ライフサイエンスコーパス: deregulation

1 d splicing is at least partially driving HOX deregulation.

2 r proposed to be driven solely by epigenetic deregulation.

3 n cancer, resulting in widespread epigenetic deregulation.

4 fords novel insights into the impact of SOX2 deregulation.

5 ngton's disease (HD) may evolve through gene deregulation.

6 SD1 inactivation therefore causes epigenetic deregulation across cancer sites, and has implications f

7 CRP binding, indicating possible complement deregulation also on this ligand.

8 1 (Cld-1), a tight-junction integral protein deregulation alters colonic epithelial cell (CEC) differ

9 Strikingly, deregulation among multiple auxin-related gene families

10 Cells lacking PTEN exhibit cell cycle deregulation and cell fate reprogramming.

11 Transcriptional deregulation and changes in mitochondrial bioenergetics,

12 but the relationship between transcriptional deregulation and genome organization remains largely uns

13 then validated the association between IL-36 deregulation and IFN-I over-expression in patients with

14 ncer risk by FXR inactivation, leading to BA deregulation and increased colon cell proliferation.

15 ta provide new insights into MPNST signaling deregulation and suggest that co-targeting of PAK1/2/3 a

16 inflammation in pancreatitis, mechanisms of deregulation, and connections among disordered pathways.

17 irm the EZH2-dependent activation, metabolic deregulation, and tumor growth in BLCA.

18 id differentiation mainly through epigenetic deregulations, and impairs haematopoietic stem-cell self

19 We discuss CRTC deregulation as a new driver of aging that integrates th

20 h) pathway mutations in BSCs, implicating Hh deregulation as the primary driving event in BSC.

21 e metabolic flux through the SGOCP and their deregulation, as well as how the actions of this metabol

22 chemokine ligands/receptors whose epigenetic deregulation associates with key epigenetic enzymes, rep

23 tive data integration method to characterize deregulation between miRNA and mRNA due to environmental

24 nisms underlying aSyn-mediated transcription deregulation by assessing its effects in the nucleus and

25 rtieth of the FH concentration), and resists deregulation by FH-related proteins.

26 Transcriptional deregulation can arise due to genetic and/or non-genetic

27 This deregulation can explain the mitochondrial uncoupling an

28 Ciliogenesis deregulation caused by LUZP1 or EPLIN loss may thus cont

29 al exhaustion, indicating that mitochondrial deregulation caused T cell exhaustion.

30 stability of most cellular proteins, and its deregulation contributes to human diseases including can

31 drivers of HCC and elucidating how epigenome deregulation contributes to liver disease and HCC.

32 on and tumorigenesis and suggests that Kaiso deregulation contributes to MTG16-dependent colitis and

33 ulators of cytoskeletal remodeling and their deregulation contributes to numerous pathologies.

34 osine deaminase associated with RNA1 (ADAR1) deregulation contributes to therapeutic resistance in ma

35 lin C and regulatory subunit MED12, with its deregulation contributing to numerous malignancies.

36 While such immune deregulations did not impact endosymbiont load, they did

37 In addition to network connectivity deregulation, different biological processes are specifi

38 ng of multiple ERVs, we demonstrate that ERV deregulation directly alters the expression of adjacent

39 beta-Catenin deregulation directly disrupts cilium maintenance and si

40 Mutations underlying HIF deregulation drive multifactorial aberrations in angioge

41 SOX2 deregulation drives dysplasia, and loss of tumor promote

42 Our results demonstrate that miRNA deregulation happens very early in HCC in humans, implyi

43 y, in a separate analysis (step 3), the IL-8 deregulation has also appeared to be an important progno

44 E2F, a family of transcription factors whose deregulation has been associated to cancer progression,

45 Its deregulation has been implicated in many diseases, inclu

46 ar physiology, showed a significant systemic deregulation in blood and venous tissue after AV loop pl

47 the cell multiplication decision and in its deregulation in cancer cells.

48 Our results suggest that epigenetic deregulation in cancer not only targets tissue-specific

49 Our results provide an example of EGFR deregulation in cancer through silencing of components o

50 c screen comparing two common events of PI3K deregulation in cancer: oncogenic Pik3ca mutation (Pik3c

51 Greater understanding of Hippo pathway deregulation in cancers will be essential to guide the i

52 al for cortical function and may be sites of deregulation in developmental brain disorders.

