ライフサイエンスコーパス: design of

1 The rational design of 3D structures (MOFs, COFs, etc.) is presently

2 , previously reported by our group, prompted design of a 3D structure that maximizes cellular interac

3 ould be useful as a shutoff mechanism in the design of a bacterial cell-growth system.

4 Herein we report the design of a bacteriochlorin-based nanoscale metal-organi

5 We report the design of a bifunctional metal-organic layer (MOL), Hf(1

6 ted evolution (DE) are studied aiming at the design of a biosensor for H(2)O(2) detection.

7 Here, we provide a conceptually different design of a cell with two orthogonal protein synthesis s

8 We report here the design of a construct corresponding to the prefusion SAR

9 his work offers a proof of principle for the design of a gene drive in viruses.

10 In this work, we propose a novel design of a GRIN-PC in which neighboring layers are sepa

11 Here, a fractal web design of a hemispherical photodetector array that conta

12 This strategy resulted in the design of a macrocyclic peptide that competes with the L

13 and locations combined with the appropriate design of a microchip holder to suitably position the mi

14 ential smart window device after the optimum design of a multilayered thin film structure made out of

15 r characterization is needed, which requires design of a multitude of reliable experimental setups an

16 urrent level of understanding allows for the design of a nanopore which promotes wetting over dewetti

17 erature using previous catalysts, led to the design of a new dialkylbiaryl monophosphine ligand.

18 see text] may be used as a scaffold for the design of a new generation of probes for intra- and extr

19 We report the design of a new multifunctional metal-organic layer (MOL

20 the 2015 screening deck were applied to the design of a next generation in 2019.

21 The design of a non-viral gene delivery system that can rele

22 Here, we describe the design of a novel series of potent PI3Kgamma inhibitors

23 Here, we present the design of a novel TRPM2 antagonist, tatM2NX, which preve

24 ent an attractive starting point for further design of a protein-protein interaction detection system

25 Presented herein is the design of a redox stimuli activatable metal-free photose

26 surgical procedures of the hindfoot; and the design of a replacement subtalar joint prosthesis.

27 As a proof-of-concept, we demonstrate a design of a sensor for EGFR tyrosine kinase-an important

28 Here we report the design of a series of inositol phosphate analogs as crys

29 ponses develop is essential for the rational design of a subunit-based vaccine that would be safe, an

30 c plant promoters enabling the computational design of a suite of synthetic promoters of different st

31 es that NeuralXC is a first step towards the design of a universal, highly accurate functional valid

32 easiness of the measurements, we report the design of a versatile and airtight EQCM cell setup that

33 Therefore, the design of a ZIKV vaccine requires particular care.

34 ta), and provides general guidelines for the design of active electrocatalysts.

35 alline droplets and has implications for the design of active soft materials.

36 ic insights provide a framework for improved design of age-specific vaccination strategies that requi

37 regulation and may lay new foundation in the design of allosteric agents.

38 eral approach of drug discovery based on the design of allosteric modulators of protein-protein inter

39 These data should help in the design of an effective pan-LASV vaccine.

40 Computational protein design of an ensemble of conformations for one protein-i

41 iment thus suggests that the chemical signal design of animals can shift rapidly and predictably in n

42 This has inspired the design of antibacterial implant surfaces with insect-win

43 explains how the features of the mechanical design of apertures influence the pollen folding pattern

44 g of these aspects is largely missing in the design of artificial catalysts.

45 The design of artificial oxyanion receptors with switchable

46 Design of asymmetric catalysts generally involves time-

47 d, suggesting new modular approaches for the design of autonomous molecular machines that emulate nat

48 ults reported here have implications for the design of beta sheet proteins with tunable self-assembli

49 relationships that would enable the rational design of better materials.

50 To enable computational design of binders, we developed a unit of protein struct

51 pply at different spatial scales, making the design of biodiversity-friendly landscapes challenging.

52 nthesis, and deciphering, reconstruction and design of biological machine assembly lines.

53 y be useful in the context of peptidomimetic design of biologically relevant compounds.

54 ticipate this will have ramifications in the design of biomaterials to enhance therapeutic applicatio

55 pproach for the identification and efficient design of biopolymer stabilized soil systems.

56 , which provides a guiding principle for the design of both phase-preserving and phase-sensitive mult

57 As such, proper design of cancer immune nanomedicine requires scrutiny o

58 lipid immunogens, and live mutants lead the design of canonical vaccines aimed at disrupting infecti

59 is expected to provide a leap forward in the design of catalysts for asymmetric transformations.

