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1  fraction alters body weight and behavioural despair.
2 munity- and state-level solutions to address despair.
3 oes not ask what protects those nations from despair.
4 ely contributed to the rise in the deaths of despair.
5 and protecting individuals and families from despair.
6 l in responding to the epidemic of deaths of despair.
7 h (R,S)-ketamine and FENM reduced behavioral despair.
8 aveling through times of both excitement and despair.
9  not be explained by anhedonia or behavioral despair.
10 ation facilitated depression-like behavioral despair.
11 MDA receptor antagonist, reversed behavioral despair.
12 viduals either show resilience or succumb to despair.
13 ly correlated with the extent of behavioural despair.
14 elicited anhedonia and increased anxiety and despair.
15 feeding behaviour, anhedonia and behavioural despair.
16 emselves at the crossroads of prosperity and despair.
17 arch toward clinically useful definitions of despair.
18 fear and decreased stress-induced behavioral despair.
19 te populations) had higher RRs for deaths of despair.
20 duction in reward responsivity and increased despair.
21 al deficits such as anhedonia and behavioral despair [1, 2].
22 cts (8 items), acute distress (4 items), and despair (7 items).
23 , leaving some anxiety (if not confusion and despair) about molecular monitoring in the day-to-day tr
24 y, increased aversive memory, and behavioral despair, acting at the medulla, prefrontal cortex, and a
25 alpha5-preferring GABA-NAMs demonstrate anti-despair actions, they are largely not anxiolytic.
26 ed become resilient, withstanding behavioral despair after an adverse experience.
27 r 2000 or 2010 had higher rates of deaths of despair and all-cause midlife mortality at baseline but
28 pathway is critical for mediating behavioral despair and antidepressant-like responses to leptin.
29 , diazepam attenuated CUS-induced behavioral despair and cognitive impairments.
30 d psychological distress (PD) as a proxy for despair and drew data from the US National Health Interv
31 onomic insecurity and increases in deaths of despair and midlife all-cause mortality in US counties d
32 iven after stress, FENM decreased behavioral despair and reduced perseverative behavior.
33 t on adolescent and young adult behaviors of despair and self-destruction.
34  factors may be associated with perpetuating despair and with public health.
35 al areas with high prevalence of diseases of despair, and 1 focus group with 17 members in a high-pre
36 sufficient to cause helplessness, behavioral despair, and anxiety-like behavior in mice, establishing
37 eductions in stress-induced fear, behavioral despair, and hyponeophagia.
38 ht gain on high-fat diet, reduced behavioral despair, and increased anxiety-like behaviors.
39 types in behavioral paradigms for anhedonia, despair, and learned helplessness.
40 sponse to acute stress, increased behavioral despair, and no behavioral response to antidepressant, m
41  and suggest that distinct pathways regulate despair- and anxiety-related behaviors.
42 venile or adult windows, increased anxiety-, despair-, and schizophrenia-like behavior in adulthood.
43 tivation, together with increased behavioral despair, anhedonia, and anxiety-related behavior in the
44                             Hopelessness and despair are growing problems particularly in the U.S. Th
45 le mortality (SDAM)-often labeled "deaths of despair"-are increasing among working-aged individuals i
46 not increases in measurements of behavioural despair, are prevented by blocking these melanocortin 4
47             This study directly investigated despair as a determinant of death and the temporal varia
48                                              Despair behavior using the modified forced swim test (FS
49    In direct measures of their resistance to despair behavior, TASK-3 knock-outs displayed significan
50      In chronically stressed mice displaying despair behavior, we found that the microbiota compositi
51 o discrete categories of "reward behavior," "despair behavior," "anxiety-like behavior," and "cogniti
52 test the role of the microbiota in mediating despair behavior.
53 c behavioral paradigms, and generally reduce despair behavior.
54 nsor Ahr in the development of stressinduced despair behavior.
55 RP neurons completely reverses anhedonic and despair behaviors induced by chronic unpredictable stres
56 is sufficient to drive microbiome shifts and despair behaviors.
57 iates either social withdrawal or behavioral despair, but not both.
58 enriched in this area and opposes behavioral despair by promoting active defense responses.
59 , a commonly used animal model of behavioral despair/depression, leads to an increase in central or p
60                                    Deaths of Despair (DoD) are socially patterned causes of death enc
61 allel increases in corresponding diseases of despair (DoD), indicating that there could be an associa
62 unpredictable stress and improved behavioral despair dose-dependently in the forced swim test (FST),
63 th needs may improve processes to screen for despair (eg, social history taking) and codesign primary
64  underestimated the mortality consequence of despair for Whites and Blacks but overestimated it for H
65      Results indicate that rising "deaths of despair" for both Black and White Americans are overwhel
66 ontribute more meaningfully to the deaths of despair framework (i.e., conceptualizing rises in suicid
67 Research) database on county-level deaths of despair from 2000 to 2019 across racial and ethnic group
68 e but similar rates of increase in deaths of despair from 2001 to 2015 compared with counties with st
69                          The devastation and despair gripping Ukraine following the unprovoked invasi
70 d common factors associated with diseases of despair, highlighting the association between long-term
71 e decline focused on increases in "deaths of despair" (i.e., deaths from suicide, drug use, and alcoh
72                                  Diseases of despair (ie, mortality or morbidity from suicidality, dr
73 he probability of exhibiting any behavior of despair in adolescence and young adulthood.
74 reverse CUS-induced anhedonia and behavioral despair in both sexes.
