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1 s)) that lack cholesterol and likely contain desmosterol.
2 to be reliable for the analysis of 7-DHC and desmosterol.
3 terol and lanosterol and increased levels of desmosterol.
4 meostatic and anti-inflammatory functions of desmosterol.
5 en cultures were supplemented with exogenous desmosterol.
6 thosterol, without significant reductions in desmosterol.
7 5-dependent increases in RORgammat's agonist desmosterol.
8 ient conversion yet of a C22 intermediate to desmosterol (5) or its acetate 6.
9 ro cell assay and led to the accumulation of desmosterol, a Delta5,24 sterol precursor of cholesterol
10                          The accumulation of desmosterol, a known liver-X receptor (LXR) activator, w
11                                              Desmosterol, a late precursor containing the same 5-6 do
12                                    Decreased desmosterol accumulation in mitochondria promotes macrop
13                                              Desmosterol activated liver X receptor (LXR) signaling t
14                                              Desmosterol also inhibited processing of the sterol resp
15  the steady-state abundance of intracellular desmosterol, an immediate precursor of cholesterol, resu
16 d a significant steady-state accumulation of desmosterol, an immediate precursor to cholesterol.
17 l was substituted with various sterols, only desmosterol and 7-dehydrocholesterol supported internali
18 ro, to participate in the cellular efflux of desmosterol and amyloid-beta peptide (Abeta).
19 ression of Abcg1 or Abcg4 promoted efflux of desmosterol and cholesterol from cells to HDL, and combi
20 d significantly higher ratios of cholesterol/desmosterol and cholesterol/7-dehydrocholesterol (which
21 24 unsaturated cholesterol precursor sterols desmosterol and zymosterol exerting the largest effects.
22  antagonized by its putative natural ligand, desmosterol (and possibly cholesterol).
23 explored the effects of immediate (7-DHC and desmosterol) and evolutionary (ergosterol) precursors of
24 osterol, dihydrocholesterol, ergosterol, and desmosterol), and six do not (25-hydroxycholesterol, lan
25 astrocytes, promoting efflux of cholesterol, desmosterol, and possibly other sterol biosynthetic inte
26                   Our assay also showed that desmosterol antagonized the export of Abeta, presumably
27 thetic intermediates, such as lanosterol and desmosterol, are emergent immune regulators of macrophag
28 show that Abcg4 was able to export Abeta and desmosterol at the BBB level and these processes could b
29                                              Desmosterol bound to purified LXRalpha and LXRbeta in vi
30  sterol requirement for HSV-1 entry and that desmosterol can operate in virus entry.
31  70% and doubled the rate of plasma membrane desmosterol conversion to cholesterol.
32                    Levels of serum and liver desmosterol correlated strongly (r = 0.667, P = 1 x 10(-
33 asome activity and atherogenesis observed in desmosterol-depleted macrophages.
34 ates, including elevated 7-DHC and decreased desmosterol (DES) levels across all investigated models.
35                                              Desmosterol failed to increase expression of the LXR tar
36 plex virus 1 (HSV-1) required cholesterol or desmosterol for virion-induced membrane fusion.
37                                 Depletion of desmosterol from these cells resulted in diminished HSV-
38                                        Serum desmosterol had a higher correlation with the accumulati
39                                      Whether desmosterol has a more specific role in the pathophysiol
40 imate connection between HCV replication and desmosterol homeostasis and that the enzymes responsible
41                                 Depletion of desmosterol in myeloid cells by overexpression of 3B-hyd
42                                    Levels of desmosterol in serum and the liver were associated with
43 findings underscore the critical function of desmosterol in the atherosclerotic plaque to dampen infl
44 es) were similar, suggesting cholesterol and desmosterol in the HSV envelope support similar levels o
45 4 and that this results in the enrichment of desmosterol in the membranes where NS3-4A and DHCR24 co-
46 erotic plaques demonstrate that depletion of desmosterol increases interferon responses and attenuate
47  vivo macrophage foam cells demonstrate that desmosterol is a major endogenous liver X receptor (LXR)
48             These results suggest that serum desmosterol is a marker of disturbed cholesterol metabol
49 the cholesterol biosynthetic pathway, namely desmosterol, lathosterol, and lanosterol, as well as 27-
50                                        Serum desmosterol levels (P = 2 x 10(-6) ) and the serum desmo
51                                        Serum desmosterol levels and the desmosterol-to-cholesterol ra
52                         Both serum and liver desmosterol levels correlated positively with steatosis
53 hat the enzymes responsible for synthesis of desmosterol may be novel targets for antiviral design.
54 l, campesterol, cholestanol), and synthesis (desmosterol) (P < 0.0001) and fold change in PBMC LDL-re
55     A subset of these lipids (e.g. oleamide, desmosterol) serve as ligands for nuclear receptors PPAR
56 ng studies of the Abcg4 dimer suggested that desmosterol showed thermodynamically favorable binding a
57 Cholesterol functioned more effectively than desmosterol, suggesting that the hydrocarbon tail of cho
58 ain (e.g., campesterol, beta-sitosterol, and desmosterol) supported long-term growth of mutant cells,
59 olesterol, microglia/macrophages synthesized desmosterol, the immediate cholesterol precursor.
60                         Here, we report that desmosterol, the most abundant cholesterol biosynthetic
61 24), the enzyme that catalyzes conversion of desmosterol to cholesterol, promotes the progression of
62 24), the enzyme that catalyzes conversion of desmosterol to cholesterol.
63 this reduces the intracellular conversion of desmosterol to cholesterol.
64  were genetically defined to synthesize only desmosterol to demonstrate that cholesterol is important
65 ully entered DHCR24(-/-) cells, which lack a desmosterol-to-cholesterol conversion enzyme, indicating
66 1 on DHCR24(-/-) fibroblasts, which lack the desmosterol-to-cholesterol conversion enzyme, resulted i
67 terol levels (P = 2 x 10(-6) ) and the serum desmosterol-to-cholesterol ratio (P = 5 x 10(-5) ) were
68             Serum desmosterol levels and the desmosterol-to-cholesterol ratio were higher in individu
69  had a much lower DHA concentration, a lower desmosterol-to-cholesterol ratio, reduced motility, abno
70 o sperm motility, to sperm count, and to the desmosterol-to-cholesterol ratio.
71 vide evidence that regulated accumulation of desmosterol underlies many of the homeostatic responses,
72 25-, and 27-hydroxylase; thus, the effect of desmosterol was LXR-dependent and did not require conver
73                     In vitro, lanosterol and desmosterol were found to protect striatal neurons expre
74                              Lathosterol and desmosterol were measured by gas-chromatography mass spe
75 ol precursors (cholestenol, lathosterol, and desmosterol) were measured in 50 IF patients at a median
76 esponsible for HCV's effect on intracellular desmosterol, whereby the HCV NS3-4A protease controls ac