ライフサイエンスコーパス: destabilize

1 railty) may be inadvertently exacerbated and destabilized.

2 t or wet conditions the polymers are rapidly destabilized.

3 xposures (25 min) the s-MNPs/SOD1 dispersion destabilizes.

4 trostatic effects in the cavity are strongly destabilizing.

5 that mutualistic interactions are inherently destabilizing.

6 se protein aggregates, indicating that m-Tyr destabilized a large fraction of the proteome.

7 mic simulations, we found that this mutation destabilizes a critical ADD3-ACTIN binding site.

8 terminal trihelix DNA-binding domain (GTL1N) destabilizes a hydrophobic core of GTL1N and allosterica

9 The Clp protease system destabilizes a zinc-bound form of Mpy recruitment factor

10 tricts JNK activation by phosphorylating and destabilizing a small GTPase, Rho1.

11 r work reveals a novel function of NLRP10 in destabilizing Abin-1, resulting in enhanced proinflammat

12 exposure of a new N-terminal residue that is destabilizing according to the N-end rule.

13 y contrast, enhanced reversal performance by destabilizing action values.

14 the higher characteristic distortivity (more destabilizing activation strain) associated with this pa

15 steered to the S(N)2 reaction channel (less-destabilizing activation strain).

16 However, the mechanism underlying Polo-destabilizing activity remains elusive.

17 igosertib is responsible for the microtubule-destabilizing activity.

18 re larger than reduced alphaA-crystallin and destabilized against unfolding, are active chaperones an

19 one (abbreviated as QW-296), a novel tubulin destabilizing agent with little susceptible to transport

20 ity of the L240F TUBB mutant for microtubule-destabilizing agents has been confirmed independently.

21 early stage clinical trials with microtubule destabilizing agents, such as vintafolide and EC1456.

22 Clemastine destabilized all eight P. falciparum TRiC subunits based

23 we propose that the ability of FACT to both destabilize and assemble nucleosomes allows it to monito

24 disruption of the autoinhibited conformation destabilized and activated the TrioC module in vitro.

25 hat, under heme-deficient conditions, HO2 is destabilized and targeted for degradation, suggesting th

26 e process by which metastable aggregates are destabilized and transformed into the favored kagome lat

27 stent, but, on retrieval, become temporarily destabilized and vulnerable to disruptions, followed by

28 The shell hydrolyses into 'flocs' and destabilizes and enmeshes colloidal particles while the

29 hem1 catalysis of acyl-CoA, whereas 18:1 LPC destabilizes and inhibits activity, which we verify in c

30 r (FRET)-based assay to detect triplex/H-DNA-destabilizing and -stabilizing ligands.

31 those found on the protein surface were less destabilizing and potentially most favorable for therape

32 ese observations, OXPHOS supercomplexes were destabilized, and OXPHOS enzymatic activities were reduc

33 edominantly tetravalent lead (PbO(2)) scales destabilized as a result of disinfectant change.

34 Surprisingly, this disruption destabilizes astral microtubules, but not kinetochore-mi

35 d region (3'-UTR): introduction of copies of destabilizing AU-rich elements into the 3'-UTR or swappi

36 stabilisation of EGCG in NPs complexes and a destabilized BBB led to higher therapeutic EGCG concentr

37 s close to boiling point so can entropically destabilize biomacromolecular systems.

38 tochore-microtubule attachments that are not destabilized by Aurora B.

39 vely regulate plant freezing tolerance, were destabilized by cold stress in a phytochrome-dependent m

40 Networks were destabilized by glucose and stabilized by ketones, irres

41 are known to inhibit DNA replication unless destabilized by helicases, such as Bloom helicase (BLM).

42 ior, with a core region that was selectively destabilized by increasing temperature.

43 tor orbitals and occupied molecular orbitals destabilized by strong mixing between amido nitrogen ato

44 Peptoid folds are generally destabilized by the cis/trans backbone-amide isomerizati

45 we report that paused Pol II can be actively destabilized by the Integrator complex.

