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1 CE constituents, including downregulation of desmoglein 1.
2 n disease mediated by autoantibodies against desmoglein 1.
3 g in an endemic area have antibodies against desmoglein 1.
4  of junctional integrity through cleavage of desmoglein 1.
5 lysis) and pathogenic autoantibodies against desmoglein 1.
6 ease characterized by autoantibodies against desmoglein 1.
7 mes (CD) as well as CD constituent proteins, desmoglein 1.
8 ssed no E-cadherin and significantly reduced Desmoglein 1.
9 s in the desmosomal proteins desmoplakin and desmoglein 1.
10 -dependent manner by desmoglein-3 but not by desmoglein-1.
11 how that repeats 1-4 are involved in binding desmoglein-1.
12 athogenic antibodies to the EC1-2 domains of desmoglein-1.
13 mao Verde differ in IgG subclass response to desmoglein-1.
14 oped world, is mediated by IgG antibodies to desmoglein-1.
15 associated with acquisition of antibodies to desmoglein-1.
16 ation of complexes formed by plakoglobin and desmoglein 1, 2, or 3 are further examined through immun
17  human desmoglein cDNA sharing homology with desmogleins 1, 2, 3 and we name this desmoglein 4.
18 ression patterns of the desmoglein isotypes, desmogleins 1, 2, and 3 in the cutaneous epithelium, and
19 ein isoforms have been characterized, namely desmogleins 1, 2, and 3 that are expressed in a tissue-
20                     Intercellular junctions (desmoglein-1/3, desmoplakin, E-cadherin) and epithelial-
21  desmoglein 4 shares 41% identity with human desmoglein 1, 37% with human desmoglein 2, and 50% with
22  circulating autoantibodies directed against desmoglein 1, a 160 kDa transmembrane desmosomal molecul
23 ion relied largely upon the up-regulation of desmoglein 1, a desmosomal cadherin that maintains the i
24     Western blotting revealed degradation of desmoglein 1, a key corneodesmosome structural protein,
25                                 DSG1 encodes desmoglein 1, a major constituent of desmosomes, which c
26 he cutaneous epithelium, and discovered that desmoglein 1 and 2 expression correlated with the state
27 ponents, including desmoplakin, plakoglobin, desmoglein 1 and 2, and desmocollin 1a and 2a.
28 ning of other desmosomal proteins, including desmoglein 1 and 2, plakophilin 2, and plakoglobin.
29 esmoglein 3 to obtain affinity-purified anti-desmoglein 1 and anti-desmoglein 3 autoantibodies from p
30             In addition, the pathogenic anti-desmoglein 1 and anti-desmoglein 3 autoantibodies in pem
31    By immunoprecipitation, the purified anti-desmoglein 1 and anti-desmoglein 3 showed no cross-react
32  Moderate or low correlations were seen with desmoglein 1 and bullous pemphigoid 180 titers.
33 aggrin processing and delayed degradation of desmoglein 1 and corneodesmosin.
34 newborn animals with decreased expression of desmoglein 1 and corneodesmosin.
35 soluble recombinant extracellular domains of desmoglein 1 and desmoglein 3 to obtain affinity-purifie
36 hs in understanding the interactions between desmoglein 1 and plakogloben in staphylococcal-mediated
37 et was coimmunoprecipitated with E-cadherin, Desmoglein 1 and Plakoglobin, suggesting that they form
38 eads to decreased cell surface expression of desmoglein 1 and re-localization of its C terminus diffu
39  is characterized by autoantibody binding to desmoglein 1 and/or 3 (dsg1/dsg3).
40 us epithelia there are two major isoforms of desmoglein, 1 and 3, with different distributions in epi
41                      We produced recombinant desmoglein-1 and desmoglein-3, and used them in highly s
42 antibody capable of cross-reacting with both desmoglein-1 and desmoglein-3.
43  to S. aureus showed enhanced degradation of desmoglein-1 and filaggrin, whereas small interfering RN
44                    EcpA was shown to degrade desmoglein-1 and LL-37 in vitro, disrupt the physical ba
45 st, the major pathogenic antibody recognizes desmoglein-1 and mediates cutaneous disease only.
46 linked immunosorbent assay using recombinant desmoglein-1 and standardized the assay to enable compar
47  No significant changes in the expression of desmogleins 1 and 2 were detected.
48 creased the protein levels of E-cadherin and desmogleins 1 and 3 by 300, 180, and 40%, respectively.
