ライフサイエンスコーパス: desmosome

1 dium channel, gap junctions, and the cardiac desmosome.

2 of the intercellular adhesive junction, the desmosome.

3 provide new insight into Perp's role in the desmosome.

4 ble scaffold for cytoplasmic assembly at the desmosome.

5 des desmoglein-2, a component of the cardiac desmosome.

6 g structural components of the sarcomere and desmosome.

7 hose of the sarcomere, the cytoskeleton, and desmosomes.

8 electron tomography reconstructions of human desmosomes.

9 y inducing calcium-independent hyperadhesive desmosomes.

10 e causes structural alterations of epidermal desmosomes.

11 horylation and subsequent destabilization of desmosomes.

12 minantly on the interaction of keratins with desmosomes.

13 though keratin filaments no longer anchor at desmosomes.

14 reduced exchange in and out of hyperadhesive desmosomes.

15 esive core of intercellular junctions called desmosomes.

16 of adherens junctions, tight junctions, and desmosomes.

17 ive core of intercellular junctions known as desmosomes.

18 are transmembrane cell adhesion proteins of desmosomes.

19 e adjacent myocardium with gap junctions and desmosomes.

20 in (Dsc) is the fundamental adhesive unit of desmosomes.

21 ARVC, at least in a subset, is a disease of desmosomes.

22 sistent with the absence of alpha-catenin in desmosomes.

23 trom, limited by the inherent flexibility of desmosomes.

24 usion of beta-catenin and alpha-catenin from desmosomes.

25 et of Exocyst complexes that are enriched at desmosomes.

26 in structural integrity in tissues that lack desmosomes.

27 in the cytoplasm and translocate to nascent desmosomes.

28 odulating adhesive strength and stability of desmosomes.

29 e change in the known protein composition of desmosomes.

30 e cohesive than cells with calcium-dependent desmosomes.

31 ort for the concept of hyper-adhesiveness in desmosomes.

32 ncorporated into both adherens junctions and desmosomes.

33 structure, including adherens junctions and desmosomes.

34 er of the p120ctn subfamily that is found in desmosomes.

35 pates in cell-cell adhesion mediated through desmosomes.

36 ns, tight junctions, gap junctions (GJ), and desmosomes.

37 ions, cadherin-based adherens junctions, and desmosomes.

38 to core components of adherens junctions or desmosomes.

39 decorating the extracellular faces of split desmosomes.

40 led dilated intercellular spaces and reduced desmosomes.

41 te organization of keratin cytoskeletons and desmosomes.

42 herens junctions and desmosomal cadherins in desmosomes.

43 Intercalated discs composed of desmosomes, adherens junctions, and gap junctions provid

44 Furthermore, PKP-1 expression transforms desmosome adhesion from a calcium-dependent to a calcium

45 Perp localizes specifically to desmosomes, adhesion junctions important for tissue inte

46 st complex in the assembly or maintenance of desmosomes, adhesive junctions that link intermediate fi

47 s and connexin 43 in the skin, and result in desmosome aggregation, widening of intercellular spaces,

48 ese findings reveal Pkp3 as a coordinator of desmosome and adherens junction assembly and maturation

49 The pathways driving desmosome and adherens junction assembly are temporally

50 tions confirms that ARVC is a disease of the desmosome and cell junction.

51 ike junctions display structural features of desmosome and gap junctions, but its function at the BTB

52 revealed that K14(+) cells were enriched for desmosome and hemidesmosome adhesion complex genes, and

53 Furthermore, desmosome and hemidesmosome defects were identified in t

54 as galvanized interest in the biology of the desmosome and its interactions with other junctional mol

55 Plakophilin-2 (PKP2) is a component of the desmosome and known for its role in cell-cell adhesion.

56 re, we review the molecular blueprint of the desmosome and models for assembling its protein componen

57 gene, which encodes a major component of the desmosome and the adherens junction, had been identified

58 p-1 armadillo repeat domain localized to the desmosome and the cytosol.

