ライフサイエンスコーパス: design

1 pointing the way for future terpene synthase design.

2 pitopes that can be used in rational vaccine design.

3 s achieved through structure-based inhibitor design.

4 le for both structure prediction and protein design.

5 dings have important implications to vaccine design.

6 ng to a double-blind, randomised, cross-over design.

7 nable to broad application in pharmaceutical design.

8 s principles of enzyme function for catalyst design.

9 ionization that could enable novel membrane design.

10 stabilization through computational library design.

11 odies and the template for vaccine immunogen design.

12 (Ficedula hypoleuca) using a full factorial design.

13 ectromyography-driven simulation, and device design.

14 flumes in a central composite face factorial design.

15 dded a synthetic adjuvant (RS09) to the mvPC design.

16 uation for next-generation rotavirus vaccine design.

17 studies with venom compounds, PIs, and drug design.

18 countries and sharing the same experimental design.

19 1, 2009 and followed the original 2018 study design.

20 mizing the SS-RJW100 scaffold for antagonist design.

21 predictive power persists in between-sibling designs.

22 Designing 3D printed micro-architectures using electroni

23 To explore the conceptual validity, we design a CRISPR-array-mediated primer-exchange-reaction-

24 Herein, we rationally design a DNA-based artificial molecular signaling system

25 Herein, we rationally design a new In single-atom catalyst containing exclusiv

26 Herein, we deliberately design a Th-metal-organic framework (MOF) for highly eff

27 pacts on prefrontal and parietal regions, we designed a dual route decision-making model that mimics

28 We designed a flexible spatial working memory task that req

29 by SARS-CoV-2 and seasonal coronaviruses, we designed a focused high-coverage CRISPR-Cas9 library tar

30 rmacokinetic parameters of TLZ in humans, we designed a long-acting PEG~TLZ for humans that may be su

31 In addition, we designed a microfluidic system to recapitulate the shear

32 aphy (PET)-directed treatment approaches, we designed a National Clinical Trials Network (NCTN) study

33 In this work, we designed a new chemotherapeutic drug candidate against c

34 We designed a novel digital therapeutic that modifies patie

35 er PLP antigen may better engage B cells and designed a peptide encompassing the extracellular domain

36 We designed a probabilistic predictive model and trained it

37 To address this problem, we designed a sensing platform based on poly(ethylene terep

38 lene)diphosphate (AOPCP) with human CD73, we designed a series of novel monophosphonate small-molecul

39 ons dramatically increases the difficulty of designing a DC library and leads to the creation of many

40 with evidence-based, active-learning course designs across the STEM disciplines and suggest that inn

41 These results provide guidance for designing advanced EMI shielding materials but also high

42 Here, we present a protein design algorithm called TopoBuilder, with which we engin

43 A key step of an automated computational design algorithm is molecule generation, where the machi

44 The design allows for the formation of ordered arrays of reo

45 Its modular design also enables characterization of non-tumor hemody

46 ridged art theory and cognitive research and designed an experiment leveraging construal level theory

47 In this study, we designed an experimental approach based on potentiometri

48 We designed an open-label, randomized, multicenter, two-arm

49 Our study provides a design and analysis methodology for land use change stud

50 Over time, the design and analysis methods were further modified to all

51 s and provide guidance to researchers on the design and analysis of pooled CRISPR screens.

52 LR2 agonistic scaffolds and also covered the design and chemistry for the conjugation of TLR2 agonist

53 r environment, with implications for protein design and combatting antibiotic resistance.

54 similarities between click and DEL reaction design and deployment in combinatorial library settings,

55 ement of carboxysomes have inspired rational design and engineering of new nanomaterials to incorpora

56 These data provide insight into the vaccine design and evaluation of immunogenicity to enable rapid

57 We design and fabricate multilayered morphing electronics,

58 ts highlight the potential of new microscale design and fabrication techniques for realizing viable d

59 emonstrated capabilities enable the rational design and holistic engineering of novel materials for m

60 e in 2D COFs, which motivate their continued design and implementation into optoelectronic devices.

61 the possibility of context dependence in the design and interpretation of preference experiments.

62 nging capacity is a useful parameter for the design and operation of an advanced oxidation process (A

63 ansfer coefficient is a key parameter to the design and operation of biotrickling filters that govern

64 This ligand mimetic design and optimization approach can be expanded to appl

65 -reactivity relationships is critical to the design and optimization of cysteine-targeted covalent in

66 Herein, we describe the design and performance of an integrated microfluidic pro

67 eir mechanism of actions but also guides the design and selection of drug candidate molecules.

