ライフサイエンスコーパス: desaturase

1 sF (the latter encodes a putative fatty acid desaturase).

2 thase, fatty acid synthase, and stearoyl-CoA desaturase.

3 them from the archetype Delta9 stearoyl-ACP desaturase.

4 anes by transcriptionally regulating a lipid desaturase.

5 f the binuclear nonheme iron enzyme Delta(9) desaturase.

6 of a marker of sebaceous glands, Steroyl-CoA desaturase.

7 almitoyl-monogalactosyldiacylglycerol Delta7 desaturase.

8 o an additional, poorly regiospecific Delta9-desaturase.

9 on pathway that is dependent on stearoyl-CoA desaturase.

10 1 enzymes have been shown to be retinoid 3,4-desaturases.

11 through the action of elongases (ELOVLs) and desaturases.

12 network that upregulates delta-9 fatty acid desaturases.

13 zation, like the soluble plastidial acyl-ACP desaturases.

14 nse to cold, thanks to regiospecific Delta12-desaturases.

15 methane monooxygenase (sMMO) and fatty acid desaturases.

16 mice, we deleted the enzyme dihydroceramide desaturase 1 (DES1), which normally inserts a conserved

17 omerase of this pathway, sphingolipid delta4 desaturase 1 (Des1).

18 olymorphisms were assessed in the fatty acid desaturase 1 (FADS1-rs174556) and 2 (FADS2-rs174575) gen

19 demonstrate that inhibition of stearoyl-CoA desaturase 1 (SCD-1) halts the biosynthesis of unsaturat

20 we show that expression of the stearoyl-CoA desaturase 1 (Scd1) gene is downregulated in LSCs and th

21 lipid reprogramming upon stearoyl-coenzyme A desaturase 1 (SCD1) inhibition.

22 Stearoyl CoA desaturase 1 (SCD1) is a critical lipogenic enzyme that

23 Stearoyl CoA desaturase 1 (SCD1) is a key enzyme in lipogenesis as it

24 Stearoyl-CoA desaturase 1 (SCD1) is a membrane-embedded metalloenzyme

25 Recent evidences suggest that stearoyl-CoA-desaturase 1 (SCD1), the enzyme involved in monounsatura

26 xpression induced expression of stearoyl-CoA desaturase 1 (Scd1), the enzyme responsible for the conv

27 expression and activity of the Stearoyl-CoA Desaturase 1 (SCD1), the hepatic Delta9-desaturase invol

28 Stearoyl-CoA desaturase 1 (SCD1), the key enzyme involved in endogeno

29 tty acid synthase activity from stearoyl-CoA desaturase 1 (SCD1)-mediated desaturation.

30 fatty acid synthase (FASN), and stearoyl CoA desaturase 1 (SCD1)] to AML and eBL cell lines treated w

31 ey lipogenic enzymes, including stearoyl CoA desaturase 1 (SCD1/SCD).

32 x 10(-8)) as a marker of stearoyl coenzyme A desaturase 1 activity, and the ratio of 20:3n-6 to 18:2n

33 onse element-binding protein or stearoyl-CoA desaturase 1 resulted in lethality on high sugar diets.

34 unmasked AR-driven pathways, dihydroceramide desaturase 1 was identified as an AR-regulated gene in m

35 n the FADS1 gene, encoding FADS1 (fatty acid desaturase 1), with risk of several cardiovascular outco

36 es (fatty acid synthase, stearoyl-coenzyme A desaturase 1, and perilipin 2) was drastically reduced b

37 the polymorphisms of coding genes fatty acid desaturase 1-3 for the desaturase enzymes that convert s

38 s in central adiposity and SCD (stearoyl-CoA desaturase)-1 enzyme activity index.

39 ernative retinoid isomerase, dihydroceramide desaturase-1 (DES1), is expressed in RPE and Muller cell

40 entified capacity to inhibit dihydroceramide desaturase-1 (Des1).

41 ctivity of the lipogenic enzyme stearoyl-CoA desaturase-1 (SCD-1), has been shown to be related to ca

42 provides an overview of stearoyl-coenzyme A desaturase-1 (SCD1) as a novel therapeutic target for me

43 Stearoyl-CoA desaturase-1 (SCD1) catalyzes de novo synthesis of monou

44 ffect ORCTL3 targets the enzyme stearoyl-CoA desaturase-1 (SCD1) in fatty acid metabolism.