46 5,6), an injected monochromatic wave becomes destabilized by the interplay between the resonator disp

47 ower mantle by subducted oceanic lithosphere destabilizes carbon-bearing metals to form diamond, with

48 The core destabilizing cavity-creating I98A mutation apparently i

49 ct was hierarchical as removal of HVR1 fully destabilized closed conformations, irrespective of glyca

50 tioning of priority effects into fitness and destabilizing components can elucidate the pathways thro

51 that HIV-1 remains susceptible to the capsid-destabilizing compound PF74 following nuclear import, re

52 able, but as infection proceeds, vimentin is destabilized, concurrent with its phosphorylation and vi

53 Self-destabilizing conditionally stable motifs suggest a gene

54 tration of misfolded proteins due to protein-destabilizing conditions, as well as constitutively expr

55 Under mildly destabilizing conditions, these proteins were found to p

56 lters the ability of several stabilizing and destabilizing cosolutes to modulate protein folding ther

57 I from NADH, disrupt complex I activity, or destabilize cristae and inhibit NADH-dependent respirati

58 rease zinc affinity, but also mutations that destabilize DBD without impairing zinc binding.

59 und heterozygous WABS cases, each displaying destabilized DDX11 protein and residual DDX11 function a

60 If destabilized, decomposition of this vast C bank could ac

61 beneficial to protein function because they destabilize deleterious misfolded conformations and inte

62 Finally, blocking epidermal sheath formation destabilized dendrite branches and reduced nociceptive s

63 Naked/NKD destabilizes Dishevelled, which assembles Wnt signalosom

64 xcision repair on structurally diverse helix-destabilizing/distorting DNA lesions by selectively 'ope

65 establish whether a solute will stabilize or destabilize domain phase separation.

66 The binding of the new compounds to the destabilizing domain was determined using a fluorescence

67 Similarly, microtubule-destabilizing drugs abrogated LPS-induced IL18 expressio

68 A, by deficiencies in ADAR1 (which edits and destabilizes dsRNA), PDE12 or AKAP7 (which degrade 2-5A)

69 pe and content, all protein-XG foams at pH 3 destabilized due to large insoluble complexes, however,

70 vealed that non-enzymatic alphaTAT1 activity destabilizes dynamic microtubules but does not substanti

71 small-molecule inhibitors of filovirus entry destabilize EBOV GP and uncovered evidence that the most

72 in a global pandemic, affecting millions and destabilizing economies.

73 ividual species simultaneously stabilize and destabilize ecosystems along different dimensions of sta

74 Differential scanning fluorimetry shows a destabilizing effect induced by PGRN on proCTSD folding

75 The destabilizing effect is more pronounced when cysteine re

76 nctional MLH1 is required for the CAG repeat destabilizing effect of FAN1 loss.

77 er concentrations (>10 mol %), we observed a destabilizing effect of GMs on the phase coexistence.

78 The destabilizing effect of heparin is more pronounced in th

79 the increase of ethanol concentration had a destabilizing effect on the protein unfolding.

80 barriers to drug delivery, including severe destabilizing effects in the blood circulation, the bloo

81 tural mechanisms that underlie the potential destabilizing effects of additives like drugs, anti-oxid

82 meostasis is indispensable to counteract the destabilizing effects of Hebbian plasticity.

83 This allowed us to predict destabilizing effects of the G501R and G511R mutations a

84 e(II) in bulk electrolyte also significantly destabilizes electrolyte components with its unique solv

85 1-associated MB(SHH) were characterized by a destabilized Elongator complex, loss of Elongator-depend

86 Simultaneous reduction in activity of fat destabilizing enzymes (lipase and lipoxygenase), contami

87 s delays acute T-starvation; 2) T-starvation destabilizes even nonreplicating chromosomes, while T-hy

88 The destabilizing factor in fetal bovine serum, identified a

89 osphorylation and recruitment of microtubule destabilizing factors, leading to detachment of selfish

90 athway but modulate it differently to enrich destabilizing factors.

91 nic processing of APP impairs iron export by destabilizing ferroportin on the cell surface.

92 n pairwise species interactions, which could destabilize food webs at the higher organizational level

93 Strong memories do not destabilize, for instance, although why they are resilie

94 ata uncover a novel mechanism by which RFWD3 destabilizes forks in BRCA2-deficient cells.

95 of Ppm1 or the loss of the PP2A methylation destabilizes Gcn4 even when methionine is abundant, lead

96 d GFP, while deletion of the acidic residues destabilized GFP::SpxA1(tail) .