53 We propose that in obesity, there is deregulation in differentiation of intestinal epithelial

54 ngs highlight the involvement of AMPK/mTORC1 deregulation in DM1 muscle pathophysiology and may open

55 eate super-enhancer-mediated transcriptional deregulation in Ewing sarcoma, and uncover numerous cand

56 ole transcriptome analysis revealed a global deregulation in genes implicated in apoptosis and immuni

57 l an important mechanism contributing to Myc deregulation in human breast cancer.

58 a pivotal role in animal development and its deregulation in humans causes birth defects and several

59 ems to facilitate further study of chromatin deregulation in lung cancer.

60 lso found large transcriptional and splicing deregulation in mesial temporal lobe epilepsy with hippo

61 s the number of neurons with delayed calcium deregulation in response to high concentrations of gluta

62 pathway is the primary cause of neurogenesis deregulation in the absence of CSP-alpha.

63 a previously unappreciated role of epigenome deregulation in the genesis of 13% of HPV-negative HNSCC

64 This cognitive deficit is consecutive to PKA deregulation in the mPFC that prevents Ophn1 KO mice to

65 Deregulation in the number of centrosomes triggers tumor

66 of acute APC loss and subsequent Wnt pathway deregulation in vivo.

67 issue microenvironment in regulating barrier deregulations in tissue-specific manner.

68 und that aSyn induced severe transcriptional deregulation, including the downregulation of important

69 MicroRNA deregulation is a consistent feature of glioblastoma, ye

70 Epigenetic deregulation is a hallmark of cancer characterized by fr

71 Metabolic deregulation is a hallmark of human cancers, and the gly

72 isease; (2) to test the hypothesis that SOX2 deregulation is a key early event in the pathogenesis of

73 ds to environmental and genetic cues and its deregulation is a major driver of liver disease.

74 Thus, we propose that mitochondrial calcium deregulation is a novel pathogenic mechanism of cognitiv

75 Hippo pathway deregulation is also enriched in squamous epithelial can

76 MicroRNA (miRNA) deregulation is common in human colorectal cancers, but

77 has potent signaling functions and that its deregulation is connected to disease.

78 crucial for cellular homeostasis, and their deregulation is frequently associated with tumorigenesis

79 se to type I IFNs, another key pathway whose deregulation is linked to autoimmunity.

80 ining molecular events underlying PPM1A/PTEN deregulation is necessary to develop expression rescue a

81 Transcriptional deregulation is one of the core tenets of cancer biology

82 Sample-specific network neighborhood deregulation is quantified via the error incurred in pre

83 ous types of T-cell lymphomas, the extent of deregulation is significantly higher in BIA-ALCL, as ind

84 Its deregulation is strongly linked to disease onset and pro

85 an size control and tissue homeostasis, with deregulation leading to cancer.

86 glucose metabolism, malate-aspartate shuttle deregulation leads to a specific proliferative block due

87 lly important to T cell development, and its deregulation leads to leukemia.

88 in maintaining cellular homeostasis, and its deregulation leads to the corruption of a plethora of ce

89 oRNA (miRNA) and messenger RNA (mRNA), whose deregulation may be sensitive to environmental insult le

90 her, our data suggest that FUS-driven Sema5a deregulation may underlie the cognitive deficits in FUS

91 model for haploinsufficient transcriptional deregulation mediated by higher order genome architectur

92 ylation contribute to the observed recurrent deregulation of 235 lncRNAs.

93 quently activates the NLRP3 inflammasome, to deregulation of a tumor virus, and 4) demonstrate that B

94 -) mice display sex-specific transcriptional deregulation of a wide range of bile and steroid metabol

95 Deregulation of adherens junctions by downregulation of

96 In sum, deregulation of all three PPs appears central to neoplas

97 tability, localisation and coding potential, deregulation of APA can disrupt gene expression and this

98 These tumors lack deregulation of APC/beta-catenin signaling components, w

99 that inability to produce threonine leads to deregulation of aspartate kinase, causing flux imbalance

100 berrant synaptic development and ion channel deregulation of auditory brainstem circuits, to impaired

101 Deregulation of autophagy is involved in numerous diseas

102 data for these leukaemia risk loci suggests deregulation of B-cell development and the cell cycle as

103 lack of the SLE risk variant Def6 results in deregulation of Bcl6 protein synthesis in T cells as a r

104 tigate the dire consequences of simultaneous deregulation of both the Ras and Hippo pathways.