60 ransition metal compounds is crucial for the design of cathode materials in aqueous electrochemical c

61 t, to obtain understanding in the biological design of cells and, second, as a possible basis for the

62 allows for analytic solutions to the inverse design of centrally symmetric and even general surfaces,

63 Herein, a nacre-inspired design of ceramic/polymer solid composite electrolytes w

64 s a suitable pharmacophoric scaffold for the design of chemically stable, highly potent and selective

65 indings are important considerations for the design of clinical trials, and might improve our underst

66 therapies, a principal challenge will be the design of clinical trials.

67 in the modern paradigm of AEG management and design of clinical trials.

68 cal modeling can help optimize and guide the design of clinical trials.

69 e clinical management of patients and future designs of clinical trials.

70 ixing of people is important, such as in the design of cluster randomized trials for studying interve

71 ombination of computational and experimental design of cobaltocene metallo-cations that have distinct

72 nces of lesions and their future role in the design of cognitive neurorehabilitation therapies.

73 In this review, we focus on the design of collective motions that are achieved by integr

74 ation that may be leveraged for the rational design of combinatorial strategies.

75 , which in turn is dependent on the breeding designs of companies that supply inbred mice to research

76 though the problem is difficult, the careful design of complementary cavities can lead to surprisingl

77 es to medicine, agriculture, and energy, the design of completely novel biological circuit components

78 fforts, with some evidence of success in the design of completely novel opioids with unique efficacie

79 tease dysregulation in cancer and guides the design of conditional diagnostics and therapeutics.

80 so present a simple predictive model for the design of configurationally stable secondary diarylamine

81 The design of controllable dynamic systems is vital for the

82 These compounds may pave the way for the design of covalent PROTACs for a wide variety of challen

83 he receptor-binding motif and will guide the design of COVID-19 vaccines and therapeutics.

84 Ps); however, very little is known about the design of CPPs for efficient transcellular transport.

85 e mouse loxP alleles by integrating a unique design of CRISPR donor with the new oviduct electroporat

86 s becomes an inevitable step in experimental design of current biomedical research.

87 ds of DNA nanotechnology enable the rational design of custom shapes that self-assemble in solution f

88 the following three parts: (1) The ingenious design of device structure; (2) Application and synthesi

89 er science tools are converging to guide the design of diagnostics that leverage enzymatic activity t

90 We explore the relationship between the design of differentiated bonds and a formation of one-(1

91 f malaria-protective immunity and inform the design of disease-modifying adjunctive therapies and nex

92 The design of dissipative systems, which operate out-of-equi

93 since such amplifiers require the intricate design of DNA sequences and reaction conditions.

94 Design of drug delivery vehicles, cell and tissue matric

95 ples, advance our understanding and rational design of dynamic polymer networks, improving our abilit

96 ischemia and Abeta toxicity will help in the design of effective and alternative therapeutics that ma

97 A crucial step toward the design of effective policies is to better understand the

98 of the mosquitoes' ecological role, and the design of efficient sugar-baited traps will all benefit

99 the abundant 3d metals, is important in the design of electrocatalysts and organometallic catalysts.

100 made in electrocatalysis due to the rational design of electrocatalysts at the nanoscale level.

101 , carbon black has been re-discovered in the design of electrochemical (bio)sensors thanks to its int

102 range using a single model, simplifying the design of electronic systems of integrated plant cell se

103 A Design of Experiment approach was used for the identific

104 dry powders was systematically evaluated by design of experiments (DOEs) using three different FDA-a

105 ve relationship provides guidance toward the design of extremely tough soft composites.

106 omising push-pull fluorophore systems in the design of fluorometric sensor materials due to the effec

107 al acoustic confinement releases the lateral design of freedom, and enables negligible cross-talk and

108 matic hydrocarbons is a critical tool in the design of functional electronic materials.

109 r vertically stacked devices and, hence, the design of functional interfaces.

110 These studies pave the way for the design of functional ion pairs that have the potential t

111 nning from biomineralization to the rational design of functional nanocomposites.

112 vdMs may enable design of functional proteins for applications in sensin

113 d pattern formation, and perspectives on the design of functional smectic microarrays.

114 eactants may provide a new direction for the design of functional supramolecular systems.

115 directly provides the direct molecular-based design of functionalized polymer/carbon spheres.

116 ypothesis and has important implications for design of functionally selective GPCR-targeted drugs.

117 ion of a wide range of existing data and the design of further experiments to elucidate signalling me

118 can be exploited for the structure-assisted design of future A9g-based derivatives with improved bin

119 these structures provide a blueprint for the design of future anti-malarials targeting both the glide

120 c variation may be necessary to optimize the design of future clinical studies with GLA-containing oi

121 terpretation of previous findings and in the design of future clinical trials.

