ライフサイエンスコーパス: derepression

1 rved Dut motif IV is also implicated in SaPI derepression.

2 harmacodynamics using downstream target gene derepression.

3 ceRNA expression change required to observe derepression.

4 t shock promoters, supporting a mechanism of derepression.

5 e-dependent BACH1 degradation and rapid Spic derepression.

6 bition of the PI3K/AKT pathway leads to gene derepression.

7 the same biological outcome, transcriptional derepression.

8 mechanisms of transcriptional repression and derepression.

9 y correlate with the level of VirB-dependent derepression.

10 ur's facile switching between repression and derepression.

11 epression of piRNA metabolism and transposon derepression.

12 which subsequently leads to transcriptional derepression.

13 d H3K4me2 methylation on HSPC genes and gene derepression.

14 o RcnR in six-coordinate sites, resulting in derepression.

15 ousands of genomic sites and associated gene derepression.

16 from the catastrophic consequences of their derepression.

17 el, but in this case, independent of Xi gene derepression.

18 lly retain sufficient H3K27me3 to avoid gene derepression.

19 sed BCL6 targets were enriched for early cGH derepression.

20 1 neonates because of intestinal UGT1A1 gene derepression.

21 ss of H3K9me3 deposition and transcriptional derepression.

22 pose the physical coupling of activation and derepression activities coordinates transcriptional acti

23 ced at ERVs upon H3.3 deletion, resulting in derepression and dysregulation of adjacent, endogenous g

24 ly, these data demonstrate preferential gene derepression and ERV reactivation in AML with chromosoma

25 he SaPIbov1 Stl master repressor, leading to derepression and mobilization.

26 omatin, whereby FACT knockdown results in ES derepression and more open chromatin around silent ES pr

27 d mouse primary lymphoma cells leads to RBL2 derepression and RB1 reactivation, which in turn inhibit

28 only the apo form of DutNM1 is active in Stl derepression and that dUTPase activity is not necessary

29 CsMAF1 affinity to CsC34, leading to Pol III derepression, and that Ser 45, found only in plant MAF1

30 tumor cells), a window of opportunity for L1 derepression arises, and additional restriction mechanis

31 protein stability and identifies proteolytic derepression as highly dynamic in regulating the transcr

32 erase 3B (DNMT3B) are a likely cause of D4Z4 derepression associated with low levels of DUX4 expressi

33 uctive elongation state, accompanied by gene derepression at nascent and processed transcript levels.

34 ant flies are sterile and exhibit transposon derepression because piRNA-loaded Piwi is unable to esta

35 referential alkaline-expression results from derepression by depletion of the acid-prevalent PacC(72)

36 ment of dUTP binding and dUTPase activity in derepression by DutNM1.

37 the slow mutant: 3' UTR shortening and gene derepression by premature transcription termination of u

38 Zur is well-studied, little is known on how derepression by Zur could be facilitated.

39 rmore, we demonstrate that tunable levels of derepression can be achieved (up to 95%) by designing as

40 Several defects were observed in the derepression circuit in Neurog2(-/-);Ascl1(-/-) mutants:

41 However, Neurog2 was unable to influence the derepression circuit when misexpressed in late cortical

42 arly cortical progenitors via input into the derepression circuit while also influencing other tempor

43 Derepression comes from unbinding of the regulator, whic

44 Gene derepression correlates with a decrease in H3K27me3 and

45 etting of a beta-lactam compound, (2) stable derepression due to mutations in ampC regulatory genes,

46 lete, however, allowing G2/M-specific VSG ES derepression following knockdown of histone H3.

47 deletions of rsmA, rsmE or rsmI caused minor derepression in CfcR translation compared to a DeltarsmI

48 ese genes in the absence of iron, as well as derepression in the absence of Fur.

49 3K27me3-lacking sperm chromosomes results in derepression in the germline of somatic genes, especiall

50 had reduced DNA methylation correlated with derepression in the pkl mutant, though for the majority,

51 ehavior is the Hox gene Ultrabithorax, whose derepression in two metameric neurons leads to self-righ

52 nts effectively reversed the transcriptional derepression incurred in the UBR5 and BMI1 KO cells.