105 cordingly, surgically or genetically induced deregulation of brain rhythmicity led to disrupted circa

106 The deregulation of c-Myc is frequently associated with canc

107 Deregulation of C/EBPalpha by microRNAs during granulopo

108 oliferative deficiencies and transcriptional deregulation of cancer genes CCNB1IP1, CDH1, and CDKN2B,

109 kidney disease, a phenotype associated with deregulation of canonical (beta-catenin-dependent) Wnt s

110 ugh two distinct mechanisms, both leading to deregulation of canonical kinesin motor activity.

111 ibits bile acid binding to FXR, resulting in deregulation of cellular bile homeostasis.

112 M1-associated muscle pathology is related to deregulation of central metabolic pathways, which may id

113 We suggest that the deregulation of central, interaction-prone proteins may

114 Our data revealed the deregulation of certain transcripts in T2D patients.

115 y-causing lamin A mutation to an unsuspected deregulation of chromatin states and spatial conformatio

116 These early events were concomitant with deregulation of circulating miRNAs, which were predicted

117 plement regulator Factor H, resulting in the deregulation of complement activation.

118 We conclude that the deregulation of complement regulation by the FHR5 mutant

119 Deregulation of consolidation and reprocessing of mnemon

120 biophysical measurements to investigate how deregulation of cortex tension in the oocyte contributes

121 One such mechanism is deregulation of CREB-regulated transcriptional coactivat

122 The present study confirmed a deregulation of CREB1 protein in the clear cell type of

123 observed signaling changes may contribute to deregulation of critical developmental signaling cascade

124 Deregulation of CRTC1 dephosphorylation, nuclear translo

125 f AR indifferent growth, which was caused by deregulation of cyclin D/E, E2F1, RB1, and increased Myc

126 Deregulation of cyclin-dependent kinases 4 and 6 (CDK4/6

127 This work connects deregulation of differentiation with increased prolifera

128 enotoxic stress response pathways, including deregulation of DNA damage/replication stress response,

129 Conversely, deregulation of Dnmt3b is thought to generally promote t

130 nding and innate GTPase activity, leading to deregulation of downstream signal transduction.

131 , to fight metastasis and therapy resistance.Deregulation of E2F family transcription factors is asso

132 Such molecular re-programming results in deregulation of early development checkpoints culminatin

133 chondrial dysfunction has been linked to the deregulation of energy homeostasis, the precise mechanis

134 Our data demonstrate significant deregulation of epigenetic regulators combined with disr

135 onditions as nondiabetic PTECs, signified by deregulation of fibrotic and transport-associated genes

136 Deregulation of FOXM1 occurs in a wide variety of epithe

137 Crohn's disease could lead to or result from deregulation of FOXP3/EZH2-enforced T cell gene networks

138 rons derived from ID patients have extensive deregulation of gene expression affecting pathways neces

139 th patients frequently exhibiting mutations, deregulation of gene expression, or alterations in the f

140 f of all chromatin loops in mESCs and causes deregulation of gene expression.

141 lla nrpd1 microspores was accompanied by the deregulation of genes targeted by Pol IV-dependent siRNA

142 s provide the pathophysiologic basis for the deregulation of glucose and NaCl homeostasis of diabetes

143 ty, diabetes, and hypertension triad (ODHT), deregulation of glucose and NaCl homeostasis, respective

144 Our device design was based on the deregulation of HfQ protein in E.coli in microgravity, w

145 t heightened inflammation is associated with deregulation of homeostatic interactions between intesti

146 The anemia signature indicated deregulation of host erythropoiesis, and the lung inflam

147 Deregulation of innate immune TLR4 signaling contributes

148 re, we discuss the mechanisms leading to the deregulation of integrin signaling in cancer and its var

149 d mucosa proteomic analysis indicated severe deregulation of intracellular bile acid (BA) homeostasis

150 Deregulation of IP(3)Rs leads to pathological calcium si

151 Mutations in human DDX3X and deregulation of its expression are linked to tumorigenes

152 iASPP cellular localization, with consequent deregulation of its function.