122 This framework will inform the design of future IgA-based therapeutics.

123 Finally, we present suggestions for the design of future inhibitors of this highly attractive ta

124 o-based lead generation and also inspire the design of future macrocycle screening collections.

125 The results will aid in the design of future spiropyran-based MRI sensors.

126 es using GW9662 and make better experimental design of future studies necessary.

127 ositive translational impact on the rational design of general microbiota-based therapeutics.

128 recent advances in circuit engineering, the design of genetic networks in mammalian cells is still p

129 system has prospective implications for the design of granular materials in a multitude of physical

130 We discuss the details of structural designs of graphene electronics, use cases of salivary b

131 for many biological applications such as the design of guide RNA for CRISPR experiments.

132 ved in our study will assist in the rational design of guide RNAs for ADAR-mediated RNA base editing.

133 e payment reforms and more generally for the design of healthcare policy.

134 This knowledge will guide the design of helical hydrocarbons as rigid scaffolds or as

135 The design of heterogeneous catalysts relies on understandin

136 lates have been successfully employed in the design of heterometallic coordination systems offering a

137 In the design of high-affinity and enzyme isoform-selective inh

138 ling mechanism that will facilitate rational design of high-affinity SERT allosteric inhibitors.

139 thode and provides new insights for improved design of high-capacity battery materials.

140 heterointerface offers opportunities for new design of high-performance memristor devices.

141 s highly anisotropic building-blocks for the design of high-performance molecule-based magnetic mater

142 ithms used here offer prospects for tailored design of highly evolved, genetically encoded organophos

143 ty as a solid pharmacophore template for the design of highly potent modulators of TRPM8-mediated act

144 on human health and to improve the rational design of immune approaches to treatment of cancers.

145 ovide new understanding and guide predictive design of improved catalysts.

146 f novel antituberculars through the rational design of improved MbtI inhibitors.

147 pping of human epitopes on other Ags and the design of improved therapeutics.

148 etal batteries with LCO cathode, through the design of in situ formed, stable electrode/electrolyte i

149 mplications of motivation laundering for the design of incentive systems and behavioral change.

150 on receptor has helped to drive the rational design of innovative peptide molecules that hold promise

151 to the identification of substrates for the design of innovative smoking cessation aids.

152 al sense of taste has become a basis for the design of instruments, operation principles and paramete

153 mplexes and the related structure-based drug design of integrin inhibitors.

154 N-7 MTase may be a novel target for rational design of live attenuated vaccines and antiviral drugs.

155 fundamental scientific understanding and the design of materials, which can in turn tune the function

156 This reactivity has been leveraged in the design of mechanism-based enzyme inhibitors and has infl

157 utation is necessary to guide the structural design of mechanophores.

158 Our approach advances the design of metabolic analysis for early cancer detection

159 amical matrix (or Hamiltonian), enabling the design of metamaterials with emergent properties that es

160 A new design of microelectrode was introduced to generate elec

161 Results can be further exploited in design of microfluidic devices for rare cells immunocapt

162 tion as an alloy design tool, and enable the design of microstructures that maximize the useful impac

163 nding of the dynamics of PSM can support the design of MOFs with increasingly sophisticated architect

164 This motivated the design of molecular translators to convert molecular inp

165 Such discoveries will aid in the design of more effective approaches to control pertussis

166 he Ag species dispersion will benefit future design of more efficient supported Ag catalysts.

167 upramolecular gel and sets the basis for the design of more tailored supramolecular gels for drug del

168 The design of most high-impact critical care trials biased r

169 Chemical design of multicomponent nanocrystals requires atomic-le

170 lutionary aspects and can inspire innovative designs of multifunctional, biomimetic pressure-sensitiv

171 of 78% in 8-13 mum wavelength range, and the design of nanofibres with a controlled diameter allows f

172 ysregulated in human disease would allow the design of network-correcting therapies that treat the co

173 Our results are significant for the design of new antiviral prodrugs.

174 This observation might assist with rational design of new catalysts.

175 nal labeling reagents continues to drive the design of new compounds that are capable of fast and pre

176 rary settings, providing a framework for the design of new DEL synthesis technologies to enable next-

177 nAChR interaction might be exploited for the design of new drugs based on the nicotine scaffold.

178 catalysts and shows a great potential toward design of new energy conversion devices, such as water s

179 This work will inform the design of new generations of glycosidase inhibitors with

180 nd represents a key step toward the rational design of new heterogeneous catalysts.

