ライフサイエンスコーパス: descent

1 13 793 cases and 14 027 controls of European descent).

2 ian descent, and 7215 individuals of African descent).

3 o test if those shared CNAs are identical by descent.

4 within a framework incorporating identity-by-descent.

5 cancer cases and 49,793 controls of European descent.

6 lines by sequencing multiple lines of common descent.

7 half of all people with PACG are of Chinese descent.

8 ion studies are based on samples of European descent.

9 rived primarily from populations of European descent.

10 ne receptor type 2) macrophages of embryonic descent.

11 d 6435 cannabis-exposed controls of European descent.

12 and 12,966 individuals without T2D of Latino descent.

13 east cancers in young individuals of African descent.

14 from two unrelated families of Puerto Rican descent.

15 ts and 561 healthy controls, all of Japanese descent.

16 controls from five study groups of European descent.

17 ung premenopausal women and women of African descent.

18 All individuals were of European descent.

19 by men of Asian (27%) and then African (25%) descent.

20 sociated with HD in populations of Caucasian descent.

21 of 37,930 individuals of European and Asian descent.

22 s of oral clefts in a population of European descent.

23 45 604 controls from predominantly European descent.

24 h spectral embedding and stochastic gradient descent.

25 ering therapies in HD patients of East Asian descent.

26 out, but few have been conducted for Chinese descent.

27 ists predominantly in individuals of African descent.

28 were women, and all were of Southeast Asian descent.

29 in studies in cohorts of primarily European descent.

30 tion to current local climate than by common descent.

31 based on studies in populations of European descent.

32 ice the rate seen in populations of European descent.

33 ere predominantly (1296 [92.4%]) of European descent.

34 nantly nonconsanguineous parents of European descent.

35 ffects in 64,421 individuals of non-European descent.

36 e horizontal plane, which simulates vertical descent.

37 romosome and are maintained through vertical descent.

38 eralisability to populations not of European descent.

39 Asian, African American and Mexican American descent.

40 mutagenized BTx623 seeds through single-seed descent.

41 itional results from populations of European descent.

42 to fields that examine and use genealogical descent.

43 ation testing in two populations of European descent.

44 no acid replacement were clonally related by descent.

45 oportionately affects individuals of African descent.

46 ge and Ag pop-out as well as step ascent and descent.

47 e concentrated mainly on cohorts of European descent.

48 ion of these operators via proximal gradient descent.

49 are settings and populations not of European descent.

50 nherits two haplotypes that are identical by descent.

51 ffspring, making microbiomes more similar by descent.

52 g 5321 cases and 16,666 controls of European descent.

53 grants, and fine-scale structure in European descents.

54 lence is 5.5-fold higher in those of African descent (~1:4.1 million).

55 (85.4% vs. 50.6%), and more often of African descent (25.4% vs. 0.5%) than the ROW.

56 are predominantly of self-reported European descent (38%-100%), mostly male (44%-91%) with mean ages

57 tate cancer to be highest in men of European descent (49%), followed by men of Asian (27%) and then A

58 ed services and the majority were of African descent (76.2%) and male (95.2%).

59 individuals (63,526 individuals of European descent, 8765 individuals of Asian Indian descent, and 7

60 d that they were homozygous and identical by descent across their genome.

61 xist, specifically between people of African descent (AD) and European descent (ED) in normal ocular

62 Individuals of African descent (AD) and European descent (ED) with primary open

63 taPPA differs between individuals of African descent (AD) and European descent (ED).

64 cipants of European descent (ED) and African descent (AD) were compared.

65 ntosa (RP) patients of Ashkenazi Jewish (AJ) descent, aiming to identify genotype-phenotype correlati

66 This new method adopts a coordinate descent algorithm to estimate parameters (marker effects

67 ential can be optimized by a simple gradient descent algorithm to generate structures without complex

68 computationally efficient than a coordinate descent algorithm with a local search.

69 ps into the extremely fast cyclic coordinate descent algorithm.

70 ing using empirical estimates of identity-by-descent allele sharing may be useful for studies of comp

71 iate, and we implement a stochastic gradient descent (AMA-SGD) routine for filter learning.

72 ons in 14 genes that were shared identity-by-descent among affected family members.

73 hromosome was identified through identity-by-descent analysis of 3 affected males.

74 puted SNPs in 9,055 participants of European descent and 2,119 African Americans.

75 48 (73.4%) self-identified as being of Cuban descent and 407 (19.2%) self-identified as being from Ce

76 eyes of 67 subjects (24 patients of African descent and 43 of European descent) from the Diagnostic

77 157 healthy subjects (88 patients of African descent and 69 of European descent) and 73 progressing g

78 ved from a merger between a host of archaeal descent and an alphaproteobacterial endosymbiont.