53 pomethylation, loss of H3K9me and transposon derepression indicate that S-adenosylmethionine-dependen

54 However, disentangling primary target derepression induced by miRNA inhibition from secondary

55 This argues that the observed ES derepression is a direct consequence of histone chaperon

56 these data suggest that biosynthetic pathway derepression is a general consequence of some antibiotic

57 LINE-1 derepression is associated with a number of disease stat

58 Somatic DUX4 derepression is caused either by a 1-10 unit repeat-arra

59 The control of NCoR1 function and derepression is linked to IKKbeta function, as validated

60 Derepression is marked by accelerated metabolic and oxid

61 ational change leading to substrate-mediated derepression is primarily caused by a rigid body rotatio

62 formational changes leading to drug-mediated derepression is primarily due to a rigid body rotational

63 The derepression is specific to telomeric ESs, and it coinci

64 odel of hair cell regeneration, we show that derepression is sufficient to induce Atoh1 expression, s

65 deficiency sensitized CD8(+) T cells to Cd4 derepression mediated by compromised functions of histon

66 nd BC for liver fibrosis by way of Ppargamma derepression mediated by suppression of canonical Wnt si

67 A derepression mode of cell-fate specification involving t

68 Consistent with p53 derepression, NF90/NF45-depleted HeLa cells displayed el

69 ional and posttranscriptional mechanisms, L1 derepression occurs in developmental and pathologic cont

70 FOXO1 represses DIO2 during fasting and that derepression occurs via nutritional activation of the PI

71 n reducing serotonergic neurotransmission by derepression of 5-HT1A autoreceptors.

72 tif for the ARID5B repressor, which leads to derepression of a potent preadipocyte enhancer and a dou

73 induced lignification can be achieved by the derepression of a set of lignin genes.

74 ndamental link between Nodal signalling, the derepression of a specific class of poised promoters dur

75 on concentrated near the chromosome ends and derepression of a subset of associated subtelomeric gene

76 of one of the tail subunits SIN4 results in derepression of a subset of genes, including FLR1, by a

77 these changes were attributable, in part, to derepression of ACTA2 transcription.

78 equestration in the cytoplasm and subsequent derepression of AI-2-related genes necessary for quorum

79 r results in degradation of the Aux/IAAs and derepression of ARF-based transcription.

80 s heterochromatin at late origins and causes derepression of associated genes.

81 ns, leading to lower RNAII transcription and derepression of aur transcription.

82 degraded via the 26S proteasome, leading to derepression of auxin response factors (ARFs).

83 rains except that encoding G154D BirA showed derepression of bio operon transcription upon overproduc

84 This is mediated in part by derepression of Bmp4 and the tumor suppressor Rb1, which

85 iron limitation in B. subtilis resulting in derepression of both Fur- and PerR-regulated genes.

86 ipt levels of the auxin transporter PIN1 and derepression of bud outgrowth.

87 g a signaling mechanism involving NO-induced derepression of catalytic activity.

88 oth miR-449a and miR-424 in OS, resulting in derepression of CCNA2 and appearance of aggressive cance

89 loss of TCF-1 and LEF-1 unexpectedly caused derepression of CD4 expression in T cells committed to t

90 ion at the large pre-B-cell stage and caused derepression of cell adhesion and cell migration signali

91 retinogenesis, the most dramatic change was derepression of cell-type-specific differentiation progr

92 Compromised cellular identity occurs by derepression of characteristic stomach genes, some of wh

93 that is probably secondary to inappropriate derepression of cholesterol biosynthesis.

94 to tetrameric CsoRs mediates transcriptional derepression of copper resistance genes.

95 chondrocyte proliferation is due in part to derepression of cyclin-dependent kinase inhibitors Ink4a

96 in imgi2 is caused by a development-specific derepression of cytokinin signaling that involves cross

97 nto the rot promoter by IS256 results in the derepression of cytotoxin expression and increased virul

98 nt, incurable myopathy, linked to epigenetic derepression of D4Z4 repeats on chromosome 4q, leading t

99 PK3 plants are dwarfed and display a massive derepression of defense genes associated with spontaneou

100 ouse embryonic stem cells (mESCs) causes the derepression of developmental genes and induction of ear

101 which leads to epigenetic reprogramming and derepression of developmentally silenced genes.

102 The underlying mechanism is transcriptional derepression of DIO2 through the mTORC2 pathway as defin

103 psis genes, AtMORC1 and AtMORC6, which cause derepression of DNA-methylated genes and TEs but no loss

104 hat in vivo occupancy of Fur correlates with derepression of each operon, and the graded response obs

105 he EGFR promoter, results in transcriptional derepression of EGFR, and increased EGFR pathway output.