181 diabetic neuropathy that can be used in the design of new interventional trials and for personalized

182 This has implications for the design of new long-residence-time TSPO ligands.

183 The design of new molecules with high ionic conductivity and

184 Our approach can facilitate the design of new network structure for cognitive functions

185 In this work, SR is used to guide the design of new oxide perovskite catalysts with improved o

186 ther development of the field, including the design of new photoactivation modalities, the continuous

187 n the appropriate use of the drug and in the design of new regimens for the treatment of RA.

188 ze protection, quantify risk, and inform the design of new system architectures.

189 Ni-catalyzed radical cross-couplings and the design of new transformations are discussed.

190 in cDC1s and have major implications for the design of new vaccination strategies with adoptive T cel

191 enign conditions as a means of informing the design of next generation synthetic catalysts.

192 ability is a novel approach for the rational design of next-generation batteries.

193 ters and a general strategy for the rational design of next-generation nano-probes, sensors and switc

194 promising and underexplored strategy for the design of next-generation O(2) adsorbents.

195 enes in bacteria can provide targets for the design of novel antibiotic compounds or antimicrobial st

196 uman hemoglobin and are drug targets for the design of novel antimalarial agents.

197 ture and provides important guidance for the design of novel capsid inhibitors.

198 ystal engineering approach, for example, the design of novel dynamic functional soft materials for fu

199 promise for the fundamentals-based bottom-up design of novel heterogeneous catalysts, which are at th

200 diverse channel structures and will aid the design of novel nanopores.

201 ation of conserved mechanisms as well as the design of novel strategies that can better serve the phy

202 rstanding of these processes may lead to the design of novel therapeutic strategies complementary to

203 tinent clinical phenotype may facilitate the design of novel therapeutic strategies targeting these '

204 ding of this remarkable process may help the design of novel therapeutics for neurodegeneration and o

205 In this Review, we discuss the innovative designs of novel CAR T cell products that are being deve

206 of membrane structures and inspire creative designs of novel membranes, promoting the sustainable de

207 metastable phases have been the basis of the design of numerous alloys, yet research on metastable hi

208 r imaging experiments in animals through the design of optical contrast agents for the shortwave infr

209 The structure and design of optimal supply networks is an important topic

210 Our observations encourage the rational design of optimized ThyX inhibitors that ultimately may

211 y of their assemblies, thereby assisting the design of ordered, anisotropic nanomaterials but also br

212 mportant structural information for rational design of PAICS inhibitors as potential anticancer drugs

213 ctural and functional knowledge for rational design of panserotype DENV capsid inhibitors.

214 Rational design of parent zeolites with concentrated and non-prot

215 one reduces side effects, guiding the future design of partial agonists as selective GR modulators wi

216 fers an efficient algorithm for the rational design of personalized probiotic cocktails to decolonize

217 at an individual level and could inform the design of personalized treatment strategies that can be

218 Rational design of pharmaceutical drugs targeting integral membra

219 ting field of science rooted in the rational design of photochromic molecules for task-specific bio-,

220 idated by this study may enable the rational design of photoswitchable systems whose reactivity can b

221 sults will provide insight into the rational design of polymeric inhibitors and improve our understan

222 ), resulting in considerable interest in the design of pore-containing proteins.

223 plications for molecular diagnostics and the design of potential vaccines.

224 rovided in this report should facilitate the design of preclinical evaluations for potential DMD ther

225 ll help improve understanding and inform the design of preventative strategies to improve long-term c

226 ation', but which have been neglected in the design of protected area networks in the tropics, merit

227 generally applicable strategy for in silico design of protein models that are computationally testab

228 hanisms in diverse populations and guide the design of randomized controlled trials to control exposu

229 odel material system to explore the rational design of redox-active molecules in nonaqueous systems.

230 peutics could crucially depend on thoughtful design of rigorous presymptomatic trials.

231 linical treatment of flatfoot disorders, the design of robotic feet and the study of foot function in

232 terial science have boosted a new era in the design of robust and sensitive biosensors.

233 t status and future trends on the structural design of robust MOFs with high connectivity is provided

234 l complexes could provide a template for the design of safer and more effective therapies.

235 Computer modelling is widely used in the design of scientific instrumentation for manipulating ch

236 r the past 3 decades with an emphasis on the design of selective inhibitors that discriminate between

237 tes and to translate this knowledge into the design of selective inhibitors.

