ライフサイエンスコーパス: destabilization

1 borne Hh pathway inhibitors required for Smo destabilization.

2 tabilize each other but also cause their own destabilization.

3 rgoing various types of diffusion upon actin destabilization.

4 ity and physical aggregation and is prone to destabilization.

5 ve oxygen species (ROS)-triggered sequential destabilization.

6 e CMPs and were associated with triple-helix destabilization.

7 by membrane invagination and rapid membrane destabilization.

8 ase role for Mad1 in tumor promotion via p53 destabilization.

9 r PtdIns(4,5)P(2) association results in p53 destabilization.

10 lls to cisplatin predominantly through MAST1 destabilization.

11 ge site through A2-domain-fold thermodynamic destabilization.

12 icyte loss alone is sufficient for capillary destabilization.

13 confirm that larvae are subject to constant destabilization.

14 ination on TBA-7 may be responsible for this destabilization.

15 cient nodes fail to mature and undergo rapid destabilization.

16 sclerotic process, from initiation to plaque destabilization.

17 ISPR/Cas9 activity based on conditional Cas9 destabilization.

18 nsight into how strain accumulates to induce destabilization.

19 uscle cell (SMC) death contributes to plaque destabilization.

20 Numb uncouple Numb from p53 and lead to p53 destabilization.

21 e oxidative stress and the PKC pathway in TJ destabilization.

22 ion through translational inhibition or mRNA destabilization.

23 ontribute to plaque calcification and plaque destabilization.

24 ation and inhibit parasite-promoted membrane destabilization.

25 e occurrence of galvanic corrosion and scale destabilization.

26 lk can be one of the main causes of UHT milk destabilization.

27 of the role of ROS in pathogenesis of plaque destabilization.

28 us of confinement of the receptor upon actin destabilization.

29 ods exhibit a strong bias towards predicting destabilization.

30 icytes by PGE2 is a key process for vascular destabilization.

31 nner and inhibit hnRNPA1-mediated transcript destabilization.

32 aintained following memory retrieval-induced destabilization.

33 SCs without substantial messenger RNA (mRNA) destabilization.

34 uch as phreato-magmatic eruptions or volcano destabilizations.

35 because they induce relatively low indirect destabilizations.

36 dy sought to determine whether microvascular destabilization affects organ function and therapeutic n

37 of cell migration and also found that talin destabilization affects the usage of different integrin

38 we demonstrate that retrieval-induced memory destabilization also allows that memory to be strengthen

39 rine with BMAA in SOD1 results in structural destabilization and aberrant dynamics, promoting neuroto

40 for traumatic events by modulating cellular destabilization and activity.

41 dings, depletion of PIH1D1 resulted in MRE11 destabilization and affected DNA-damage repair processes

42 The WTp53 and the [R273H]p53 show the least destabilization and aggregation propensity.

43 g force of Rca is fine-tuned to avoid global destabilization and allow for precise enzyme repair.

44 ctivated after ligand stimulation because of destabilization and degradation of c-Cbl and Cbl-b.

45 ed that ClpXP promotes rapid MinCD copolymer destabilization and direct MinD degradation by ClpXP.

46 otein and its co-factors play a role in mRNA destabilization and how this activity might regulate ear

47 uced barrier disruption is accompanied by MT destabilization and increased histone deacetylase-6 (HDA

48 ltimately causing complex I and supercomplex destabilization and inefficiency of oxidative phosphoryl

49 p2) transgene cassette which, increasing RNA destabilization and inefficient protein translation of t

50 event T cell proliferation and reduce plaque destabilization and inflammatory markers thus providing

51 e inflammatory responses that drive vascular destabilization and leakage.

52 e cardiac myocytes results in SR/ER membrane destabilization and luminal vacuolization along with dec

53 phosphorylation, which is accompanied by its destabilization and nuclear export.

54 Microwave heating led to destabilization and obvious phase separation.

55 Steeper gradients caused lipid bilayer destabilization and pore instability, limiting the total

56 bition of NOX activity resulted in HIF1alpha destabilization and reduced levels of cyclin D2, a marke

57 que storage- and pH-dependent conformational destabilization and refolding of the hole-hole homodimer

58 The failure to form synapses can cause the destabilization and secondary retraction of axon termina

59 hich surprisingly revealed that ground state destabilization and transition state stabilizing effects

60 lants, which may lead to eventual glomerular destabilization and transplant glomerulopathy.