45 notypic shift was controlled by stearoyl-CoA desaturase-1 (SCD1), an enzyme responsible for the desat

46 Inhibiting the activities of stearoyl-CoA desaturase-1 (SCD1), nuclear factor kappaB (NF-kappaB),

47 synthesis with the activity of stearoyl-CoA desaturase-1 (SCD1).

48 n of lipogenic genes, including stearoyl-CoA desaturase-1 (SCD1).

49 We identify stearoyl-CoA desaturase-1 as a MSI1 target, revealing a feedback loop

50 Aramchol, an oral stearoyl-coenzyme-A-desaturase-1 inhibitor, has been shown to reduce hepatic

51 Mice with a deletion of the Delta(9)-desaturase-1 isoform (SCD1) either globally (Scd1(-/-))

52 the chromophore produced by dihydroceramide desaturase-1, the putative all-trans retinol isomerase i

53 sence of functionally diversified fatty acyl desaturase 2 (Fads2) enzymes, since many teleosts have l

54 thway requiring repeated use of a fatty acid desaturase 2 (FADS2) protein to perform Delta6 desaturat

55 Overexpression of fatty acid desaturase 2 (fads2), which metabolizes LA to downstream

56 rrin (TF), hemochromatosis (HFE), fatty acid desaturase 2 (FADS2)/myelin regulatory factor (MYRF), tr

57 for eSNPs in 3 additional genes: fatty acid desaturase 2 (FADS2; P = .002), N-acetyl-alpha-D-galacto

58 tock with different expression of fatty acid desaturase 2 gene (fads2) a key enzyme in synthesis of l

59 ernatively, some teleosts possess fatty acyl desaturases 2 (Fads2) that enable them to biosynthesis D

60 The fatty acid desaturase-2 rs1535 variant, associated with low baselin

61 y (GWAS) revealed variants in the fatty acid desaturase 3 (FADS3) gene to be significantly associated

62 In parallel, the expression of Fatty Acid Desaturase 3-2 (FAD3-2; converts 18:2 fatty acids to 18:

63 ative stress, and a modulation of fatty acid desaturase activities and plasma and membrane PUFAs towa

64 ated the potential of estimated elongase and desaturase activities for use as predictive markers for

65 Intervention had no effect on estimated desaturase activities.

66 ng increase Delta(9) and Delta(5) + Delta(6) desaturase activities.

67 alysis, each SD increase of log-stearoyl-coA desaturase activity (16:1n-7/16:0 ratio) was positively

68 ed approximately 60% increase in steroyl-CoA desaturase activity and approximately 40% decrease in ve

69 ven divergent FAD2 members that lack Delta12-desaturase activity and differ from canonical FAD2 enzym

70 ed Tmem189 gene lacked plasmanylethanolamine desaturase activity and had dramatically lowered plasmal

71 d 442insA in ahFAD2B eliminate or knock down desaturase activity and have been demonstrated to produc

72 An association between desaturase activity and risk of type 2 diabetes (T2D) ha

73 In contrast, the FADS1 Delta5-desaturase activity and the FADS2 Delta6-desaturase acti

74 hesis of the signal depends on zeta-carotene desaturase activity encoded by the zeta-CAROTENE DESATUR

75 he-sites reactivity could potentially buffer desaturase activity from oxidative inactivation.

76 st study to demonstrate decreased fatty acid desaturase activity in humans with asthma.

77 lines are the only mammals that lack delta-6-desaturase activity in their intestines, which is requir

78 Atherogenicity index and desaturase activity indices were highest in late lactati

79 epithelial cells suggest that inhibition of desaturase activity leads to airway hyper-responsiveness

80 Overall desaturase activity measured with omega-3 fatty acids wa

81 All seven have previously undescribed desaturase activity on very-long-chain fatty acid (VLCFA

82 6 (P = 9.4 x 10(-7)) as a marker of Delta(6)-desaturase activity significantly predicted the worsenin

83 Delta5 and Delta6 desaturase activity was assessed by the product-to-precu

84 ta5-desaturase activity and the FADS2 Delta6-desaturase activity were decreased.

85 be diverted to catalytic, mixed hydroxylase/desaturase activity with aliphatic C-H bonds.