106 decreases in H4K20me3 and H3K9me3 levels and derepression of endogenous LTR- and LINE-repetitive DNA

107 ggered loss of SUMO-modified TRIM28 leads to derepression of endogenous retroviral (ERV) elements, un

108 Deleting either motif led to the derepression of Esco1-proximal genes and functional unco

109 n has been attributed to the transcriptional derepression of Esrrb, the molecular mechanism mediated

110 Transcriptional derepression of F-box protein 32 (FBXO32) (Atrogin1/MAFb

111 the exoribonuclease Xrn1, to compensate the derepression of FET4.

112 degeneration throughout postnatal life, via derepression of fetal expression of Six1 and its targets

113 any different promoters and is necessary for derepression of FLR1 in sin4Delta cells.

114 chanistic model for formaldehyde-sensing and derepression of frmRA(B) expression in numerous bacteria

115 rrest in far1 cln2 cells, along with partial derepression of G1/S genes, which implies a repressor-in

116 es, resulting in reduced DNA methylation and derepression of genes at subtelomeres, e.g. Zscan4.

117 Here, we show that an extensive derepression of genes involved in DNA metabolism and cel

118 then contributes to heterochromatin loss and derepression of genes involved in immune responses.

119 loop in intestinal epithelial cells lead to derepression of genes involved in intestinal maturation

120 assium channels and amino acid transporters, derepression of genes marked with histone H3 lysine 27 t

121 7-trimethylation, as well as transcriptional derepression of genes on the inactive X that cannot be r

122 omotes histone deacetylation, and attenuates derepression of genes under water stress.

123 t murine Mysm1 participates in transcription derepression of genes, among which are transcription fac

124 Derepression of germline genes, protocadherins, Rhox gen

125 the BAHCC1(BAH)-H3K27me3 interaction, causes derepression of H3K27me3-targeted genes that are involve

126 eus Molecule 1 (MOM1) causes transcriptional derepression of heterochromatin independently of changes

127 ASXL1-MT resulted in derepression of homeobox A9 (Hoxa9) and microRNA-125a (m

128 Low EZH2 levels resulted in derepression of HOX genes, and knockdown of HOXB7 and HO

129 MDS-like disease in mice is associated with derepression of Hoxa9 and miR-125a and with Clec5a dysre

130 escape senescence by mechanisms that involve derepression of hTERT expression.

131 ing the complete HPV16 genome results in the derepression of IFNK transcription and subsequent JAK/ST

132 SMRT from cultured human adipocytes promoted derepression of inflammatory transcription and elevation

133 obal yet nonuniform loss of DNA methylation, derepression of inflammatory transcriptional programs, d

134 wild-type or Trask-deficient mice revealed a derepression of integrin signaling and an enhancement of

135 ed via proteasomal degradation, allowing for derepression of iron target genes.

136 in turn inhibit PRC2 expression and trigger derepression of its CASP10, DAP1, HOXA5, and HRK pro-apo

137 liferation and angiogenic tube formation via derepression of its direct target gene angiotensin II ty

138 Deletion of a silencer caused derepression of its target gene.

139 DNA-binding activity, a mutation that causes derepression of its target genes.

140 mice induces T-ALL by a mechanism involving derepression of its well-known target, Etv4 Importantly,

141 n of the Notch ligand Jag1 in podocytes, and derepression of Jag1 by EZH2 inhibition or knockdown fac

142 ts it does so, at least in part, through the derepression of key actin-regulating proteins.

143 ogical means promoted autophagy flux through derepression of key autophagy effectors (such as ATG5, A

144 pt the epigenetic architecture, resulting in derepression of latent pro-osteogenic and -inflammatory

145 Loss of Dicer leads to derepression of let-7 targets at levels that exceed 10-f

146 on of CD36-driven inflammatory signaling and derepression of liver X receptor activity.

147 We present evidence that derepression of LXRs contributes to this paradoxical ant

148 myb118 mutants exhibit an endosperm-specific derepression of maturation-related genes associated with

149 Surprisingly, while derepression of MdrT resulted in hyperstimulation of IFN

150 ked the effects of TGF-beta, suggesting that derepression of MeCP2 after TGF-beta treatment may be re

151 by downregulating miR-30a-3p and subsequent derepression of MeCP2-mediated epigenetic silencing of S

152 intenance of self-renewing cells by inducing derepression of megabase-sized gene domains harboring do

153 ion, dispersion of heterochromatic foci, and derepression of MET-2 targets.