153 s with elevated LNJ expression levels showed deregulation of JA signaling as well and displayed reduc

154 elopmental sequence in vivo, indicating that deregulation of KCC2 could be a risk factor for the emer

155 ple-label SILAC proteomics profiles reveal a deregulation of key cell cycle regulators in lincNMR-dep

156 s within the bone marrow and transcriptional deregulation of key genes involved in adult stem cell ma

157 tome analysis shows that PHF19 loss promotes deregulation of key genes involved in growth, metastasis

158 ge phenotype transition, and transcriptional deregulation of key inflammatory and repair-related gene

159 modulate HCC prognoses through differential deregulation of key lncRNAs affecting important gene net

160 yses reveal epigenetic memory underlying the deregulation of key target genes in T2D-PTECs that may c

161 Deregulation of KRAS4b signaling pathway has been implic

162 nocarcinoma (PDA) cells, which can occur via deregulation of lineage-specifying transcription factors

163 ytokines reduces Atg2 expression, permitting deregulation of lipid droplets.

164 , hepatocyte ATX ablation and the consequent deregulation of lipid homeostasis was also shown to atte

165 ation of GM-CSF and efferocytosis as well as deregulation of lipid metabolism in residual tumor cells

166 ancreatic ER stress, impaired autophagy, and deregulation of lipid metabolism.

167 RNA-sequencing analysis following deregulation of lncRNA NPC48 revealed a potential link w

168 RNA sequencing analyses revealed the deregulation of marker genes for basal and secretory cel

169 elope, increased F-actin/G-actin ratios, and deregulation of mechanoresponsive myocardin-related tran

170 Although deregulation of MEK/extracellular signal-regulated kinas

171 Deregulation of metabolism and disruption of genome inte

172 t from hyperactivation of AKT and consequent deregulation of metabolism.

173 Finally, TRPM2 silencing resulted in deregulation of metastatic markers and abolished the tum

174 ons and nutrient factors, a link between the deregulation of microRNA (miRNA) expression and the deve

175 Deregulation of microRNAs (miRNAs) has been demonstrated

176 izure activity in chronic epilepsy, and that deregulation of miR-135a in epilepsy may alter Mef2a exp

177 ly, are identified that begin to explain how deregulation of miR-135a may contribute to epilepsy.

178 ensate for increased insulin resistance, but deregulation of miRNA expression can also directly cause

179 confirm that overexpression of DICER rescues deregulation of miRNAs by mda-7/IL-24, partially rescuin

180 Therefore, deregulation of miRNAs was assessed in whole lungs from

181 ss-of-function mutations in ANKZF1 result in deregulation of mitochondrial integrity, and this may pl

182 Deregulation of mitochondrial network in terminally diff

183 Our data also suggest that the deregulation of mitochondrial nucleoside diphosphate kin

184 SCAF4-deficient individuals revealed a broad deregulation of more than 9,000 genes and significant di

185 echanisms that result in the transcriptional deregulation of mRNA expression in melanoma cells and as

186 Deregulation of mTOR complex 1 (mTORC1) signalling incre

187 Deregulation of mTORC1 has been associated with the path

188 Thus deregulation of mTORC1-dependent pathways controlling pr

189 independent patient cohorts we confirmed the deregulation of multiple costimulatory ligands on AML bl

190 is in affected individual fibroblasts showed deregulation of multiple genes that control development.

191 omic and phosphoproteomic profiling revealed deregulation of multiple pathways, significantly the Not

192 The frequent deregulation of MYC and its elevated expression via mult

193 Deregulation of MYC plays an essential role in T cell ac

194 Accordingly, deregulation of ncRNA expression has been associated wit

195 downstream of UPF3B mutations involving the deregulation of NDD-gene networks.