86 ss both stearoyl- and palmitoyl-ACP Delta(9) desaturase activity, including the predominant isoform S

87 led to a total loss of plasmanylethanolamine desaturase activity, strongly decreased plasmalogen leve

88 ther in-tumor variety arising from decreased desaturase activity.

89 dines is essential for plasmanylethanolamine desaturase activity.

90 which encode proteins with in vitro Delta12-desaturase activity.

91 te that fenretinide inhibits dihydroceramide desaturase, an enzyme involved in the biosynthesis of li

92 nases, a fatty-acid-CoA ligase, a fatty acid desaturase and associated oxidoreductases.

93 position by gas chromatography and estimated desaturase and elongase activities as the ratio of produ

94 esters (CEs) and phospholipids and estimated desaturase and elongase activities in children.

95 tor, BMVCP5, that better maintained phytoene desaturase and heat shock protein70-1 (HSP70-1) inserts

96 showed substantial up-regulation of several desaturase and MnP genes in wood-containing medium.

97 mice confirmed that FADS3 is a bona fide LCB desaturase and required for the introduction of the Delt

98 gn the TMEM189 gene to plasmanylethanolamine desaturase and suggest that the previously characterized

99 We found that inhibition of murine delta-6-desaturase and supplementation of their diet with linole

100 use model, which lacks plasmanylethanolamine desaturase and therefore cannot form plasmenyl ether lip

101 through the activity of a fatty acyl Delta11-desaturase and two specialized alcohol-forming fatty acy

102 In nature, desaturases and acetylenases are adept at achieving this

103 n can differentially alter the expression of desaturases and elongases involved in omega-6 and omega-

104 hioesterase, or by suppression of fatty acid desaturases and elongases, resulted in new overall seed

105 Ferredoxin is a substrate of the desaturases and has been previously shown to be a major

106 se involved in chemical communication (e.g., desaturases and odorant receptors).

107 (AA1_1), xylanases (GH10, GH11), fatty acid desaturases and tannases.

108 yl functionality into Leu-Ala(P) acting as a desaturase, and addition of Gly by DhpK in a Gly-tRNA(Gl

109 ings suggest that SAD6 functions as a Delta9-desaturase, and together with FAD3 it increases the leve

110 tly regulates the expression levels of lipid desaturases, and inhibition of desaturases blocks NF-kap

111 The conserved desaturase architecture wherein a surface residue with a

112 Delta9-Desaturases are central enzymes in unsaturated fatty aci

113 tably associate at concentrations typical of desaturase assays.

114 triglycerides, whereas adjustment for other desaturase-associated biomarkers (CRP, fetuin-A, ALT, an

115 vels of lipid desaturases, and inhibition of desaturases blocks NF-kappaB signaling.

116 at is shared by an alternative type of plant desaturase but not by other mammalian proteins.

117 ice with transgenic expression of an omega-3 desaturase capable of enriching tissues with endogenous

118 DEGS1 is the desaturase catalyzing the last step in the main ceramide

119 Plant desaturases comprise two independently evolved classes,

120 ids produced by previously characterized Z11-desaturase/conjugase MsexD2.

121 ncomitant upregulation of several fatty acid desaturases controlled by sterol regulatory element-bind

122 n to physically interact with the fatty acid desaturases CrDelta4FAD and CrFAD6, likely donating elec

123 of the ATG start codon of a putative omega-3 desaturase (CrFAD7; locus Cre01.g038600).

124 In the present study, a bacterial desaturase (crtI) from Pantoea ananatis has been overexp

125 enzymes involved in PUFA metabolism, Delta5 desaturase (D5D) and Delta6 desaturase (D6D), with T2D r

126 of the association between estimated Delta5 desaturase (D5D), Delta6 desaturase (D6D), and stearoyl-

127 en estimated Delta5 desaturase (D5D), Delta6 desaturase (D6D), and stearoyl-CoA desaturase (SCD) acti

128 We examined the hypothesis that delta-6 desaturase (D6D), the rate-limiting enzyme in long-chain

129 tabolism, Delta5 desaturase (D5D) and Delta6 desaturase (D6D), with T2D risk to determine whether ser

130 We demonstrate that plasmanylethanolamine desaturase deficiency causes an accumulation of plasmany

131 ependent fashion and is catalyzed by the DHC desaturase (DEGS) in the de novo ceramide pathway.