61 mily detergents may lead to membrane protein destabilization and unfolding.

62 agonists may be associated with TTR tetramer destabilization and, potentially, TTR amyloid formation.

63 Although helix destabilization and/or unfolding was not observed at the

64 e energy change, which contributes to fibril destabilization, and a increased aggregation rate.

65 tin loop relaxation required for nucleosomal destabilization, and by comparative analyses of the inte

66 megafauna extinction, resulting in regional destabilization, and combining with more proximal human

67 ds to a loss of this suppression, filopodial destabilization, and reduced synapse formation.

68 duced hPAC is necessary for avoidance memory destabilization, and that artificial induction of this p

69 The requirement for memory destabilization, and thus reconsolidation, for the retri

70 A visual destabilization appeared after 8days of storage with the

71 ypass PLA2G16 and identify additional virion destabilization as a potential mechanism to circumvent P

72 om ARHGAP18-knockout mice showed microtubule destabilization, as evidenced by altered morphology and

73 We find that introduction of cysteine causes destabilization at several of the 26 lipid-facing sites

74 LRP1 activation in the context of N-terminal destabilization, but decreases NLRP1 activation on dipep

75 uncover a new function for TREX1 in protein destabilization, but they also suggest a novel mechanism

76 ficient of the receptor increases upon actin destabilization by cytochalasin D.

77 at Thbs3 antithetically promotes sarcolemmal destabilization by reducing integrin function, augmentin

78 In the case of BB, cleavage leads to destabilization by the RING E3 ligase PROTEOLYSIS 1 (PRT

79 tin matrix, which was not affected by H-bond destabilization by urea.

80 A glycosylase (UDG) can achieve ground state destabilization, by polarizing substrates to mimic rare

81 bilization causing SOC accrual, but also SOC destabilization causing SOC loss.

82 The effects of PolyDOTS on lysosomal destabilization, cell viability, and free radical damage

83 kidneys and kidney function showed vascular destabilization, characterized by mesangiolysis, capilla

84 Across the life span, brain network destabilization correlated with decreased brain activity

85 Overall, HA destabilization decreased virulence in mice by boosting

86 We suggest a two-step nucleosome destabilization-depletion model, in which the same intri

87 r pharmacological interventions that prevent destabilization did not disrupt any capacity to attenuat

88 mutation), promoter methylation, and protein destabilization did not fully explain PTEN loss in melan

89 We propose that duplex DNA destabilization during cellular processes (for example,

90 rgents with characteristic stabilization and destabilization effects for selected targets.

91 ion of endothelial cells through microtubule destabilization, enhanced the plasma membrane-bound frac

92 tion of an ice-water interface is a critical destabilization factor for the protein, which can be off

93 rtantly, tau knockdown uncouples microtubule destabilization from glucose stimulation.

94 regions are likely to accelerate soil carbon destabilization, further increasing atmospheric carbon d

95 bial activity extends beyond simple membrane destabilization, helping to rationalize its broader spec

96 rom the core region resulted merely in rotor destabilization (ie, drifting).

97 ification in the upper ocean, thus favouring destabilization in 2016 and 2017.

98 Considering the prominence of vascular destabilization in decompensated cirrhosis, we evaluated

99 We demonstrate that heat-induced DV destabilization in PI(3)P-deficient P. falciparum preced

100 Of note, the H12 destabilization in the active state shifts the conformat

101 tudy suggests that the mechanism of emulsion destabilization in the gastric environment and the type

102 nvironments and Red 40 exhibits the greatest destabilization in the soft drink solution.