238 The design of self-immolative and crosslinkable hydrophobic

239 Here, we performed structure-based design of several epitopes of the HCV E2 envelope glycop

240 ead to several policy insights regarding the design of similar agri-platforms in developing countries

241 This innovative and versatile molecular design of single-ion conducting polymers leads to unprec

242 Recommendations for improving the design of sintering experiments and for new research are

243 th cellular receptors, can be useful for the design of small molecule inhibitors and vaccine developm

244 igase, increasing the potential for rational design of small molecule RGS2 protein stabilizers.

245 es of beta(1)AR provide a foundation for the design of small molecules that could bias signalling in

246 NPs at liquid-liquid interface, enabling the design of smart responsive structured-liquid systems.

247 tal engineering community, whose goal is the design of solids with bespoke properties.

248 We explored three approaches to the design of splint oligonucleotides that enable efficient

249 ctronic effects that can be harnessed in the design of stereoselective reactions, including chemical

250 uctures is of great interest in the chemical design of stimuli-responsive materials that mimic the co

251 ould provide a helpful tool for the rational design of strand-displacement reaction networks.

252 y captured by atomistic simulations, and the design of such materials from first principles is still

253 ractivity become inseparable in the rational design of such materials.

254 sfully control these processes via selective design of sulfiphilic/sulfiphobic substrates.

255 ussed in this review, can be utilized in the design of supported metal NCs highly resistant to sinter

256 ate-cavitands were used as receptors for the design of supramolecular sensors for creatinine and its

257 unities, which is a major impediment for the design of sustainable peptide-based antibiotics that can

258 robust modelling framework for the rational design of synthetic communities with optimized growth su

259 enabling new approaches to the model-driven design of synthetic gene networks, the fast and portable

260 ding of molecular-scale cell biology and the design of synthetic machines.

261 nits in a confined space is critical for the design of synthetic molecular machines.

262 y materials also hold great potential in the design of systems for photovoltaics in which intermolecu

263 he low cost of PMMA manufacture and flexible designs of TADF molecules, pure organic, large-scale, co

264 rk provides basic information needed for the design of tandem mass spectrometry-based CAD sequencing

265 s as presented in this work will improve the design of targeted therapeutics against SARS-CoV-2.

266 The design of the azobenzene-modified linking DNA is critica

267 tween different cell populations, the custom design of the cell cycle and cleavage properties, the pr

268 equires knowledge of the protocol before the design of the chip.

269 ion capability is attributed to the enhanced design of the CSRR sensing elements that expose the gluc

270 The design of the demonstrated assay consists of a rolling c

271 on the choice of adversarial images and the design of the experiment.

272 The design of the LightR module ensures broad applicability

273 obe microsampling device (DPM), based on the design of the liquid microjunction surface sampling prob

274 h a heuristic optimisation technique for the design of the metamaterial, where the local height of th

275 Here, using structure guided design of the murine STING CDN binding domain, we engine

276 Our findings inform the molecular design of the next generation of stable blue carbene-met

277 h-space interactions could be manipulated by design of the organic modifiers.

278 ng the release of primary human cells or the design of the paper-based diagnostic, require an additio

279 registration number NCT03702582Rationale and Design of the Randomized Controlled Trial of New Oral An

280 hide derivatives, aiding the future rational design of the reaction condition, structural modificatio

281 eed, we developed general guidelines for the design of the sensing, signal detection, and data interp

282 ween patient groups given the non-randomised design of the studies included.

283 nary heart disease or total mortality to the design of the trial, the multiple centers involved, and

284 New designs of the cryo-EM grids-aimed at preserving thin, u

285 current understanding and challenges in the design of thermoresponsive hydrogels for CNS therapy are

286 -function models that allow for the rational design of these devices, and in delivering insights in,

287 the series of discoveries that prompted the design of this cascade coupling.

288 ed the discovery, optimization, and rational design of three major categories of oxide cathodes for l

289 Importantly, we demonstrate the design of tightly regulated aptamers with strong target

290 istry, discussing the key parameters for the design of transformers and generators as well as the dev

291 Here, we demonstrate a rational design of triple combination regimen, including relaxin

292 rimental studies were employed to inform the design of triple ligation systems that encompass three o

293 Chemical biology-inspired design of tunable chemical tools has aided in clinical d

294 y of this methodology is demonstrated by the design of two distinct types of reactions: Giese-type ad

295 Here, we describe the design of two-input AND, OR, NAND, NOR, XNOR, and NOT ga

296 tumor microenvironment and the personalized design of upconversion nanoparticles will result in more

297 ned and provide critical information for the design of vaccination strategies intended to provoke cel

298 ing developed for SARS-CoV-2 to aid rational design of vaccines and therapeutics.

299 any different applications, ranging from the design of wearable robots that interact with humans to t

300 during catalysis and will assist the future design of zeolites for their applications.