ライフサイエンスコーパス: deregulate

1 seases where known transcription factors are deregulated.

2 that the interleukin-6-JAK1-STAT3 pathway is deregulated.

3 ietic cells in which MYC expression has been deregulated.

4 macrophage transcriptome and metabolome are deregulated.

5 Our findings define a crucial role of deregulated 5hmC epigenetics in the events leading to AD

6 easoned that different NUP98-fusion proteins deregulate a common set of transcriptional targets that

7 ously revealed how disease-causing mutations deregulate a subtle dynamic conformational equilibrium i

8 We identified 102 genes consistently deregulated across all UPF3B mutant cell lines.

9 We find that promoters are deregulated across tissues, cancer types, and patients,

10 While the deregulated activation of DNMT1 or KIT has been implicat

11 We found that INF2 mutations lead to deregulated activation of formin and a constitutive stre

12 Deregulated activation of the latent oncogenic transcrip

13 d with wild-type TnpA, these mutants exhibit deregulated activities.

14 we demonstrate that restoring Notch and Wnt deregulated activity in LSCs attenuates disease progress

15 Deregulated AKT kinase activity due to PTEN deficiency i

16 prior to meiotic prophase I, mice bearing a deregulated allele (Cdk2(Y15S) ) are severely deficient

17 veral human pathologies are characterized by deregulated angiogenesis and unstable blood vessels.

18 We observed only a small set of genes to be deregulated at the transcriptional level at 7 days posti

19 l to reveal novel mechanisms of how CEBPA is deregulated at the transcriptional level.

20 We identify deregulated Aurora A activity as a mechanism contributin

21 ablation of TFEB and TFE3 in mice results in deregulated autophagy over the diurnal cycle and altered

22 CLL-associated cellular processes, including deregulated B cell receptor signaling, which we also ide

23 APC deletion deregulates beta-catenin, leads to high Wnt tone, and di

24 entification, analysis, and visualization of deregulated biological processes.

25 hown previously to cleave human Factor V and deregulate blood coagulation, as the most abundant type

26 infiltration, suggesting that HE4 may cause deregulated blood vessel formation and suppress proper T

27 unosuppressed marrow microenvironment, which deregulate bone turnover and result in bone loss and ske

28 len tube-female gametophyte contact, thereby deregulating BUPS-ANXUR signaling and in turn leading to

29 MECOM (also known as EVI1) proto-oncogene is deregulated by chromosomal translocations in some cases

30 clock, which in cancer cells is, curiously, deregulated by endoplasmic reticulum (ER) stress.

31 ught to identify the host genes specifically deregulated by MCPyV, as opposed to other PyVs, in order

32 sion profiles revealed 28 genes specifically deregulated by MCPyV.

33 CK2 provoked by p53 ablation and irrevocably deregulated by NHEJ inactivation.

34 ovel insights on how these mechanisms may be deregulated by oncoproteins or mutations/variants in CEB

35 that Rbfox2-TGF-beta-Tak1 signaling axis is deregulated by Rbfox2 deletion.

36 inal-B (Abd-B) represents one of the targets deregulated by several SR-miRNAs.

37 le that inhibiting IP3R3 degradation in PTEN-deregulated cancers represents a valid therapeutic strat

38 We validated the deregulated candidates Tex26, Syngr4, and Plekhb1 mRNAs

39 whole-genome transcriptome analysis examined deregulated canonical pathways.

40 Ps, and in CMs their loss results in broadly deregulated cardiac gene expression.

41 hallmarks of malignant transformation, with deregulated cell death and/or cell proliferation, loss o

42 Deregulated cell proliferation is an established feature

43 uces a decrease of H3K36(me2), especially in deregulated cell-cycle-related genes.

44 ation, stem cell exhaustion, senescence, and deregulated cell/tissue homeostasis.

45 reased mitochondrial permeability in MEK-ERK-deregulated cells to an extent that triggered cell death

46 As a result of deregulated cellular signaling pathways, cancer cells of

47 tion of its downstream effector, Inpp5e, and deregulates ciliary-PI3K/AKT signaling.