79 ties in genomic medicine, the Men of African Descent and Carcinoma of the Prostate (MADCaP) Network h

80 ants (84.5% of participants) of West African descent and clinically normal corneas were included.

81 ividuals (1090 eyes) enrolled in the African Descent and Evaluation Study (ADAGES) with a diagnosis o

82 vations in Glaucoma Study (DIGS) and African Descent and Glaucoma Evaluation Study (ADAGES) with at l

83 evelopment cohort, n = 151), and the African Descent and Glaucoma Evaluation Study (ADAGES; validatio

84 Innovations in Glaucoma Study or the African Descent and Glaucoma Evaluation Study (DIGS/ADAGES).

85 Participants from the multicenter African Descent and Glaucoma Evaluation Study and Diagnostic Inn

86 nnovations in Glaucoma Study and the African Descent and Glaucoma Evaluation Study were included.

87 ociated with HD in populations of East Asian descent and in a minority of patients from other ethnic

88 mainly afflicts young individuals of African descent and is resistant to all targeted agents used to

89 cts between 5% and 25% of people of European descent and is the most common inherited disease of conn

90 rcent of US patients were of Southeast Asian descent and there was a stronger female predominance (91

91 rmed in n=1436 total HF patients of European descent and with ejection fraction <50%.

92 tients of African descent and 69 of European descent) and 73 progressing glaucoma eyes of 67 subjects

93 predominantly comprising people of European descent) and the Taiwan NDCMP, a predominantly ethnic Ch

94 an descent, 8765 individuals of Asian Indian descent, and 7215 individuals of African descent).

95 reased cancer risk in individuals of African descent, and our findings highlight the need to assess t

96 C) and 48,312 (for WHR) individuals of Asian descent, and replicated 33 selected SNPs among 3,762 to

97 Hutterites, a founder population of European descent, and subsequent imputation revealed 660,238 sing

98 ously thought in populations of non-European descent, and the disease is now recognised in many regio

99 ajority of families were of Ashkenazi Jewish descent, and the TP53 c.1000G>C allele was found on a co

100 an, Indian or Asian descent, white [European descent], and coloured [of mixed ancestry according to t

101 is not yet known, but individuals of African descent appear vulnerable.

102 her in the subset of individuals of European descent ( approximately 423 000).

103 layan Sherpas, a human population of Tibetan descent, are highly adapted to life in the hypobaric hyp

104 (13 327 cases and 13 328 controls of Chinese descent as well as 13 793 cases and 14 027 controls of E

105 ollow-up SD OCT line scans showed a flat ELM descent at least once at 34 borders (47%), a curved ELM

106 A coordinate descent based iteratively reweighed least squares (IRLS)

107 For all of these stochastic gradient-descent based learning algorithms, we find that the opti

108 eters, in contrast to conventional (gradient descent based or genetic optimization) time-intensive op

109 Here, we describe a framework for gradient descent-based training of excitatory-inhibitory RNNs tha

110 was present and individuals made distinctive descents before sunrise and sunset.

111 hich showed the strongest recent identity-by-descent between populations.

112 m (iPS) cell lines from subjects of European descent (both male and female) and probed the impact of

113 focused primarily on populations of European descent, but it is essential that diverse populations be

114 tructures are key indicators of evolutionary descent, but the mechanisms underlying their development

115 KD rates among populations of recent African descent, but the underlying molecular mechanisms are unk

116 according to age in individuals of European descent, but we did not observe evidence of statisticall

117 linical population of predominantly European descent, but with limited electronic health record-based

118 or a set of variants is shared identical-by-descent by some or all affected relatives provides evide

119 ity (BMD) identified from people of European descent can help improve the prediction of osteoporotic

120 nese; and GRF of BMD from people of European descent cannot help improve the accuracy of the fracture

121 regions was found in this worldwide European-descent cohort and correlated inversely with variation i

122 This "double-descent" curve subsumes the textbook U-shaped bias-varia

123 ated with IBD risk in only people of African descent demonstrates the importance of studying the gene

124 ontigs present in the populations of African descent, demonstrating that the African pan-genome conta

125 ved across ocean regions(4) and that daytime descent depths increase with water clarity(4,5), indicat

126 riately, show which alleles are identical by descent despite the presence of untyped individuals.

127 ization schemes, such as stochastic gradient descent, do not end up trapped in local minima with high

128 of fracture identified in people of European descent does not contributes to improve the fracture pre

129 sity (cpCD) loss in participants of European descent (ED) and African descent (AD) were compared.