132 NHFe(2) family of enzymes: soluble Delta(9) desaturase (Delta(9)D), which desaturates rather than pe

133 scued by inhibitors or mutations of phytoene desaturase, demonstrating that phytofluene and/or zeta-c

134 enases, the nature of a fifth oxidase, GA(4) desaturase (DES), is unknown.

135 this noncanonical pathway is dihydroceramide desaturase (DES1), which catalyzes equilibrium isomeriza

136 We also found the expression of Stearoyl-CoA desaturase, Desat1 mRNA significantly higher in FB overe

137 pecific in planta, as other fatty acids (FA) desaturases do not require peroxiredoxins for their acti

138 dentified that encodes plasmanylethanolamine desaturase (E.C. 1.14.99.19), the enzyme introducing the

139 Inhibition of lipid desaturases effectively eliminated CSCs, suppressed sphe

140 expansion of the number of C. subvermispora desaturase-encoding genes putatively involved in lipid m

141 This might be an indication of increased desaturase enzyme activity for Hurma olives during natur

142 ding genes fatty acid desaturase 1-3 for the desaturase enzymes that convert short-chain polyunsatura

143 s studies have shown that fish can also have desaturase enzymes, endogenous synthesis of these FA can

144 In particular, the genes encoding desaturase enzymes, which is a key to the temperature st

145 ed, respectively, by fatty acyl elongase and desaturase enzymes.

146 gnition of substrates by the hydroxylase and desaturase enzymes.

147 posed mechanism for desaturation in iron-2OG desaturase enzymes.

148 w that CrFAD7 is the only omega-3 fatty acid desaturase expressed in C. reinhardtii, and we discuss p

149 The abundance of a plastid acyl-ACP desaturase (FAB2) is decreased to the same degree as fer

150 rs of the plant integral membrane fatty acid desaturase (FAD) family, FAD2, FAD3, FAD6, FAD7, and FAD

151 ssion of Delta4 and Delta6 Delta5 fatty acyl desaturases (Fad), key enzymes for LC-PUFA biosynthesis,

152 Further, the endoplasmic reticulum-localized desaturase FAD2 can associate with FAD3, as can the plas

153 gase enzymes that are homologs of the oleate desaturases FAD2.

154 addressed by reducing activity of the oleate desaturase, FAD2, in oilseeds.

155 he microsomal omega-6 and omega-3 fatty acid desaturases, FAD2 and FAD3.

156 Transgenic over-expression of a fatty acid desaturase (fad3C) gene of soybean driven by 2S albumin

157 ticipants, 31 SNPs in or near the fatty acid desaturase (FADS) 1 and 2 cluster were associated with c

158 hese steps are encoded for by the fatty acid desaturase (FADS) cluster (chromosome 11, 11q12.2-q13) a

159 otide polymorphisms (SNPs) in the fatty acid desaturase (FADS) gene affect the activity and efficienc

160 r alleles of polymorphisms in the fatty acid desaturase (FADS) gene cluster have been associated with

161 (SNPs) rs1535 and rs174448 in the fatty acid desaturase (FADS) gene cluster have opposite effects on

162 d by genetic variation within the fatty acid desaturase (FADS) gene cluster that is associated with c

163 modified by polymorphisms in the fatty acid desaturase (FADS) gene cluster.

164 Fatty acid desaturase (FADS) genes and their variants have been ass

165 c components, such as variants of fatty acid desaturase (FADS) genes, determine the composition of n6

166 s of LC-PUFAs is regulated by the fatty acid desaturase (FADS) genes, of which a human-specific haplo

167 nes coding for microsomal Delta12 fatty acid desaturases (FADs) from the two Santalaceae species were

168 an event is the evolution of the fatty acid desaturases (FADS) genes, which have been claimed to har

169 identified pheromone-biosynthetic fatty acid desaturases (FADs) MsexD3, MsexD5, and MsexD6 abundantly

170 eleosts have lost the gene encoding a Delta5 desaturase (Fads1).

171 ain fatty acids (FAs) is mediated through FA desaturases (FADS1-FADS2) and may be influenced by dieta

172 lysis, revealing increased expression of the desaturase Fads6 and the key proresolving enzyme Alox-12

173 intaining the expression of the stearoyl-CoA desaturase FAT-7, an oxygen consuming, rate-limiting enz

174 ates heat adaptation by regulating the lipid desaturase FAT-7.