49   Specific staining of KC for E-cadherin and desmogleins 1 and 3 increased by 235, 228, and 148%, res
50 addition to AuAbs against adhesion molecules desmogleins 1 and 3, PV patients also produce an AuAb ag
51                                     The anti-desmoglein 1 antibodies in pemphigus foliaceus and anti-
52         These findings suggest that the anti-desmoglein 1 antibodies in pemphigus vulgaris are pathog
53         As tissue damage is mediated by anti-desmoglein 1 antibodies, an initial T cell response is a
54      In this study we have searched for anti-desmoglein-1 antibodies in sera from parasitic (leishman
55           Collectively, our results identify desmoglein 1 as a novel caspase and metalloproteinase su
56 uring keratinocyte apoptosis and also reveal desmoglein 1 as a previously unrecognized regulator of a
57                                     The anti-desmoglein 1 autoantibodies in pemphigus vulgaris induce
58 dies; however, the pathogenicity of the anti-desmoglein 1 autoantibodies in pemphigus vulgaris remain
59 of pemphigus vulgaris sera also contain anti-desmoglein 1 autoantibodies; however, the pathogenicity
60 antigenic peptide candidates triggering anti-Desmoglein-1 autoantibodies.
61             Previous work has suggested that desmoglein 1 binds to its catenin partner, plakoglobin,
62 orbed in a concentration-dependent manner by desmoglein-1 but not desmoglein-3.
63                  A change in conformation of desmoglein 1 by calcium depletion was shown, with immuno
64                    Depletion of calcium from desmoglein 1 completely inhibited its cleavage by exfoli
65 owever, the stoichiometry of the plakoglobin/desmoglein 1 complex does not appear to exceed 2:1.
66 ase in corneodesmosome density and increased desmoglein-1 content, with a decline in serine protease
67                           Also antibodies to desmoglein-1 could be absorbed in a concentration-depend
68 hat UV-induced caspase cleavage of the human desmoglein 1 cytoplasmic tail results in distinct 17- an
69  the E-cadherin extracellular domain and the desmoglein-1 cytoplasmic domain, and these cells formed
70                                 In contrast, desmoglein 1 defined more differentiated cell population
71 eatment significantly increased abundance of desmoglein-1, desmocollin-1 and plakoglobin in the BPD g
72 ent in every sample, the desmosome proteins: desmoglein-1, desmocollin-1 and plakoglobin were signifi
73                              Some undegraded desmoglein 1/desmocollin 1 redistribute uniformly into c
74 me recovery remained impaired as a result of desmoglein-1 downregulation.
75  D (SdrD) adhesin and the human skin protein desmoglein-1 (DSG-1), withstanding forces exceeding 2 na
76  protease activity, resulting in accelerated desmoglein-1 (DSG-1)/corneodesmosome degradation.
77 egulation of KLK5 and abnormal expression of desmoglein 1 (DSG1) and filaggrin, but not PAR2 were ide
78 ase Area Index (PDAI) score of 45 or higher, desmoglein 1 (DSG1) antibodies greater than 20 IU/mL, an
79 that autoantibodies against desmoglein 3 and desmoglein 1 (Dsg1) are relevant in the pathogenesis of
80          We recently identified keratinocyte desmoglein 1 (DSG1) as an mediator of keratinocyte:melan
81 ated by pathogenic, predominantly IgG4, anti-desmoglein 1 (Dsg1) autoantibodies and is endemic in Lim
82 us (PF), is characterized by pathogenic anti-desmoglein 1 (DSG1) autoantibodies.
83 higus foliaceus (PF), autoantibodies against desmoglein 1 (Dsg1) cause blisters.
84 G4 autoantibody response to the self-antigen desmoglein 1 (Dsg1) cross-reacts with the LJM11 sand fly
85                                              Desmoglein 1 (Dsg1) is a cadherin restricted to stratifi
86                                              Desmoglein 1 (Dsg1) is a desmosomal cadherin that is ess
87  wasting (SAM) syndrome, caused by biallelic desmoglein 1 (DSG1) mutations, exhibit skin lesions remi
88 ecular specificity to cleave mouse and human desmoglein 1 (Dsg1) once after glutamic acid residue 381
89 istering disease caused by autoantibodies to desmoglein 1 (Dsg1) that cause loss of epidermal cell ad
90  loss of the keratinocyte-specific cadherin, Desmoglein 1 (Dsg1), controls paracrine signaling betwee
91 fferentiation-associated proteins, including desmoglein 1 (Dsg1), desmocollin 1 (Dsc1), and keratins
92 nds to DP and Dsc1a, and to a lesser extent, desmoglein 1 (Dsg1), while PG binds to Dsg1 and more wea
93  caused by pathogenic IgG4 autoantibodies to desmoglein 1 (DSG1).
94 ed by pathogenic IgG4 autoantibodies against desmoglein 1 (Dsg1).
95 leavage of the desmosomal cadherin component desmoglein 1 (Dsg1).
96 ted between extracellular domains 3 and 4 of desmoglein 1 (Dsg1).