59 Desmosomes and adherens junctions are intercellular adhe

60 s revealed the disruption of the assembly of desmosomes and adherens junctions in Jup mutant epidermi

61 Plakoglobin is a component of both desmosomes and adherens junctions located at the interca

62 lar junctions formed by cadherins, including desmosomes and adherens junctions, comprise two dimensio

63 Mechanical continuity is provided by desmosomes and adherens junctions, while gap junctions p

64 occurs for the adhesive function provided by desmosomes and adherens junctions.

65 ization of tight junctions, deterioration of desmosomes and basement membrane (BM), and hyperbranchin

66 lar prion protein (PrP(c)) is a component of desmosomes and contributes to the intestinal barrier fun

67 as accompanied by a loss of desmoplakin from desmosomes and decreased adhesive strength following 18-

68 us vulgaris (PV) IgG is reduced in maturated desmosomes and dependent on PKC signaling.

69 er disruption, mediated in part by defective desmosomes and dysregulated transforming growth factor b

70 ighlight the essential role of PERP in human desmosomes and epidermal homeostasis and further expand

71 Desmosomes and gap junctions are distinct structural com

72 onents of specialized cell junctions such as desmosomes and hemidesmosomes are mediated through the s

73 cardiomyocytes to maintain the integrity of desmosomes and intermediate filament networks in vitro a

74 the primary force transducer between cardiac desmosomes and intermediate filaments, cause an arrhythm

75 tosis with genistein prevented disruption of desmosomes and loss of adhesion in the presence of PV Ig

76 iation, the presence of junctional complexes/desmosomes and microvilli, and the production of membran

77 s represent the fundamental adhesive unit of desmosomes and provide a structural framework for unders

78 highlights the tissue-specific functions of desmosomes and reveals that the canonical functions for

79 altering the dynamics of Dsg3 assembly into desmosomes and the turnover of cell surface pools of Dsg

80 play a critical role in the organization of desmosomes and tissue integrity.

81 are desmogleins (cell adhesion molecules in desmosomes), and pemphigoid antigens are found in hemide

82 osed of tight junctions, adherens junctions, desmosomes, and an associated actomyosin cytoskeleton, f

83 Coated pits, junctional complexes, desmosomes, and basement membranes appeared normal in mu

84 in tight junctions (TJ), adherens junctions, desmosomes, and gap junction complexes.

85 terations in tight junctions (TJ), adherens, desmosomes, and gap junctions, suggesting perturbations

86 ns (TJs), basal ectoplasmic specializations, desmosomes, and gap junctions.

87 mimics the toxin-cleaved cadherin, disrupts desmosomes, and reduces the mechanical integrity of kera

88 Since desmosomes appear early in mouse tissue development we h

89 re of the desmosomal cadherins is known, the desmosome architecture-which is essential for mediating

90 Desmosomes are adhesive intercellular junctions prominen

91 Desmosomes are adhesive junctions that provide mechanica

92 Desmosomes are anchoring junctions that exist in cells t

93 We show that epidermal desmosomes are calcium-dependent until embryonic day 12

94 Desmosomes are cell adhesion junctions required for the

95 Desmosomes are cell-cell adhesion structures that integr

96 Desmosomes are cell-cell adhesions necessary for the mai

97 Desmosomes are cell-cell junctions that link tissue cell

98 Desmosomes are cell-cell junctions that maintain tissue

99 Desmosomes are cell-cell junctions that provide mechanic

100 Desmosomes are critical elements of intercellular juncti

101 novel target of AHR signaling and show that desmosomes are critical for AHR agonists to block branch

102 Desmosomes are dynamic junctions between cells that main

103 Desmosomes are highly specialized anchoring junctions th

104 Desmosomes are intercellular adhesive junctions and atta

105 Desmosomes are intercellular adhesive junctions that imp

106 Desmosomes are macromolecular cell-cell junctions that p

107 ws that HaCaT cells with calcium-independent desmosomes are more cohesive than cells with calcium-dep

108 ntegrity, and numerous structural defects in desmosomes are observed in Perp-deficient skin, suggesti

109 Desmosomes are prominent adhesive junctions present betw

110 However, the notion that desmosomes are static structures that exist simply to gl

111 ocollins (DSCs), transmembrane components of desmosomes, are regulated at the transcriptional level.