196 oblastoma and suggest that events leading to deregulation of neurodevelopmental processes, such as in

197 certain regulatory elements, the subsequent deregulation of oncogenic gene expression can drive or e

198 Transcriptional deregulation of oncogenic pathways is a hallmark of canc

199 Deregulation of p16INK4A is a critical event in melanoma

200 orly understood; recent studies suggest that deregulation of p25/Cyclin-dependent kinase 5 (Cdk5) act

201 e STAT3, which provides evidence linking the deregulation of palmitoylation to inflammation and cance

202 Deregulation of paRNA-based epigenetic networks may cont

203 Our results demonstrate that the deregulation of pathways involved in T cell-mediated all

204 Here, we investigated how deregulation of PIP2;5 expression affects water relation

205 PRC2 catalytic subunit EZH2, and genome-wide deregulation of polycomb-regulated genes.

206 sults reveal systematic and multidimensional deregulation of protein synthesis, showing how this majo

207 Deregulation of proteolytic systems is a known path lead

208 s de-novo variants and expected to result in deregulation of purine metabolism.

209 Deregulation of PV5 expression renders P. berghei hypers

210 Transcriptional deregulation of PV5 in the rodent parasite Plasmodium be

211 Deregulation of quiescence exit is associated with many

212 DFUs, which is facilitated by FOXM1-mediated deregulation of recruitment of neutrophils and macrophag

213 scription outside coding sequence identifies deregulation of repetitive elements in Morc2a mutants an

214 sed demand for nucleotides stemming from the deregulation of RNA polymerase (pol) III transcription.

215 me, where it participated in rapalog-induced deregulation of RNA splicing.

216 vity is reduced by rapamycin suggesting that deregulation of S6K1 activity may be beneficial in HD.

217 caused reduction in mitochondrial number and deregulation of several mitochondrial genes, suggesting

218 ric disorders, which are associated with the deregulation of several neurotransmission systems.

219 germline hypomorphic variants of SUFU cause deregulation of SHH signaling, resulting in recessive de

220 Deregulation of some aspects of DDR orchestration is pot

221 ropose a novel mechanism responsible for the deregulation of SOS autoactivation, where I24N, T50I, V1

222 enetic and microenvironmental context, acute deregulation of SOX2 drives bronchial dysplasia.

223 A growing body of evidence links deregulation of sphingolipids to several diseases, inclu

224 drome and its development is associated with deregulation of systemic lipid and glucose homeostasis.

225 demonstrate that TbPolIE depletion leads to deregulation of telomeric variant surface glycoprotein g

226 Deregulation of TGF-beta family signaling leads to devel

227 In turn, cell-intrinsic deregulation of TGF-beta signaling is associated with in

228 , many vascular malformations are related to deregulation of TGF-beta/BMP signaling.

229 d vascular malformations that are induced by deregulation of TGF-beta/BMP signaling: hereditary hemor

230 atic ductal adenocarcinoma, resulting in the deregulation of the apoptotic pathway.

231 At diagnosis, deregulation of the bone morphogenetic protein (BMP) pat

232 ultaneous targeting of AKT and WEE1 enhanced deregulation of the cell cycle and DNA damage repair pat

233 Deregulation of the cell cycle machinery is a hallmark o

234 limited data are available to understand if deregulation of the cell-cell adhesion programme is impo

235 epithelial tissue integrity and support the deregulation of the cell-cell adhesion programme,which p

236 colony stimulating factor (GM-CSF), through deregulation of the expression of cell-to-cell interacti

237 ostulated that it may be responsible for the deregulation of the filtering bleb and subsequent loss o

238 etion of this locus via CRISPR-Cas9 leads to deregulation of the genes predicted to interact with the

239 Deregulation of the HECT-type ubiquitin ligase E6AP (UBE

240 BAP1-deficient tumors exhibit deregulation of the Hippo pathway.See related commentary

241 Deregulation of the HPA axis and a feed-forward effect o

242 Thus, deregulation of the IGF2 and adhesion-mediated signaling

243 ks) support a disease mechanism in which the deregulation of the IL21 signalling pathway, in addition

244 Notably, we found that deregulation of the Lin28/let-7 axis with reduced produc

245 le in lung tumorigenesis, demonstrating that deregulation of the LINC00261/FOXA2 locus disrupts DNA d

246 tively activated macrophages, contributed by deregulation of the miR-155 target gene the liver X rece

