ライフサイエンスコーパス: desmoplastic

1 s with low PDGF, though tumorigenic, are non-desmoplastic.

2 70%), lentigo maligna (~15%), nodular (~5%), desmoplastic (~4%), amelanotic (2%-8%), spitzoid (<2%),

3 appears to be related more to the degree of desmoplastic activity and cellular proliferation than ne

4 tic ductal adenocarcinoma (PDAC) is a highly desmoplastic, aggressive cancer that frequently progress

5 mpanied by hyperplastic changes in cells and desmoplastic alterations in the surrounding stroma.

6 The xenografts are desmoplastic and comprised of 30% myofibroblasts and 60

7 D, and one tumor showed combined features of desmoplastic and conventional.

8 atty acid translocase CD36, which is seen in desmoplastic and disease-free high mammographic density

9 Mechanistically, Pin1 drives the desmoplastic and immunosuppressive TME by acting on CAFs

10 locks multiple cancer pathways, disrupts the desmoplastic and immunosuppressive TME, and upregulates

11 of only 13%, PDAC has proven to be extremely desmoplastic and immunosuppressive to most current thera

12 er with limited treatment options due to its desmoplastic and immunosuppressive tumor microenvironmen

13 d to inherent tumor heterogeneity and highly desmoplastic and immunosuppressive tumor microenvironmen

14 Malignant cells drive the generation of a desmoplastic and immunosuppressive tumor microenvironmen

15 c ductal adenocarcinoma (PDAC) is profoundly desmoplastic and immunosuppressive.

16 ic factors facilitating the induction of pro-desmoplastic and pro-tumorigenic transcriptional program

17 chinery in stromal components to establish a desmoplastic and therapeutic resistant tumor microenviro

18 r analysis, including 38 classic, 30 nodular desmoplastic, and 18 large-cell anaplastic (LCA) medullo

19 arcinoma (PDAC) tumors have a nutrient-poor, desmoplastic, and highly innervated tumor microenvironme

20 models, loss of Prox1 promoted the growth of desmoplastic, angiogenic, and immunologically silent tum

21 r prospero homeobox 1 (PROX1) was reduced in desmoplastic APC-mutant human CRCs.

22 cancers with Snail1(+) CAF tended to exhibit desmoplastic areas with anisotropic fibers, lymph node i

23 CCA is a highly desmoplastic cancer and targeting the tumour immune micr

24 oor prognosis in cholangiocarcinoma (CCA), a desmoplastic cancer enriched in cancer-associated fibrob

25 or instance, for lung fibrosis or the highly desmoplastic cancer of the pancreas.

26 tic ductal adenocarcinoma (PDAC) is a highly desmoplastic cancer with limited treatment options.

27 ons of cancer-associated fibroblasts in this desmoplastic cancer.

28 ma in neoadjuvant chemotherapy-treated human desmoplastic cancers and orthotopic tumor xenografts rev

29 h it influences patient survival and enables desmoplastic cancers to escape nutrient limitation, rema

30 roblasts (CAF) are abundant in the stroma of desmoplastic cancers where they promote tumor progressio

31 CCAs are also highly desmoplastic cancers with a tumor microenvironment rich

32 nhance the efficacy of immunotherapy against desmoplastic cancers.

33 onse and extending survival of mice carrying desmoplastic cancers.

34 Patients with desmoplastic CRC have a significantly worse prognosis an

35 therapeutic strategy for chemoresistant and desmoplastic CRCs.

36 They find that PNI occurs exclusively in desmoplastic CSCC, and desmoplasia is independently asso

37 RETp was assessed in 71 non-desmoplastic cutaneous melanomas (non-DMs) and 70 desmop

38 incidence of tumors closely resembling human desmoplastic ductal cholangiocarcinomas in their morphol

39 ation of the composition and distribution of desmoplastic elements and T-cell infiltration is necessa

40 en fibers which suggested that variations in desmoplastic elements does not limit infiltration of [Fo

41 cinoma (CCA) is characterized by an abundant desmoplastic environment.

42 CAF apoptosis, diminishing expression of the desmoplastic extracellular matrix protein tenascin C, su

43 y human CRC revealed that mesenchymal and/or desmoplastic features combined with an immunosuppressive

44 om 19 patients diagnosed with desmoid tumor, desmoplastic fibroma, periosteal desmoid tumor, osteofib

45 both redundant and specific tumor-supportive desmoplastic functions.