103 mammalian evolution has caused local protein destabilization in two human proteins linked to disease:

104 Foxp3 destabilization in Usp22-deficient T(reg) cells could be

105 nd varies from slight stabilization to large destabilization, in some cases leading to formation of o

106 In contrast, the local destabilization induced by a mismatch or an abasic site

107 inal memory, then it would be predicted that destabilization, induced by prediction error, would be c

108 Actin destabilization initiates TD-related retrograde signalin

109 tPA was released through liposomal membrane destabilization involving membrane fusion upon incubatio

110 The duplex destabilization is mediated, in part, by Cas9/guide RNA

111 The destabilization is minimal (0.5-1.5 kcal/mol) when the m

112 This DND1-dependent mRNA destabilization is required for the survival of mouse PG

113 One reason for this destabilization is the disruption of a conserved U32.A38

114 Atherosclerotic plaque destabilization is the major determinant of most acute c

115 ith p73alpha, indicating that oncosuppressor destabilization largely mirrors the low intracellular st

116 city than carbonate molecule or anion, whose destabilization leads to sustained consumption.

117 This difference in nucleosome destabilization may explain why Nhp6A and Hmo1 function

118 ther, our results suggest that brain network destabilization may reflect early signs of hypometabolis

119 These results identify NOXA mRNA destabilization/MCL-1 adaptation as a non-genomic mechan

120 SOC turnover through both stabilization and destabilization mechanisms.

121 NA repair by HR, thereby accelerating genome destabilization, micronucleus generation, and cell death

122 at levels where no such sign of microbubble destabilization occurred resulted in safe BBB openings,

123 These suggest that PTEN destabilization occurs mainly via the PKCalpha-Src axis.

124 The TFAM-catalyzed AP-DNA destabilization occurs with nonspecific DNA or mitochond

125 -O bond in the Phax conformer and additional destabilization of 3-Pheq conformer by repulsion of unid

126 This latter interaction is notable for the destabilization of a flexible helix that bridges the pho

127 nd that this is dependent on TARBP2-mediated destabilization of ABCA3 and FOXN3.

128 port of dendrin, indicating an occurrence of destabilization of adherens complexes in APOL1 risk mili

129 splayed nuclear import of dendrin indicating destabilization of adherens complexes in podocytes; more

130 l counterpart, as a consequence of increased destabilization of anomeric charge development by the el

131 The destabilization of AR - CHK2 interactions induced by CHK

132 ed against endogenous RIN4, we show that the destabilization of AvrRpt2-cleaved RIN4 fragments is ind

133 lating the balance between stabilization and destabilization of barnase provides proof of concept for

134 associated lysosome complex, contributing to destabilization of cancer cell lysosomes and triggering

135 thought to have been driven primarily by the destabilization of carbon from surface sedimentary reser

136 A case in point is the alleged destabilization of complex I in the absence of complex I

137 Rcf1 and partner proteins and results in the destabilization of complex IV and alteration of its enzy

138 horylation of beta-tubulin and the resulting destabilization of cortical microtubules.

139 and Y380 by reactive nitrogen species cause destabilization of CYP2B6, which may act synergistically

140 irectly influence the relative stabilization/destabilization of different oxidation states of the act

141 way, known to induce amoeboid properties and destabilization of endothelial junctions.

142 tration of bacteria and neutrophils, diffuse destabilization of epithelial and endothelial junctions,

143 and genetic means led to ubiquitination and destabilization of EZH2 protein.

144 hat acute exposure of neurons to E2 leads to destabilization of GABAARs and gephyrin at inhibitory sy

145 Loss of PCM1 results in destabilization of GABARAP, but not LC3B, through protea

146 iants FlrC(C)-Y290A and FlrC(C)-R291A showed destabilization of heptameric assembly with concomitant

147 repressed ATPase activity of FlrC(C) through destabilization of heptameric assembly, especially at lo

148 by an unusual mechanism involving the robust destabilization of human LRRK2 protein in the brain rela

149 nt structures revealed some local structural destabilization of KREP but not in its shallow pocket.

150 cause of the high water lead levels was the destabilization of lead-bearing corrosion rust layers th

151 wn shedding of satellite droplets during the destabilization of liquid ridges that form during the la

152 effects-are a consequence of the occasional destabilization of magnetic fields rooted in active regi

153 f age, WT and cKO mice were subjected to the destabilization of medial meniscus (DMM) model of post-t

154 We hypothesized that the destabilization of microbubbles exposed to a critical le

155 uses dissociation of tau from and subsequent destabilization of microtubules.

