk of metabolic derangements (particularly involving calcium homeostasis

265 of severe events or if progressive metabolic derangement persists after therapeutic interventions hav

266 RI permeability technique to detect baseline derangements predictive of various forms of HT after rec

267 nhance the investigation of the metabolic PH derangements, provides a tool to accurately assess the t

268 thromboelastography profiles with additional derangements related to fibrinogen and platelet function

269 The severe derangements seen in lipoprotein metabolism in patients

270 ion of sepsis has changed from a physiologic derangement (Sepsis-1 and -2) to organ dysfunction (Seps

271 Analysis of the mechanisms underlying this derangement suggested that a marked reduction in tubulog

272 ting PI3K alone led to more severe metabolic derangement than inhibiting both PI3K and mTOR.

273 e of TIH involves a more extensive metabolic derangement than previously recognized.

274 cause ACLF patients have greater hemodynamic derangements than patients with decompensated cirrhosis,

275 nsamination to cope with the liver metabolic derangement that is associated with greater gluconeogene

276 s of HRS-1 is largely viewed as a functional derangement that ultimately affects renal vasculature to

277 ew, without an understanding of the vascular derangements that accompany it.

278 profound, occurring in a timely manner, with derangements that are greater and more protracted than p

279 and is correlated with classical hemodynamic derangements that develop with stress.

280 (ACOX1(-/-)) mice manifest hepatic metabolic derangements that lead to the development of steatohepat

281 Here, we explore vascular derangements that might also contribute to brain damage.

282 eomics was used to identify energy metabolic derangements that occur during the development of cardia

283 Mitochondrial energy metabolic derangements that occur during the early development of

284 the physiological control of feeding and the derangements that occur in obesity and their restoration

285 st to detect early imaging signs of internal derangement, thereby avoiding the evolution of this cond

286 onsequences of CVID-associated CD4(+) T-cell derangements to hypogammaglobulinemia, autoantibody prod

287 hwann cells was retarded without significant derangements to myelination or axon caliber.

288 ch signaling in the pathogenesis of anatomic derangements underlying cerebrovascular accidents.

289 anted >3 months, admitted due to hemodynamic derangements, underwent simultaneous comprehensive echoc

290 apy of unexpected bleeding when a hemostatic derangement was not anticipated preoperatively.

291 vel permeability technique to illustrate BBB derangements was based on the detection of decreased sig

292 The number of children with metabolic derangements was higher among adolescents with NAFLD tha

293 These derangements were associated with a reduced capacity of

294 Many but not all physiological derangements were more closely associated with the TAPSE

295 Marked mitochondrial structural derangements were observed in hearts of PGC-1alpha/beta-

296 Metabolic derangements were the most common identifiable cause of

297 n ICU, admission diagnosis and physiological derangements, which accurately predicted outcome on admi

298 Bloods showed multi-organ derangement with leukocytosis, lactic acidosis, haemolyt

299 traumatic brain hypoxia and microcirculatory derangements with cell edema, we investigated the effect

300 We outline the immune pathway derangements within the head and neck cancer microenviro