130 people of African descent (AD) and European descent (ED) in normal ocular health.

131 AD signal was observed at the 9p21 European descent (ED) POAG signal (rs79721419; P < 6.5x10(-5)) in

132 viduals of African descent (AD) and European descent (ED) with primary open-angle glaucoma (POAG) and

133 viduals of African descent (AD) and European descent (ED).

134 Addition of AA data to those of EUR and EAS descent enabled identification of seven novel high-confi

135 e genomic random effect, we used identity-by-descent estimates from accurately phased genome-wide dat

136 cluding participants of European and African descent (EUR and AFR, respectively).

137 )D3 (N = 40,562) in participants of European descent (European Prospective Investigation into Cancer

138 Minority groups of African descent experience disproportionately greater asthma mor

139 IOP measurements with individuals of African descent experiencing the highest IOP when compared with

140 from 2 main ethnic groups (Fijians of Indian descent [FID] and Indigenous Fijians [iTaukei]) in Fiji

141 apes of the external limiting membrane (ELM) descent (flat, curved, reflected, and scrolled) at the b

142 nd hospital visitor controls, both of Indian descent, followed by imputation across the genome.

143 uencing identified individuals homozygous-by-descent for a rare variant in RIC1 and, through a guided

144 nce for the existence and ubiquity of double descent for a wide spectrum of models and datasets, and

145 We find a common Bantu and Austronesian descent for all Malagasy individuals with a limited pate

146 tudies largely focused on people of European descent for disease or risk factor prediction in other e

147 thm has been developed within the coordinate descent framework where optimization of the regularized

148 13,807 non-diabetic individuals of European descent from nine cohorts.

149 the origin of viruses have been considered: descent from primordial, precellular genetic elements, r

150 ng data from 446,237 individuals of European descent from the UK Biobank study.

151 h Initiative (WHI), and a sample of European descent from the UK Biobank.

152 study of African descent, women of European descent from the Women Health Initiative (WHI), and a sa

153 8,384 cases and 11,955 controls of European descent from two large consortium studies using the summ

154 tients of African descent and 43 of European descent) from the Diagnostic Innovations in Glaucoma Stu

155 previously discovered in a people of African descent generalized.

156 independent cohorts, three of white European descent (Germany, n = 4,975; the Netherlands, n = 613; a

157 evidence for a multigenerational matrilineal descent group.

158 igher frequency among populations of African descent (>20%) compared with other ethnic groups (<10%).

159 present a method for detecting identical-by-descent haplotype segments in phased genotype data.

160 mic features that manifest when identical-by-descent haplotypes are inherited from parents.

161 n kidney lesion among individuals of African descent, has largely disappeared in these regions.

162 However, few populations of African descent have been studied to date.

163 particular, the dynamics of typical gradient descent have the same critical points as the constrained

164 h haplotype of an individual of Puerto Rican descent (HG00733) in the absence of parental data.

165 ortion of the genome they share identical by descent, i.e. in their realised or actual relationship.

166 ationally detected DNA segments identical-by-descent (IBD) and runs of homozygosity (ROH), we identif

167 tion across Southeast Asia using identity-by-descent (IBD) approaches based on genome-wide single nuc

168 Segments of identity by descent (IBD) are used in many genetic analyses.

169 en individuals, through pairwise identity by descent (IBD) estimates.

170 unusually high amount of shared identical-by-descent (IBD) genomic segments between several Siberian

171 r of strains, their proportions, identity-by-descent (IBD) profiles and individual haplotypes.

172 Identity by descent (IBD) refers to a haplotype segment of a chromos

173 orm a large-scale genome-wide inheritance-by-descent (IBD) scan, but accurate assessment of the signi

174 Identity-by-descent (IBD) segments are a useful tool for application

175 Detection of Identical-By-Descent (IBD) segments provides a fundamental measure of

176 st methods for fast detection of identity by descent (IBD) segments report identity by state segments

177 CREST utilizes identity by descent (IBD) segments shared between a pair of samples

178 ds these limitations is based on identity by descent (IBD) segments that arise from common ancestry w

179 mating kinship coefficients from identity by descent (IBD) segments.

180 g a hidden Markov model (HMM) of identity-by-descent (IBD) states along the genome.

181 usually manifested as segments identical by descent (IBD), is ubiquitous in modern large biobanks, c

182 udy share regions of the genome identical by descent (IBD), it is possible to use this information in

183 terozygosity (AOH) burden due to identity-by-descent (IBD).