46 prior diagnosis of liver lesions, had proved desmoplastic hepatic metastases that resembled cirrhosis

47 est patients where they were associated with desmoplastic histology.

48 ification of these mutations among the dense desmoplastic host reaction characteristic of primary pan

49 or vascular density and restrained growth of desmoplastic human lung cancer xenografts and syngeneic

50 n summary, our data demonstrate promotion of desmoplastic ICC growth by therapeutically targetable CA

51 This dramatic desmoplastic ICC-like phenotype, which was not observed

52 alignant grading in this 3D culture model of desmoplastic ICC.

53 arcinoma (2 children), ependymoma (1 child), desmoplastic infantile ganglioglioma (2 children), and m

54 y epithelial cells that subsequently induces desmoplastic-like phenotypes in neighboring fibroblasts.

55 rahepatic cholangiocarcinoma (ICC), a highly desmoplastic liver tumor.

56 Desmoplastic malignancies such as cholangiocarcinoma (CC

57 Desmoplastic malignancies, such as cholangiocarcinoma (C

58 sults in loss of the structural integrity of desmoplastic matrix.

59 Five years after diagnosis, patients with desmoplastic medulloblastoma (DMB) or medulloblastoma wi

60 Nodular desmoplastic medulloblastoma (ND) and medulloblastoma wi

61 ns were responsible for a high proportion of desmoplastic medulloblastoma in children younger than 3

62 studies have established that patients with desmoplastic melanoma (DM) have thicker primary tumors.

63 Desmoplastic melanoma (DM) is a variant of melanoma char

64 DM behaves differently from conventional non-desmoplastic melanoma (NDM).

65 on burden (median of 62 mutations/Mb) ranked desmoplastic melanoma among the most highly mutated canc

66 Patients with advanced desmoplastic melanoma have a high response rate to singl

67 Desmoplastic melanoma is a distinct subtype of melanoma

68 Desmoplastic melanoma is an uncommon variant of melanoma

69 which enrolled 27 patients with unresectable desmoplastic melanoma receiving pembrolizumab 200 mg int

70 table (cohort A) and unresectable (cohort B) desmoplastic melanoma.

71 plastic cutaneous melanomas (non-DMs) and 70 desmoplastic melanomas (DMs).

72 Melanocytic nevus cells in the dermis and desmoplastic melanomas often display characteristics of

73 ome and high-coverage exome sequencing of 20 desmoplastic melanomas, followed by targeted sequencing

74 inoma (PDAC) is characterized by a prominent desmoplastic microenvironment that contains many differe

75 al adenocarcinoma (PDAC) exists in a complex desmoplastic microenvironment, which includes cancer-ass

76 ecause of specific tissue characteristics of desmoplastic MMs, we hypothesize that these lesions may

77 e-dependent reduction in stromal collagen in desmoplastic models of human breast, pancreatic, and ski

78 cal patterns (morphotypes): complex tubular, desmoplastic, mucinous, papillary, serrated, and solid/t

79 Single-cell RNA sequencing of a highly desmoplastic murine PDAC model, Ptf1aCre/+; LSL-KrasG12D

80 Rather, desmoplastic murine stroma dominates the xenograft micro

81 on of the immunosuppressive TME in different desmoplastic murine tumor models.

82 In addition, the desmoplastic nature of the tumor-associated stroma acts

83 omas, 34 medulloblastomas (23 classic, eight desmoplastic-nodular, two large cell, one anaplastic), 1

84 and OS were both 89% (95% CI, 67 to 100) for desmoplastic/nodular (n = 11), 61% (95% CI, 51 to 71) an

85 Histology (hazard ratio, 0.19 for desmoplastic/nodular and 45.97 for large-cell/anaplastic

86 a with extensive nodularity, four of 20 with desmoplastic/nodular medulloblastomas, and one of 108 wi

87 Analysis showed that the desmoplastic/nodular subtype was a favorable factor in p

88 ure studies will use histopathologic typing (desmoplastic/nodular versus nondesmoplastic/nodular) to

89 py-resistant cancer that thrives in a highly desmoplastic, nutrient-deprived microenvironment.

90 ness; 7 of 171 melanomas [4.1%]) were mostly desmoplastic or nodular (4 of 7), self-detected (2 of 7)

91 s dense tumor extracellular matrix of highly desmoplastic pancreatic cancer, was complexed with biode

92 matrix (ECM) proteins, which are abundant in desmoplastic pancreatic tumor, are as potent as growth f

93 chanisms involved, here we treat established desmoplastic pancreatic tumors with CAR T cells directed

94 ng drives a minority of MB, correlating with desmoplastic pathology and favorable outcome.