97 CCR5-bound conformation and may irreversibly destabilize gp41 to initiate fusion.

98 AD-causing mutations destabilize GSEC-APP/Abeta(n) interactions and thus enha

99 omising fitness in standard cell cultures, a destabilizing H1N1 HA stalk mutation greatly diminishes

100 These analyses suggest that Hap2-Ino80 destabilizes H3 nucleosomes on centromere DNA through tr

101 e, we investigated the mechanisms by which a destabilizing HA mutation, Y17H (activation pH, 6.0), at

102 e HA protein have suffered resistance due to destabilizing HA mutations that do not compromise replic

103 Linker domain contacts primarily function to destabilize Hb-heme interactions, thereby lowering Delta

104 hat binding of Era to the mature 30S subunit destabilized helix 44 and the decoding center preventing

105 chromatic domain would have the potential to destabilize heterochromatin.

106 or HilD, and altering translational fidelity destabilizes HilD protein via enhanced degradation by Lo

107 , loss of heme binding to the catalytic site destabilizes HO2.

108 ound that the extent to which guanidinium (a destabilizing Hofmeister cation), sulfate (a stabilizing

109 t, we design targeted protein mutations that destabilize homeodomain binding both in vitro and in viv

110 We found that disrupting these interactions destabilizes homodimerization of full-length PTPRJ in ce

111 s surface reaches temperatures sufficient to destabilize hydrated materials.

112 Although an Ala substitution locally destabilized hydrogen bonding and enhanced mobility, it

113 s simulations showed that specific mutations destabilize IL-11Ralpha and may have indirect effects on

114 hypoxia to activate anaerobic genes but are destabilized in normoxic conditions through the action o

115 Further, the 32-38 pair is destabilized in the context of a near-cognate codon-anti

116 Br) , which failed to interact with SKP1, is destabilized in vivo.

117 faces close to the (100) plane, the etch pit destabilizes in a second growth stage, by etching faster

118 wn how synovial lubricin is affected by knee-destabilizing injuries in large animals.

119 n-anticodon contexts and the lack of m(1)G37 destabilize interactions of tRNA(Pro) with the P site of

120 ch include stabilizing RNA conformations and destabilizing interactions with varied RNA-binding prote

121 Second, oxidation destabilizes intrapeptide interactions and expands bound

122 conserved histidine cluster within Axin, to destabilize it along with Dishevelled, possibly via the

123 -cleavage function of the ICA homo-trimer by destabilizing its homo-trimeric assembly.

124 regulates nonmuscle myosin IIA activity, and destabilizes kidney podocyte adhesion.

125 has been implicated in both stabilizing and destabilizing kinetochore-microtubule attachments.

126 We found that SS-31 binding does not destabilize lamellar bilayers even at the highest bindin

127 Identification of small molecules that destabilize latency and allow immune clearance of infect

128 tetramerization domain, thus disrupting and destabilizing LDH tetramers.

129 rme1(-/-)) mice, the BRCA2-MEILB2 complex is destabilized, leading to defects in DSB repair, homolog

130 cy for genes in a core developmental pathway destabilizes left/right identity.

131 oss the full TM region, whereas the fumarate-destabilized linker dimer converts the signal on the cyt

132 ome crowded, generating steric pressure that destabilizes lipid tubules.

133 In contrast, M3 receptor blockade destabilizes locomotor-related bursting.

134 While the Aurora B protein kinase destabilizes low-tension attachments by phosphorylating

135 h low-lying pai*-energy levels, sufficiently destabilize MC states and stabilize supermolecular MLCT

136 We collected uninjured and destabilized medial meniscus (DMM)-injured knees from 8-

137 of lin-65, but not arle-14, mislocalizes and destabilizes MET-2, resulting in decreased H3K9 dimethyl

138 le intracellular binding is tolerant of many destabilizing MHC-I substitutions.

139 es that modulate microtubule stability, both destabilize microtubules in cells and in vitro, and expr

140 Thus, rigosertib kills cancer cells by destabilizing microtubules, in agreement with our origin

141 e III clinical trials, kills cancer cells by destabilizing microtubules.

142 c precursor cells mimics H3.3K4M expression, destabilizes MLL3/4 proteins, and prevents adipose tissu

143 vents enhancer activation in adipogenesis by destabilizing MLL3/4 proteins but not other Set1-like H3

144 t 1400 degrees C) formed highly strained and destabilized MoAl(1-x)B, which was size-selectively prec

145 ogenic controls, we uncovered that TnT-R173W destabilizes molecular interactions of troponin with tro

146 ts (ARE), CCUC, and CUGC elements emerged as destabilizing motifs, with miR-430 and AREs causing mRNA

147 um stresses acting among self-propelled rods destabilize motility-induced phase separation and facili

148 Increasing the spacer length beyond 6 nt destabilizes mRNA-tRNA-ribosome interactions and results

149 y, an unstructured A-rich element in 5' UTRs destabilizes mRNAs in the absence of translation, althou

150 PARN knockdown destabilizes multiple miRNAs that repress p53 translatio

151 gher than that of WT virus revealed that the destabilized mutant virus triggered the upregulation of

152 Broadly, destabilized mutants had higher affinities for and were

153 The destabilizing mutation also increased early infectivity

154 dification can be tuned by the choice of the destabilizing mutation and does not interfere with rever

155 ve neurons in animals carrying a microtubule-destabilizing mutation in a tubulin subunit.