48 The role of deregulated Cld-1 expression in CAC and the underlying m

49 Importantly, these effects of deregulated Cld-1 were not associated with altered tight

50 Deregulated cyclin D1 expression also causes resistance

51 We previously reported that deregulated cyclin E activity causes defective terminal

52 E2F-2 deletion; however, anemia in mice with deregulated cyclin E is not improved by E2F-2-loss, whic

53 a network of targets associated with STAT3, deregulate cytokine-mediated gene activation, suppress a

54 nction share a similar pathogenic pathway in deregulating DAergic neuron SV endocytosis and that they

55 Accordingly, mice lacking RhoJ show deregulated deposition of fibronectin around vessels dur

56 ectopic overexpression results in lines with deregulated diurnal gene expression profiles compared wi

57 fects, recurrent genomic rearrangements, and deregulated DNA integrity checkpoints, reminiscent of hu

58 basis for genome instability resulting from deregulated DNA replication, observed in cancer and othe

59 te that LINE-1 retrotransposons often become deregulated during progression of ovarian cancer precurs

60 Starting from the transcriptome of auxin-deregulated embryos, we identified an auxin-dependent ba

61 and its epigenetic LXRalpha target that when deregulated enables pathogenic pulmonary fibrosis.

62 ring RAB8A function, pathogenic G2019S LRRK2 deregulates endolysosomal transport and endocytic recycl

63 We uncover a large number of deregulated enhancers and altered transcriptional circui

64 increased transcriptional noise, indicating deregulated epigenetic control.

65 Mechanistic studies of deregulated ERG in prostate cancer and other cancers con

66 gnaling through the H2AX histone variant was deregulated, especially within the proliferating progeni

67 Deregulated expression of circular RNAs (circRNAs) is as

68 BMC, ovalbumin-sensitized females unveiled a deregulated expression of genes involved in asthma patho

69 Additionally, we found deregulated expression of proteins with relevant functio

70 For many years, it has been established that deregulated expression of transcription factors, impairm

71 n neuronal pathways, knockdown of circZNF827 deregulates expression of numerous genes including nerve

72 g of MSI1 to its endogenous targets, thereby deregulating expression of factors implicated in neural

73 Deregulated extracellular signal-regulated kinase (ERK)

74 nd transcriptional characterization indicate deregulated fatty acid and cholesterol biosynthesis and

75 s not a monolithic disorder: female patients deregulate fewer genes and clinically behave differently

76 tools in the treatment of human cancers with deregulated FKBP51.

77 ages of infection and using transgenic lines deregulated for the expression of RKS1, a gene underlyin

78 We also discuss the effects of deregulated fork resection on genomic instability and on

79 To elucidate the deregulated functional modules that drive clear cell ren

80 d an important data set for the detection of deregulated functionally active miRNAs in DLBCLs and cou

81 ly in white and brown preadipocytes leads to deregulated gene expression and blocks differentiation t

82 in excessive ATF4 binding to DNA targets and deregulated gene expression.

83 s of tight genetic cooperativity enriched in deregulated genes (critical phases), pre-symptomatically

84 may lead to a core keratoconus signature of deregulated genes and a better understanding of its path

85 revealed a high degree of similarity between deregulated genes and pathways induced by CS.

86 Among the shared deregulated genes between mouse and human are important

87 egulators jointly exert maximal control over deregulated genes but minimal control over unperturbed g

88 the MED12 activation helix to correlate with deregulated genes in breast and colon cancer.

89 capture microdissection revealed hundreds of deregulated genes in Tbx3 (+/-) mutants.

90 The majority of deregulated genes in the ABOi and HLAi groups consisted

91 enase-1 (Hmox1), one of the most stringently deregulated genes in the Bach1 knockout in macrophages,

92 sequencing to explore the changed miRNAs and deregulated genes in the spleen of three groups of broil

93 AML) is induced by the cooperative action of deregulated genes that perturb self-renewal, proliferati

94 Deregulated genes were used for pathway enrichment analy

95 plants and jazD revealed a large overlap of deregulated genes, suggesting that ectopic LNJ expressio

96 Deregulated global mRNA translation is an emerging featu

97 ic mechanisms reported to be associated with deregulated HCC-associated lncRNAs.

98 The crosstalk between deregulated hepatocyte metabolism and cells within the t

99 uding scrambled patterns of DNA methylation, deregulated histone acetylation, altered gene expression

100 n autoregulatory feedback mechanism, thereby deregulating HNRNPH1 protein expression.

101 Sustained TLR4 activation may deregulate homeostatic anti-inflammatory BVRA/mTORC2 sig

102 a life-threatening organ failure caused by a deregulated host response to infection.