75 ike effect of leptin in reversing behavioral despair in both the tail suspension and forced swim test
76 We observed similar resistance to behavioral despair in distinct mutant mice lacking HCN1 or HCN2.
77 ime and saccharin preference, and behavioral despair in female mice and enhanced stress-induced decre
78 ufficient to induce anhedonia and behavioral despair in males but not females under non-stress condit
79                                    Deaths of despair in midlife adults, due to suicide, alcohol-relat
80 tual well-being, depression, and end-of-life despair in terminally-ill cancer patients.
81 isparities in infant mortality and deaths of despair in the 19 US CDs of Pennsylvania for the 111th-1
82 nt after acute stress, increased behavioural despair in the forced swim test, and decreased sucrose p
83 xperience-dependent expression of behavioral despair in the forced swim test.
84 g offers some protection against end-of-life despair in those for whom death is imminent.
85 ncreasing midlife death rates and "deaths of despair," including suicide, chronic liver disease, and
86 ear extinction deficit, increased behavioral despair, increased anxiety-related behaviors in the ligh
87 able stress-induced anhedonia and behavioral despair, indicating an antidepressant-like effect.
88 -type and SERT knockout mice from behavioral despair induced by chronic stress.
89                              The clinician's despair is only exacerbated by uncertainty regarding the
90 sease (collectively referred to as deaths of despair) is a critical public health crisis.
91  via 2 distinct Hb circuits, contributing to despair-like behavior (Hb-MOR/interpeduncular nucleus) a
92 ons - negative processing biases, anhedonia, despair-like behavior (learned helplessness) - affords u
93 elevated plus maze, and marble burying), and despair-like behavior (tail suspension).
94 the forebrain of mice induces alterations in despair-like behavior and HPA axis function, reminiscent
95 8) treatment with the impact on anxiety- and despair-like behavior examined in adulthood, along with
96  mechanisms underlying reward responding and despair-like behavior have remained unclear.
97 tent with the elevation in hyponeophagia and despair-like behavior in females.
98 e same treatment increases hyponeophagia and despair-like behavior in females.
99 ng-lasting, opposing changes in anxiety- and despair-like behavior in male, but not female, rats.
100 mobile (WMI) substrain shows high immobility/despair-like behavior in the forced swim test (FST), whi
101                                              Despair-like behavior was measured in rats using the for
102                             The PNFlx-evoked despair-like behavior was reversed by adult-onset treatm
103 evoked increase and decrease in anxiety- and despair-like behavior, respectively, were accompanied by
104 ining body weight and developed anxiety- and despair-like behavior.
105 creased social deficit, anxiety-related, and despair-like behaviors during protracted forced abstinen
106 lfactory perception, circadian activity, and despair-like behaviors were unchanged.
107                             Furthermore, the despair-like changes were normalized with antidepressant
108 ior in the Elevated Plus Maze and behavioral despair-like immobility in the Forced Swim Test are cont
109 lt mice revealed a persistent anxiogenic and despair-like phenotype.
110 ar nucleus terminals triggered avoidance and despair-like responses with no anxiety-related effect, w
111 rced swim test (FST) which was indicative of despair-like state, and loss of taste preference in sacc
112 l effects of SSRIs in the chronic behavioral despair model of depression both in the presence and in
113 tated in animals subjected to the behavioral despair model, which was prevented by SSRI treatment.
114 nt-like phenotype, as shown using behavioral-despair models of depression.
115 ic advancement in deciphering the "deaths of despair" narrative, most relevant studies have focused o
116 mpathized with the initial hope and ultimate despair of potential recipients who must continue their
117 ity and lower social mobility with deaths of despair on both the additive and multiplicative scales f
118 es in cardiovascular diseases and "deaths of despair" over this period.
119  the antidepressant fluoxetine in behavioral despair paradigms, whereas fluoxetine normalizes their a
120 s but overestimated it for Hispanics; and 2) despair partially contributed to the DAS trend among Whi
121 yed using assays to measure fear, behavioral despair, perseverative, and/or hyponeophagia.
122 spect to awareness and believed causation of despair-related illness, and participants identified com
123 cial services and infrastructure to mitigate despair-related illness.
124 sociated with additional risks for deaths of despair, suggesting that addressing the underlying socia
125 he rise is largely attributable to deaths of despair (suicide and poisoning by alcohol and drugs) wit
126 ificant, unexplained physical, distress, and despair symptom reporting by White patients.
127 loskeletal, cardiorespiratory, distress, and despair symptoms at baseline and increases during the fo
128 nterrelated to the progress of anhedonia and despair symptoms of T. gondii-infected subjects.
129 nt-like effect in the forced swim behavioral despair test, and this effect was blocked by ablation of
130                              Among deaths of despair, the individual and community correlates of US s
131 that precede these -often denoted-"deaths of despair." This paper examines whether a childhood interv
132                             Hopelessness and despair threaten health and longevity.
133  around 2 themes: (1) building resilience to despair through better community and organizational coor
134  locales with high prevalence of diseases of despair to learn their perspectives.
135 tion between religiosity and the diseases of despair via regression, sibling fixed effects (SFE) anal
136 ehold income, and no feelings of sadness and despair was associated with a small increase.
137 buted to the dramatic rise in the "deaths of despair." We contribute to the recent epidemiologic lite
138 dy, high-prevalence hotspots for diseases of despair were identified from health insurance claims dat
139 d, 152 350, 149 589, and 1 250 156 deaths of despair were recorded for working-age Hispanic, non-Hisp
140 cedure commonly used for inducing behavioral despair, were simultaneously monitored in real time.
141 d resistance to multiple tasks of behavioral despair with high predictive validity for antidepressant
142  nurses, and researchers today, the depth of despair wrought by the HIV/AIDS epidemic at that time is

 
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