175 t of nematode C-lectin (clec) and fatty acid desaturase (fat) genes.

176 and this reaction is catalyzed by a Delta12-desaturase, FATTY ACID DESATURASE2 (FAD2).

177 onstrated that, with the exception of Delta4 desaturases, fish Fads2 have the ability to operate as D

178 y related very-long-chain fatty acyl (VLCFA) desaturases from Arabidopsis, ADS1.2 and ADS1.4, which h

179 This change in desaturase function enabled the orchid to perfect its ch

180 -insensitive2 (ssi2-2) mutant to confirm the desaturase function of SAD6.

181 g the YXXN domain responsible for the Delta4 desaturase function, and consequently enabling these spe

182 his FoMV vector system, four genes, phytoene desaturase (functions in carotenoid biosynthesis), lesio

183 less fat-1 transgenic mice harboring omega-3 desaturase gene capable of converting omega-6 to omega-3

184 th increased hepatic FAS activity and Delta9 desaturase gene expression.

185 e independent duplications of the fatty acid desaturase gene Fads2 in stickleback lineages that subse

186 d metabolism genes, including the fatty acid desaturase gene OLE1, which is essential for BMV RNA rep

187 The phytoene desaturase gene was silenced with a transient hairpin RN

188 apable of inducing silencing of the PHYTOENE DESATURASE gene.

189 t, M23, with a known FAD2-1A (for fatty acid desaturase) gene deletion.

190 The desaturase genes displayed specific distributions direct

191 be the latitudinal distribution of the lipid desaturase genes in the oceans.

192 ty acids and strongly express two fatty acid desaturase genes, omega3 FATTY ACID DESATURASE3 (FAD3) a

193 Further, we identified a pair of fungal desaturase homologs which contained either an Ile or a G

194 Expression of tung tree FA conjugase/desaturase in Arabidopsis produced approximately 7.5% ES

195 in the function of Ole1, the sole fatty acyl desaturase in yeast.

196 mportance of membrane fluidity modulation by desaturases in the adaptive strategies of Synechococcus

197 Delta9 fatty acyl desaturases introduce a cis-double bond between C9 and C

198 -CoA Desaturase 1 (SCD1), the hepatic Delta9-desaturase involved in the formation of mono-unsaturated

199 ubation, we discovered that wild-type castor desaturase is also capable of forming erythro-9,10-dihyd

200 an indicus-specific extra copy of fatty acid desaturase is under positive selection.

201 In bacteria and fungi one desaturase/isomerase enzyme completes the same series of

202 ng temperature shifts to regulation of lipid desaturase levels and membrane fluidity via an unprecede

203 (Arabidopsis thaliana) acyl-coenzyme A (CoA) desaturase-like (ADS) gene family contains nine genes en

204 mily contains nine genes encoding fatty acid desaturase-like proteins.

205 ation relative to the ancestral housekeeping desaturase may have allowed proto-SAD5's reaction produc

206 possible mechanisms of how a plastid-located desaturase may impact the omega-3 fatty acid content of

207 al di-proline motif in the Drosophila Delta9-desaturase mediates protein degradation by a calcium-dep

208 mediated expression of an omega-3 fatty acid desaturase, mfat-1, normalized blood glucose and insulin

209 APDH) mRNA with a concomitant fall in Delta9 desaturase mRNA expression in LmNcb5or null cell line.

210 crystal structure of the mouse stearoyl-CoA desaturase (mSCD1) it was proposed that Tyr-104, a surfa

211 antage of an Arabidopsis thaliana fatty acid desaturase mutant (fad5) that constitutively forms semic

212 in this work we generated individual castor desaturase mutants carrying residue changes correspondin

213 bservations suggest that ADS2 encodes a 16:0 desaturase of MGDG and PG.

214 species and confirmed the function as Delta4 desaturases of Fads2 from medaka and Nile tilapia.

215 which promotes synthesis of the fatty acids desaturase Ole1.