184 ork of over 500 million genetic (identity-by-descent, IBD) connections among 770,000 genotyped indivi

185 nce of TMPRSS2:ERG fusions in men of African descent implies that alternative genomic mechanisms migh

186 Thus our results imply that gradient descent in deep networks minimize the expected error.

187 rare, damaging mutations shared identity-by-descent in families with BD could be associated with dis

188 2807 patients and 6441 controls of European descent in our two-stage genome-wide association study.

189 rk pigmentation in Africans are identical by descent in South Asian and Australo-Melanesian populatio

190 effective regularization effect of gradient descent in terms of the normalized weights that are rele

191 for researchers with individuals of African descent in their study populations.

192 ts to identify individuals of white European descent in UK Biobank in the half of the population with

193 ancers among 367,643 individuals of European descent in UK Biobank who were 37 to 73 years of age whe

194 estimated in 327,478 individuals of European descent in UK Biobank, of whom 19,526 (5.96%) reported f

195 tion (SEP) Latinos (predominantly of Mexican descent) in Sacramento, California, we examined whether

196 ndividuals (all individuals were of European descent), including child and adult samples (mean age ra

197 0, 2011, to October 2, 2013, were of African descent, including 57 USAAs and 180 FBAAs (76%).

198 eta-analysis (88,383 individuals of European descent, including 7,292 with AF).

199 s a frequent polymorphism present in African descent individuals but is unrelated to examined differe

200 About 30% of African descent individuals had at least one e756del allele.

201 Essential for fetal testis descent, INSL3 has been implicated in testicular and spe

202 hich may have modulated the climate system's descent into the last ice age.

203 xploitation by extortionist strategies and a descent into uncooperativeness.

204 ogress', where each organism along a line of descent is more fit than all those that came before it.

205 exaggeration and overall number of gradient descent iterations in a dataset-specific manner.

206 many species are unbound by strict vertical descent: Large differences in gene content can occur amo

207 together with opt-SNE adjustment of gradient descent learning rate dramatically improves computation

208 sion loss and blindness in people of African descent living in resource-limited regions.

209 ied the genome-wide diversity of the African-descent Makranis, who reside on the Arabian Sea coast of

210 ality SNPs and a high-resolution identity-by-descent map, which account for an average of 75% of the

211 ng variant correlations included identity-by-descent mapping and the optimal strategy for joint testi

212 acterized genetically by using single-family descent mapping in progenies segregating for the traits.

213 Identity-by-descent mapping using empirical estimates of identity-by

214 METHODS AND Through identity-by-descent mapping, using approximately 400 000 single-nucl

215 ress, and therefore, mammals with testicular descent may be at a greater risk in the event of scrotal

216 y because GRF of BMD from people of European descent may not contribute to BMD prediction in Chinese.

217 69) present in ~9% of individuals of African descent may regulate ACE2 expression and may be associat

218 Gradient descent methods such as Levenberg-Marquardt function are

219 mization approach, and a stochastic gradient descent model is employed to learn node embedding on a h

220 cterial serpins incompatible with a vertical descent model.

221 licate in samples of European and East Asian descent (N = 13,608 - 21,277).

222 d second-generation healthy women of Mexican descent (n = 53) were randomly assigned in a crossover d

223 ntromeric recombination have occurred during descent of the 2 lineages from their common ancestor.

224 In this population predominantly of European descent, OH was associated with an increase in long-term

225 ic leukemia (ALL) in populations of European descent; only a few loci could be confirmed in Asian pop

226 Moreover, a block coordinate gradient descent optimization algorithm is proposed for high dime

227 We use gradient-descent optimization algorithms from machine learning to

228 el FP reconstruction method under a gradient descent optimization framework in this paper.

229 arameter selection, each depends on gradient descent optimization functions.

230 Older age (P < .001), Ashkenazi descent (P < .001), genetic mutations (P = .006), person

231 European, South Asian, African, and Hispanic descent (pan-ancestry, approximately 475 000), and the o

232 ned meta-analysis including 123,659 European descent participants, unraveling two novel loci; a commo

233 For individuals of European descent, PGS provided a significant increase in variatio

234 n the largest consortium to date of European-descent population-based studies.

235 rphism at codon 47 in TP53 exists in African-descent populations (P47S, rs1800371; referred to here a

236 47Ser variant of p53 (S47) exists in African-descent populations and is associated with increased can

237 t within this region is common among African-descent populations but not among Europeans or Native Am

238 t of TP53, which exists primarily in African-descent populations, associates with an elevated abundan

239 ased risk of asthma in offspring in European descent populations, but has not been studied in Latino

240 In contrast to European descent populations, younger maternal age was associated

241 ally afford greater improvement for European-descent populations.

242 ptibility to PAD, especially in non-European descent populations.