112 which is accompanied by severe disruption of desmosome as well as costamere architecture and composit

113 are more extended in wild type than knockout desmosomes, as if intermediate filament connections prod

114 Without keratins, desmosomes assemble but are endocytosed at accelerated r

115 o protein plakophilin 3 (Pkp3) mediates both desmosome assembly and E-cadherin maturation through Rap

116 The mechanisms controlling desmosome assembly and remodeling in epithelial and card

117 nocytes largely through its contributions to desmosome assembly and structure.

118 Nguyen et al. demonstrate a role for Perp in desmosome assembly and trafficking and pemphigus IgG-med

119 at SERCA2-deficiency is sufficient to impede desmosome assembly and weaken intercellular adhesive str

120 derived cell lines was sufficient to disrupt desmosome assembly and weaken intercellular adhesive str

121 on of truncated Dsg2 protein interferes with desmosome assembly and/or maintenance to disrupt cell-ce

122 esults suggest that EGFR inhibition promotes desmosome assembly in oral squamous cell carcinoma cells

123 Instead, impaired adhesion through aberrant desmosome assembly may explain the diminished tumor deve

124 ent to rescue the defective DP localization, desmosome assembly, and intercellular adhesive strength

125 rnalization of newly synthesized Dsg3 during desmosome assembly, correlating with their pathogenic ac

126 e data suggest that in addition to mediating desmosome assembly, the nuclear pool of Pkp can influenc

127 , a known regulator of DP-IF association and desmosome assembly, to the plasma membrane by up to 70%.

128 During calcium-induced desmosome assembly, treatment of primary human keratinoc

129 e, promoting its activation and facilitating desmosome assembly.

130 ulate DP-IF interactions required for normal desmosome assembly.

131 contribute to actin-dependent regulation of desmosome assembly.

132 Dsg3, thereby driving Dsg3 biosynthesis and desmosome assembly.

133 ey may also participate in the regulation of desmosome assembly.

134 termine the role of plakophilin-1 in de novo desmosome assembly.

135 cruitment of desmoplakin to the membrane and desmosome assembly.

136 ese effects, indicating a key role for PG in desmosome assembly.

137 ide a structural framework for understanding desmosome assembly.

138 e we identify a potential mechanism by which desmosomes assist the de-neddylating COP9 signalosome (C

139 sm of localization and function of two novel desmosome-associated adaptor proteins enriched in the de

140 ay provide novel treatments for PV and other desmosome-associated blistering diseases.

141 This work reveals essential desmosome-associated components that control cortical mi

142 We validated a number of these novel desmosome-associated proteins and find that many are mem

143 caused late depletion of Dsg3 from preformed desmosomes at 24 hours, with effects on multiple desmoso

144 Desmosomes at blister sites were occasionally split, wit

145 ace through costameres at the sarcolemma and desmosomes at intercalated disks.

146 some signaling may be effective for treating desmosome autoimmune blistering disorders.

147 ve junctions and discovered the formation of desmosomes between the invading and entotic cells.

148 hesion may not be a state acquired by entire desmosomes but rather is paralleled by enhanced binding

149 lost from the centrosome and is recruited to desmosomes by desmoplakin (DP).

150 ons in PERP, encoding a crucial component of desmosomes, cause both dominant and recessive human kera

151 lapse of the cytoskeleton and disassembly of desmosomes caused by upstream events involving Src and E

152 hat appears to be unstably incorporated into desmosomes, causes Olmsted syndrome with severe periorif

153 isease; and arrhythmogenic cardiomyopathy as desmosome, cell junction disease.

154 Similarly, trophectodermal desmosomes change from calcium-dependence to hyper-adhes

155 Desmosomes change to a lower affinity, calcium-dependent

156 l et al. (2014) now show that the structural desmosome complex participates in targeted trafficking o

157 Desmoglein 3 is a transmembrane component of desmosome complexes that mediate epidermal cell-to-cell

158 Plakophilin 2 (PKP2), a desmosome component, modulates the activity and localiza

159 a key signaling event, phosphorylation of a desmosome component, PKP1 (plakophilin-1) by RIPK4 (rece

160 maintenance of adherens junctions and other desmosome components at the plasma membrane.