156 Amyloid fibril formation results from a destabilizing mutation in hereditary ATTR amyloidosis (h

157 combination of proteolytic cleavage and the destabilizing mutation trigger conformational changes th

158 All three clamps with destabilizing mutations had perturbed loading on DNA.

159 s limitation by harnessing gain-of-function, destabilizing mutations in MEK.

160 designing and characterizing stabilizing and destabilizing mutations in the clamp.

161 Here, we demonstrate that dMMR-induced destabilizing mutations lead to proteome instability in

162 predicts the effects of both stabilizing and destabilizing mutations, while most other methods exhibi

163 can stabilize antagonistic interactions and destabilize mutualistic ones; as a species or type becom

164 We validated compounds that stabilized or destabilized MYC and then focused on one compound, UNC10

165 Therapeutic approaches aiming to destabilize MYCN protein, such as small-molecule inhibit

166 Aurora kinase A inhibition also destabilized MYCN, which is both a functionally importan

167 gnificance, we showed that the variants that destabilized myosin conformations were associated with h

168 de can act, in cognate sequence contexts, as destabilizing N-terminal residues.

169 bilizing negative charge on the pyridine and destabilizing negative charge on the anthracene will fav

170 Knocking out Larp4 in mice destabilized Nfkappab1 mRNAs and reduced secretion of in

171 We propose that DELLAs are destabilized not only by the canonical GA-dependent path

172 t step, already before ZGA, Pou5f3 and Nanog destabilize nucleosomes at HNAR centers genome-wide.

173 scription elongation factor whose ability to destabilize nucleosomes promotes RNAPII progression on c

174 GC-rich sequences were destabilizing of reporter mRNAs and come from more rapid

175 Context-drug associative memories become destabilized on retrieval and must be reconsolidated int

176 RNA duplexes are destabilized, on average, 1.02 kcal/mol in the presence

177 s received deleterious scores by potentially destabilizing or preventing the disulfide bond formation

178 s, the PC-containing inner leaflet tended to destabilize ordered domain formation in the SM+PC-contai

179 ble into inclusion bodies (IBs), whereas the destabilizing osmolyte urea does not.

180 se phenotypes were dependent on beta-HPV 8E6 destabilizing p300 and did not completely attenuate the

181 annually, with the persistent potential for destabilizing pandemics.

182 d calcium were found to permeate through the destabilized PbO(2) material and react with divalent lea

183 the effect of this treatment chemical on the destabilized PbO(2) scales was examined.

184 c-Cbl destabilized PD-1 through ubiquitination- proteasomal de

185 nitrations of CYP2B6 would cause significant destabilizing perturbations of secondary structure and r

186 t the three lysines in the lyase active site destabilize pol beta when bound to DNA nonspecifically,

187 reasingly frequent rain-on-snow events could destabilize populations.

188 alcifications in atherosclerotic plaques are destabilizing, predict adverse cardiovascular events, an

189 out exposure to conventional detergents that destabilize protein structures and induce fibrillization

190 actin filament fragmentation by other actin-destabilizing proteins.

191 xes and that its activation is sufficient to destabilize PV cell connectivity and to restore cortical

192 as transient replication blocks, most genome-destabilizing replication fork stalling likely occurs be

193 previous candidates that were susceptible to destabilizing resistance mutations.

194 ve the physiological level, highlighting the destabilizing role played by electrostatic interactions

195 contacts from the N3 subsite play a similar destabilizing role, but also form a bridge through which

196 tion of native MS, native top-down MS, MS of destabilized samples, and liquid chromatography MS, we i

197 rt chain (ETC) complexes III, IV, and V, and destabilizing sarcoendoplasmic reticulum Ca(2+)-ATPase 2

198 of key morphogenetic regulators, while also destabilizing sentinel mRNAs that are primed to activate

199 ion of the irreversible inhibitor moxalactam destabilized several mutants, and these typically bound

200 that several kinases in the MEK/ERK2 pathway destabilize Shank3 and that genetic deletion and pharmac

201 in human cancers, and inactivation of OTUB1 destabilized SLC7A11 and led to growth suppression of tu

202 brane has a 25% lower bending rigidity, thus destabilizing smooth [Formula: see text]um curvature rad

203 two further multimeric forms comprising the destabilized spike attached to Fab.