103 Current concepts invoke a deregulated immune reaction involving features of hyperi

104 characterized by a dysbiotic microbiota and deregulated immune response and resulting in tooth loss

105 Deregulated immune response to a dysbiotic resident micr

106 e aetiology of IBD is partly attributed to a deregulated immune response to gut microbiome dysbiosis.

107 We defined 172 genes as markers for this deregulated immune response, which we called the immune-

108 ication of these key lncRNAs signatures that deregulate important network of genes in key cancer path

109 MYC is deregulated in > 50% of human cancers, rendering it an a

110 opposite of these antisense genes were also deregulated in 42% of the observed sense-antisense gene

111 In cancer, PAX8 expression is deregulated in a key set of neoplasms, including those a

112 f mRNAs and lncRNAs showed that lncRNAs were deregulated in a more tumor-specific manner.

113 We identified 63 miRNAs deregulated in a statistically significant way.

114 P2A.IMPORTANCE UNC5B, PP2A, and netrin-1 are deregulated in a variety of cancers.

115 G9a is genetically deregulated in a variety of tumor types and can silence

116 Phosphoinositide 3-kinase (PI3K) is deregulated in a wide variety of human tumors and trigge

117 the m(6)A demethylase FTO, which is commonly deregulated in acute myeloid leukemia (AML).

118 ling normal hematopoiesis and are frequently deregulated in acute myeloid leukemia (AML).

119 L-XL(+) /myeloid cell leukemia 1+ signature, deregulated in Alb-R26(Met) tumors, characterizes a subg

120 mouse, SINE RNAs constitute a novel pathway deregulated in amyloid beta pathology, with potential im

121 The Hippo pathway was deregulated in BAP1-deficient pancreatic tumors, with th

122 olesterol-5,6-epoxide (5,6-EC) metabolism is deregulated in BC but the molecular origin of this is un

123 ere, we show that the apoptosis mechanism is deregulated in beta-catenin S45F mutants, resulting in d

124 thma (ovalbumin and house dust mite); miRNAs deregulated in both models were further tested in a huma

125 MicroRNAs (miRNAs) are often deregulated in cancer and are thought to play an importa

126 clin-dependent kinases (CDKs) are frequently deregulated in cancer and represent promising drug targe

127 ETS transcription factors are commonly deregulated in cancer by chromosomal translocation, over

128 They are specifically deregulated in cancer cells and contain regulators that

129 ions suggest that beta-globin is selectively deregulated in cancer cells, mediating a cytoprotective

130 rofiling technique distinguished genes truly deregulated in cancer from genes that identify cellular

131 apicobasal polarity, both of which are often deregulated in cancer.

132 ositide 3-kinase (PI3K) pathway are commonly deregulated in cancer.

133 regulators of gene expression and are often deregulated in cancer.

134 ny lncRNAs are genetically or epigenetically deregulated in cancer.

135 nuclear proto-oncogene (SET) that often are deregulated in cancers.

136 suggests that the mTOR signaling pathway is deregulated in CDK8-deficient cells and, accordingly, th

137 Furthermore, cell cycle genes were not deregulated in cells infected with a virus lacking E7 de

138 g as a myeloid cell intrinsic factor that is deregulated in chronic wounds.

139 mTOR signaling is deregulated in common diseases, like cancer and epilepsy

140 Among 200 and 324 miRNAs significantly deregulated in CRC and AA tissues, respectively, 7 and 5

141 e we identify major transcriptional networks deregulated in DFUs that result in decreased neutrophils

142 ls many aspects of animal development and is deregulated in different human cancers.

143 for targeting pathways that are specifically deregulated in different tumors.

144 PRC2 function is often deregulated in disease and is a promising candidate for

145 Their activity is frequently deregulated in disease and targeting this class of prote

146 es that finely tune cell homeostasis and are deregulated in disease states, including hepatocellular

147 ate non-catalytic functions of pseudokinases deregulated in disease.

148 and 5 of these miRNAs were also found to be deregulated in feces (technical validation).

149 This form of plasticity is deregulated in Fragile X Syndrome, a monogenic form of a

150 es involved in sphingolipid metabolism to be deregulated in HNF1A deficiency: Ormdl1, sphingosine kin

151 , proliferation and metabolism, and is often deregulated in human cancer.