161 dium is underscored by frequent mutations of desmosome components found in human patients and animal

162 Silencing CSN or desmosome components shifts the balance of EGFR modifica

163 skeleton-unbound and a cytoskeleton-anchored desmosome-containing pool revealed that Dsg3, in contras

164 ts the cellular and molecular biology of the desmosome, current knowledge on the relation of desmosom

165 t in identifying novel proteins required for desmosome-dependent epidermal integrity.

166 of microtubules to cell-cell junctions in a desmosome-dependent manner.

167 and DP as central players in coordination of desmosome-dependent TGF-beta1/p38 MAPK signaling in card

168 Dsg, intracellular signaling events causing desmosome destabilization, or both.

169 These mutations involve proteins that form desmosomes, directly implicating altered cellular biomec

170 Three phases of desmosome disassembly were distinguished.

171 n in response to adhesion formation, altered desmosome distribution, and mechanically defective adhes

172 i-Dsg antibodies prevent assembly of nascent desmosomes due to steric hindrance, thus rendering acant

173 age likely contributes to the dismantling of desmosomes during keratinocyte apoptosis and also reveal

174 Our findings support a functional role for desmosomes during mammary morphogenesis and also in bloc

175 activation accelerated DP redistribution to desmosomes during the first hour of junction assembly, w

176 on status of desmosomal cadherins can affect desmosome dynamics.

177 ein palmitoylation as a mechanism regulating desmosome dynamics.

178 inant inheritance, reduced penetrance, and 7 desmosome-encoding causative genes are known.

179 merase chain reaction (PCR) amplification of desmosome-encoding genes was performed, PCR products wer

180 all of the proteins necessary to assemble a desmosome, except plakophilin-1.

181 roteins that show a dependence on functional desmosomes for their cortical localization.

182 oxin caused actin rearrangement and impaired desmosome formation, consistent with impaired barrier fu

183 that a novel Nrf2-miR-29-Dsc2 axis controls desmosome function and cutaneous homeostasis.

184 r human genetic alterations may also disrupt desmosome function and induce a disease course distinct

185 ng protein desmoplakin (DP) is essential for desmosome function and tissue integrity, but its role in

186 Loss of desmosome function is associated with severe congenital

187 Desmosome function is inseparably linked to structure, a

188 standing the critical role of desmoplakin in desmosome function.

189 ents that modulate canonical or noncanonical desmosome functions still remain largely unexplored.

190 Over 50% of affected individuals have desmosome gene mutations, most commonly in PKP2, encodin

191 opathy (ARVC) is associated with variants in desmosome genes.

192 Desmosomes govern epidermal integrity while GJs facilita

193 blished in simple epithelia, the function of desmosomes has not been addressed.

194 A fundamental difference is that desmosomes have a highly ordered structure in their extr

195 While desmosomes have a molecular blueprint that is similar to

196 While the core components of desmosomes have been identified, peripheral components t

197 Desmosomes have two distinct adhesive states, calcium-de

198 philin-2, a gene highly expressed in cardiac desmosomes, have been shown to cause ARVC.

199 f the IF-binding plakin family to create the desmosome-IF linking complex.

200 In stratified epithelia, desmosomes impart mechanical strength to tissues by orga

201 Desmosomes in adult tissues are termed hyper-adhesive be

202 bilisation is one of several roles played by desmosomes in animal development.

203 Electron microscopy showed smaller and fewer desmosomes in cells expressing mutant plakoglobin.

204 ocyte line HaCaT acquire calcium-independent desmosomes in confluent culture.

205 icroscopy demonstrated a lack of well-formed desmosomes in keratinocytes treated with pathogenic comp

206 ociation and fosters Ca(2+) insensitivity of desmosomes in keratinocytes, presumably by rendering DP

207 Dsc2 impairs the formation of hyper-adhesive desmosomes in keratinocytes, whereas Dsc2 overexpression

208 The importance of desmosomes in maintaining the homeostasis of the myocard

209 microscopy identified widened and distorted desmosomes in the ARVC-hiPSC-CMs.