68 odels for oxyfluorides, needed for materials design and structure-property control, is often still a

69 s study would open new possibilities for the design and synthesis of molecular cages with novel topol

70 We report the design and synthesis of the compounds and binding result

71 generalized to other applications in battery design and, more broadly, other scientific domains that

72 This study successfully designed and developed dry powder inhaler (DPI) formulat

73 In this work, we designed and fabricated Pd/Au bimetallic thin film elect

74 us crystalline organic materials that can be designed and synthesized from the bottom up.

75 ped heptacene with high thermal stability is designed and synthesized in good yields.

76 eta oligomers, our laboratory has previously designed and synthesized macrocyclic peptides derived fr

77 To explore and expand the current view, we designed and synthesized molecules where two isomeric, y

78 Therefore, we designed and synthesized new functional and cross-linkin

79 nted helical foldamers have been effectively designed and synthesized.

80 ollected and analyzed using nonoptimal study designs and analysis approaches.

81 he high risk of bias identified in the study designs and analysis for reported results.

82 nance, application scenarios, and integrated design) and emerging technical opportunities that we arg

83 king in the areas of drug discovery, vaccine design, and biomedical and biotechnology research.

84 This work describes the concept, design, and realization of the first multisite peach (Pr

85 o supramolecular polymers composed of custom-designed anion and receptor monomers and demonstrates th

86 The efficient ligand-based design approach adopted demonstrates its versatility in

87 Here, we show that this toughness design approach can be applied to synthetic adhesives.

88 Previous design approaches use complex geometries that are challe

89 The naturally designed architecture, semi-permeability, and catalytic

90 Our results show the value of model-guided design as an approach for generating useful DNA parts.

91 The sample design based on the low concentration of nanoparticles a

92 ivity and resolution, using novel collimator designs based on tungsten.

93 were determined by a proprietary application designed by Aldatu Biosciences.

94 matic multiple risk-factor intervention, one designed by Institute staff and operated under contract.

95 trating and mucoadhesive particles have been designed by tuning the chemical composition, the size, t

96 sufficiently large to enable proteins to be designed by using only examples of structural motifs fro

97 significantly depleted genes, optimal screen design can nevertheless enable robust screen performance

98 ongoing challenge in chemical research is to design catalysts that select the outcomes of the reactio

99 rbent were optimized using central composite design (CCD) methodology.

100 l applications, which concerns novel monomer design, chemical methodology/strategy establishment, and

101 In this paper, a newly designed composite acoustic lens that can achieve wave c

102 The designed compounds containing such a salt bridge reached

103 ional analysis, we discovered unique spatial designs comprising mixed interbacterial species and inte

104 he feasibility of the intentionally nonlocal design concept and its ability to achieve a fully passiv

105 d series of compounds, using structure-based design concepts, coupled with optimization of cellular p

106 the prevalence and impact of limitations in design, conduct, analysis, and reporting of research.

107 recommendations related to prediction study design, conduct, and reporting.

108 a webserver for RNA structure prediction and design corresponding to tools developed using our RNA-As

109 Computational protein design (CPD) can address the inverse folding problem, ex

110 When dispersed in aqueous solution, the designed CPT prodrug spontaneously assembles into supram

111 Minimizing the number and duration of design cycles needed to optimize hit or lead compounds i

112 Eight cases were discordant due to probe design differences, with focal abnormalities detectable

113 identifying dominant drivers is crucial for designing efficient mitigation policies.

114 tment and data collection through innovative design elements.

115 We designed embryo traps and engineered a protocol allowing

116 ETPs along with cytotoxic evaluation of our designed ETPs against A549, DU 145, HeLa, HCT 116, and M

117 Here, we designed, fabricated and characterized the first biochem

118 f apple by-products (AP) recycling through a designed fermentation by selected autochthonous Lactobac

119 Overall, our work provides a roadmap for designing fluorophores, photoswitching agents, and tripl

120 Herein, single-atom catalytic electrodes design for advanced battery systems is addressed.

121 Moreover, we propose an efficient hardware design for clinically viable iBCIs, and suggest that the

122 s when using such a conventional optogenetic design for the fibroblast growth factor receptor (FGFR).

123 model in order to identify the ideal prodrug design for the most effective and safe treatment of infl

124 sis with rMATS-turbo, purpose-built software designed for large-scale analyses of splicing, and ident

125 suitability (appropriateness) of online PEMs designed for people with AMD.