216 that the Delta(9) acyl-CoA integral membrane desaturase Ole1p from Saccharomyces cerevisiae exhibits

217 Regulation of expression of the fatty acid desaturase Ole1p was hitherto the only known mechanism g

218 hesis of jasmonate (JA), the effects of this desaturase on aphid resistance are not dependent on JA;

219 Silencing of a desaturase (PDS or ZDS) resulted in the induction of the

220 d differed statistically in normal, phytoene desaturase (PDS) gene silent and diseased (infected by B

221 0 progeny plants of Cas12a-mediated phytoene desaturase (PDS) mutagenized regenerants, as well as reg

222 sing the VIGS constructs to silence Phytoene desaturase (PDS) or a ribosomal protein-encoding gene, R

223 ne synthase (PSY), two desaturases (phytoene desaturase [PDS] and zeta-carotene desaturase [ZDS]), an

224 ay catalyzed by phytoene synthase (PSY), two desaturases (phytoene desaturase [PDS] and zeta-carotene

225 FADS1 and FADS2 (desaturases) polymorphisms were associated with higher 1

226 We identified seven elongases and five desaturases possibly involved in EPA production in Nanno

227 and heterozygous deletion of dihydroceramide desaturase prevented vascular dysfunction and hypertensi

228 dipose triglyceride lipase, and stearoyl-CoA desaturase protein was higher in the NWA group, correspo

229 t1 transcripts-all of which yielded the same desaturase protein-and constructed transgenes with the d

230 The phytoene synthase, and carotene desaturase proteins did not display sequence similarity

231 f TMEM189 protein, but not of other selected desaturases, recovered this deficit.

232 This study also demonstrates that the four desaturases redundantly contribute to storage lipid prod

233 Fatty acid desaturases regulate the unsaturation status of cellular

234 This study provides new details of desaturase regulation with therapeutic implications for

235 That soluble desaturases require only one active subunit per dimer fo

236 e identification of two Delta9 palmitoyl-ACP desaturases responsible for omega-7 FA biosynthesis, whi

237 The increased activities of the desaturases resulted in significantly better health indi

238 inding model to the structure of steroyl-CoA desaturase revealed significant differences in the archi

239 he structure-function relationship for these desaturases reveals that their particular substrate spec

240 Stearoyl-acyl carrier protein desaturase (SACPD) activity is essential for production

241 mutated in the stearoyl-acyl carrier protein desaturase (sacpd-c) gene, which were previously shown t

242 Stearoyl-acyl carrier protein desaturase (SACPD-C) has been reported to control the ac

243 action of the stearoyl-acyl-carrier-protein desaturase (SAD) homolog SAD5.

244 y, we observed that four Delta9 stearoyl-ACP desaturase (SAD)-coding genes (FATTY ACID BIOSYNTHESIS2

245 ), Delta6 desaturase (D6D), and stearoyl-CoA desaturase (SCD) activity and T2D risk.

246 Lipid metabolites of stearoyl-CoA-desaturase (SCD) activity were associated with aberrant

247 c acid (PA) catalyzed by stearoyl-coenzyme A desaturase (SCD) activity.

248 tor of the key lipogenic enzyme stearoyl-CoA desaturase (SCD) and that SCD is required for MITF(High)

249 e have shown that repression of stearoyl-CoA desaturase (SCD) enzymes, which regulate the intracellul

250 Changes in stearoyl-coenzyme A desaturase (SCD) expression and activity were evaluated

251 uptake and synthesis and higher stearoyl-CoA desaturase (SCD) expression, Ncb5or(-/-) liver accumulat

252 ucted a mouse trial of a stearoyl-coenzyme A desaturase (SCD) inhibitor ("5b") that prevented alphaS-

253 Stearoyl-CoA desaturase (SCD) is conserved in all eukaryotes and intr

254 Remarkably, liver stearoyl-CoA desaturase (Scd) mRNA expression was by far the most hig

255 screen identified inhibitors of stearoyl-CoA desaturase (SCD) that robustly prevent the alphaS inclus

256 essing the OA-generating enzyme stearoyl-CoA-desaturase (SCD) was protective.

257 s, such as fatty-acid synthase, stearoyl-CoA desaturase (SCD)-1, and apoB.

258 abolism, including induction of stearoyl-CoA desaturase (SCD)-1, which converts saturated to monounsa

259 lls into an active inhibitor of stearoyl-CoA desaturase (SCD).

260 by the oxygen-consuming enzyme stearoyl-CoA desaturase (SCD)1.