154 Max deletion in SCLC resulted in derepression of metabolic genes involved in serine and o

155 /ETS fusion protein function that results in derepression of metastasis-associated gene programs.

156 4 enhances myogenesis by contributing to the derepression of MHC transcription.

157 Furthermore, AP-1 is critical for derepression of MIE-driven transcripts and downstream ea

158 c, and immunologically silent tumors through derepression of Mmp14.

159 all six members of this miRNA family causes derepression of multiple cell cycle-promoting proteins,

160 to defects in piRNA biogenesis, resulting in derepression of multiple TE families, gametogenesis defe

161 iber size, impaired muscle regeneration, and derepression of muscle developmental genes.

162 ions in the CAF-I complex caused genome-wide derepression of nascent divergent noncoding transcriptio

163 splay sensitivity to EZH2 inhibitors, due to derepression of neurogenesis genes, including a subset o

164 The derepression of neuronal genes was associated with a los

165 ferentially regulated transcripts, including derepression of non-coding repetitive sequences and thei

166 g in muscle satellite stem cells, leading to derepression of non-muscle-specific genes and p16INK4a,

167 nhibition of the LSD1 demethylase can induce derepression of NOTCH receptor genes and subsequent acti

168 s by integrating activation of NF-kappaB and derepression of NOTCH/RBPJ in myeloid cells through inhi

169 acyl-chain length to determine the degree of derepression of Opi1 target genes.

170 Notably, the VirB-dependent derepression of ospZ requires the same VirB binding site

171 , but not under anaerobic conditions, led to derepression of P(iscR).

172 s of Pbx causes downregulation of Nkx2-5 and derepression of p15Ink4b in spleen mesenchymal progenito

173 irreversible pre-senescence state, caused by derepression of p16(INK4a) (also called Cdkn2a).

174 Loss of Slug promotes derepression of p16(Ink4a) in SCs and accelerates the en

175 ly to be involved in transactivator-mediated derepression of PAI-2 transcription in macrophage-like c

176 rmation of the evening complex, resulting in derepression of PIF4/5.

177 leads to spatial redistribution of PRC2 and derepression of Polycomb responsive genes.

178 atory elements such as enhancers, leading to derepression of polycomb targets including Cdkn2a.

179 (PRC2) loss-of-function phenotypes, causing derepression of PRC2 target genes and developmental pert

180 talytically inactive form of BRG1 results in derepression of PRMT7 target DNA repair genes.

181 tion to pyruvate, are herein associated with derepression of QrpR-repressed pdhQ.

182 arison of transcriptomes indicated a partial derepression of quiescence-related transcriptional progr

183 ar wild-type levels, and efficiently induced derepression of quiescent HSV-1 genomes.

184 uctive reactivation from latency and induces derepression of quiescent viral genomes.

185 GIC displacement was mediated by derepression of Rap1gap and subsequent inhibition of RAP

186 The ensuing derepression of rDNA transcription promotes cell prolife

187 n neighboring cells, due at least in part to derepression of reelin transcription in a manner depende

188 he transcription factor REST) and subsequent derepression of REST-downstream genes GRIA2, NFkappaB2,

189 r, the Zur2:Zn3 form loses Zn(II) leading to derepression of RpsNB(S14*) and FolE2, which allow conti

190 Derepression of RRS1-R or RRS1-S involves effector-trigg

191 such a context, depletion of Tip60 leads to derepression of satellite transcription, decompaction of

192 d fewer in number, which is coupled with the derepression of select TEs.

193 ingly, we found that Eed inactivation causes derepression of several genes, e.g., Sonic hedgehog (Shh

194 orylated at serine 141 (pS141) that mediates derepression of several immune outputs.

195 to anterior forelimb defects resulting from derepression of Shh expression.

196 gfr2 loss-of-function in the ectoderm caused derepression of Shh, revealing a role for FGF in Shh reg

197 YRP in bloodstream form T. brucei results in derepression of silent variant surface glycoprotein ESs,

198 residues within SloR that cause significant derepression of sloABC promoter activity (P < 0.05) comp

199 D because of increased ligand expression and derepression of SMA mothers against decapentaplegic 2/3

200 Derepression of SOCS3 enhances the anti-inflammatory res

201 bition of Cup9 degradation and consequently, derepression of SOK1 transcription.