126 mple sizes; and use single case experimental designs for better pragmatic and explanatory biological

127 logy of self-harm using multivariate genetic designs for causal inference.

128 tings, such as being introduced into circuit designs for synthetic biology applications.

129 cultivars, develop crops and production, and design functional products rich in flavonols and caroten

130 en defects are essential building blocks for designing functional oxides with remarkable properties,

131 so providing new insights into the molecular design guidelines for the next generation of high-perfor

132 The homopolymer designs have a drug reservoir potential of well over a y

133 d the catalytic potential of simple, de novo-designed heme proteins.

134 -based structures enhances the capability to design high-performance ion-regulating devices and promo

135 generation, where the machine is required to design high-quality, drug-like molecules within the appr

136 ach may be a general principle applicable to designing higher performance electronics, transportation

137 The circuit behaves as designed; however, it is riddled with genetic errors, in

138 onhuman primates, cocktails of three de novo-designed immunogens induced robust neutralizing response

139 g of TM ions in biological systems, and drug design in metalloprotein platforms.

140 toreactivity, water quality, and engineering design in the sunlight inactivation of viruses, we model

141 Distinctly, organic linkers are judiciously designed in order to promote the deployment of the 12-co

142 e conservation when compared to single-state designs in all cases.

143 nd cultures in two of the most commonly used designs in experimental economics.

144 ognition and signal generation regions to be designed independently.

145 to School initiatives, and the microscale of design interventions and placemaking such as building or

146 Our design is based on standardized recombinase-driven DNA s

147 Drug design is catered for by updates from the IUPHAR/BPS Gui

148 Results: The instrument design is described, and its physical performance measur

149 In some applications, BLAS design is preferable over monolithic sensors because of

150 antigenic profile in several cases, and one design led to improvement of cross-neutralization of het

151 Methods: Five rationally designed low-molecular-weight ligands (L1-L5) were synth

152 This trial design may be useful for other GA repurposing drug trial

153 t materials can be judiciously combined with designed microstructures.

154 METHODS/DESIGN: Multicenter non-inferiority randomised controlle

155 ical properties, which may pave a new way to design new 3D graphene devices with preserved 2D electro

156 can facilitate researchers and clinicians in designing new approaches for precision immunotherapy.

157 Our study then suggests two strategies to design next-generation fouling-resistant RO membranes vi

158 s show that the performance of our optimized designs not only surpasses that of the gyroid and other

159 the concept of aurophilicity and its use in designing novel materials is a true example of innovatio

160 We designed NTD-CTD hybrid proteins, and hybrid res sites c

161 his work offers a proof of principle for the design of a gene drive in viruses.

162 Here, a fractal web design of a hemispherical photodetector array that conta

163 ent an attractive starting point for further design of a protein-protein interaction detection system

164 Presented herein is the design of a redox stimuli activatable metal-free photose

165 g of these aspects is largely missing in the design of artificial catalysts.

166 pproach for the identification and efficient design of biopolymer stabilized soil systems.

167 , which provides a guiding principle for the design of both phase-preserving and phase-sensitive mult

168 lipid immunogens, and live mutants lead the design of canonical vaccines aimed at disrupting infecti

169 cal modeling can help optimize and guide the design of clinical trials.

170 Ps); however, very little is known about the design of CPPs for efficient transcellular transport.

171 s becomes an inevitable step in experimental design of current biomedical research.

172 the abundant 3d metals, is important in the design of electrocatalysts and organometallic catalysts.

173 , carbon black has been re-discovered in the design of electrochemical (bio)sensors thanks to its int

174 dry powders was systematically evaluated by design of experiments (DOEs) using three different FDA-a

175 These studies pave the way for the design of functional ion pairs that have the potential t

176 directly provides the direct molecular-based design of functionalized polymer/carbon spheres.

177 o-based lead generation and also inspire the design of future macrocycle screening collections.

178 for many biological applications such as the design of guide RNA for CRISPR experiments.

179 ithms used here offer prospects for tailored design of highly evolved, genetically encoded organophos

180 N-7 MTase may be a novel target for rational design of live attenuated vaccines and antiviral drugs.

181 amical matrix (or Hamiltonian), enabling the design of metamaterials with emergent properties that es

182 tion as an alloy design tool, and enable the design of microstructures that maximize the useful impac

183 This motivated the design of molecular translators to convert molecular inp

184 he Ag species dispersion will benefit future design of more efficient supported Ag catalysts.