152 h plays critical roles in development and is deregulated in human spinocerebellar ataxia and cancers.

153 Only a subset of functions deregulated in initial tumors was similarly deregulated

154 s transcription and genomic stability and is deregulated in leukemia.

155 rt of a novel negative feedback loop that is deregulated in liver and kidney cancer.See related artic

156 drivers of cell proliferation, are commonly deregulated in lung cancer where they may serve as oncog

157 Amino acid metabolism is deregulated in many cancers, with changes in branched-ch

158 TNKS are deregulated in many different cancer types, and inhibiti

159 onds to diverse environmental signals and is deregulated in many human diseases, including cancer and

160 Thus, we identified SYNGR4 and PLEKHB1 to be deregulated in MNs at motor symptom onset in TDP-43-driv

161 mTOR signaling pathway is deregulated in most cancers and uncontrolled cell cycle

162 Netrin-1 and UNC5B are deregulated in multiple cancers, including colorectal, n

163 ines, we identify mSWI/SNF subunits that are deregulated in NEPC and demonstrate that SMARCA4 (BRG1)

164 utamine metabolism pathways were shown to be deregulated in pancreatic ductal adenocarcinoma (PDAC).

165 Because copper homeostasis is deregulated in PD, it is of great significance to study

166 n all, 607 and 396 miRNAs were significantly deregulated in PDAC and IPMN versus C.

167 Promoters of genes deregulated in pp7l-1 were enriched in PHYTOCHROME-INTER

168 Thirty-eight genes deregulated in PSC were identified, among these IGJ and

169 that the actin nucleator Formin 2 (Fmn2) is deregulated in PTSD and in Alzheimer's disease (AD) pati

170 deregulated in initial tumors was similarly deregulated in recurrent tumors thereby indicating that

171 Notch signaling is reported to be deregulated in several malignancies, including breast, a

172 This pathway is deregulated in several tumors, including colorectal canc

173 genes, (antisense) long non-coding RNAs are deregulated in skin tissue of systemic sclerosis patient

174 jority of methylation and expression changes deregulated in the absence of Dnmt3b, and as a result, m

175 The metabolism of ceramides is deregulated in the brain of Alzheimer's disease (AD) pat

176 in sustaining genome integrity and typically deregulated in tumorigenesis.

177 searched for proteins which are specifically deregulated in UHCA.

178 Since the Hippo pathway is deregulated in various cancers, designing inhibitors of

179 t kinases are therapeutic targets frequently deregulated in various cancers.

180 me activation is essential for host defense, deregulated inflammasome responses and excessive release

181 ent of infants with diseases associated with deregulated inflammation.

182 signature of sepsis for cytokine storm, and deregulated inflammatory reaction and proapoptotic envir

183 pation of parasite-sustained inflammation or deregulated innate immune responses in treatment failure

184 There is compelling evidence that deregulated insulin activities or cerebral insulin resis

185 Various mechanisms deregulate integrin signaling in cancer, empowering tumo

186 cytokine and immune regulator; however, when deregulated, it leads to several major chronic inflammat

187 Deregulated JAK2 signaling has emerged as the central ph

188 InsSer (herein referred to as JAK2ex13InDel) deregulates JAK2 through a mechanism similar to JAK2V617

189 Deregulated kinase signaling networks drive the growth a

190 tutes the GC B cell division timer that when deregulated leads to emergence of B cell lymphoma.

191 egration of miRNA with mRNA targets revealed deregulated let-7 and miR-16 target genes, similar to pu

192 cle deficiency led to liver inflammation and deregulated lipid metabolism.

193 mycobacterial survival within macrophages by deregulating lipid droplets via ATG2 repression.

194 We have thus identified an epigenetically deregulated lncRNA, whose loss of expression in LUAD pro

195 The expression patterns of 917 recurrently deregulated lncRNAs are correlated with clinical data in

196 Notably, 63 deregulated lncRNAs are significantly associated with cl

197 Twenty-three deregulated lncRNAs associated with both tumor and metas

198 his review maps the oncogenic roles of these deregulated lncRNAs by integrating diverse datasets incl

199 Seventy-four deregulated lncRNAs have been identified in HCC, of whic

200 -expression network analysis revealed that 5 deregulated lncRNAs having maximum connections with diff

201 adipogenic gene expression by epigenetically deregulating long-range enhancers of the anti-adipogenic

202 Thus, miR-144 and miR-451 deregulate <10% of mRNAs that they bind, a characteristi

203 pon DNA damage is an important mechanism for deregulating MDM2, thereby leading to p53 activation.