243 rray to genotype 753 individuals of European descent presenting specifically with non-familial, spora

244 The identity by descent probabilities were calculated using FlexQTL soft

245 Our original Random Coordinate Descent (RCD) loop closure algorithm has been greatly im

246 nd site-matched controls of African-American descent recruited from the population-based African Amer

247 was characterized predominantly by hydraulic descent relative to hydraulic lift.

248 calculated from rare variants or identity-by-descent segments can correct this stratification for som

249 e sequencing of 97 trios of Ashkenazi Jewish descent, selecting "simplex" families with no family his

250 l parameters such as (i) stochastic gradient descent (SGD) and its multiple variations, (ii) structur

251 function, typically by a stochastic gradient descent (SGD) strategy.

252 centration in 45,889 individuals of European descent (stage 1 discovery) and 17,637 additional indivi

253 nd 17,637 additional individuals of European descent (stage 2 replication), and a transethnic meta-an

254 ociation results across large-scale European-descent studies including up to 78,592 individuals.

255 and homocysteine concentrations in European-descent subjects.

256 onal preferences of limited common ancestral descent, such as in the case of influenza type A hemaggl

257 tissues develop, groups of cells related by descent tend to associate in clonal populations rather t

258 tified at 22 loci in populations of European descent, the genetic architecture of QRS duration in non

259 rcent of US patients were of Southeast Asian descent; there was a stronger female predominance (91%)

260 er improvements in 5-step regular-pace stair descent time [net difference (95% CI): -0.09 s (-0.18, 0

261 lecting data from 480,842 people of European descent to decipher the genetic architecture of alcohol

262 als from independent populations of European descent to examine the mechanism underlying endometriosi

263 IBDrecomb, for using segments of identity by descent to infer recombination rates.

264 adopt the idea of sequential coordinate-wise descent to NMF to increase the convergence rate.

265 at uses estimates of genome-wide identity by descent to reconstruct pedigrees consistent with observe

266 smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central ad

267 d dataset of 910 individuals, all of African descent, to construct a set of DNA sequences that is pre

268 and social outcome data for >7,000 European-descent UK and US young people in the E-Risk and Add Hea

269 Republic, n = 521), and one of black African descent (United States, n = 1,657), totaling 7,766 subje

270 Haplotypes are coloured based on identity by descent using a novel A* search algorithm and we provide

271 One individual of mixed Hispanic/European descent was found to be compound heterozygous for c.460G

272 5115 cases and 354 072 controls of European descent, was performed.

273 actors for breast cancer in women of African descent, we conducted a meta-analysis of two genome-wide

274 Using stochastic gradient descent, we derive how the activity in 'tutor' circuits

275 e 20 vs 63 years), both of Northern European descent, we found that there was no significant RNFL thi

276 up to 46,000 children and adults of European descent, we identify association with final HC and/or fi

277 ge cohort of healthy individuals of European-descent, we show that the amount of Neanderthal-originat

278 iously identified in populations of European descent were enriched for significant SNP associations w

279 Persons of Asian descent were excluded because of their higher prevalence

280 14,803 cases and 12,262 controls of European descent were genotyped on the OncoArray and combined wit

281 erogeneity, only centres of largely European descent were included for analysis.

282 Patients of African descent were more likely to have an abnormal 10-2 result

283 ants without glaucoma of African or European descent were recruited from 5 study centers in different

284 metry, endurance time, and maximal diaphragm descent were significantly correlated.

285 ations discovered in populations of European descent were transferable to African Americans when adeq

286 iated genes identified in people of European descent were used to build a logistic regression model w

287 BMD-associated genes from people of European descent were used to build a multiple linear regression

288 such as penis and preputial size, and testis descent, were greater in Sgta(-/-).

289 weight stability in healthy women of Mexican descent, while having no impact on biomarkers of inflamm

290 lation group (black African, Indian or Asian descent, white [European descent], and coloured [of mixe

291 s naturalized and US-born citizens of Latino descent who are largely immune to deportation but whose

292 rily affects individuals of northern Swedish descent who share a single point mutation in the fourth

293 ion variant common in individuals of African descent with glaucoma-related phenotypes.

294 g in 101 North American patients of European descent with isolated BA (including 30 parent-child trio

295 onal traits-is explicitly based on Darwin's "descent with modification," provides students with a rat

296 h of which are transmitted in populations by descent with modification-genes vertically by Mendel's l

297 deadly kidney cancer in patients of African descent with sickle cell trait.

298 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with P

299 PBC cases and 4,036 controls of Han Chinese descent, with subsequent replication in a separate cohor

300 n Brazilians, the COGENT-BP study of African descent, women of European descent from the Women Health