185 Chemical design of multicomponent nanocrystals requires atomic-le

186 ysregulated in human disease would allow the design of network-correcting therapies that treat the co

187 rary settings, providing a framework for the design of new DEL synthesis technologies to enable next-

188 This has implications for the design of new long-residence-time TSPO ligands.

189 uman hemoglobin and are drug targets for the design of novel antimalarial agents.

190 ystal engineering approach, for example, the design of novel dynamic functional soft materials for fu

191 ding of this remarkable process may help the design of novel therapeutics for neurodegeneration and o

192 Rational design of parent zeolites with concentrated and non-prot

193 at an individual level and could inform the design of personalized treatment strategies that can be

194 peutics could crucially depend on thoughtful design of rigorous presymptomatic trials.

195 r the past 3 decades with an emphasis on the design of selective inhibitors that discriminate between

196 tal engineering community, whose goal is the design of solids with bespoke properties.

197 uctures is of great interest in the chemical design of stimuli-responsive materials that mimic the co

198 ould provide a helpful tool for the rational design of strand-displacement reaction networks.

199 unities, which is a major impediment for the design of sustainable peptide-based antibiotics that can

200 enabling new approaches to the model-driven design of synthetic gene networks, the fast and portable

201 nits in a confined space is critical for the design of synthetic molecular machines.

202 rk provides basic information needed for the design of tandem mass spectrometry-based CAD sequencing

203 y of this methodology is demonstrated by the design of two distinct types of reactions: Giese-type ad

204 In this Review, we discuss the innovative designs of novel CAR T cell products that are being deve

205 Novel clinical trial designs offer potential solutions by attempting to obtai

206 Using this cut-off, we were able to design olfactory metamers-pairs of non-overlapping molec

207 The included studies were not designed or powered to assess atrophy as a primary outco

208 mizing the effects of liposomal nanoparticle design parameters for enhancement of tumor selectivity t

209 y viable iBCIs, and suggest that the circuit design parameters of current recording iBCIs can be rela

210 model explains the trade-off among chemical design parameters such as the surface density of enzymes

211 outputs, toward integrated approaches from a design perspective is critically developed.

212 By study design, PET/CT scans were performed at baseline and befo

213 However, it is always challenging to design platinum complexes suitable for such research.

214 The strategy provides a general design principle for synthesizing abiotic polymer inhibi

215 ct manifests tapering symmetry, a felicitous design principle that may have evolved not only to aid t

216 The design principles dictating the spatio-temporal organisa

217 ting a comprehensive theory of five rational design principles for achieving giant intrinsic SHE in t

218 AL metabolic regulation, but also elucidated design principles for ratio-sensing signal processing th

219 properties together with the opportunity to design probes against any sequenced genome.

220 ut it also sharpens our understanding of the design problems solved by evolution in nature.

221 ersion properties, are attached to a de novo-designed protein, conferring entirely novel functions on

222 tructure space and offers a new paradigm for designing proteins with tunable geometries that may be c

223 th commercially available but also specially designed representatives of this compound class.

224 m regenerating and metamorphosing organisms, designing robots capable of editing their own structure

225 enefits of autonomous AI, and understand its design, safety, efficacy and equity, validation, and lia

226 g structural elucidation to enable chemistry design/SAR development.

227 hods that integrate small-peptide units into designed scaffolds.

228 a new generation of anti-viral vaccines, we designed self-assembling protein nanoparticles with geom

229 erated by RAG Sampler, and (c) RAG Designer: designs sequences that fold onto novel RNA motifs (descr

230 DESIGN, SETTING, AND PARTICIPANTS: A retrospective cohor

231 DESIGN, SETTING, AND PARTICIPANTS: Multicenter randomize

232 DESIGN, SETTING, AND PARTICIPANTS: Multicenter, noninfer

233 DESIGN, SETTING, AND PARTICIPANTS: Open-label, randomize

234 DESIGN, SETTING, AND PARTICIPANTS: Representative sample

235 DESIGN, SETTING, AND PARTICIPANTS: The Vein of Marshall

236 Here we design small peptidic inhibitors based on the atomic str

237 -intensive experiments and multi-dimensional design spaces.

238 etection, the sequential-parallel comparison design (SPCD) was chosen.