95 s (PSCs) are key to the treatment-refractory desmoplastic phenotype of pancreatic ductal adenocarcino

96 mour cell Wnt7a expression correlates with a desmoplastic, poor-prognosis stroma and poor patient out

97 in architecture enable the activation of pro-desmoplastic programs directed by serum response factor

98 predicted by pathological evaluation of the desmoplastic reaction (DR), tumor budding (TB) and tumor

99 ocarcinoma (PDAC) is the presence of a dense desmoplastic reaction (stroma) that impedes drug deliver

100 ng collagen-rich milieu and suggest that the desmoplastic reaction actively contributes to PDAC progr

101 s undertaken to test the hypothesis that the desmoplastic reaction alters PDAC gene expression and ce

102 lar and molecular interactions mediating the desmoplastic reaction and aggressive malignancy of mass-

103 le myofibroblasts that are implicated in the desmoplastic reaction and metastatic growth.

104 We show here that this desmoplastic reaction generates inordinately high inters

105 thelial-stromal interactions responsible for desmoplastic reaction in breast cancer using cultured 3T

106 Stromal desmoplastic reaction in pancreatic ductal adenocarcinom

107 s contained large hypertrophic cytoplasm and desmoplastic reaction in the prostatic intra-epithelial

108 onal hepatocellular carcinoma is a prominent desmoplastic reaction manifested as a dense fibro-collag

109 The desmoplastic reaction of pancreas cancer may begin as a

110 In summary, desmoplastic reaction primarily occurs via the action of

111 pic culture model reproduced key features of desmoplastic reaction that closely mimicked those of the

112 Pancreatic cancer is characterized by a desmoplastic reaction that creates a dense fibroinflamma

113 therapeutic approaches to block the stromal desmoplastic reaction that likely plays an important rol

114 plays a predominant role in the formation of desmoplastic reaction through the synthesis of connectiv

115 However, when cases with extensive desmoplastic reaction were excluded, a statistically sig

116 und malignant breast epithelial cells (i.e., desmoplastic reaction) arises from the breast adipose ti

117 ollowing histologic factors: neovascularity, desmoplastic reaction, cellular proliferation and mitoch

118 renchymal changes, which include peritumoral desmoplastic reaction, inflammatory cell infiltration, a

119 a thick tumor border containing peritumoral desmoplastic reaction, peritumoral inflammation, and vas

120 sues revealed significant down regulation of desmoplastic reaction, SHH, Gli-1, MUC4, and Ki67 compar

121 to IL17A knockout mice to show an extensive desmoplastic reaction, without impaired immune infiltrat

122 fibrotic reaction around the tumor known as desmoplastic reaction.

123 preserving adjacent organs with macroscopic desmoplastic reaction.

124 e most abundant mesenchymal cell type in the desmoplastic reaction.

125 s are characterized by a dense collagen-rich desmoplastic reaction.

126 as well as within peri- and intraneoplastic desmoplastic reaction.

127 a pronounced collagen-rich fibrosis known as desmoplastic reaction; however, the role of fibrosis in

128 lon, and pancreatic tumors often show strong desmoplastic reactions, which result in a dominant prese

129 expression studies in tumours accompanied by desmoplastic reactions.

130 a in cirrhotic liver tissues as well as with desmoplastic regions of human HCC samples.

131 This process underlies the desmoplastic remodelling of the tumour microenvironment

132 ombinant GRN alone was sufficient to promote desmoplastic responding tumor growth.

133 in pancreatic cancer cell lines and the host desmoplastic response in the resected pancreatic cancer

134 adenocarcinoma (PDAC) is characterized by a desmoplastic response that promotes hypovascularity, imm

135 The desmoplastic response to human breast carcinoma is a hos

136 ression data primarily mirrors the prominent desmoplastic response to the infiltrating neoplasm.

137 stromal and/or angioendothelial cells of the desmoplastic response to the invasive tumor, and four of

138 impedes fundamental elements of the stromal desmoplastic response, including collagen and proinflamm

139 sive pancreatic cancers and their associated desmoplastic response, we performed in situ hybridizatio

140 fferences in gene expression within the host desmoplastic response.

141 s characterized by an exuberant inflammatory desmoplastic response.

142 Desmoplastic responses were evident through vimentin, al

143 pecific or organ-specific differences in the desmoplastic responses.