204 s emerge through an instability triggered by deregulated mechanical coupling between the nascent epit

205 These findings characterize multiple deregulated mechanisms of genome stability that lead to

206 avior of cancer and other diseases linked to deregulated membrane signaling states.

207 We propose that DNMT1 RFTS mutations deregulate metabolism lowering ATP levels, as a result o

208 to disrupted circadian ILC3 oscillations, a deregulated microbiome and altered lipid metabolism.

209 meostasis, impaired epithelial reactivity, a deregulated microbiome, increased susceptibility to bowe

210 egulatory pairs were identified within these deregulated microRNAs and mRNAs, which consisted of 17 u

211 Among the 9 significantly deregulated microRNAs, miR-17-5p was upregulated in pati

212 led at the carotid lesion site, identified 8 deregulated miRNAs (miR-15b, miR-29c, miR-30c/d, miR-150

213 Most of the deregulated miRNAs are involved in progression of T1DM.

214 the DLBCL miRNA profiles identified sets of deregulated miRNAs by Ago2-RIP-seq.

215 by the validation of the most significantly deregulated miRNAs by RT-qPCR in an independent sample s

216 We explored deregulated miRNAs in an glomeruloendothelial in vitro m

217 used microarray-based profiling to discover deregulated miRNAs in pre- and postchemotherapy plasma s

218 es with respect to C, with a large number of deregulated miRNAs shared by both neoplastic lesions.

219 many genes could be confirmed as targets for deregulated miRNAs, the impact of differentially express

220 ion of a mouse model, we show that H. pylori deregulates mitochondria by two novel mechanisms, both r

221 Deregulated mitochondrial dynamics resulting in defectiv

222 Interference with this pathway deregulates mitochondrial dynamics, shuts off subcellula

223 atients; however, with few exceptions, these deregulated molecular pathways cannot be targeted therap

224 ling and metabolic studies revealed that the deregulated MTHFR cells undergo continuous transmethylat

225 ulation reflect failure of the F17 mutant to deregulate mTOR and stimulate protein production.

226 es, from protein synthesis to autophagy, and deregulated mTOR signaling is implicated in the progress

227 to create a series of feedback-insensitive, deregulated mutants.

228 toma multiforme (GBM) which presents largely deregulated Myc activity.

229 Deregulated MYC alone was not tumorigenic, but coexpress

230 peutic utility of this approach in targeting deregulated MYC breast cancers.

231 -neuroendocrine lineage heterogeneity, while deregulated MYC expression in KRAS mutant mice increases

232 e basis for a dependency of tumor cells with deregulated MYC on the kinase NUAK1, which acts through

233 and characterizing the functional effects of deregulating MYC expression in the murine NeuNT model of

234 ression of downstream genes and consequently deregulating myelopoiesis.

235 We demonstrate that deregulated necroptosis results in systemic inflammation

236 Our results show deregulated neddylation in clinical fibrosis and both in

237 Interestingly, 676 deregulated non-coding genes were detected, 257 of which

238 eptors (A(2A) R) had deleterious effects and deregulated normal timing for progenitor and precursor c

239 Deregulated Notch signaling within the breast tumor and

240 fects viral life cycles, a number of viruses deregulate Nrf2 pathways.

241 Accordingly, deregulated nucleic acid sensing contributes to the orig

242 ochondrial dysfunction, cellular senescence, deregulated nutrient sensing, stem cell exhaustion and a

243 man cells, clinical biopsies or endogenously deregulated oncogenic pathways.

244 Replication stress and deregulated origin firing increase the number of HO coll

245 ation induced in Saccharomyces cerevisiae by deregulated origin licensing is non-random and defined b

246 Deregulated overexpression of MYC is implicated in the d

247 Deregulating p120-catenin further prevents diffuse gliom

248 lyses, we observed that NOTCH signaling is a deregulated pathway in enzalutamide-resistant cells.

249 nd progenitor cells, providing insights into deregulated pathways of mutant and non-mutant cells.

250 xis with the advantage of targeting multiple deregulated pathways simultaneously.