239 We then introduce a new approach designed specifically to find radically distributed repr

240 This should be considered when designing strategies for HIV prevention for PWID.

241 A drug design strategy is here reported, which took SAC and ACE

242 l acene ring is a highly effective molecular design strategy to optimize the thermoelectric performan

243 By applying this design strategy, we achieved CO(2) electroreduction on c

244 We did a seamless design study at 14 cancer centres in the USA.

245 st interactions offers new opportunities for designing such architectures for a broader range of cata

246 Here we report the design, synthesis, and biological evaluation of several

247 We describe our design, synthesis, and chemical study of a set of functi

248 mergence of innovative tools, we examine the design, synthesis, and properties of light-activated deg

249 7,8) and are, to our knowledge, unique among designed systems(9-13) in that they possess tightly pack

250 We describe a specimen support design that eliminates buckling and reduces electron bea

251 This work presents a new design that will significantly simplify the fabrication/

252 ied using the Gaussian beam approximation to design the incident beam such that the beam waist is ali

253 n addition to providing guidance for vaccine design, the antibodies described here are promising cand

254 organic framework design, TM-based catalyst design, the trafficking of TM ions in biological systems

255 ncorporating biological variation into study design through diversifying study samples and conditions

256 tion areas including metal organic framework design, TM-based catalyst design, the trafficking of TM

257 me/metagenomic studies follow a longitudinal design to collect samples, which further complicates the

258 trates the potential of structure-based drug design to develop more subtype-selective GPCR ligands wi

259 We used a self-controlled case series (SCCS) design to evaluate the relative incidence of deaths with

260 nmated or singly mated in a fully reciprocal design to males from the same three genotypic background

261 rtion for fusion, pave the way for immunogen design to protect against pathogenic hantaviruses.

262 isualization and comparison options that are designed to assist in novel hypothesis generation, as we

263 The model is designed to be compatible with prevalent payment models

264 A colorimetric box was designed to capture images of sample solutions.

265 low and practices within laboratories and is designed to cultivate a campus culture of ethical scienc

266 t suggest that similar scale federal reforms designed to demilitarize police would have the downside

267 The study was designed to detect improvement in outcomes of patients w

268 Future studies should be designed to determine if our findings directly impact va

269 rming precautions for protein-based vaccines designed to elicit germline versions of neutralizing Abs

270 a significant protective effect and was not designed to evaluate source control.

271 Here, we report three Turing-inspired tests designed to evaluate the performance of molecular genera

272 present Easy-HLA, a web-based software suite designed to facilitate analysis and gain knowledge from

273 ET/CT imaging of mini image-quality phantoms designed to fit the new imaging system.

274 Herein, we present two resources designed to improve interoperability between the RCSB Pr

275 ea and an increasing number of interventions designed to improve psychological well-being, the field

276 inding group and a Cys-reactive warhead-were designed to leverage both affinity and reactivity.

277 The workflow is designed to maximize the diagnostic yield and increase t

278 the Tox21 portfolio are assays specifically designed to measure interference in the form of lucifera

279 t constrained 31-residue-peptides ('msR4Ms') designed to mimic the CXCR4-binding site to MIF, selecti

280 This platform, designed to mimic the tight extracellular migration trac

281 ent need to establish protocols specifically designed to overcome the inevitable variations in sample

282 These patterns are designed to partially mimic the branch geometry of the e

283 esulted in additional challenges for systems designed to perform expeditious primary percutaneous cor

284 Biosecurity protocols designed to prevent the spread of invasive alien species

285 c device with 10 distributed Coulter sensors designed to produce distinct signal waveforms and perfor

286 This study was designed to quantify the spatial variability in number,

287 rst regional market-based regulatory program designed to reduce greenhouse gas emissions from the ele

288 vLUME is a virtual reality software package designed to render large three-dimensional single-molecu

289 synthetic biological module, however, can be designed to reprogram the host proteome, which in turn e

290 at 80 Hz) in cyclical work loop experiments designed to simulate the in vivo dynamics of muscle fibe

291 ermetallic coating layer (ICL) is rationally designed to stabilize Sn through a structural reconstruc

292 These probes are often designed to target specific enzymes associated with dise

293 full potential of GB segregation as an alloy design tool, and enable the design of microstructures th

294 ased on structural and affinity analyses, we designed two cyclic peptide mimics of the TAR-binding be

295 The design was observational, 21 of 36 studies had serious R

296 s using a cross-sectional and a longitudinal design were tested to assess genetic structure in sympat

297 Designs were tested in vitro and in vivo, demonstrating

298 measure was freedom from distant metastases, designed with 80% power to detect an improvement from 90

299 mmary, the concept of miniaturized microcage designs with such straight-forward assembly and scalabil

300 onent for machine-driven medicinal chemistry design workflows.