202 of DICER1 hotspot endometrial tumors reveals derepression of specific miRNA target signatures.

203 Derepression of spxA2 in a saiR mutant required SpxA2, i

204 Our findings suggest that epigenetic derepression of stromal PR could be a potential therapeu

205 ervention had little effect on acid-mediated derepression of sweet neuron or feeding responses to eit

206 Decreased PRMT7 expression also resulted in derepression of target DNA repair genes and enhanced cel

207 tment of PKA activator forskolin resulted in derepression of target genes by reducing its interaction

208 progresses normally in rest mutants despite derepression of target genes during embryogenesis.

209 -transcriptional repressors and differential derepression of targets to enhance T(H)17 differentiatio

210 in the nucleus and involving tissue-specific derepression of TCF by Lbx2.

211 Furthermore, the pattern of derepression of TE families in interspecific hybrids can

212 Depletion of TbOrc1 resulted in derepression of telomere-linked silent VSGs in both BF a

213 Derepression of testis genes, and inappropriate Phf7 exp

214 m cells without Sxl protein exhibit a global derepression of testis genes, including Phf7, a male ger

215 This occurred through derepression of TGF-beta signaling.

216 ated with the transcriptional and epigenetic derepression of the alpha-cell-determining Arx gene in e

217 In particular, derepression of the AmpC beta-lactamase is a common mech

218 the E3 ligase Cul3, or of Bcl6, induced the derepression of the Bcl6 target genes Batf (basic leucin

219 d during growth in nitrate to facilitate the derepression of the chaperonin genes.

220 The pah1Delta mutation resulted in the derepression of the CHO1-encoded phosphatidylserine synt

221 ithin RRS1 that results in distinct modes of derepression of the complex by PopP2 and AvrRps4.

222 spective operator DNAs, which will result in derepression of the corresponding mmpL genes.

223 atin relaxation of the D4Z4 repeat array and derepression of the D4Z4-encoded DUX4 retrogene coding f

224 sites as are required for the VirB-dependent derepression of the divergent icsP gene.

225 Derepression of the Dleu2 promoter via inhibition of his

226 CS develop dozens to hundreds of BCCs due to derepression of the downstream G-protein-coupled recepto

227 ated with local chromatin decondensation and derepression of the DUX4 retrogene.

228 inal transcription factor Hnf4alpha leads to derepression of the embryonal proto-oncogene Hmga2 in Nk

229 on, FAS can be upregulated epigenetically by derepression of the FAS promoter using methotrexate, whi

230 of the coagulation factors V and VIII and a derepression of the fibrinolysis with high plasma levels

231 When iron is limiting for growth, derepression of the Fur regulon increases the cellular c

232 prevents adult beta cell replication through derepression of the gene encoding cyclin-dependent kinas

233 m their cognate promoters, thus resulting in derepression of the glycolytic genes to overcome H2O2-st

234 how that PKA inhibition by ARHGAP36 promotes derepression of the Hedgehog signalling pathway, thereby

235 reaks their anergic phenotype and results in derepression of the Il2 locus, allowing Tregs to display

236 his variant alters RARG function, leading to derepression of the key ACT genetic determinant Top2b, a

237 vated, like other Ca2+-regulated kinases, by derepression of the kinase domain (KD).

238 In the val1 val2 double mutant, derepression of the LEC1, LEC1-LIKE (L1L), and AFL (LAFL

239 the acquisition of effector function through derepression of the let-7 targets, including Myc and Eom

240 (Pol II)-dependent transcripts produced upon derepression of the loci are derived primarily from one

241 th arrest, through a mechanism involving the derepression of the lysomal protease cathepsin B.

242 nd it also displays a growth phase-dependent derepression of the mexAB-oprM operon.

243 e and myofibroblasts and was associated with derepression of the miR-143 target Igfbp5, which impaire

244 Additionally, ZEB1-dependent derepression of the miR-200 and miR-183 target friend of

245 sequently, reduced miRNA processing leads to derepression of the miR-200 target ZEB1, stimulates the

246 Deep RNA-seq revealed a significant derepression of the miR-21 targetome in antimiR-21-treat

247 s9 method differentiate despite the expected derepression of the miRNA targets.