251 rophy (EDMD), we show here that lamin A loss deregulated PcG positioning in muscle satellite stem cel

252 elevated in OSAS patients, which indicates a deregulated PD-1/PD-L1 cross-talk between these cells.

253 ges, lymphoid cells from the animals exhibit deregulated phospholipid metabolism and an aberrant indu

254 RMT1 (Tg) and NIC-PRMT6 (Tg) mice revealed a deregulated PI3K-AKT pathway.

255 is question, we analyzed the consequences of deregulating Plk4 (the master centriole duplication kina

256 associated mutations within THRAP3 result in deregulated processing of THRAP3/BCLAF1-regulated transc

257 reduction of plastidic TIG1 levels leads to deregulated protein biogenesis at the expense of increas

258 Deregulated PU.1 gene expression is linked to dysregulat

259 mouse prone 8 mice, which are known to have deregulated reactive oxygen species metabolism and accel

260 ctivation of signaling processes caused by a deregulated recruitment of downstream effector proteins.

261 lance of ripoptosome assembly is required as deregulated ripoptosome activity modulates PLK1-dependen

262 B1 as the critical ETS transcription factors deregulating SDHD expression in the context of highly re

263 Hg, PAHs) with elevated oxidative stress and deregulated serum acylcarnitines, including inosine mono

264 t cancer cells are dependent on a network of deregulated signaling pathways for survival and are inse

265 ndicated that the four clusters shared major deregulated signaling pathways implicated on energy, gro

266 ing and pharmacogenetic analyses to identify deregulated signaling pathways in EAC tissues that might

267 multiple tumors had different mutations that deregulated similar pathways.

268 Deregulated SOX2 alters critical genes implicated in hal

269 We tested the impact of deregulated SOX2 expression in a novel organotypic syste

270 euronal CB(1) cannabinoid receptors, chiefly deregulating Stat3-dependent transcriptional cascades ot

271 ge of LRRK2 and SYNJ1 pathogenic pathways in deregulating SV trafficking in MB neurons as an underlyi

272 iated with markedly enhanced respiration and deregulated TCA cycle dynamics suggesting decreased reso

273 hypothesis suggests that hybridization could deregulate TEs and trigger their accumulation, although

274 in ERBB2IP (ERBB2IP(mut) ) have evidence of deregulated TGF-beta signaling with increased regulatory

275 ome Ras mutants I24N, T50I, V152G, and D153V deregulate the autoactivation of SOS to populate their a

276 Reduced levels of aspartate deregulated the malate-aspartate shuttle, which is impor

277 Although Pax5 significantly deregulated the plasma cell expression program, key plas

278 posi's sarcoma-associated herpesvirus (KSHV) deregulates the activity of APC/C during the lytic repli

279 duced cytoplasmic accumulation of MAL, which deregulates the activity of serum response factor (SRF).

280 Second, RB inactivation deregulates the expression of cell-state-determining fac

281 lso increases the activation of calpains and deregulates the gene expression of the members of the FG

282 field and emerging evidence suggesting that deregulating these pathways might have dramatic conseque

283 with DR3 then have the potential to prevent deregulated tissue cell activity in lung diseases that i

284 We report that deregulated transcription following BRD4 loss in cancer

285 3 patient cells exhibit measurable levels of deregulated transcription.

286 ns for understanding how their co-expression deregulates transcription in cancer.

287 We also describe how these deregulated transcriptional pathways represent new oppor

288 T2A) generate oncogenic fusion proteins with deregulated transcriptional potential.

289 Specifically, these deregulated transcriptional programs can become liabilit

290 ften upregulated and mislocalized in MEK/ERK-deregulated tumors.

291 Overexpression of the deregulated TyrA enzymes led to hyper-accumulation of ty

292 ugh a central metabolic pathway that becomes deregulated under specific conditions.

293 Deregulated UPR signaling, which often occurs in hematop

294 le tags to reinstall cell cycle control to a deregulated version of Yen1, showing that its premature

295 ditions for centrosome duplication to become deregulated with consequences for genome instability.

296 sease and mild cognitive impairment (MCI) is deregulated with highly increased or decreased transcrip

297 Deregulated Wnt signaling and altered lipid metabolism h

298 Deregulated WNT signaling has been shown to favor malign

299 novel therapeutic targets for tumors having deregulated Wnt/beta-catenin signaling induced by this m

300 mutations and an inability to shield against deregulated X-linked genes that engage in p53 networks.