210 , we identified Nrf2 as a novel regulator of desmosomes in the epidermis through the regulation of mi

211 n, and increased the quality and quantity of desmosomes in the oral mucosa measured in the tongue and

212 Desmosomes in tissues are resistant to disruption by che

213 protein desmoplakin (DP) into newly forming desmosomes, in part by disrupting PKC-dependent regulati

214 tations in several components of the cardiac desmosome including plakophilin-2 (PKP2), the most preva

215 genes encoding cell adhesion proteins of the desmosome, including plakoglobin (JUP).

216 sed DSC2 protein plays a role in maintaining desmosome integrity and function.

217 s destabilize desmoplakin and thereby impair desmosome integrity under tension.

218 Similarly, loss of desmosomes (intercellular junctions) was seen in placent

219 encodes desmoplakin, a primary component of desmosomes, intercellular adhesion junctions most abunda

220 sduction machinery; however, the role of the desmosome-intermediate filament (DSM-IF) network is poor

221 en calcium-dependent and calcium-independent desmosomes involves no quantitative change in the known

222 ce of plakophilin (PKP)2, a component of the desmosome, is essential for the proper function and dist

223 Although skeletal muscle lacks desmosomes, it contains multiple desmosomal components,

224 hibit epidermal hyperproliferation, immature desmosomes lacking a dense midline observed via electron

225 3 and PKP2 form a protein complex within the desmosome-like junction to regulate cell adhesion at the

226 , basal ectoplasmic specialization (ES), and desmosome-like junction.

227 ls of junction proteins of TJ, basal ES, and desmosome-like junction.

228 uch as cell-cell intermediate filament-based desmosome-like junctions and cell-cell actin-based adher

229 ut keratinocytes form substantial numbers of desmosome-like junctions and have a relatively normal in

230 Desmosome-like junctions display structural features of

231 Electron microscopy revealed absence of desmosome-like structures and regional loss of intercala

232 r blocking of endocytosis reconstituted both desmosome localization at the plasma membrane and epithe

233 ight junctions become calcium-independent as desmosomes mature.

234 To better understand how PV IgG alters desmosome morphology and function in vivo, biopsies from

235 ulted in perinatal lethality with defects in desmosome morphology and keratin organization, thus demo

236 Perp is a component of the desmosomes, multiprotein complexes involved in cell-to-c

237 ions, and gap junctions (GJs), together with desmosomes near the basement membrane, constitute the bl

238 established, the significance of keratins in desmosome organization has not been fully resolved.

239 koglobin levels rescues cadherin expression, desmosome organization, and functional adhesion in cells

240 protein (P-cadherin) and eight components of desmosomes (plakophilin (PKP) 1 and 2, desmoplakin, plak

241 whereas sustained RhoA activity compromised desmosome plaque maturation.

242 that PKP2 loss prevents the incorporation of desmosome precursors enriched in the plaque protein desm

243 panied by increased EGFR activity, increased desmosome processing and the presence of immature epider

244 Members of the desmosome protein family are integral components of the

245 Mice lacking the desmosome protein Perp exhibit blistering in their strat

246 gap junction protein connexin 43 (Cx43) and desmosome protein plakophilin-2 are working synergistica

247 eg):THY1(neg):DDR2(neg) signature, expresses desmosome proteins and differentiates to adipocytes in A

248 10 cleaves cadherins and tight junction plus desmosome proteins and is well characterized for its rol

249 ell-cell adhesion protein E-cadherin and the desmosome proteins DSG2 and DSC2 are important for aggre

250 reduced binding of PG(TR) but not PG(WT) to desmosome proteins DSP and DSG2.

251 ed in cell-cell junctions and interacts with desmosome proteins in the intestinal epithelium.

252 FAPs expressed desmosome proteins, including desmoplakin, predominantly

253 P20 is not known to cleave tight junction or desmosome proteins.

254 oint mutations in genes encoding for cardiac desmosome proteins.