144 One patient (desmoplastic round cell tumor [DSRCT]) achieved a confir

145 arcomas, two alveolar rhabdomyosarcomas, two desmoplastic round cell tumors, and one each of infantil

146 sarcoma (SS), clear cell sarcoma (CCS), and desmoplastic small round cell tumor (DSRCT) are soft-tis

147 Desmoplastic small round cell tumor (DSRCT) is a rare di

148 Desmoplastic small round cell tumor (DSRCT) is a rare sa

149 Desmoplastic small round cell tumor (DSRCT) is a rare, r

150 Desmoplastic small round cell tumor (DSRCT) is an abdomi

151 Desmoplastic small round cell tumor (DSRCT) is an aggres

152 Desmoplastic small round cell tumor (DSRCT) is defined b

153 her understand the molecular pathogenesis of desmoplastic small round cell tumor (DSRCT), a fatal mal

154 Desmoplastic small round cell tumor (DSRCT), a rare sarc

155 nderlie several human malignancies including Desmoplastic Small Round Cell Tumor (DSRCT), an aggressi

156 This translocation underlies desmoplastic small round cell tumor (DSRCT), which is no

157 One patient each with hepatoblastoma or desmoplastic small round cell tumor achieved a partial r

158 Eleven of 14 patients with desmoplastic small round cell tumor had primary abdomina

159 Methods: Eligible patients diagnosed with desmoplastic small round cell tumor with peritoneal invo

160 one primitive neuroectodermal tumor, and one desmoplastic small round cell tumor).

161 ry site are characteristic of intraabdominal desmoplastic small round cell tumor.

162 inistered intraperitoneally in patients with desmoplastic small round cell tumor.

163 nslocation EWSR1-WT1 found in the aggressive desmoplastic small round cell tumor.

164 phroma, dermatofibrosarcoma protuberans, and desmoplastic small round cell tumor; one sarcoma predisp

165 Desmoplastic small round cell tumors (DSRCT) are a type

166 ound cell sarcomas, including 173 ES and 104 desmoplastic small round cell tumors (DSRCT), to detect

167 cells, the only available in vitro model for Desmoplastic Small Round Cell Tumors (DSRCT), while havi

168 with metastatic Ewing family tumors (EFT) or desmoplastic small round cell tumors (DSRCT).

169 EWSR1::WT1 is essential for desmoplastic small round cell tumors and upregulates the

170 yosarcomas, 28 of 29 osteosarcomas, 35 of 37 desmoplastic small round cell tumors, 2 of 3 synovial sa

171 related primitive neuroectodermal tumors and desmoplastic small round cell tumors.

172 11;22)(p13;q12) and descriptively designated desmoplastic small round-cell tumor (DSRCT) are a distin

173 is the defining chromosomal translocation in desmoplastic small round-cell tumors (DSRCT), a rare but

174 lterations were shared with Ewing sarcoma or desmoplastic, small round cell tumors, which are other E

175 In this Review, we focus on the desmoplastic stroma and both the intratumoural and inter

176 own poor efficacy in PDAC, partly due to the desmoplastic stroma and low immunogenicity.

177 gies aimed at deconstructing the surrounding desmoplastic stroma and targeting the immunosuppressive

178 ion to proteins involved in the formation of desmoplastic stroma and to immunosuppression by driving

179 Myofibroblasts produce desmoplastic stroma around tumors and have emerged as th

180 allmark of pancreatic tumors is their highly desmoplastic stroma composed of fibroblasts, immune cell

181 highly lethal tumors characterized by dense desmoplastic stroma composed predominantly of cancer-ass

182 The desmoplastic stroma comprises many inflammatory cells, i

183 An in vitro model of the desmoplastic stroma comprising cancer-associated fibrobl

184 t of rectal cancer, a tumor characterized by desmoplastic stroma containing cancer-associated fibrobl

185 d molecular information sufficient to induce desmoplastic stroma differentiation of normal fibroblast

186 , decreasing tumor growth and formation of a desmoplastic stroma in mouse models of PDAC.

187 The desmoplastic stroma in solid tumors presents a formidabl

188 situ transcript labeling to characterize the desmoplastic stroma induced by infiltrating ductal carci

189 of pancreatic ductal adenocarcinoma (PDAC), desmoplastic stroma poses a significant obstacle for tre

190 al adenocarcinoma (PDAC) is characterized by desmoplastic stroma surrounding most tumors.