204 g showed reduced dendritic spine density and destabilized spines of hippocampal pyramidal neurons 4 w

205 roblasts, we validated that the R38Q variant destabilizes SSBP1 dimer/tetramer formation, affects mtD

206 states susceptible to aggregation, including destabilized states related to cellular stress.

207 -d(8)/D(2)O); its longevity is correlated to destabilizing steric clash between substituents upon rin

208 chaperones and can transfer the disulfide to destabilized substrate proteins.

209 demonstrate that EEFs more readily stabilize/destabilize systems with larger, more polarizable, dipol

210 designed mutation (F349A), which selectively destabilizes Syt1 oligomerization.

211 rotein accumulates in the light but does not destabilize target proteins before dusk.

212 anonical polymerase that oligoadenylates and destabilizes telomerase RNA component (TERC).

213 th genetic depletion, we discovered that p53 destabilized TET2 at the protein level by promoting its

214 ignaling mechanism similar to shade, as both destabilize the active form of the photoreceptor and the

215 An alternative approach is to destabilize the amyloid beta precursor protein (APP) fro

216 ein are significantly altered such that they destabilize the CaM N-domain.

217 /- 66 degrees , N = 89) of only a few bursts destabilize the cell-swimming direction.

218 s do promote cSCCs, they are hypothesized to destabilize the cellular genome.

219 otrophy) may feed back to the atmosphere and destabilize the climate, triggering a transient global g

220 phosphorylation and oxidation of the protein destabilize the closed state of the channel, resulting i

221 Ai exclusive to the open complex that should destabilize the closed state.

222 ed mutants in the N-terminal domain strongly destabilize the coiled-coil structure.

223 mutational stress result in the events that destabilize the DBD and initiate unfolding.

224 hobic core of the transmembrane, which could destabilize the domain and thus impair either its assemb

225 distant sites, circulating tumor cells must destabilize the endothelial barrier and transmigrate acr

226 TNF-alpha did not destabilize the Fbxl2 transcript (half-life [t (1/2)], ~

227 rged glutamate residue at position 787 could destabilize the finger domain of UL54 DNA polymerase.

228 Instead, they may destabilize the genome in the early stages of cancer dev

229 activation and phosphorylation allows it to destabilize the hub, producing smaller assemblies that m

230 e SNARE motifs and the membranes, helping to destabilize the hydrophilic-hydrophobic boundary in the

231 upting constitutive ANGPT1-TIE2 signaling to destabilize the microvasculature during pathologic disor

232 irment together with elevated calcium burden destabilize the mitochondrial antioxidant defense only i

233 Mutations that destabilize the packing of the domain's hydrophobic core

234 ant from free chlorine to monochloramine can destabilize the PbO(2(s)) and result in dramatic increas

235 aborating with the mRNA decay factor KSRP to destabilize the PGC-1alpha mRNA.

236 Disease-mutations disrupt catalysis or destabilize the protein fold.

237 Modelling revealed that the mutations will destabilize the protein structure by varying extents con

238 nd in vitro assays suggest that both alleles destabilize the protein.

239 that ANGPTL4 and VEGF act synergistically to destabilize the retinal vascular barrier.

240 ted to compromise inter-protein contacts and destabilize the small subunit.

241 structures describe ACE2-binding events that destabilize the spike trimer, progressively opening up,

242 ight chains, and an increased ADP:ATP ratio, destabilize the SRX population.

243 components of the reaction do not affect or destabilize the supramolecular polymer, whereas in ambie

244 ative interactions with mutations in U3 that destabilize the U3/pre-rRNA base-pair interactions or re

245 Five variants destabilized the catalytic domain-fold as assessed by lo

246 lu-83 in subunit g (gGlu-83) with Ala or Lys destabilized the digitonin-extracted F-ATP synthase, res

247 d the stimulatory effect of SIRT6 on NER and destabilized the genome due to (i) partial loss of enzym

248 from the lumen of the connecting cilium (CC) destabilized the photoreceptor axoneme and reduced the C

249 kidney epithelial MDCK II cells mechanically destabilizes the acinus.

