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1 C-42, and a third by structural analogs of N-desmethylclozapine.
2  about its biologically active metabolite, N-desmethylclozapine.
3 azol-2-one) , and the clozapine metabolite N-desmethylclozapine.
4 perties of AC-42 and AC-260584 but not for N-desmethylclozapine and clozapine, indicating that they m
5               TCC were also activated with N-desmethylclozapine and olanzapine at supratherapeutic co
6 oro-4H-benzo[1,4]oxazin-3-one (AC-260584), N-desmethylclozapine, and clozapine with the M(1) muscarin
7     Western blots revealed that Clozapine, N-desmethylclozapine, and DETC reduce the phosphorylation
8 ns studied, and the docking indicated that N-desmethylclozapine bound to a site distinct from AC-42 a
9 se observations raise the possibility that N-desmethylclozapine contributes to clozapine's clinical a
10 ly, these results indicate that Clozapine, N-desmethylclozapine, DETC, and U0126 protect PC-12 cells
11    In contrast, the functional activity of N-desmethylclozapine did not require Phe77.
12                              Clozapine and N-desmethylclozapine displayed substantially increased max
13 idence that the brain penetrant metabolite N-desmethylclozapine is a potent, allosteric agonist at hu
14 y M(1) and M(4), and its major metabolite, N-desmethylclozapine, is a full agonist at M(1).
15 verse allosteric agonists AC-42, TBPB, and N-desmethylclozapine may interact with different subsets o
16         In contrast, its major metabolite, N-desmethylclozapine (NDMC), is thought to enhance working
17  prompted us to investigate the effects of N-desmethylclozapine on cloned human M1-M5 muscarinic rece
18 r map the binding site of AC-42, TBPB, and N-desmethylclozapine, point mutations previously reported
19 irected mutagenesis studies suggested that N-desmethylclozapine preferentially activated M1 receptors
20                                            N-desmethylclozapine preferentially bound to M1 muscarinic
21 chotic disorders, the neuronal activity of N-desmethylclozapine was electrophysiologically investigat
22               In contrast, the activity of N-desmethylclozapine was generally unaffected by the point
23                                            N-desmethylclozapine was shown to dose-dependently potenti
24                    The clozapine metabolite, desmethylclozapine, was considerably more potent than th
25 ponses to AC-42, AC-260584, clozapine, and N-desmethylclozapine were all substantially reduced, but u
26 llosteric compounds such as WIN 51,708 and N-desmethylclozapine were noncompetitive inhibitors.
27 ssues is demonstrated, where clozapine and N-desmethylclozapine were observed from mouse and rat brai
28 omocytoma (PC-12) cell line, Clozapine and N-desmethylclozapine were tested for their ability to prot