247 The present study confirms the deregulation of the NF-kappaB alternative pathway in NSC

248 Taken together, our data demonstrate that deregulation of the PI3K-AKT/ mTORC1/ p70S6K pathways, a

249 T58I, and G60E-populate their active form by deregulation of the previously documented Ras GTPase act

250 Deregulation of the RAS GTPase cycle due to mutations in

251 d to the 22q11.2 region, it is proposed that deregulation of the SPECC1L gene could be implicated in

252 etween gene expression and the proteome, and deregulation of the splicing machinery is linked to seve

253 ale spiking activity recordings a concurrent deregulation of the spontaneous network activity and hom

254 h the anticancer compound Minnelide revealed deregulation of the TGFbeta signaling pathway in CAF, re

255 Deregulation of the transcriptional repressor BCL6 enabl

256 Together, these results implicate deregulation of the Wnt/beta-catenin pathway in CNS infl

257 Loss of APC function results in deregulation of the Wnt/beta-catenin signaling pathway c

258 Deregulation of the Wnt/beta-catenin signaling pathway d

259 ception is in RPGN where podocytes undergo a deregulation of their differentiated phenotype and proli

260 new approach for subtyping samples based on deregulation of their gene networks.

261 depend on the growth stage of cells and that deregulation of their relative abundance alters LD morph

262 es in biomass and flowering time suggested a deregulation of their respective regulatory genes CIRCAD

263 The deregulation of these mechanisms can account for the bal

264 Deregulation of these molecular machines may lead to str

265 Herein, we review the mechanisms of deregulation of these oncogenes.

266 Deregulation of this centralized signaling pathway has b

267 The deregulation of this enzyme results in dampened mitochon

268 the inositol ring of phosphoinositides, and deregulation of this pathway has implications in many di

269 Deregulation of TJ is a hallmark of epithelial-mesenchym

270 impaired in FL-N/35 primary hepatocytes via deregulation of TNFalpha/SOCS3.

271 Deregulation of transcription factors (TFs) is an import

272 Deregulation of transcription factors is a frequent occu

273 ic and epigenetic alterations that result in deregulation of transcriptional networks.

274 n, and many diseases are associated with the deregulation of transcriptional networks.

275 neurodevelopmental syndromes associated with deregulation of ubiquitin signaling.

276 enomic and transcriptomic profiling revealed deregulation of various genes involved in genome stabili

277 nsformation and carcinogenesis involving the deregulation of various molecular processes such as lipi

278 Deregulation of VHR is observed in various malignant dis

279 om cell cycle control to developmental fate, deregulation of which contributes to developmental defec

280 but often poorly described functions and the deregulation of which leads to numerous diseases.

281 ant R-spondin/LGR4 signaling with consequent deregulation of Wnt (co)receptor turnover as a driver of

282 erebellar disease pathogenesis caused due to deregulation of Wnt signaling.

283 ition gene for Atopic dermatitis, suggesting deregulation of Wnt/FZD signaling a possible cause for t

284 Emerging evidence indicates that deregulation of YAP/TAZ signaling may be a major mechani

285 Deregulation of ZAP-70 using tyrosine kinase inhibitors,

286 However, the impact of gene deregulation on the dynamics of genetic cooperativity in

287 oid system and highlight the impact of their deregulation, placing a particular emphasis on their 'da

288 common post-translational modification whose deregulation plays a key role in the pathogenesis of man

289 naling, as two key pathways where epigenetic deregulation preferentially targets extracellular compon

290 o tumor invasion and metastases, whereas its deregulation reduces resistance to chemotherapeutic drug

291 a (T-ALL), yet the mechanisms underlying its deregulation remain elusive.

292 MDM2, but the underlying molecular basis for deregulation remains elusive.

293 Finally, these corticostriatal deregulations resulted in a behavioral phenotype suggest

294 il recently, the paradigm was that oncogenic deregulation results from either loss of growth restrain

295 It is also unknown whether barrier deregulations, similar to the gut, characterize other vi

296 rt a novel mechanism of alternative splicing deregulation that may play a role in various other disea

297 evious efforts to understand transcriptional deregulation through transcription factor networks, the

298 tive memory, and provide evidence that CRTC1 deregulation underlies memory deficits during neurodegen

299 Importantly, transcriptional deregulation was concomitant with reduced binding of aSy

300 olving EP300 and CREBBP may cause epigenetic deregulation with potential for therapeutic targeting.