156 gressive restriction of attachment geometry, destabilization of misaligned attachments, and attachmen

157 e1-dependent cleavage of MLL1 results in the destabilization of MLL.

158 Interestingly, destabilization of MLL3/4 by H3.3K4M in adipocytes does

159 show that downregulation of RBFOX1 leads to destabilization of mRNAs encoding for synaptic transmiss

160 that RagC phosphorylation is associated with destabilization of mTORC1 and is essential for both grow

161 Destabilization of myosin energy-conserving states promo

162 s can evoke anticancer immunity upon genomic destabilization of neoplastic cells.

163 nchrony within neuronal ensembles leading to destabilization of network "attractors" could be a defin

164 with this dysfunctional Ca(2+) signaling is destabilization of neuronal dendritic spines.

165 L)-V(L) and C(L)-C(L) dimer interfaces, with destabilization of one interface adversely affecting the

166 This selective stabilization or destabilization of oxidation states can preferentially p

167 tiana benthamiana SKP1 ortholog leads to the destabilization of P0(Br) .

168 tion of PI3K/Akt/MDM2 pathway results in the destabilization of p53 protein, while the activation of

169 ck activation promoted dephosphorylation and destabilization of Pck2, whereas it enhanced Pck1 levels

170 ar vesicles to the periphery, which leads to destabilization of peripheral membranes.

171 e H4 binds to and lyses SMCs, leading to the destabilization of plaques; conversely, the neutralizati

172 ecreased formation of beta-sheet structures, destabilization of preformed beta-sheets, and suppressio

173 d structural changes, ubiquitin mediates the destabilization of proteins in the 60S P-stalk and in th

174 ce of metastatic cells, Angpt2(443) promoted destabilization of pulmonary vasculature and lung metast

175 F through activation of c-src and subsequent destabilization of pVHL.

176 CtIP deficiency promoted the helicase-driven destabilization of RAD51 nucleofilaments at damaged DNA

177 olayers could lead to both stabilization and destabilization of reentrant activity.

178 rgan formation in plants by coordinating the destabilization of regulatory proteins.

179 e includes severe morphological changes with destabilization of SDs and their replacement by junction

180 es reveal the molecular basis for allosteric destabilization of small and large interfaces required f

181 ted cardiomyopathy that is associated with a destabilization of small HSPs as the result of a disrupt

182 f the carbon stored in soils globally(1), so destabilization of soil organic matter caused by the war

183 the Mg(2+)-RNA interactions actually lead to destabilization of specific nonsequential phosphate-phos

184 outward-facing conformations or in a global destabilization of structure.

185 Destabilization of target programs shifts leukemia cell

186 abilization of the (E)-boronic acids and the destabilization of the (E)-boronic esters.

187 crease in activity mainly occurs through the destabilization of the active site loop involved in subs

188 ein the reactivity is driven by ground-state destabilization of the amide bond.

189 ma subunit is greatly reduced, demonstrating destabilization of the AP-1 complex.

190 of dominant clusters is consistent with the destabilization of the B2 structure measured by calorime

191 type, and this appears to be correlated with destabilization of the beta-annulus at the icosahedral 3

192 ple 2 excited species: The first may involve destabilization of the beta3- and beta3'-strands at the

193 ion of water into the cavity, and consequent destabilization of the bound sterol.

194 tive ssDNA binding and SSB function but that destabilization of the bridge interface is tolerated in

195 In this study, we show that destabilization of the CA lattice leads to premature dis

196 Importantly, destabilization of the CA lattice led to premature disso

197 d support a mechanism driven by ground-state destabilization of the carboxylate group being cleaved b

198 uted PICs with a UUG start codon, indicating destabilization of the closed complex.

199 mRNA harboring a UUG start codon, indicating destabilization of the closed PIN state with a UUG-antic

200 Destabilization of the coiled-coil domains by site-direc

201 nd another common mutation, L444P, result in destabilization of the complex and reduced GCase activat

202 g site) and the V3 crown, suggesting general destabilization of the distal region of the trimer apex.