248 n transcription factor Prospero, followed by derepression of the neuroblast factors Deadpan, Asense a

249 environmental conditions that stimulate the derepression of the NRT2.1 gene influences resistance to

250 Targeting of SOCS2 by miR-194 resulted in derepression of the oncogenic kinases FLT3 and JAK2, lea

251 ory region and that loss of Dnmt1 results in derepression of the p53 locus.

252 This derepression of the pap_2 operon is abolished following

253 SdiA in the ydiV mutant does not affect the derepression of the pap_2 operon, suggesting that YdiV c

254 ers was found to correlate with the level of derepression of the reporter genes between the two had6

255 In particular, epigenetic derepression of the RET proto-oncogene by loss of PRC2 r

256 This deletion leads to derepression of the retrotransposon ZAM in the somatic f

257 The initial step in mobilization is the derepression of the SaPI by the interaction of a phage p

258 functional preexisting TA complex as well as derepression of the TA operon.

259 and fibroblasts resulted in transcriptional derepression of the testis genes, indicating that they m

260 at at chromosome 4q35, leading to epigenetic derepression of the transcription factor DUX4; coupled w

261 l for the hfq-negative phenotype were due to derepression of the transcriptional factor RovM.

262 s with ribosomes to facilitate translational derepression of the var2csa coding sequence.

263 silencers in mice results in transcriptional derepression of their interacting genes and pleiotropic

264 methylation of chromatin and transcriptional derepression of these loci.

265 a population of endothelial cells, and that derepression of these programs augments haematopoietic o

266 ing in vivo anti-miR dosing, suggesting that derepression of these targets directly reflects changes

267 Moreover, derepression of this gene network was associated with RU

268 Sustained derepression of this inhibitor after birth represents th

269 We also show that derepression of this operon greatly reduces PQS concentr

270 that the absence of RpoS and the consequent derepression of tick-phase genes impart a Stay signal re

271 ins often leads to concerted upregulation or derepression of tick-specific spirochetal antigens in th

272 wn of the noncoding RNAs was associated with derepression of TNF mRNA and diminished binding of LRRFI

273 tors, only sigL inactivation resulted in the derepression of toxin gene expression in the presence of

274 KAP1 suppression of PRC1 binding or for KAP1 derepression of transcription at pluripotency-associated

275 Shortening of BGRDs is linked to derepression of transcription.

276 Derepression of transposons upon Piwi depletion correlat

277 p binding efficiency and resulted in partial derepression of Ume6p-regulated genes.

278 vere defect in HSPC mobilization through the derepression of Vcam1 in bone marrow stromal cells (BMSC

279 ycistron inactivation was the consequence of derepression of vitamin D signaling via suppression of C

280 chondrocytes, the mutation causes widespread derepression of wild-type miR-140-5p targets and repress

281 Derepression of wild-type p53 by suppressing its negativ

282 le PRMT5 inhibitor, CMP-5, not only leads to derepression of WNT antagonists and decreased levels of

283 taneous disruption of Tsix and PRC2 leads to derepression of Xist and in turn silencing of the single

284 r lysine at position 36 causes a significant derepression of Xist.

285 MD-mediated mRNA stability and translational derepression offers a dynamic mechanism for the rapid ac

286 ciated from chromatin before transcriptional derepression on DNA damage and oxidative stress.

287 nscriptional repressor, RBPJ, and consequent derepression or activation of associated gene promoters.

288 st, increasing HO-1 expression through siRNA derepression or with nonselective pharmacologic inducers

289 dentified egl-1 as a phenotypic target whose derepression partially phenocopies the mir-35-42 mutant

290 hat dUTPase activity may be important to the derepression process.

291 f H3K27me2 results in global transcriptional derepression proportionally greatest in silent or weakly

292 cence response and is mediated by epigenetic derepression through the H3K27-specific demethylase (KDM

293 phorylation that contributes to subtelomeric derepression to a limited extent.

294 Consistent with derepression, up to 311 features are observed in antibio

295 When CAF-1 was lacking, Cd4 derepression was markedly enhanced in the absence of the

296 In addition, Fur derepression was not sufficient for viability in the abs

297 still able to increase Arf, indicating that derepression was not the sole factor.

298 Derepression was particularly noteworthy in metal ion-bi

299 Among the latter were GRHL3, whose derepression was required for the premature differentiat

300 ear relationship with downstream target gene derepression while providing a substantially higher dyna