250 Water destabilizes the adsorbed H atoms, decreasing the heat o

251 eyond the chromosome, T-hyperstarvation also destabilizes the cell envelope.

252 at variants of the TOP domain finger 1 motif destabilizes the channel structure and impairs channel o

253 of VPA, indicated that the drug binds to and destabilizes the channel, but not the pore-only construc

254 ion of the Pol delta accessory subunit POLD2 destabilizes the complex, resulting in degradation of bo

255 In the monomer the extended C terminus destabilizes the core domain to produce highly extended

256 Thermodynamic studies showed that AP destabilizes the duplex, enabling a structural transitio

257 Aggregated alpha-syn destabilizes the G4Q leading to unfolding.

258 tion of G-quadruplexes using small molecules destabilizes the i-motifs, and vice versa, indicating th

259 sis state of RagC, which explain how SLC38A9 destabilizes the LFC and so promotes Rag dimer activatio

260 solute carrier family 38 member 9 (SLC38A9) destabilizes the LFC and thereby triggers GAP activity o

261 all drug-like isothiourea derivative-rapidly destabilizes the oligomeric structure, whereas AMD3100,

262 In conclusion, Nutlin-3 fully destabilizes the p53-MDM2-MDM4 complex and synergizes wi

263 ion indicate that a ribose 2'-hydroxyl group destabilizes the pai-pai stacking of the target cytosine

264 HopO1-1 physically interacts with and destabilizes the plant PD-located protein PDLP7 and poss

265 The mutation destabilizes the Poldelta complex, leading to ineffectiv

266 m1 VHS, suggesting that the phosphoinositide destabilizes the protein domain.

267 turnover is rapid, and hyperglycemia further destabilizes the protein.

268 rize hGBP1 as an LPS-binding surfactant that destabilizes the rigidity of the outer membrane to exert

269 etion of Bud4 or its Bud3-interacting domain destabilizes the transitional hourglass, especially at t

270 modeling also allows the role of heparin in destabilizing the ACE2/RBD association to be studied, pr

271 tent with a model where resistance occurs by destabilizing the closed conformation of the active site

272 SH2 domain, drives spurious BTK activity by destabilizing the compact autoinhibitory conformation of

273 Destabilizing the GFP by circular permutation allows deg

274 r helix, populating the ON state, relatively destabilizing the OFF state.

275 ntermediate) state is stabilized rather than destabilizing the open (active) state.

276 proteins undetectable in the same cells and destabilizing the ORC1, ORC3, and ORC4 proteins.

277 e a mechanism whereby PGRN binds to proCTSD, destabilizing the propeptide from the enzyme catalytic c

278 Destabilizing the scanning complex results in misinitiat

279 ed the development of Chinese civilizations, destabilizing the topsoil and thereby increasing the dus

280 determined by strong C3/P-[1,2] interactions destabilizing the transition state of olefination.

281 pidly and directly interacting with virions, destabilizing the viral envelope, and driving virus aggr

282 cutely aware of how participation might have destabilized their surgical identity because they might

283 f cations that can enter their cages without destabilizing their overall structure.

284 he molecular regions that can be targeted to destabilize them.

285 ics in some dimensions, while simultaneously destabilizing them in others.

286 RX conformation, whereas pathogenic variants destabilized these and increased the proportion of myosi

287 gating and provide evidence that VS movement destabilizes these interactions to promote channel openi

288 ytoplasmic domain, and signaling inputs that destabilize this domain (ligand binding and demethylatio

289 r alternative splicing are all sufficient to destabilize this local structure and trigger spontaneous

290 zing mutations rescue the expression of TCRs destabilized through variable domain mutation.

291 Preventing Canoe tyrosine phosphorylation destabilizes tricellular adhesion, and anchoring Canoe a

292 mpared to wild type TOC159, TOC159K1370R was destabilized under UPS-inducing stress conditions.

293 tside the Ure2 prion-determining region that destabilize [URE3].

294 o Finally, siRNA-mediated knockdown of wdr48 destabilizes USP46 in mammalian cells.

295 ysis showed the largest perturbations in the destabilized variants, consistent with the observed chan

296 Subsequently, these activated peptidases destabilize various positive growth regulators.

297 The resulting destabilized vesicles are concentrated, introduced into

298 Interestingly, the alphaC helix is destabilized when the activation loop is fully phosphory

299 Changes in cortical excitation destabilized within-trial memory maintenance and could n

300 XPGcat, and both XP-G and XP-G/CS mutations destabilize XPG and reduce its cellular protein levels.