203 This perturbation leads to destabilization of the domain-domain interface-thereby p

204 ipid molecule at this site does not modulate destabilization of the E2 state, a step required to init

205 Bioinformatics analysis predicted a destabilization of the EF-Ts variants complex with EF-Tu

206 e role of these residues may be ground state destabilization of the enzyme-substrate complex or, alte

207 ced excitation in GABAergic neurons and that destabilization of the excitatory/inhibitory balance in

208 expected from the documented linkage between destabilization of the folded state and formation of mis

209 emagglutinin (HA), respectively, and induced destabilization of the HA stem domain.

210 We also observe that activation involves destabilization of the helices in the dimerization and h

211 at activation of CaMKII-alpha results in the destabilization of the holoenzyme.

212 a direct role for both HPV E6 and E7 in the destabilization of the host genome by blocking the homol

213 as much reduced despite the mutation-induced destabilization of the Ig20 structure that supposedly we

214 Together, this study describes Mab-induced destabilization of the influenza HA stem domain, faster

215 ative pai -> sigma*(CF) interactions and the destabilization of the keto tautomer by the electron wit

216 atalysts containing Buchwald ligands reveals destabilization of the L(2)Pd species as a major non-eno

217 es, vinculin activation requires substantial destabilization of the main head-tail interface, which i

218 nuated articular cartilage damage induced by destabilization of the medial meniscus (DMM) OA-inducing

219 In this study, we performed the destabilization of the medial meniscus (DMM) surgery at

220 s (OA), yet surgical OA mouse models such as destabilization of the medial meniscus (DMM) used for ev

221 with SAM-resistant 1 (SAMR1) as control; (2) destabilization of the medial meniscus in C57BL/6 mice a

222 This suggests that destabilization of the membrane-proximal coiled coil res

223 cles become highly water-soluble, leading to destabilization of the micelle.

224 the preterminal integrity, and when absent, destabilization of the motor nerves results in muscle re

225 domonas can regulate gene expression both by destabilization of the mRNA and by translational repress

226 at these protective effects are conferred by destabilization of the mutant protein due to an increase

227 system and autophagy pathway play a role in destabilization of the mutant protein.

228 his adaptation requires a pathway leading to destabilization of the NOXA mRNA transcript.

229 inding protein, IGF2BP3, which prevented the destabilization of the nuclear RNA 7SK, a process normal

230 atform domain closure explains this relative destabilization of the OFF state at higher magnesium con

231 sociation at UUG codons in vitro, indicating destabilization of the open complex.

232 h terminally deleted viruses could be due to destabilization of the ribonucleoprotein complexes forme

233 leavage event is required for and results in destabilization of the rimO transcript.

234 sodes have the potential to induce a drastic destabilization of the Sahelian agroecosystem.

235 Destabilization of the scaffold would disrupt the entire

236 tochondrial translation defect was caused by destabilization of the small mitoribosomal subunit and i

237 R403Q myosin, recapitulated the ADP-induced destabilization of the SRX state.

238 hich involves Asp614(13-15) and leads to the destabilization of the structure of S2 proximal to the s

239 We show that this leads to specific destabilization of the supercomplex, and that changes in

240 gned mutations, we demonstrate that stepwise destabilization of the talin rod R3 subdomain decreases

241 on of inflammatory transcriptional programs, destabilization of the Treg lineage, and spontaneous inf

242 were significantly weakened by the mutation, destabilization of the TTT complex likely contributes to

243 t aggregation of the samples correlates with destabilization of the turn-like structure defined by ph

244 evidence that the kinesin-13 KLP-7 promotes destabilization of the whole cellular microtubule networ

245 Only destabilization of their 2H phase via external means, su

246 and that pathophysiology of HCM results from destabilization of these conformations.

247 Destabilization of this compartment through IRAP deletio

248 eted of METTL3, suggesting an m(6)A-elicited destabilization of this mRNA.

249 Destabilization of Tom1 VHS structure was also observed

250 r augmented by binding to 14-3-3, leading to destabilization of TOMM34's secondary structure.