97 y severe skin blistering and pathogenic anti-desmoglein-1 (Dsg1) autoantibodies.
98                                              Desmoglein-1 (DSG1), a desmosomal protein, maintains the
99 he desmosomal cadherins to mediate adhesion, desmoglein-1 (Dsg1), desmocollin-2 (Dsc2a) and plakoglob
100                     The desmosomal cadherin, desmoglein-1 (DSG1), promotes keratinocyte differentiati
101 s autoantibodies are desmoglein-3 (Dsg3) and desmoglein-1 (Dsg1), respectively.
102 utoantibodies against the desmosomal antigen desmoglein-1 (Dsg1).
103 mponent, VPS35, and the desmosomal cadherin, desmoglein-1 (Dsg1).
104 ies against the desmosomal core glycoprotein desmoglein-1 (Dsg1).
105 ntibodies against a desmosomal glycoprotein, desmoglein-1 (Dsg1).
106 multiple markers of differentiation (such as desmoglein-1 [Dsg1], keratin-1, and loricrin) and abroga
107  directed against desmoglein 3 (Dsg3) and/or desmoglein 1(Dsg1).
108 taxis (eotaxin 3, CCL26), barrier molecules (desmoglein 1, DSG1), tissue remodeling (periostin, POSTN
109 s foliaceus (PF) possess pathogenic IgG anti-desmoglein 1-(Dsg1) autoantibodies.
110                     A specific and sensitive desmoglein-1 ELISA detected antibodies in 34 of 41 oncho
111  with an increase in corneodesmosomes and in desmoglein 1 expression.
112 barrier function in association with loss of desmoglein-1 expression and has a regulatory role in rep
113 cognized syndrome caused by mutations in the desmoglein 1 gene (DSG1).
114 t the complex formed between plakoglobin and desmoglein 1 has an overall molecular weight greater tha
115 tion of the superficial desmosomal cadherin, desmoglein 1, impedes basal stratification in an in vitr
116 l, short hairpin RNA-mediated suppression of desmoglein 1 in differentiated keratinocytes protected c
117 nosorbent assay to detect antibodies against desmoglein 1 in serum samples from 60 patients with ende
118     We previously detected IgG antibodies to desmoglein-1 in 97% of patients, but also in 55% of norm
119 paired barrier function (mediated by loss of desmoglein-1), increased production and/or activity of t
120 PF), autoantibodies against desmoglein-3 and desmoglein-1 induce epidermal cell detachment (acantholy
121 , suggesting that the proper conformation of desmoglein 1 is critical for its cleavage.
122         The prevalence of antibodies against desmoglein 1 is high among normal subjects living in an
123 pt that the production of antibodies against desmoglein 1 is initiated by exposure to an unknown envi
124 l that a 276-residue DSCR construct of human desmoglein 1 is intrinsically disordered and forms an in
125                                        Dsg1 (desmoglein 1) is a member of the cadherin family of Ca(2
126 d both by electron microscopy and by reduced desmoglein 1 levels in the stratum corneum (shown by imm
127                                          The desmoglein 1 membrane proximal region also interacts wit
128           In contrast, beta-catenin binds to desmoglein-1 more weakly than does plakoglobin.
129              Exfoliative toxin cannot cleave desmoglein 1 pretreated at 56 degrees C or higher or at
130                     Full affinity binding of desmoglein-1 requires sequences C-terminal to the region
131 specificity of exfoliative toxin cleavage of desmoglein 1 resides not only in simple amino acid seque
132 and pemphigus foliaceus are desmoglein 3 and desmoglein 1, respectively.
133  highly structured calcium-binding domain of desmoglein 1, resulting in loss of its function.
134       Complementary DNA was isolated from 17 desmoglein 1 specific T cell clones generated from pemph
135                                       In PF, desmoglein-1-specific autoantibodies induce blistering.
136        Because cleavage occurs in an area of desmoglein 1 stabilized by calcium, we determined if the
137 ratinocytes by downregulating E-cadherin and Desmoglein 1, therefore frees melanoma cells from the co
138 ), filaggrin, E-cadherin, claudin, occludin, desmoglein-1 was found, independent of CS therapy.
139 mosomal junction proteins corneodesmosin and desmoglein-1, was down-regulated by histamine.
140 th HGF-expressing adenovirus, E-cadherin and Desmoglein 1 were decreased in melanocytes, WM164 and WM
141                           Antibodies against desmoglein 1 were detected in 59 of the 60 patients with
142  WM35, expressed normal level E-cadherin and Desmoglein 1, whereas most melanomas (18 out of 20) expr
143 spase-3 as the preferred enzyme that cleaves desmoglein 1 within its unique repeating unit domain at

 
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