255 sed primarily by mutations in genes encoding desmosome proteins.

256 labeling approaches to further elaborate the desmosome proteome in epidermal keratinocytes.

257 -associated adaptor proteins enriched in the desmosome proteome, Crk and Crk-like (CrkL).

258 mechanism in DSG2-related and probably other desmosome-related ACs.

259 ions, gap junctions, adherens junctions, and desmosomes represent intricate structural intercellular

260 PV dsg3 autoantibodies were used to initiate desmosome signaling in human keratinocyte cell cultures.

261 ing the end-organ by inhibiting keratinocyte desmosome signaling may be effective for treating desmos

262 Targeting desmosome signaling via inhibition of p38MAPK and HSP27

263 cellular domain is ordered at the individual desmosome, single cell, and cell population levels compa

264 and endocytosis are associated with reduced desmosome size and adhesion defects in tissue of patient

265 However, due to desmosome size, molecular complexity, and dynamics, the

266 variants in genes encoding components of the desmosome, specialized intercellular junctions that conf

267 Desmosome splitting was recapitulated in vitro by exposi

268 hat plakophilin-1 plays an important role in desmosome stability and/or assembly.

269 ding further insights into the complexity of desmosome structure and regulation.

270 hypothesized to drive hyperadhesion, but how desmosome structure confers adhesive state is still elus

271 drome, and skin from these patients exhibits desmosomes that are reduced in size and number.

272 conclude that kazrin is a novel component of desmosomes that associates with periplakin.

273 y may be key to explaining the plasticity of desmosomes that maintain tissue integrity in their hyper

274 esion of keratinocytes depends critically on desmosomes that, during maturation, acquire a hyperadhes

275 Mutations in genes that encode components of desmosomes, the adhesive junctions that connect cardiomy

276 Although mutant Dsg2 localizes to endogenous desmosomes, there is a significant delay in its incorpor

277 ange confers plasticity on calcium-dependent desmosomes, thereby providing rapid control of adhesion.

278 essed, defects extend to adherens junctions, desmosomes, tight junctions and cortical actin dynamics.

279 Although the importance of desmosomes to epidermal coherence and keratin organizati

280 ell-cell borders and prevents alterations in desmosome ultrastructure in keratinocytes treated with P

281 ICD were decreased, consistent with altered desmosome ultrastructure in plakoglobin CKO hearts.

282 ssing and the presence of immature epidermal desmosomes, upregulated epidermal transglutaminase activ

283 in functioning at the adherens junctions and desmosomes, was shown to be either lost or weakly expres

284 In the developing lens, which has no desmosomes, we discovered that vimentin became linked to

285 omparing tomograms of wild type and knockout desmosomes, we have assigned particular densities to des

286 Ultra-structural analyses revealed that desmosomes were absent in Jup mutant myocardia, whereas

287 plakophilin-1 was expressed in these cells, desmosomes were assembled, as assessed by electron micro

288 g to Dsg3, electron microscopy revealed that desmosomes were dramatically disrupted and keratinocyte

289 The desmosomes were intact in all strains.

290 Numerous, large desmosomes were present at this interface in wild-type m

291 te levels of desmoglein 3 were decreased and desmosomes were reduced in size in patient tissue.

292 e adhesion persisted in the mutant mice, the desmosomes were smaller and less numerous.

293 catenin, is also a structural constituent of desmosomes, where it binds to the cytoplasmic domains of

294 Desmoplakin (DP) is an integral part of desmosomes, where it links desmosomal cadherins to the i

295 erin-based intercellular junction called the desmosome, which allowed for the creation of more comple

296 ing tight junctions, adherens junctions, and desmosomes, which concentrate in the apical junctional r

297 encodes desmoglein 1, a major constituent of desmosomes, which connect the cell surface to the kerati

298 etically determined abnormalities of cardiac desmosomes, which leads to detachment of myocytes and al

299 by proteins are "locked in" to hyperadhesive desmosomes while protein exchange confers plasticity on

300 rment of both the morphology and function of desmosomes, without noticeable effect on adherens juncti