251 Surprisingly, bile salt destabilization of ToxRp enhanced the interaction betwee

252 l-ligand covalency thus buffers the expected destabilization of transition-metal (TM)-silyl sigma*-or

253 dosis is an underdiagnosed disease caused by destabilization of TTR due to pathogenic mutations or ag

254 d increased benzene methylation barriers and destabilization of typical aromatic intermediates, where

255 erine/threonine protein kinase 3 (RIPK3) and destabilization of vascular endothelial cadherin (VE-cad

256 phosphate has a greater contribution to the destabilization of vulnerable particulate OM, while lime

257 Similarly, destabilization of wild-type E-S complexes by temperatur

258 y approaches, we assessed the impact of core destabilization on the intrinsic stability of the CA lat

259 alleles resulted in loss-of-function due to destabilization or altered function of subunits.

260 This paradox points to nucleosome destabilization or eviction as a defining feature of the

261 of the retrieval-extinction effect on memory destabilization or prediction error was investigated in

262 embly process through solvent evaporation or destabilization or through DNA-guided crystallization.

263 acellular signaling events causing desmosome destabilization, or both.

264 omplexes leads to slow but progressive nodal destabilization over 10 months, primarily affecting beta

265 standing of processes of C stabilization and destabilization over various timescales, soil types, and

266 in addition to the emulsions caused emulsion destabilization probably due to depletion or bridging ef

267 This memory destabilization process is regulated by protein degradat

268 n, and therefore a better assessment of this destabilization process is required to prevent loss of l

269 cells in the amygdala, indicating increased destabilization processes and cellular activity, and bot

270 Contrary to the destabilization proposed for Type-I X(2) interactions, B

271 sidence time on InhA due to transition-state destabilization rather than ground-state stabilization.

272 f which are established mechanisms of memory destabilization-reconsolidation.

273 Our results indicate that hPAC mediates the destabilization required for avoidance memory reconsolid

274 ARPIN-deficient cells, PACRG prevented LUBAC destabilization, restored HOIP-dependent linear ubiquity

275 t regions of stress-induced DNA double helix destabilization (SIDD)(2-4).

276 retrieval-extinction does not require memory destabilization, since behavioral or pharmacological int

277 The combination of chemical destabilization, size-selective precipitation, and low-t

278 er mechanisms of interface stabilization and destabilization that have not been discussed before for

279 supposed to be a major factor in microtubule destabilization, the binding of 14-3-3zeta to MAP2c enha

280 These results strongly suggest that Nox2 destabilization through disrupting TRPC3-Nox2 complex un

281 ractions with anionic membranes, 2) membrane destabilization through lipid extraction, and 3) membran

282 We also show that MPS destabilization through NMII inactivation affects axonal

283 ntagonizes subsequent HCMV-mediated vimentin destabilization, thus suppressing HCMV replication.

284 Second, both caused Lipoplex destabilization to release double- and single-strand siR

285 oviding an under-appreciated mechanism for C destabilization under elevated moisture.

286 luding that: (i) modifying the stem leads to destabilization unless adenosine is the opposing basepai

287 f [((ket)guan)Co(N(3))(py)](2) (4a) leads to destabilization via activation of the nitride unit, resu

288 lbicans, stress triggers adaptive chromosome destabilization via erasure a centromeric histone H3, CE

289 UHT milk destabilization was investigated during 90days of storag

290 The functional implication of such actin destabilization was manifested as an increase in specifi

291 Strong emulsion destabilization was observed, with smaller aggregates an

292 The destabilization was rescued by inhibition of ROCK and hi

293 n membranes less susceptible to HDP-mediated destabilization, we found that Chol does not affect the

294 Aberrant splicing and transcript destabilization were associated with 2 missense variants

295 Oxidative auto-inactivation and destabilization were observed in the absence of a suitab

296 Products of Lipoplex destabilization were separated, identified, and/or quant

297 ting silent synapse re-maturation within the destabilization window decreases cue-induced cocaine see

298 ter, defining the onset and termination of a destabilization window of cocaine memories.

299 g, respectively, the silent synapse-mediated destabilization window.

300 normal morphology, which undergo accelerated destabilization within a month, resulting in rapid volta