191 iated immunosuppressive cells and a uniquely desmoplastic stroma that functions as a barrier to T cel

192 malignancy and is characterized by a dense, desmoplastic stroma that modulates PDAC progression.

193 cterized by its highly reactive inflammatory desmoplastic stroma with evidence of an extensive tumor

194 re largely microsatellite-stable and display desmoplastic stroma with poor immune infiltration.

195 Desmoplastic stroma, a consistent hallmark of PDAC, has

196 ast tumors are characterized by an extensive desmoplastic stroma, abundantly populated by fibroblasts

197 The robust desmoplastic stroma, along with an extensive extracellul

198 r-associated fibroblasts (CAFs) that produce desmoplastic stroma, thereby modulating disease progress

199 tology, become hypovascular and accumulate a desmoplastic stroma, ultimately recapitulating the prima

200 by a KRAS-driven inflammatory program and a desmoplastic stroma, which contribute to the profoundly

201 (PDAC) is characterized by a fibroblast-rich desmoplastic stroma.

202 in combination with gemcitabine depleted the desmoplastic stroma.

203 ty of neoplastic cells embedded in a densely desmoplastic stroma.

204 trated that organoid-activated CAFs produced desmoplastic stroma.

205 PDAC), drives formation of a fibroblast-rich desmoplastic stroma.

206 tumors that form with a myofibroblast-rich, desmoplastic stroma.

207 ancreatic cancer is characterized by densely desmoplastic stroma.

208 geneity; presence of a robust, reactive, and desmoplastic stroma; and the crosstalk between the diffe

209 ETV1 is critical in the desmoplastic stromal expansion and metastatic progressio

210 l cancer and the induction of its associated desmoplastic stromal niche.

211 The characteristic desmoplastic stromal reaction of pancreatic adenocarcino

212 examination revealed osteolysis and a strong desmoplastic stromal response, which indicated intense s

213 PC3 and LNCaP bone tumors showed a desmoplastic stromal response, which indicated intense s

214 aplasia and ductal dysplasia with remarkable desmoplastic stromal responses in all 25 bitransgenic mi

215 The desmoplastic structure of the tumor and the immunosuppre

216 Cutaneous melanomas, particularly the desmoplastic subtype, are highly neurotropic; thus we so

217 ly found in cutaneous melanoma, particularly desmoplastic subtypes, and responds to GDNF inducing eve

218 ow thickness, 3 of which were histologically desmoplastic; the other 2 had nodular components.

219 y, which has revolutionized drug delivery in desmoplastic tissues, harnessing physiochemical characte

220 me the stromal barrier for the management of desmoplastic triple-negative breast cancer (TNBC).

221 The dense stroma of desmoplastic tumor limits nanotherapeutic penetration an

222 The biological significance of the desmoplastic tumor microenvironment (TME) of ICC has bee

223 The biological significance of the desmoplastic tumor microenvironment (TME) of ICC has bee

224 avors the development of early lesions, to a desmoplastic tumor microenvironment that is highly fibro

225 Using cholangiocarcinoma as a desmoplastic tumor model, we investigated the sensitivit

226 In an orthotopic model using desmoplastic tumor organoids, global or fibroblast-speci

227 ancreatic ductal adenocarcinoma (PDAC) has a desmoplastic tumor stroma and immunosuppressive microenv

228 atic ductal adenocarcinoma (PDAC), where the desmoplastic tumor stroma challenges effective treatment

229 nificantly promoted metastasis, generating a desmoplastic tumor stroma highly reminiscent of metastat

230 tumor heterogeneity and an immunosuppressive desmoplastic tumor stroma that impacts interactions with

231 hic sarcoma (UPS), an immunologically active desmoplastic tumor.

232 ted Protein-CAR-T cells for the treatment of desmoplastic tumors such as pancreatic ductal adenocarci

233 sis serves as a major therapeutic barrier in desmoplastic tumors.

234 s is highly limited in stiff tissues such as desmoplastic tumors.

235 f decreased hydraulic conductivity common in desmoplastic tumors.

236 fficacy of nanotherapeutics in patients with desmoplastic tumors.

237 heterogeneous NP distribution in stroma-rich desmoplastic tumors; namely the abnormal tumor vasculatu

238 herapy dose rate, where more rigid and dense desmoplastic tumours are more sensitive to FLASH radioth

239 -95) for classic histology, 77% (49-100) for desmoplastic tumours, and 57% (33-80) for large-cell ana

240 mCRC) is microsatellite stable (MSS), highly desmoplastic, with CD8(+) T cells excluded to the stroma