261 of the lipid metabolism enzymes stearoyl-CoA-desaturases (SCD) and S-adenosyl methionine synthetase (

262 We predicted that inhibiting the fatty acid desaturase SCD1 may selectively kill cancer cells based

263 nal interaction between Snx14 and Delta-9 FA desaturase SCD1.

264 Tesfay and colleagues show that stearoyl CoA desaturase (SCD1) is expressed at high levels in differe

265 contribution to ferroptosis of stearoyl-CoA desaturase (SCD1, SCD), an enzyme that catalyzes the rat

266 these fatty acids (FA) is influenced by the desaturases, SCD1-4 and the elongase, ELOVL6.

267 of Aspergillus nidulans sphingolipid Delta8-desaturase (SdeA), sphingolipid C9-methyltransferases (S

268 double bond produced by sphingoid LCB Delta8 desaturase (SLD).

269 uble castor Delta9-18:0-acyl carrier protein desaturase, specifically, the hypothesis that the enzyme

270 yl substrate binding tunnel introduces E/Z14-desaturase specificity to mutated MsexD2.

271 ent to a heteroatom (N or O) for most native desaturase substrates.

272 nistic difference from the membrane class of desaturases such as the Delta9-acyl-CoA, Ole1p, from yea

273 ime PCR studies demonstrate a higher Delta12 desaturase, superoxide dismutase, and glyceraldehyde 3-p

274 Conversely, natural desaturase systems proceed through stepwise hydrogen ato

275 ndings should encourage further study of the desaturase systems that may contain unique H-bonding mot

276 inus communis) stearoyl-Acyl Carrier Protein desaturase (T117R/G188L/D280K) that, in addition to intr

277 the fab1 phenotype, we used transgenic 16:0 desaturases targeted to the endoplasmic reticulum and th

278 Caenorhabditis elegans, encoding an n-3 PUFA desaturase that catalyzes conversion of n-6 into n-3 PUF

279 rome P450 CYP710A1, which encodes C22-sterol desaturase that converts beta-sitosterol to stigmasterol

280 that MDT-15 up-regulates fat-7, a fatty acid desaturase that converts saturated fatty acids (SFAs) to

281 st signal located in a cluster of fatty acid desaturases that determine PUFA levels.

282 Moreover, expression of stearoyl-CoA desaturase, the enzyme required for the generation of mo

283 ce by deletion of keratinocyte lathosterol 5-desaturase, then UVR accelerates ionizing radiation-indu

284 Our results unravel FADS3 as a Delta14Z LCB desaturase, thereby disclosing the last missing enzyme o

285 and thereby revealed the functions of these desaturases throughout seed development.

286 Fads2 have the ability to operate as Delta6 desaturases towards C24 PUFA enabling them to synthesise

287 ntact RNA showed that the amount of phytoene desaturase transcripts increased after HHP treatment, an

288 This 'portable desaturase' (Tz(o)Cl) is a bench-stable, commercial enti

289 e-12t-18:1) by a newly identified fatty acid desaturase, UfaD.

290 tion and showed that only the Gly-containing desaturase was capable of very-long-chain desaturation.

291 e biosynthetic activity upstream of phytoene desaturase was similar in Newhall and Cara Cara.

292 lls lacking functional FADS2-mediated Delta6-desaturase were stably transformed with FADS2, FADS1, or

293 ient in the chloroplast 16:1/18:1 fatty acyl desaturase, were discovered to be suppressors.

294 e fat-1 gene encoding for omega-3 fatty acid desaturase, which leads to an increase in endogenous ome

295 , possibly due to the loss of function of FA desaturases, which are iron-requiring enzymes with diiro

296 sm enzymes expressed in skin is the Delta(9)-desaturases, which catalyze the synthesis in Delta(9)-mo

297 with FAD3, as can the plastid-localized FAD6 desaturase with either FAD7 or FAD8.

298 om S. salpa and C. labrosus were both Delta6 desaturases with further Delta8 activity while P. lascar

299 turase activity encoded by the zeta-CAROTENE DESATURASE (ZDS)/CHLOROPLAST BIOGENESIS5 (CLB5) gene in

300 (phytoene desaturase [PDS] and zeta-carotene desaturase [ZDS]), and two cis-trans isomerases (zeta-ca